Clinical trials: Generations
Amputation Wound, Peripheral Arterial Disease
Wound Imaging Study to Gather Clinical References for a Device to Assist Selecting Level-of-amputation in PAD Patients
This is a proof-of-concept study to collect images to train a CADe algorithm to predict the correct level of amputation in individuals scheduled for amputation secondary to PAD.
- Trial name
- WISCR (NCT03611361)
- Testing
- SpectralMD DeepView Wound Imaging System 2.0
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- SpectralMD
Coronary Artery Disease, Coronary Restenosis
DEB Versus 2nd Generation DES in Patients With In-Scaffold Restenosis of Bioresorbable Vascular Scaffold
The aim of the study is to compare angiographic outcomes following revascularization using drug-eluting balloon (DEB) versus 2nd generation drug-eluting stent (DES) in treatment of Bioresorbable Vascular Scaffold Restenosis.
- Trial name
- SMART-BRS-ISR (NCT03074305)
- Testing
- PCI for in-bioresorbable scaffold stenosis
- Where
- South Korea
- Sponsor
- Samsung Medical Center
Chronic Myeloid Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Study to Evaluate Tolerability, Safety, Pharmacokinetics and Preliminary Efficacy of PF-114 for Oral Administration in Adults With Ph+ Chronic Myeloid Leukemia, Which is Resistant to the 2-nd Generation Bcr-Abl Inhibitors or Has T315I Mutation in the BCR-ABL Gene
A multicenter, open label cohort Phase 1 dose finding study to evaluate tolerability, safety, pharmacokinetics and preliminary efficacy of PF-114 for oral administration in adult patients with Philadelphia chromosome positive…
- Trial name
- NCT02885766
- Testing
- PF-114
- Where
- 3 sites in Russia
- Volunteers
- 65 people
- Sponsor
- Fusion Pharma LLC
Trained Immunity, BCG Vaccine
BCG-induced Epigenetic Modifications in the NEXT Generation
Non-specific protective effects resulting from the BCG vaccine appear to be paternally inheritable. Since the BCG vaccine is known to induce trained immunity, epigenetics might explain the fathers' contribution to the immune…
- Conditions
- Trained Immunity, BCG Vaccine, Epigenetics
- Trial name
- NEXT (NCT05766345)
- Testing
- BCG-Vaccine SSI [Statens Serum Institut]) Danish strain 1331
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Lifestyle
Do Cardiac Health: Advanced New Generation Ecosystem
The primary objective of Do CHANGE is to develop a health ecosystem for integrated disease management of citizens with high blood pressure and patients with ischemic heart disease or heart failure.
- Trial name
- Do CHANGE (NCT02946281)
- Testing
- Do CHANGE
- Where
- 2 sites in Netherlands, Spain
- Volunteers
- 149 people
- Sponsor
- Elisabeth-TweeSteden Ziekenhuis
Postoperative Complications, Rehabilitation
Pulmonary Expansion Device in Tracheostomized Patients Therapies in Tracheostomized Patients
The goal of this clinical trial is to evaluate the safety and efficacy of using PED (Pulmonary Expansion Device) in tracheostomized patients requiring lung reexpansion therapy within a single institution.
- Conditions
- Postoperative Complications, Rehabilitation, Postoperative Care
- Trial name
- PEDTRAQ (NCT06075381)
- Testing
- Pulmonary Expansion Device (PED), Conventional management
- Volunteers
- 50 people
- Sponsor
- Fundacion Clinica Valle del Lili
Gender Dysphoria, Adult, Blood Coagulation
Comparing the Effects of Sublingual Estradiol Treatment Versus Oral Estradiol With Cyproterone Acetate (CPA) Treatment on The Coagulation System in Transgender Women: A Prospective, Controlled Cohort Study
The goal of this clinical trial is to learn about the effects of different routes of estradiol administration on blood clotting in transgender women starting gender-affirming hormone therapy.
- Conditions
- Gender Dysphoria, Adult, Blood Coagulation, Coagulation Factors, Transgender Persons, M01.777.500
- Trial name
- NCT07145281
- Testing
- Estradiol (E2), Cyproterone Acetate (Androcur, BAY94-8367)
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Acute Lymphoblastic Leukemia
Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL) Patients
This is a prospective data collection study evaluating the feasibility of using the ChromoSeq® assay for upfront classification in a real-time clinical setting of pediatric and young patients suspected of having ALL.
- Trial name
- NCT07313592
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Infertility, Implantation Rate
Hyaluronan-enriched Medium and Euploid Blastocyst Transfers
It has been proposed that enriching transfer media with hyaluronan (EmbryoGlue medium) improves pregnancy outcomes compared with media containing lower concentrations of this molecule.
- Conditions
- Infertility, Implantation Rate, Clinical Pregnancy Rate, Live Birth Rate
- Trial name
- GluePloid (NCT06165367)
- Testing
- EmbryoGlue Medium
- Where
- United Arab Emirates
- Volunteers
- 783 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Chronic Spontaneous Urticaria
Remibrutinib in Real-world Clinical Practice - a Germany Sub-study (REASSERT)
Prospective, non-interventional study in patients with CSU where the treatment decision prior enrolment has been made to escalate/switch current treatment to remibrutinib.
- Trial name
- NCT07642557
- Where
- Germany
- Volunteers
- 470 people
- Sponsor
- Novartis Pharmaceuticals
Cancer, NGS
Performance Indicators and Impact on the Care Pathway of Sequencing on the SeqOIA and AURAGEN (Seqogen) Platforms for Oncology Patients
As part of the French Genomic Medicine Plan 2025 (FGM), the SeqOIA and AURAGEN platforms were selected to perform high-throughput genomic sequencing.
- Conditions
- Cancer, NGS, Tumor, RARE DISEASE
- Trial name
- SONCO (NCT07147465)
- Where
- 3 sites in France
- Volunteers
- 3,149 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Muscle-Invasive Bladder Cancer (MIBC), Upper Tract Urothelial Carcinoma
Validation of a Circulating Tumor DNA Blood Test in Muscle-Invasive Bladder and Upper Tract Urothelial Cancer
This prospective observational study evaluates a blood-based circulating tumor DNA (ctDNA) test in patients with muscle-invasive bladder cancer or upper tract urothelial cancer.
- Conditions
- Muscle-Invasive Bladder Cancer (MIBC), Upper Tract Urothelial Carcinoma, Urothelial Carcinoma (UC)
- Trial name
- BLUT-DNA (NCT07756437)
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- AZ Sint-Lucas Gent
Paediatric B Cell-related Autoimmune Diseases, Autoimmune Diseases
Exploratory Clinical Study of Second-generation CD19/BCMA Chimeric Antigen Receptor NK Cell Injection in Treating Paediatric B Cell-related Autoimmune Diseases
Evaluating the efficacy and safety of anti-CD19/BCMA CAR-NK Cells in Paediatric B cell-related autoimmune diseases
- Conditions
- Paediatric B Cell-related Autoimmune Diseases, Autoimmune Diseases, CAR
- Trial name
- NCT07283315
- Testing
- anti-CD19/BCMA CAR NK cells (KN5601-K)
- Where
- China
- Volunteers
- 12 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Non-Immune Hydrops Fetalis
Multicentric Prospective Study to Screen Inborn Errors of Metabolism in Non-immune Hydrops (NIH) Fetalis by Massively Parallel Sequencing
A fetal hydrops, also called a fetal anasarca, is the buildup of fluid in the serosa and / or fetal subcutaneous tissue. The diagnosis is made by ultrasound, possibly from the first trimester of pregnancy.
- Trial name
- ANAMETAB-PRO (NCT04308603)
- Testing
- NON-IMMUNE HYDROPS FETALIS diagnosis
- Where
- 17 sites in France
- Volunteers
- 71 people
- Sponsor
- Hospices Civils de Lyon
Stroke
Effects on Clinical and Functional Outcome of Escitalopram in Adult Stroke Patients
Rehabilitative treatment in stroke survivors has shown to be effective in improving functional outcome and reducing dependency. Plasticity of the central nervous system, along with coping strategies and adaptations, seems to play…
- Trial name
- NCT00967408
- Testing
- Escitalopram, Rehabilitative treatment
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Asherman Syndrome, Intrauterine Adhesion
Evaluate Formation of IUAs After Third-generation Endometrial Ablation, With and Without Intrauterine Adhesion Barrier
Evaluate the formation of adhesions after third-generation endometrial ablation, with and without the intrauterine adhesion barrier.
- Trial name
- CLEAN (NCT05414760)
- Testing
- Womed Leaf
- Where
- 2 sites in Netherlands
- Volunteers
- 1 people
- Sponsor
- Remko P. Bosgraaf
Psychological Distress, Self-Assessment
Examining the Efficacy of Acceptance and Commitment Therapy (ACT) Microinterventions for Distressed First-Generation College Students
This research study aims to evaluate the feasibility, safety, and effectiveness of a micro-randomized acceptance and commitment therapy-based (ACT-based) intervention that is delivered to distressed first-generation college…
- Conditions
- Psychological Distress, Self-Assessment, Mood Change
- Trial name
- CompACT (NCT04081662)
- Testing
- compACT Intervention
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Multiple Myeloma
Study Evaluating the Safety and Tolerability of Weekly Dosing of Oral IXAZOMIB in Adult Patients With Relapsed and Refractory Multiple Myeloma
The primary objective of this study is to determine the safety profile, tolerability, and maximum tolerated dose of ixazomib citrate (MLN9708) when taken orally on a weekly dosing schedule by patients with relapsed and refractory…
- Trial name
- NCT00963820
- Testing
- Ixazomib citrate
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Catheter Related Complications
Comparison of Two New Generations Dressings in Intensive Care Unit
Intravascular devices in intensive care units are often associated to complications. The investigators estimate that 23.5% of catheters placed and used in intensive care are subject to at least one complication; the goal is to…
- Trial name
- Advanced (NCT01795391)
- Where
- France
- Volunteers
- 685 people
- Sponsor
- University Hospital, Grenoble
Periodontal Diseases
Treatment of Periodontal Intrabony Defects With A-PRF+ or EMD
The aim of this randomized clinical trial was to clinically evaluate and compare the healing of intrabony defects after treatment with advanced platelet-rich fibrin (A-PRF+) to enamel matrix derivatives (EMD) in periodontitis…
- Trial name
- NCT04404374
- Testing
- A-PRF/EMD
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Semmelweis University
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