Clinical trials: Generations
Bioelectrical Impedance Measurement of Healthy Adults
Generation of Prediction Equations to Analyze Body Composition of Obese Adults Based on BIA
The study was based on the clinical trial BCA-01 (NCT01368640) "Generation of prediction equations to analyze body composition of adults based on Bioelectrical Impedance Analysis (BIA)" and implicates an extension of the study…
- Trial name
- NCT03779932
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Seca GmbH & Co. Kg.
Intracranial Aneurysm
Neuroform Atlas Stent System Study
The primary objective of this study is to demonstrate effectiveness and safety of the Neuroform Atlas Stent System for use with bare metal embolic coils.
- Trial name
- ATLAS (NCT02340585)
- Testing
- Next Generation Neuroform Stent System
- Where
- 25 sites in United States
- Volunteers
- 298 people
- Sponsor
- Stryker Neurovascular
HIV Infection
Pathogen Detection in HIV-infected Children With Non-malarial Febrile Illnesses Using Metagenomic Sequencing
In Uganda, 130,000 children (0-14 years of age) were living with HIV in 2018. Last year, nearly 450 infants acquired HIV every day; most of them during childbirth and these are at extremely high risk of dying in the first two…
- Trial name
- PHICAMS (NCT05085158)
- Where
- Uganda
- Volunteers
- 138 people
- Sponsor
- Makerere University
Waldenstrom Macroglobulinemia
Bendamustine, Rituximab and Acalabrutinib in Waldenstrom's Macroglobulinemia
This is a multi-centre, open label, single-arm, phase II clinical trial in untreated patients with Waldenstrom's Macroglobulinemia.
- Trial name
- BRAWM (NCT04624906)
- Testing
- Acalabrutinib, Bendamustine, Rituximab
- Where
- 9 sites in Canada
- Volunteers
- 63 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prophylactic HQP1351 Therapy, Third Generation TKI
Prophylactic HQP1351 Therapy Post-transplants on Leukemia After Allo-HSCT
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) improves the long-term outcomes for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) and BC-CML.
- Trial name
- Case-Only (NCT05604755)
- Testing
- HQP1351( Olverembatinib dimesylate)
- Where
- China
- Sponsor
- xuna
Lung Neoplasms, Carcinoma Non-small-cell Lung
A Clinical Test for the Treatment of Multifocal Lung Cancers Using Genome Sequencing
The investigators are doing this research to see if they can use small tissue samples or fluid to develop a test that will determine if the tissue samples are related or not related to each other.
- Trial name
- NCT02705404
- Testing
- Multifocal Tissue Banking
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Renal Cell Carcinoma, Renal Tumor
Non-Invasive Diagnostics of Small Renal Masses
NiSAR is a Ph.D. study and consists of three substudies. Renal cancer is one of the most deadly urologic malignancies and accounts for 900 new cases and 300 deaths per year.
- Trial name
- NISar (NCT03667885)
- Testing
- Blood sample, urine sample, Multi planar MRI
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Odense University Hospital
Pulmonary Infection
mNGS for Detection of Pathogens for Pulmonary Infection
Pulmonary infections remain the leading causes of morbidity and mortality among patients worldwide. Pathogen identification is crucial yet difficult for the majority of the cases.
- Trial name
- NCT03798925
- Testing
- None Intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sir Run Run Shaw Hospital
Microbial Colonization, Burns
Understanding the Burn Wound Microbiome: Comparing Traditional Wound Cultures to Next Generation Sequencing Technology
The purpose of this investigation is to better understand the wound microbiome in burn wounds and the role it plays in outcomes and complications related to treatment.
- Trial name
- NCT05275335
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The University of Texas Medical Branch, Galveston
In Need of a Total Hip Arthroplasty
E-MAX 2nd Gen Vit E Poly On BIOLOX Delta Ceramic Heads
The purpose of this study is to monitor outcomes of total hip arthroplasties performed with E-MAX polyethylene and BIOLOX Delta Ceramic head.
- Trial name
- NCT01943149
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Renovis Surgical Technologies, Inc.
COVID-19
COVID-19 Vaccination Using a 2nd Generation (E1/E2B/E3-Deleted) Adenoviral-COVID-19 in Normal Healthy Volunteers
This is a phase 1b, open-label study in adult healthy subjects. This clinical trial is designed to assess the safety, reactogenicity, and immunogenicity of the hAd5-S-Fusion+N-ETSD vaccine and select a dose for future studies.
- Trial name
- NCT04591717
- Testing
- hAd5-S-Fusion+N-ETSD vaccine
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- ImmunityBio, Inc.
Von Willebrand Disease
Molecular and Clinical Profile of Von Willebrand Disease in Spain
The present Project is a third phase of the previous PCM-EVW-ES Project (Batlle et al. Thromb \& Haemost 2015) with the aim of its extension, further analysis with an innovation development in the field of von Willebrand disease…
- Trial name
- PCM-EVW-ES (NCT02869074)
- Testing
- VWF gene analysis
- Where
- Spain
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- Spanish Society of Thrombosis and Haemostasis
Infant, Newborn
Whole Exome Screening of Newborns
The aim of the study is to obtain the initial experience of the inclusive genetic screening of newborn. Two groups of newborns born in RCOGP will be enlisted to the study: 1.
- Trial name
- NCT05325749
- Testing
- Screening, Family history record, Questionnaire survey
- Where
- Russia
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Familial Hypercholesterolemia
Genetic Causes of Hypercholesterolaemia in the Emirati Population
The scientific aims of the project are to understand the genetic basis of Familial Hypercholesterolaemia (FH) in the Emirati population and estimate the overall prevalence of the disease.
- Trial name
- NCT03597958
- Testing
- Next generation sequencing (NGS)
- Where
- United Arab Emirates
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London Diabetes Centre
HIV, HIV Associate Weight Loss
Change in Body Weight and BMI in PWH with DOR/3TC/TDF Compared with INSTI
Patients who developed metabolic syndrome after initiation of HIV treatment or with antiretroviral therapy (ART) for at least 36 months, treated with second generation integrase inhibitors (BIC/TAF/FTC, DTG/ABC/3Tc or…
- Conditions
- HIV, HIV Associate Weight Loss, HIV-1 Infection, Integrase Inhibitors, HIV; HIV PROTEASE INHIB
- Trial name
- TLATOANI (NCT06602622)
- Testing
- Integrase inhibitor, Doravirine + tenofovir DF + lamivudine
- Where
- 2 sites in Mexico
- Volunteers
- 108 people
- Sponsor
- Instituto Mexicano del Seguro Social
Lung Cancer
Validation of Rapid On-site Diagnostics in Early Stage Lung Cancer Sampling With a Higher Harmonic Generation Microscope
The aim of this study is to verify a new microscopic technique in diagnosing patients suspected of lung cancer. Patients will undergo navigational bronchoscopy or surgical resection as a part of standard of care.
- Trial name
- VALIDIAG (NCT06007261)
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Radboud University Medical Center
Atrial Fibrillation
Effect of 3 Years of Exercise on Development of Atrial Fibrillation
This is a substudy of "Generation 100". In that study, 4000 healthy persons between 70 and 75 will be randomised to a moderate intensity training group, a high intensity training group or control group, with 3 years of exercise.
- Trial name
- NCT01680302
- Testing
- High intensity exercise, Moderate intensity exercise, Control
- Where
- Norway
- Volunteers
- 1,567 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Overweight and Obesity
Next-Generation Synbiotic in Individuals With Overweight or Obesity
This study plans to evaluate the effect of consuming a symbiotic (probiotic + prebiotic) for 3 months on body weight, body composition, glucose sensitivity, and psychological parameters, as well as on gut and blood microbial…
- Trial name
- NCT06213480
- Testing
- Synbiotic Group
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Texas Christian University
Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
Efficacy, Safety, and Pharmacokinetics of ThisCART19A Combined With Olverembatinib in Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.
This is an Open, Prospective, Single-arm Study, which is designed to evaluate the efficacy, safety and pharmacokinetics of ThisCART19A Combined With Olverembatinib for the treatment of Newly Diagnosed Ph-positive lymphoblastic…
- Trial name
- NCT07074496
- Testing
- ThisCART19A, Fludarabine, Cyclophosphamide
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Schizophrenia
Genes Polymorphisms and Metabolic Effects of the Second Generation Antipsychotic Drugs in Patients With Schizophrenia
The purpose of the study is to investigate these effects of Second-Generation Antipsychotic (SGAs) on glucose and lipid metabolic parameters in patients with schizophrenia, and explore the relationship between genes polymorphisms…
- Trial name
- NCT02964923
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xijing Hospital
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