Clinical trials: Generations
Small Cell Lung Cancer
Tempus Small Cell Lung Cancer Observational Study (Sculptor)
The study is a non-interventional evaluation of participants with extensive stage (ES) SCLC who will receive diagnostic and (where possible) post-progression tumor tissue profiling, alongside plasma ctDNA and CTC biomarker…
- Trial name
- NCT05257551
- Testing
- Observation
- Where
- 11 sites in United States
- Volunteers
- 200 people
- Sponsor
- Tempus AI
Multiple Myeloma
A Study of Ixazomib Administered in Combination With Lenalidomide and Low-Dose Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma
The purpose of Phase 1 of this study was to determine the safety, tolerability, maximum tolerated dose (MTD), and recommended Phase 2 dose (RP2D) of oral ixazomib administered in combination with lenalidomide and low-dose…
- Trial name
- NCT01217957
- Testing
- Ixazomib, Lenalidomide, Dexamethasone
- Where
- 16 sites in United States
- Volunteers
- 65 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Vancomycin-Resistant Enterococci, Probiotics
Investigation of the Optimal Cocktailed Probiotics for Decolonization of Vancomycin-resistant Enterococci in Human Gut
Vancomycin-resistant enterococci (VRE) has been a serious public health issue as an opportunistic pathogen and reservoir of antibiotic resistant genes.
- Trial name
- NCT03822819
- Testing
- probiotic cocktail capsules
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Gaucher Disease Type 1
A Second-generation AI Based Therapeutic Regimen in Patients With Gaucher Disease Treated With Enzyme Replacement Therapy.
An open-labeled, prospective, single-center proof-of-concept study. Patients with Gaucher Disease aged 18-75 who received intravenous Enzyme Replacement Therapy once every two weeks were enrolled.
- Trial name
- NCT06050967
- Testing
- Enzyme replacement therapy for Gaucher disease in combination with altus care application
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Hadassah Medical Organization
Lung Neoplasms, Carcinoma Non-small-cell Lung
Treatment of Multifocal Lung Adenocarcinoma
To gather preliminary safety and outcome data for the multimodality treatment of lung adenocarcinoma in the setting of multifocal BAC.
- Conditions
- Lung Neoplasms, Carcinoma Non-small-cell Lung, Adenocarcinoma
- Trial name
- NCT01946100
- Testing
- Multifocal Lung Adenocarcinoma
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Schizophrenia and Schizophrenia Spectrum Psychosis
Modafinil as an Adjunctive on Cognitive Functioning in Patients With Schizophrenia
Patients suffering from schizophrenia and schizophrenia spectrum psychosis frequently experience cognitive impairments. Such deficits may affect memory, attention and executive function processes.
- Trial name
- NCT00314639
- Testing
- modafinil
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Observational, Prospective
Targeted Next Generation Sequencing for the Efficacy of Trastuzumab Neoadjuvant Chemotherapy in Breast Cancer
To explore the genetic background of patients with HER2 positive breast cancer that benefit from trastuzumab combined with neoadjuvant chemotherapy, identify clinically actionable mutations that associated with trastuzumab…
- Trial name
- NCT03728829
- Testing
- Trastuzumab+TP
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Hebei Medical University Fourth Hospital
EGFR Positive Non-small Cell Lung Cancer
Retreatment With Epidermal Growth Factor Receptor(EGFR) Tyrosine Kinase Inhibitor in EGFR Mutation Positive Patients
In this trial, treatment efficacy and safety of retreatment with 1st generation epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor(TKI)s(Gefitinib/Erlotinib), will be assessed in patients with sensitizing EGFR…
- Trial name
- NCT03382795
- Testing
- EGFR
- Where
- 8 sites in South Korea
- Volunteers
- 63 people
- Sponsor
- Korea University Guro Hospital
Open Angle Glaucoma, Ocular Hypertension
Next Generation Rocklatan
The purpose of this two-stage clinical trial is to assess the safety and hypotensive efficacy of AR-17043 and PG043 ophthalmic solutions in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT).
- Trial name
- NCT06441643
- Testing
- AR-17043 Ophthalmic Solution, PG043 Ophthalmic Solution, Latanoprost 0.005% Ophthalmic Solution
- Where
- 12 sites in United States
- Volunteers
- 426 people
- Sponsor
- Alcon Research
Lung Cancer
Sacituzumab Tirumotecan (Sac-TMT) Plus Bevacizumab in 3rd Generation EGFR-TKI Treated Advanced EGFR-mutant Nonsquamous NSCLC With Brain Metastasis
This is a prospective, single-center, phase 2 clinical study to explore the efficacy and safety of Sac-TMT in combination with bevacizumab for patients with EGFR-mutated nonsquamous NSCLC with brain metastases.
- Trial name
- NCT07197008
- Testing
- Sacituzumab tirumotecan (Sac-TMT) plus bevacizumab
- Volunteers
- 50 people
- Sponsor
- Li-kun Chen
Healthy Subjects
Prospective Evaluation of Next Generation CT Reconstruction (NextGenIR)
Background: Computed Tomography (CT) is a scan that makes detailed pictures of the body. It uses radiation to do that. In 2011, about 85.3 million CT scans were done in the United States.
- Trial name
- NCT02417714
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Screening Gene Mutations in Myeloid Cancers by Next Generation Sequencing to Improve Treatment Results
Genetic mutations have closely linked to the pathogenesis and prognostication of myeloid cancers. In addition, a number of molecularly targeted agents have been developed in recent years.
- Conditions
- Acute Myeloid Leukemia, Myelodysplastic Syndromes, Myeloproliferative Neoplasm, Aplastic Anemia
- Trial name
- NCT04060485
- Where
- Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Primary Malignant Brain Tumors
A Taiwanese Oncogenetic Panel and Integrated Clinical Data Registry Study for Diffuse Glioma
Glioma is a major histological subtype of primary malignant brain tumors in Taiwan, with distinct epidemiological, clinical, and pathological features comparing to the other common cancer diseases.
- Trial name
- NCT05622409
- Where
- 8 sites in Taiwan
- Volunteers
- 250 people
- Sponsor
- National Health Research Institutes, Taiwan
Unipolar Major Depressive Episode
Strategic Use of New Generation Antidepressants for Depression
The purpose of the study is to establish the optimum treatment strategy for first-line and second-line antidepressants in the acute phase treatment of major depression.
- Trial name
- SUN(^_^)D (NCT01109693)
- Testing
- Sertraline, Mirtazapine
- Where
- 2 sites in Japan
- Volunteers
- 2,011 people
- Sponsor
- Kyoto University
Colon Cancer
Multi Parametric Test Predicting the Risk of Colorectal Neoplasia Recurrence
This project is dedicated to identify the patients with possible higher risk of adenoma recurrence who should have follow-up colonoscopy in yearly interval.
- Trial name
- NCT03434925
- Testing
- Multi-targeted next generation sequencing
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Military University Hospital, Prague
Neoplasms, Germ Cell and Embryonal
Understanding the Molecular and Genetic Differences Between Germ Cell Tumor at the Time of the Initial Diagnosis and at Late Relapse
The current proposal is a pilot study. The Investigators plan to use next generation genome sequencing (NGGS) to define the molecular and genetic profiles of 3 cases of germ cell tumor (GCT) (with a component of yolk sac tumor)…
- Trial name
- NCT02679950
- Testing
- Next generation genome sequencing
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Nasser Hanna
Primary Open Angle Glaucoma
Phase I Dose Escalation Study to Investigate the Safety of ISTH0036 in Subjects With Glaucoma Undergoing Trabeculectomy
This study evaluates the addition of ISTH0036, an antisense oligonucleotide against TGF-β2, to glaucoma filtration surgery (trabeculectomy).
- Trial name
- NCT02406833
- Testing
- TGF-β2 antisense oligonucleotide, Trabeculectomy
- Where
- 3 sites in Germany
- Volunteers
- 13 people
- Sponsor
- Isarna Therapeutics GmbH
Solar Lentigo, Nevus Zygomaticus
Advanced Harmonic Generation Microscopy for Treatment Assessment of Cutaneous Pigmentary Disorder
In this study, the investigators demonstrated that in vivo THG microscopy can differentiate Solar lentigos (SL), Nevus zygomaticus(NZ) and normal skin based on the optical nature of melanin.
- Trial name
- NCT03578315
- Testing
- HGM
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Colorectal Surgery
Trial of Antibiotic Prophylaxis in Elective Colorectal Surgery
To determine the optimal prophylactic antibiotics administration method in elective colorectal surgery
- Trial name
- NCT00292708
- Testing
- Cefmetazole (drug)
- Where
- 7 sites in Japan
- Volunteers
- 500 people
- Sponsor
- National Cancer Center, Japan
Coronary Bifurcation Lesion
Korean Coronary Bifurcation Stenting (COBIS) Registry III
The COBIS III registry is a multi-center, real-world registry of 2nd generation drug-eluting stenting in coronary bifurcation lesions in South Korea.
- Trial name
- COBIS III (NCT03068494)
- Where
- South Korea
- Volunteers
- 2,648 people
- Sponsor
- Samsung Medical Center
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