Clinical trials: Generations
Patients With a Generation 2 Medtronic Implantable Cardioverter-defibrillator(ICD)
Utility of the Audible Alert in Current Generation Medtronic Implantable Cardioverter-defibrillators
The purpose of this study is to determine whether the alert tones emitted by the latest generation of Medtronic implantable cardioverter-defibrillators (ICDs) are audible to patients.
- Trial name
- NCT01605500
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Englewood Hospital and Medical Center
In Utero Procedure Affecting Fetus or Newborn
Use of New Generation Fetoscopes in Pregnancies Affected by Fetal Diseases Amenable to Fetoscopy Therapy
The Researchers are trying to determine feasibility and safety of performing surgery in the womb with the Karl Storz fetoscopes (a tool used to access the baby in the body of the mother).
- Trial name
- NCT06281730
- Testing
- Karl Storz New Generation Fetoscope - curved 11508AAK, Karl Storz New Generation Fetoscope - straight 11506AAK
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Growth Hormone Deficiency
IGF1 Generation Test
To assess the predictive value of the short term IGF-1 stimulation test, based on IGF-1 changes, on the 24 months growth response to 2 different doses of GH in patients with conventional GH deficiency.
- Trial name
- CAREL (NCT00145457)
- Testing
- Blood sample, Radiography
- Where
- 8 sites in France
- Volunteers
- 82 people
- Sponsor
- Pfizer
Chronic Liver Disease (CLD), Healthy Volunteers
Equivalence of New Breath AnalyzerCompared to Currently BreathID System in Assessment of Liver Function
The aim of the study is to confirm that the new generation state of the art breath analyzer gives equivalent results to the previous model of the Exalenz breath analyzer.
- Trial name
- NCT02187601
- Testing
- MPBA System, BreathID
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Meridian Bioscience, Inc.
Airway Management, Anesthesia, General
Comparison of Second- and Third-Generation Laryngeal Mask Airway in Pediatric Patients
This study compares two airway devices used during general anesthesia in children: a second-generation laryngeal mask (SafeLM LMA) and a third-generation video laryngeal mask (SafeLM Video LMA).
- Conditions
- Airway Management, Anesthesia, General, Pediatric Anesthesia
- Trial name
- NCT07912619
- Testing
- Second-Generation SafeLM LMA, Third-Generation SafeLM Video LMA
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Respiratory Insufficiency, Respiratory Failure
Vela Generation II: Usability and Performance of a Non-Invasive Ventilation Mask.
Study Overview The goal of this clinical trial is to learn whether an improved non invasive ventilation mask with airway washout can reduce how often people need to breathe and perform as well as standard NIV masks when used with…
- Trial name
- NCT07484802
- Testing
- NIV interface with airway washout
- Volunteers
- 60 people
- Sponsor
- Fisher and Paykel Healthcare
Anorexia Nervosa
Patient-derived Stem Cell Models of Anorexia Nervosa
Experimental and genetic data, as well as brain imaging, support a role of the hypothalamic Arcuate nucleus neurons and their communication with surrounding microglia in anorectic conditions, but it has until recently not been…
- Trial name
- ANSTEM (NCT06259500)
- Testing
- observational
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Central Line Complication, Thrombosis, Venous
The Use of Thrombin Generation Assay in Detection of Central Line Related Thrombosis (CRT) in Critically Ill Patients
To study thrombin generation parameters in critically ill patients with and without central line related thrombosis (CRT).
- Trial name
- THROM-CRIT (NCT06094387)
- Testing
- Thrombin generation assay
- Where
- Hong Kong
- Volunteers
- 2 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Human Papillomavirus
Multi-site HPV Screening by High-throughput Sequencing in Patients With Chronic HPV-HR Infection Followed by Gynecology
The main risk of developing cervical cancer is the persistence of an High risk human papillomavirus (HPV-HR) infection, the mechanisms of which are still not understood.
- Trial name
- DEP-HPV (NCT04901351)
- Testing
- Smear
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Endodontically Treated Teeth, Primary Teeth
Accuracy of Apex Locators in Primary Teeth
The aim of this study was to evaluate the effectiveness of tactile sense, digital periapical radiograph and two different varieties of electronic apex locators at working length determination in primary molars.
- Conditions
- Endodontically Treated Teeth, Primary Teeth, Pulp Necroses
- Trial name
- NCT04638972
- Testing
- working length determination techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Eskisehir Osmangazi University
Acute Coronary Syndrome
Ticagrelor Monotherapy After 3 Months in the Patients Treated With New Generation Sirolimus Stent for Acute Coronary Syndrome (TICO Study)
To compare the clinical outcomes of dual antiplatelet therapy with aspirin and ticagrelor vs. ticagrelor monotherapy at 3 months after PCI in patients with acute coronary syndrome.
- Trial name
- NCT02494895
- Testing
- Ticagrelor monotherapy, Ticagrelor with Aspirin DAPT(dual antiplatelet treatment)
- Where
- South Korea
- Volunteers
- 3,056 people
- Sponsor
- Yonsei University
Breast Carcinoma, Neuropathy
Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Peripheral Neuropathy Receiving Paclitaxel for Breast Cancer
This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with peripheral neuropathy receiving chemotherapy for breast cancer.
- Trial name
- NCT02610439
- Testing
- Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 575 people
- Sponsor
- National Cancer Institute (NCI)
EGFR-TKI-resistant Non-Small Cell Lung Cancer
TILs Plus Third-Generation EGFR-TKI Therapy for TKI-Resistant NSCLC
This is a single-arm study designed to evaluate the safety and efficacy of TILs combined with third-generation EGFR-TKIs therapy for patients with EGFR-mutant NSCLC resistant to TKI.
- Trial name
- NCT07498595
- Testing
- TILs infusion
- Volunteers
- 50 people
- Sponsor
- Tianjin Medical University General Hospital
Chronic Spontaneous Urticaria
Phase 3b Study to Assess the Efficacy, Safety, and Tolerability of Remibrutinib in Comparison to Placebo, With Omalizumab as Active Control, in Adult CSU Patients, Followed by an Open-label 52-week Optional Extension.
The purpose of the core phase of the trial is to assess the efficacy, safety and tolerability of remibrutinib (LOU064) 25 milligrams (mg) twice a day (b.i.d.) over placebo for 24 weeks and in comparison to omalizumab 300 mg every…
- Trial name
- NCT06042478
- Testing
- Remibrutinib, Omalizumab
- Where
- 110 sites in Argentina, Brazil and 21 more
- Volunteers
- 470 people
- Sponsor
- Novartis Pharmaceuticals
Next Generation Sequencing, Pediatric Bacterial Meningitis
Application of Next Generation Sequencing Technique in Pediatric Bacterial Meningitis
Pathogen identification is of paramount importance for bacterial meningitis. At present, the pathogen of bacterial meningitis is still mainly based on Gram stain and bacterial culture.
- Trial name
- NCT03953638
- Testing
- Next Generation Sequencing
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Children's Hospital
Coronary Artery Disease
PeRcutaneous cOronary Intervention of Native Coronary arTery Versus Venous Bypass Graft in Patients With Prior CABG
Multi-centre, randomised clinical trial with anticipated 17 European centres: in the Netherlands, Belgium, Germany and UK. Patients with a dysfunctional bypass graft with a clinical indication for revascularization will be…
- Trial name
- PROCTOR (NCT03805048)
- Testing
- Percutaneous coronary intervention
- Where
- 21 sites in Belgium, Germany and 3 more
- Volunteers
- 221 people
- Sponsor
- Amsterdam UMC, location VUmc
Chronic Spontaneous Urticaria (CSU)
Study of the Efficacy and Safety of ICP-332 in Participants With Chronic Spontaneous Urticaria
The purpose of this study is to compare the efficacy and safety of ICP-332 in moderate to severe chronic spontaneous urticaria subjects inadequately controlled by second generation H1-antihistamines
- Trial name
- NCT07378527
- Testing
- ICP-332 Tablets
- Where
- 30 sites in China
- Volunteers
- 344 people
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Esophageal Cancer, Thoracic Diseases
Generation of a Surgical Field in the Left Lateral Decubitus Position
The generation of a good surgical field at the mid-lower mediastinum during thoracoscopic esophagectomy in the left lateral decubitus position is often complicated.
- Trial name
- NCT04683601
- Testing
- Thoracoscopic esophagectomy in left decubitus
- Volunteers
- 154 people
- Sponsor
- Shizuoka Cancer Center
NSCLC (Advanced Non-small Cell Lung Cancer), EGFR Gene Mutations
Sacituzumab Tirumotecan Plus Third-Generation TKI With/Without Radiotherapy for EGFR-Mutant NSCLC Brain Metastases
This is a prospective, open-label, multi-center, single-arm clinical trial
- Conditions
- NSCLC (Advanced Non-small Cell Lung Cancer), EGFR Gene Mutations, Brain Metastasis
- Trial name
- NCT07343479
- Testing
- sac-TMT plus EGFR-TKI
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Zhejiang Cancer Hospital
Antipsychotic Agents, Bipolar Disorder
Pharmacoepigenetics of Bipolar Disorder Treatment
Insulin is a hormone produced by the body to regulate blood sugar. Insulin resistance is a state when the body is not using insulin correctly, and more insulin is needed to maintain normal blood sugar.
- Trial name
- NCT02374996
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wayne State University
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