Clinical trials: Generations
Encephalitis, Meningitis
Precision Diagnosis of Acute Infectious Diseases; Neuroinflammatory Cohort
This study aims to use a clinically validated metagenomic next-generation sequencing (mNGS) assay to provide a demonstration of precision medicine for diagnosis of acute infectious disease in hospitalized patients.
- Trial name
- PDAID (NCT02910037)
- Testing
- mNGS for pathogen detection
- Where
- 7 sites in United States
- Volunteers
- 214 people
- Sponsor
- University of California, San Francisco
Breast Neoplasm Female, Therapeutics
Clinical Value of Next Generation Sequencing in Endocrine Therapy for Advanced Hormone Receptor Positive/HER-2 Negative Breast Cancer
To determine the landscape of gene mutation before and after endocrine therapy, to search for molecular markers of endocrine therapy efficacy, and to explore the clinical value of using NGS detection of ctDNA to guide precise…
- Conditions
- Breast Neoplasm Female, Therapeutics, Mutation
- Trial name
- NCT03786575
- Testing
- Next Generation Sequencing (NGS) detection
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College
Multiple Myeloma
A Study of Ixazomib Administered in Combination With Lenalidomide and Low-Dose Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma
The purpose of Phase 1 of this study was to determine the safety, tolerability, maximum tolerated dose (MTD), and recommended Phase 2 dose (RP2D) of oral ixazomib administered in combination with lenalidomide and low-dose…
- Trial name
- NCT01217957
- Testing
- Ixazomib, Lenalidomide, Dexamethasone
- Where
- 16 sites in United States
- Volunteers
- 65 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Healthy Volunteers
Generation of Biological Samples Positive to Testosterone for Anti-doping Control
Background: Testosterone is a steroid widely known to improve physical performance due to its protein-anabolic effect. Like other androgenic anabolic steroids (EAA), testosterone is included on the World Anti-Doping Agency (WADA)…
- Trial name
- TST (NCT04207684)
- Testing
- Testosterone injection
- Where
- Spain
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Ultrasound Exam in Emergency/Medical Care
Venue Ultrasound Evaluation - Israel
The study purpose is to collect images and user feedback from the Next Generation Venue Ultrasound system, components, and accessories under clinical conditions, as required for device development and optimization.
- Trial name
- NCT03861663
- Testing
- Ultrasound
- Where
- Israel
- Volunteers
- 53 people
- Sponsor
- GE Healthcare
Colorectal Cancer Metastases and Hepatocellular Carcinomas
Next Generation " Pre-clinical Model for Colorectal Cancer Metastases and Hepatocellular Carcinomas
Recently, oncology has moved to a new clinical practice, more personalized, called Predictive Oncology (PO). PO comes from our knowledge about tumor heterogeneity that implies that each disease, thus each patient, is unique.
- Trial name
- BORG (NCT05384184)
- Testing
- Tumor /metastases removal
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Thoracic Diseases, Respiratory Tract Diseases
A Phase I Study of iPS Cell Generation From Patients With COPD
As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and…
- Conditions
- Thoracic Diseases, Respiratory Tract Diseases, Cancer of Lung, Cancer of the Lung
- Trial name
- NCT01860898
- Testing
- Skin Biopsy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Mayo Clinic
Scoliosis, Adolescent Idiopathic Scoliosis (AIS)
Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis
Adolescent Idiopathic scoliosis affects 3-4% of the Canadian population, of which about 10% will need a brace treatment during pubertal growth spurt.
- Trial name
- NCT02285621
- Testing
- Optimized brace versus conventional Boston brace
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- St. Justine's Hospital
Pain Management, Postoperative Pain
PCDD Generation 1 Oral Liquid Acetaminophen Delivery Evaluation
This prospective randomized pilot study evaluates the feasibility, acceptability, and preliminary efficacy of the Patient-Controlled Dispenser and Deactivator (PCDD) Generation 1 system for patient-controlled oral liquid…
- Trial name
- NCT07765238
- Testing
- PCDD Generation 1 system
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Chest Pain
Does Vitamin D Deficiency Associated With Hypercoagulability & Increased Thrombin Generation?
Cardiovascular disease is the most common cause of mortality and morbidity worldwide. Recently, a growing body of evidence has identified Vitamin D deficiency as a potential risk factor for cardiovascular disease.
- Trial name
- NCT01799655
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- HaEmek Medical Center, Israel
Malignant Neoplasm of Body of Stomach in Situ
Taiwan Cancer Moonshot Project
The aim of this study is to establish multiomic big data under strictly collected clinical samples from tumors, adjacent normal tissue, blood, and clinical data then analyze by using integrated proteomics and genetics platform.
- Trial name
- NCT05248763
- Where
- Taiwan
- Volunteers
- 4,190 people, healthy volunteers welcome
- Sponsor
- Academia Sinica, Taiwan
Radiography, Oral Health
Large Language Models for Dental Radiology Report Generation From Structured Textual Data
The purpose of this observational methodological study is to evaluate whether large language models can transform structured dental radiology data into clear narrative radiology reports.
- Conditions
- Radiography, Oral Health, Large Language Model, Natural Language Processing (NLP)
- Trial name
- DENT-LLM (NCT07676318)
- Testing
- Large language model-assisted radiology report generation
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Hospital of the Ministry of Interior, Kielce, Poland
Acute Coronary Syndrome
Apixaban + DAPT in Lowering Platelet Reactivity and Thrombin Generation
Investigating Synergistic Effects of Apixaban with Dual Anti-Platelet Therapy (DAPT) in Lowering Platelet Reactivity and Thrombin Generation
- Trial name
- SEARCH (NCT03746782)
- Testing
- Flow Cytrometry; Thrombin Generation Assay
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CirQuest Labs, LLC
Contraception
A Dose-Finding Study to Evaluate Ovarian Function and Vaginal Bleeding in Next Generation Rings (P06109/MK-8175A/MK-8342B-012)
The primary objective of this trial was to identify at least one next generation ring (NGR) that demonstrates inhibition of ovulation (which was considered confirmed if in the subset of participants ovulation was observed in less…
- Trial name
- NCT01709318
- Testing
- Nomegestrol acetate (NOMAC), Etonogestrel (ENG), Ethinyl estradiol (EE)
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Cataract
Safety and Efficacy of Next Generation Ophthalmic Irrigating Solution Compared to BSS Plus
The purpose of this study is to determine the safety and efficacy of Next Generation Ophthalmic Irrigating Solution (NGOIS) compared to BSS Plus for use during cataract extraction and intra-ocular lens (IOL) implantation.
- Trial name
- NCT00333268
- Testing
- Next Generation Ophthalmic Irrigating Solution (NGOIS), BSS Plus
- Where
- United States
- Volunteers
- 369 people
- Sponsor
- Alcon Research
Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication
DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study
To study the correlation between novel DIC markers and thrombin generation parameters with thrombotic and hemorrhagic complications of patients on ECMO support.
- Trial name
- DIC-ECMO (NCT06095518)
- Testing
- DIC markers and Thrombin Generation Parameters
- Where
- Hong Kong
- Volunteers
- 49 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Castration-Resistant Prostate Carcinoma, Castration-Resistant Prostate Carcinoma Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents
Erdafitinib for the Treatment of Patients With Castration-Resistant Prostate Cancer
This phase II trial studies the effect of erdafitinib in treating patients with prostate cancer that grows and continues to spread despite the surgical removal of the testes or drugs to block androgen production…
- Conditions
- Castration-Resistant Prostate Carcinoma, Castration-Resistant Prostate Carcinoma Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents, Metastatic Malignant Neoplasm in the Bone, Metastatic Prostate Adenocarcinoma
- Trial name
- NCT04754425
- Testing
- Biopsy, Biospecimen Collection, Erdafitinib
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- M.D. Anderson Cancer Center
Heart Failure
Next-generation, Integrative, and Personalized Risk Assessment to Prevent Recurrent Heart Failure Events: the ORACLE Study
The aim of this study is to develop and validate an improved, comprehensive risk assessment algorithm integrating blood RNA-based biomarkers, clinical, and patient-centered data and to assess the incremental predictive value…
- Trial name
- ORACLE (NCT05679713)
- Testing
- Comprehensive risk assessment algorithm
- Where
- Spain
- Volunteers
- 1,134 people
- Sponsor
- Hospital Universitari de Bellvitge
Acute Lymphoblastic Leukemia, Pediatric
Minimal Residual Disease Quantification by Next-generation Sequencing in Pediatric B-ALL Children Patients Treated With Blinatumomab Consolidation
A retrospective analysis to investigate pediatric B-cell acute lymphoblastic leukemia patients who were treated with blinatumomab for consolidation, and who were detected as minimal residual disease (MRD) positive by next…
- Trial name
- NCT05837689
- Testing
- Blinatumomab
- Volunteers
- 20 people
- Sponsor
- Xiaojun Xu
Coronary Artery Disease
Miniaturized Extracorporeal Circulation Study
Rationale: Contemporary coronary artery bypass grafting (CABG) continues to be associated with a significant risk of postoperative bleeding.
- Trial name
- NCT03216720
- Testing
- CABG, Miniaturized extracorporeal circulation, Conventional extracorporeal circulation
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital Skejby
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