Clinical trials: Generations
Non-Small Cell Lung Cancer, Non-squamous Non-small-cell Lung Cancer
NGS Screening Protocol to Detect Mutation of KEAP1 or NRF2/NFE2L2 Genes for the KEAPSAKE (CX-839-014) Trial
This is a multicenter screening protocol designed to identify patients with NSCLC who have tumor mutations in the KEAP1 or NRF2/NFE2L2 genes in order to determine potential eligibility for a biomarker selected clinical trial…
- Conditions
- Non-Small Cell Lung Cancer, Non-squamous Non-small-cell Lung Cancer, Non-Squamous Non-Small Cell Neoplasm of Lung, KEAP1 Gene Mutation
- Trial name
- NCT04698681
- Where
- 63 sites in United States
- Volunteers
- 20 people
- Sponsor
- Calithera Biosciences, Inc
Tooth Hypersensitivity
A Clinical Study for the Effect of 4th Generation Poly AmidoAmine Dendrimer on Post-Bleaching Hypersensitivity and Shade Stability
This study assessed the impact of four desensitizing agents on both color stability and dental sensitivity following a bleaching procedure, spanning from the 24-hour to the 1-year follow-up assessment periods.
- Trial name
- NCT06358911
- Testing
- Poly amido amine dendrimer (PAMAM), Manufacturer's desensitizing agent, Ultra EZ, MI paste plus, desensitizing agent
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Sickle Cell Disease
Synthetic Generation of Hematological Data Over Federated Computing Frameworks: SCD Use Case
Haematological diseases (HDs) are a large group of disorders resulting from quantitative or qualitative abnormalities of blood cells, lymphoid organs and coagulation factors.
- Trial name
- SYNTHEMA (SCD) (NCT06794281)
- Testing
- Generate synthetic multimodal (clinical, omics and imaging) data for rare haematological diseases with a validated clinical result
- Where
- 3 sites in Italy, Netherlands and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Gestational Diabetes, GDM
Genetic Causes of Gestational Diabetes in the Emirati Population
The study aims to identify the number of MODY patients to be found among Emirati women with GDM as the incidence and prevalence of monogenic diabetes among this group of patients is unknown.
- Conditions
- Gestational Diabetes, GDM, Maturity-onset Diabetes of the Young, MODY
- Trial name
- NCT03589092
- Testing
- Next generation sequencing (NGS)
- Where
- United Arab Emirates
- Volunteers
- 600 people
- Sponsor
- Imperial College London Diabetes Centre
Primary Melanoma of the Extremity
The Registry Study of Genetic Alterations of Melanoma in Taiwan
Cutaneous melanoma is the most aggressive malignancy in skin cancers. Cutaneous melanoma is a rare disease in Taiwan with an incidence rate of around 1/100,000.
- Trial name
- Melanoma (NCT06952400)
- Where
- 16 sites in Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Fever
Ear Temperature as Predictor of Rectal Temperature Measured With Modern Devices in the Emergency Department.
Ear thermometers are often requested to be used rather than rectal thermometer (gold standard) for measuring the body temperature, as this method is faster and more user friendly.
- Trial name
- NCT02977481
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- University of Southern Denmark
Portable Ultrasound
Exploring New and Next Generation Ultrasound Technologies for Medical Education, Patient Care, and New Indications
This is a Phase I study to assess feasibility. There will be no impact on clinical care based on this study. The ultrasound system is FDA approved and could be used for clinical care independent of this research study.
- Trial name
- NCT03486444
- Testing
- Phillips Lumify Diagnostic Ultrasound System, Surveys
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Cincinnati
Cardiovascular Diseases, Type 2 Diabetes Mellitus in Obese
Implementation of a Peer Leader-facilitated Dyadic Intervention
This Pilot Study Large Application builds upon the results of our prior work to 1) Implement and pilot test a peer leader-facilitated 12-week dyadic intervention (Community Health among Asian Indian immigrants (CHAI) Dyad study)…
- Conditions
- Cardiovascular Diseases, Type 2 Diabetes Mellitus in Obese, Hyperlipidemias
- Trial name
- NCT06643806
- Testing
- CHAI dyad study
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Chronic Liver Disease
Validation of the Second Generation of the Controlled Attenuation Parameter (CAP) Using the MRI-PDFF as Reference
Chronic liver diseases (CLDs) represent a major worldwide public health burden. Worldwide estimations show that 844 million people have CLDs, a lot more than other chronic diseases such as diabetes or cardiovascular diseases.
- Trial name
- NCT03704792
- Testing
- FibroScan 530 Compact
- Where
- 5 sites in France
- Volunteers
- 207 people
- Sponsor
- Echosens
Gastro-entero-pancreatic Neoplasms
Generation of Organoids of Neuroendocrine Neoplasms of the Gastro-Entero-Pancreatic Tract Obtained From Patients Undergoing Surgery
Observational, prospective, feasibility pilot study of the preparation of organoids starting from tumor tissue and surrounding healthy tissue, collected during surgery, performed according to standard clinical practice.
- Trial name
- NCT06519500
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Regina Elena Cancer Institute
Exhaled Breath Condensate, Athlete
Small RNA Profiling in EBC in Athletes
Background: Exhaled breath condensate (EBC) is a non-invasively collected biofluid containing volatile and non-volatile compounds, including small RNAs.
- Conditions
- Exhaled Breath Condensate, Athlete, RNA Profile, Cardio-pulmonary Function
- Trial name
- AirBiopsy (NCT07324252)
- Where
- Poland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Prostate Cancer, Metastatic Prostate Cancer
Dapagliflozin Combined With Next-generation Hormonal Agent (NHA) Versus Single NHA in Participants With Metastatic Castrate-resistant Prostate Cancer
Dapagliflozin is a well-established medication being marketed and used for treatment Type 2 diabetes mellitus (T2DM). In retrospective cohort studies done by our team, we found that metastatic prostate cancer patients who…
- Trial name
- NCT07310433
- Testing
- Dapagliflozin (10mg Tab), standard medical care (ADT + NHA)
- Where
- 2 sites in China
- Volunteers
- 68 people
- Sponsor
- Yung NA
Platelet Function Tests, Thrombin Generation Tests
Point-of-care Assessment of Thrombin Generation and Platelet Function in Children Requiring Cardiopulmonary Bypass
Coagulopathy after cardiopulmonary bypass (CPB) is associated with increased morbidity and mortality. Clot formation and clot stability are important factors in coagulation and hemostasis.
- Conditions
- Platelet Function Tests, Thrombin Generation Tests, Perioperative Coagulopathy
- Trial name
- NCT02833025
- Testing
- Thrombin generation and Platelet Function Testing
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- The Hospital for Sick Children
Cocaine Use Disorder
Temporal Window and Episodic Future Thinking in CUD
The primary objective is to test the theory of Reinforcer Pathology via manipulation of the temporal window with successive Episodic Future Thinking generation in individuals with cocaine use disorder.
- Trial name
- NCT05507814
- Testing
- Episodic Future Thinking (EFT), Control Episodic Thinking
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Virginia Polytechnic Institute and State University
Bacteremia
Temocillin vs Meropenem for the Targeted Treatment of Bacteraemia Resistant to Third Gen Cephalosporins
A Phase 3, Multicenter, Randomised, Controlled, Open-Label Study to demonstrate noninferiority of temocillin (unauthorized investigational medicinal product IMP in Spain, but authorized in Belgium and UK) vs a carbapenem…
- Trial name
- ASTARTÉ (NCT04478721)
- Testing
- Temocillin, Meropenem
- Where
- 29 sites in Spain
- Volunteers
- 334 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Persistent Pulmonary Hypertension of the Newborn, Hypoxic Respiratory Failure
Post Market Clinical Follow-up to Assess the Portable Nitric Oxide Generation and Delivery System (INOwill N200) for the Treatment of Neonatal Hypoxic Respiratory Failure Complicated by Pulmonary Hypertension
Title : A multicenter clinical trial of the portable nitric oxide generation and delivery system (INOwill N200) for the treatment of neonatal hypoxic respiratory failure complicated by pulmonary hypertension Investigational…
- Trial name
- iNOwill Neonat (NCT07837921)
- Testing
- Nitric Oxide Generator and Delivery System
- Volunteers
- 50 people
- Sponsor
- Novlead Inc.
Metastatic Cancers
Phase II/Pilot Study of 2nd Generation Anti-CEA Designer T Cells in Adenocarcinomas
T cells can penetrate virtually every biologic space and have the power to dispose of normal or malignant cells as seen in viral and autoimmune diseases and in the rare spontaneous remis-sions of cancer.
- Trial name
- NCT01723306
- Testing
- Gene Modified T Cells
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Roger Williams Medical Center
Lung Cancer Stage IV
Lung Cancer Next Generation Sequencing Using the Oncomine Comprehensive Assay
Currently, publicly funded standard of care testing in Ontario for stage IV lung cancer patients uses individual gene tests to look for mutations in the EGFR and ALK genes.
- Trial name
- LU-NGS-2 (NCT03558165)
- Testing
- Oncomine Comprehensive Assay
- Where
- Canada
- Volunteers
- 134 people
- Sponsor
- University Health Network, Toronto
Preterm Birth
Study of the Risk of PREMaturité According to the Balance of Bacterial Flora VAginale
Objective To compare vaginal microbiota in the first trimester of pregnancy between spontaneous preterm and term deliveries
- Trial name
- PREMEVA2 (NCT03618836)
- Testing
- Microbiological and biological patterns on vaginal samples
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Lille
Lymphoma
A Study of IXAZOMIB in Adult Patients With Lymphoma
This study is an open-label, multicenter, phase 1, dose-escalation study of IXAZOMIB in adult patients with lymphoma. This study will be the first to administer IXAZOMIB to patients with lymphoma.
- Trial name
- NCT00893464
- Testing
- IXAZOMIB
- Where
- 7 sites in United States, Canada
- Volunteers
- 31 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
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