Clinical trials: Generalized Chronic Periodontitis
Diabetes Mellitus Type 2
Oxidative Stress Markers Evaluation Before and After Periodontal Treatment of Diabetics Type 2 Patients
Abstract Diabetes mellitus and periodontal diseases are both chronic inflammatory disorders that have a major impact on the health and well being of millions of individuals worldwide.
- Trial name
- NCT01475435
- Testing
- non- surgical periodontal treatment, Prophylaxis
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Chronic Kidney Disease, Chronic Periodontitis, Generalized, Moderate
Dental Intervention Plan for Chronic Kidney Disease Patients Awaiting or With Kidney Transplant
The study aims to understand why dental infections in end-stage kidney patients results in poor outcomes for kidney functions and eventually transplant.
- Trial name
- NCT04020458
- Testing
- dental intervention
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Augusta University
Chronic Periodontitis, Generalized
Clinical Effects of Limosilactobacillus Reuteri Probiotics as an Adjunct to the Treatment of Periodontitis
The purpose of this study is to evaluate the clinical efficacy of a probiotic lozenge containing Limosilactobacillus reuteri as an adjunct to the periodontal non-surgical treatment of patients with stage II, grade A, B and C…
- Trial name
- NCT05734274
- Testing
- Probiotics, Negative control
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Universidade do Porto
Generalized Chronic Periodontitis
Garcinia Mangostana L.Pericarp Gel as a Local Drug Delivery in Treatment of Chronic Periodontitis
A single-center, randomized controlled clinical trial was done to assess the periodontal status of the individuals and the presence of red complex microorganisms (RCM) such as Treponema denticola, Porphyromonas.gingivalis and…
- Trial name
- NCT02880397
- Testing
- Garcinia mangostana
- Volunteers
- 50 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Periodontal Diseases, Periodontitis
Interaction Between Immune Cells and Bacteria Associated With Periodontitis
This study evaluates the interaction between host immune cells and bacteria associated with periodontitis. It comprises biological material from donors with and without periodontal disease.
- Conditions
- Periodontal Diseases, Periodontitis, Aggressive Periodontitis, Immunologic Disease
- Trial name
- NCT03225950
- Testing
- In vitro stimulation of blood with periodontitis-associated- and control bacteria, Anti-CCP- and anti-P.g.-antibodies titers, Analysis of selected single nucleotide polymorphisms (SNPs)
- Where
- 2 sites in Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Periodontitis Chronic Generalized Severe
Contribution of an Antiviral Drug (Valaciclovir) in the Treatment of Generalized Periodontitis (Stage III or IV and Grade A, B or C): Prospective, Randomized and Double Blind Clinical Trial
Periodontitis is an inflammatory pathology that destroys periodontitis and causes tooth loosening. Its high incidence, combined with very high oral and systemic morbidity, places this pathology at the heart of global public…
- Trial name
- HERPARO (NCT05902208)
- Testing
- Antiviral treatment with conventional non-surgical treatment
- Where
- 3 sites in France
- Volunteers
- 142 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Generalized Periodontitis
Moxifloxacin in Situ Gel to Treat Periodontal Pocket.
In this Randomized clinical trial locally delivered moxifloxacin in situ gel was evaluated as an adjunct to scaling and root planing for efficacy in the treatment of chronic periodontitis and for short-term effects on the…
- Trial name
- NCT02016157
- Testing
- Moxifloxacin
- Where
- India
- Volunteers
- 5 people
- Sponsor
- Sri Hasanamba Dental College and Hospital
Generalized Chronic Periodontitis
Erbium Chromium: YSGG Laser Effect on Surgical Treatment of Chronic Periodontitis
Microbiological and Clinical assessment of Er,Cr:YSGG laser in conjunction to open flap debridement (OFD) in treatment of chronic periodontitis through real time PCR assay for quantification of total bacterial load.
- Trial name
- NCT03810560
- Testing
- laser device Er,Cr:YSGG laser
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- alaa
Periodontal Diseases
Quantification of CD163 Inflammatory Biomarker in Chronic Periodontitis and Diabetic Subjects
The quantification of CD163 will be analysed in the subgingival plaque samples of generalized chronic periodontitis patients with and without diabetes mellitus.
- Trial name
- NCT03727035
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Generalized Chronic Periodontitis, Osteoporosis
A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis
Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.
- Trial name
- CTROP (NCT02273128)
- Testing
- CTR Gene
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Periodontitis Chronic Generalized Severe, Periodontitis Chronic Generalized Moderate
Scaling and Root Planning With Localized Delivery of Autogenous Growth Factors- Platelet Rich Fibrin (PRF)
The purpose of this research study is to find out about the effect of growth factors extracted from blood on improving healing of periodontal pockets (Gum pockets) after deep gum cleaning.
- Trial name
- NCT04978324
- Testing
- leukocyte platelet rich fibrin (L-PRF), Scaling and Root Planing
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Periodontitis Chronic Generalized Moderate, Periodontitis Chronic Generalized Severe
Regular Home-use of Dual-light Photodynamic Therapy in the Management of Chronic Stage III-IV Periodontitis
This study is designed to determine the efficacy of the Lumoral method in chronic periodontitis with a targeted group of stage III and IV periodontitis.
- Trial name
- NCT05698823
- Testing
- Lumoral Treatment
- Where
- Lithuania
- Volunteers
- 56 people
- Sponsor
- Koite Health Oy
Periodontitis Chronic Generalized Severe, Hyperlipidemia
Effects of Non-surgical Periodontal Therapy on Severe Periodontitis and Hyperlipidemia
This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia.
- Conditions
- Periodontitis Chronic Generalized Severe, Hyperlipidemia, Gingival Crevicular Fluid, Serum
- Trial name
- NCT05548933
- Testing
- non-surgical periodontal therapy
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Generalized Aggressive Periodontitis, Chronic Periodontitis
Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods
Generalized aggressive Periodontitis (GAgP) and chronic periodontitis (CP) are inflammatory diseases. Little is known about molecular changes and signaling cascade of host response.
- Trial name
- NCT04026828
- Testing
- Periodontitis Group
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Chronic Periodontitis
Serum TRAP-5b Levels in Patients With Generalized Chronic Periodontitis
To compare the effect of non-surgical periodontal therapy with or without systemic administration of amoxicillin and metronidazole on the concentration of serum levels of TRAP-5b in patients with generalized chronic periodontitis.
- Trial name
- NCT03043066
- Testing
- Scaling and root planing, scaling and root planing along with antibiotic intervention
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Generalized Adult Periodontitis
Serological Evaluation of 77A/G and 11A/12A Gene of MMP-13 in Periodontitis Affected and Healthy Individuals
50 periodontitis 50 healthy individuals serological evaluation will done to see association of 77A/G AND 11A/12A gene polymorphisms of MMP-13
- Trial name
- SEGPPAH (NCT02423304)
- Testing
- blood samples collected from all patients
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Periodontitis Chronic Generalized Moderate, Periodontitis Chronic Generalized Severe
Clinical Evaluation of Laser Therapy Used as an Adjunct to Non-Surgical Treatment of Gum Disease
The use of lasers to treat various problems in dentistry is growing as it has in medicine. One application is the use of lasers to treat periodontal disease.
- Trial name
- NCT04027686
- Testing
- Laser Therapy, Non-surgical Scaling and Root Planing
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cyclooxygenase Two Inhibitors, Etoricoxib
EFFECT OF SELECTIVE COX-2 INHIBITOR (ETORICOXIB) ALONG WITH SCALING AND ROOT PLANING (SRP) ON CLINICAL PARAMETERS AND SALIVARY LEVEL OF SUPEROXIDE DISMUTASE IN CHRONIC GENERALIZED PERIODONTITIS A DOUBLE-BLIND, PLACEBO-CONTROLLED, DOUBLE-MASKED RANDOMIZED CONTROLLED TRIAL (RCT).
The hypothesis is that Etoricoxib act as an adjuvant to SRP in alleviating periodontal inflammation by: 1. improving clinical periodontal parameters and, 2. improving the salivary SOD levels.
- Conditions
- Cyclooxygenase Two Inhibitors, Etoricoxib, Periodontitis, Superoxide Dismutase
- Trial name
- NCT02149758
- Testing
- Etoricoxib
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tatyasaheb Kore Dental College
Periodontal Diseases, Coronary Disease
Quantification of Micro-RNA 146-a in Chronic Periodontitis and Coronary Heart Disease Subjects
The expression and quantification of Micro-RNA 146-a, was analyzed in the subgingival plaque samples of generalized chronic periodontitis patients with and without coronary heart disease.
- Trial name
- NCT03721159
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Periodontitis Chronic Generalized Moderate
Cymbopogon Citratus Gel as Local Drug Delivery Agent in Reducing Matrix Metalloproteinase-8 Levels Intra-crevicularly in the Treatment of Stage II Periodontitis
Background: Phytotherapeutics is widely used nowadays as an adjunct to scaling and root planing (SRP) to modulate inflammatory host response and eradicate microbes.
- Trial name
- NCT05241509
- Testing
- Cymbopogon citratus (lemongrass) oil gel
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Souzy Kamal