Clinical trials: Generations
Chronic Endometritis
Diagnosis of Chronic Endometritis in Endometrial Fluid Using Molecular Techniques to Improve the Outcomes of Assisted Reproductive Treatments
Chronic endometritis (CE) is a persistent inflammation of the endometrial lining caused by the infection of the uterine cavity mainly by bacterial pathogens.
- Trial name
- ChEndometritis (NCT03169621)
- Testing
- Endometrial Biopsy and endometrial fluid collection
- Where
- Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Igenomix
Pediatric Population on Second Generation Antipsychotics
Beta-carotene and Oxidative Stress in Pediatric Second Generation Antipsychotic Use
Weight gain, hypertension, high cholesterol and sugar abnormalities in childhood are strongly linked and predict the risk of further complications and early death in adulthood.
- Trial name
- NCT02363816
- Sponsor
- Wayne State University
Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver
HRX215, A First Generation MKK4 Inhibitor Drug, for the Treatment of Patients With Colorectal Liver Metastasis After Undergoing a Portal Vein Embolization
This phase IIb trial tests the effect of HRX215 in treating patients with colorectal cancer that has spread from where it first started to the liver (liver metastasis) after undergoing a portal vein embolization (PVE).
- Conditions
- Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver, Resectable Colorectal Carcinoma, Stage IV Colorectal Cancer AJCC v8
- Trial name
- NCT07612007
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Diabetes Mellitus
Role of High-Throughput Whole Genome Sequencing for the Diagnosis and Care of Atypical Diabetes
The main objective of the study is to assess the contribution of whole genome sequencing (WGS) coupled with a multidisciplinary conciliation meeting (MCM) on diagnosis of atypical forms of diabetes compared to an in-silico…
- Trial name
- GLUCOGEN (NCT06570278)
- Testing
- WGS coupled with MCM
- Where
- 26 sites in France
- Volunteers
- 1,020 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Thoracic Diseases, Respiratory Tract Diseases
A Phase I Study of iPS Cell Generation From Patients With COPD
As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and…
- Conditions
- Thoracic Diseases, Respiratory Tract Diseases, Cancer of Lung, Cancer of the Lung
- Trial name
- NCT01860898
- Testing
- Skin Biopsy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Mayo Clinic
Advanced Solid Tumors or Non-Hodgkin's Lymphoma (NHL)
A Phase 1/2 Trial of SRA737 in Subjects With Advanced Cancer
The purpose of this clinical study is to establish the safety profile, determine the maximum tolerated dose (MTD) and recommend a Phase 2 dose and schedule of SRA737; and to evaluate the efficacy of SRA737 in…
- Trial name
- NCT02797964
- Testing
- SRA737
- Where
- 15 sites in United Kingdom
- Volunteers
- 107 people
- Sponsor
- Sierra Oncology LLC - a GSK company
Breast Cancer
Generation of Heart Muscle Cells From Blood or Skin Cells of Breast Cancer Patients
The purpose of this study is to investigate whether cells from a biopsy taken from the patient skin can be transformed into cardiomyocytes the changes in cardiomyocyte (heart muscle cells) when grown in a special culture medium…
- Trial name
- NCT02772367
- Testing
- skin punch biopsy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Gastric Cancer (GC), Next-generation Sequencing
Influence of Age on the Choice of Treatment and Prognosis in Patients With Resectable Gastric Cancer
Next-generation sequencing (NGS) and biomarkers play a key role in the diagnosis and personalized therapy of gastric cancer. These technologies provide a deep understanding of the molecular basis of the disease.
- Conditions
- Gastric Cancer (GC), Next-generation Sequencing, Molecular Analysis
- Trial name
- NCT07403916
- Testing
- Next-generation sequencing
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- P. Herzen Moscow Oncology Research Institute
Bipolar I Disorder
Risperdal Consta for Bipolar Disorder
We recruited 50 consenting adult subjects with DSM-IV TR diagnoses of bipolar disorder who were about to initiate or switch their current antipsychotic agent.
- Trial name
- NCT00177164
- Testing
- Injectable Risperidone (Consta) or oral antipsychotic
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Epilepsy; Seizure, Neuromuscular Diseases
North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2
The "North Carolina Clinical Genomic Evaluation by Next-gen Exome Sequencing, 2 (NCGENES 2)" study is part of a larger consortium project investigating the clinical utility, or net benefit of an intervention on patient and family…
- Conditions
- Epilepsy; Seizure, Neuromuscular Diseases, Brain Malformation, Intellectual Disability
- Trial name
- NCGENES2 (NCT03548779)
- Testing
- Pre-visit prep, usual care + exome seq
- Where
- 3 sites in United States
- Volunteers
- 548 people
- Sponsor
- University of North Carolina, Chapel Hill
Supraglottic Airway Devices Position
New-Generation GMA Laryngeal Mask Airway Versus Conventional Inflatable Laryngeal Mask Airway
This study aims to compare the new-generation GMA laryngeal mask airway (LMA) with the traditional inflatable LMA in patients undergoing elective surgery under general anesthesia.
- Trial name
- NCT07177586
- Testing
- GMA Laryngeal Mask Airway, Inflatable Laryngeal Mask Airway
- Where
- China
- Volunteers
- 1,384 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Spine Infection
NGS for Spine Surgery Patients
During revision spinal surgery for aseptic indications, there remains a concern that the failure may have resulted from undetectable subclinical infection.
- Trial name
- NCT05013203
- Testing
- Tissue culture, Next Generation Sequencing
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Rothman Institute Orthopaedics
Hydrocephalus
Assessment of Flow in Cerebrospinal Fluid Shunts With a Second Generation Wireless Thermal Anisotropy Measurement Device
This study evaluates the performance of a thermal anisotropy measurement device for non-invasively assessing CSF shunt flow. Patients with an existing implanted shunt and symptoms of shunt malfunction who require shunt revision…
- Trial name
- NCT06409286
- Testing
- Thermal Anisotropy Measurement Device
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Rhaeos, Inc.
Congenital Anomalies, Mendelian Disorders
Evaluating Prenatal Exome Sequencing Study
This study evaluates the impact of the various outcomes of pES (definitive diagnosis, probable diagnosis and IF) on clinical decision making and on parental psychological wellbeing, compared between different analysis strategies…
- Conditions
- Congenital Anomalies, Mendelian Disorders, Genetic Diseases, Inborn
- Trial name
- EPES (NCT05290701)
- Where
- Netherlands
- Volunteers
- 235 people
- Sponsor
- Leiden University Medical Center
Atrial Fibrillation
Effect of 3 Years of Exercise on Development of Atrial Fibrillation
This is a substudy of "Generation 100". In that study, 4000 healthy persons between 70 and 75 will be randomised to a moderate intensity training group, a high intensity training group or control group, with 3 years of exercise.
- Trial name
- NCT01680302
- Testing
- High intensity exercise, Moderate intensity exercise, Control
- Where
- Norway
- Volunteers
- 1,567 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Coronary Artery Disease
BiOSS LIM C vs 2nd Generation DES in Non-LM Bifurcations
Coronary bifurcations are encountered in about 15 - 20% of percutaneous coronary interventions (PCI). They are considered technically challenging and associated with worse clinical outcomes than non-bifurcation lesions.
- Trial name
- POLBOS 3 (NCT03548272)
- Testing
- Percutaneous Coronary Intervention with stent implantation
- Where
- Poland
- Volunteers
- 518 people
- Sponsor
- Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
Obesity
Intestinal Microbiota in Patients Before and After Bariatric Surgery and Healthy Controls
Studying obesity and metabolic syndrome attention is focused more and more on gut microbiota. In humans and animals, bariatric surgery (mainly gastric bypass surgery) lead to alterations of gut microbiota, which seem to be…
- Trial name
- NCT02563119
- Testing
- Gastric Bypass or Sleeve gastrectomy
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Monogenic Diseases, Genetic Diseases, Inborn
Health Economic Evaluation of Non-Invasive Prenatal Exclusion Diagnosis
Since the discovery of a small fraction of circulating cell-free fetal DNA (ccffDNA) in the blood of the mother, non-invasive prenatal diagnosis (NIPD) techniques using a simple blood sample have been developed to 1) screen for…
- Trial name
- PRENATSAFE (NCT07469657)
- Testing
- NIPD by NGS
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia
Activated T-Cells Expressing 2nd or 3rd Generation CD19-Specific CAR, Advanced B-Cell NHL, ALL, and CLL (SAGAN)
Subjects on this study have a type of lymph gland cancer called Non-Hodgkin Lymphoma, acute lymphocytic leukemia, or chronic Lymphocytic Leukemia (these diseases will be referred to as "lymphoma" or "leukemia").
- Conditions
- Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Acute Lymphocytic Leukemia
- Trial name
- SAGAN (NCT01853631)
- Testing
- Dose Escalation Phase:CD19.CAR/28 and CD19.CAR/28137 T cells, Expansion Phase: CD19.CAR/28 and CD19.CAR/28137 T cells
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Baylor College of Medicine
B Cell Precursor Acute Lymphoblastic Leukemia, Pediatric
NGS MRD-Guided Blinatumomab Treatment for Pediatric B-ALL
The goal of this clinical trial is to determine whether pediatric B-cell acute lymphoblastic leukemia (B-ALL) patients with negative deep minimal residue disease (MRD) can benefit from blinatumomab treatment.
- Conditions
- B Cell Precursor Acute Lymphoblastic Leukemia, Pediatric, Minimal Residual Disease, Next Generation Sequencing (NGS)
- Trial name
- NCT06763302
- Testing
- Blinatumomab
- Volunteers
- 1,220 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
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