Clinical trials: Generations
Brain Injuries, Traumatic, Coagulopathy
The Influence of Noradrenaline on Coagulation and Fibrinolysis in Severe Isolated Brain Injury
Aim of the study The investigators aim to establish: Whether noradrenaline (NA) infusion has a significant effect on coagulation and fibrinolysis in patients with severe traumatic brain injury (TBI).
- Conditions
- Brain Injuries, Traumatic, Coagulopathy, Coagulation Defect; Acquired, Coagulation Defect; Bleeding
- Trial name
- NCT04515420
- Testing
- noradrenaline
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Heavy, Bad Odour From Armpit
Microbial Community Transplantation on the Armpit.
The malodour generation of a person's armpit is caused by the bacteria thriving on that armpit. In order to alter or reduce once bad body odour, the living microbial community on the armpit of a non-malodorous person will be…
- Trial name
- NCT01944566
- Testing
- Microbial transplant
- Where
- 2 sites in Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Ghent
Generation Gap, Generations
Generational Diversity in the Medical Profession
The purpose of this work is to investigate how post-graduate doctors in training (PGDiTs) experience generational diversity with their colleagues in the workplace.
- Conditions
- Generation Gap, Generations, Intergenerational Relations
- Trial name
- NCT06446297
- Testing
- Focus Group.
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
Ovarian Cancer
The Fourth Generation CART-cell Therapy for Refractory-Relapsed Ovarian Cancer
The goal of this clinical trial is to study the safety and feasibility of anti- Mesothelin Chimeric Antigen Receptor T-Cell (MESO CAR-T cells) therapy for Refractory-Relapsed Ovarian Cancer
- Trial name
- NCT03814447
- Testing
- anti- MESO CAR-T cells, Fludarabine, Cyclophosphamide
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai 6th People's Hospital
Locally Advanced Carcinoma, Metastatic Cancer
Evaluation of Efficacy of Comprehensive Genomic Tumour Profiling (CGP) From Liquid and/or Tissue Biopsy in Patients With Locally Advanced and/or Metastatic Solid Cancer
The aims of this study are to evaluate the efficacy of comprehensive genomic tumour profiling (CGP) from liquid and/or tissue biopsy in patients with locally advanced and/or metastatic solid cancer.
- Trial name
- SOUND (NCT05032092)
- Testing
- Next Generation Sequencing, Biomarker Monitoring
- Where
- 6 sites in Austria
- Volunteers
- 235 people
- Sponsor
- Medical University of Graz
Diabetes Mellitus
Evaluating Glucose Control Using a Next Generation Automated Insulin Delivery Algorithm in Adults With Type 2 Diabetes
The purpose of the study is to assess the safety and efficacy of a next generation automated insulin delivery algorithm in adults with type 2 diabetes aged 16-70 years old
- Trial name
- NCT07039981
- Testing
- Omnipod M system
- Where
- 2 sites in New Zealand
- Volunteers
- 48 people
- Sponsor
- Insulet Corporation
Thrombosis
Pharmacogentic Screening of Coumarine Based Oral Anticoagulant Using Next Generation Seguencer
As drug response is a complex trait in the majority of cases using an optimal starting dose for an individual may reduce the time taken to reach a stable INR, and reduce the risk of having either a high INR (with a risk of…
- Trial name
- NCT03180567
- Testing
- Genetic Mutations
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tanta University
Acute Lymphoblastic Leukemia
Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL) Patients
This is a prospective data collection study evaluating the feasibility of using the ChromoSeq® assay for upfront classification in a real-time clinical setting of pediatric and young patients suspected of having ALL.
- Trial name
- NCT07313592
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Infertility
Next Generation Sequencing Screening for Embryonic Ploidy Status
To evaluate the benefits of using next generation sequencing to assess embryonic aneuploidy. All viable blastocysts will be biopsied and cryopreserved for future transfer.
- Trial name
- nexgen (NCT02032264)
- Testing
- Comprehensive Chromosome Screening, Morphologically Best
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Elective Cardiac Surgery
Safety and Effectiveness of a Balanced 3rd Generation HES Solution (Tetraspan®) After Cardiac Surgery
The purpose of this randomized controlled trial in patients undergoing cardiac surgery is to show that a 3rd generation HES (Hydroxyethyl Starch) solution - Tetraspan® is as good as in terms of safety and effectiveness as the…
- Trial name
- NCT01418521
- Testing
- Balanced hydroxyethyl starch solution, Ringer- albumin
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Rambam Health Care Campus
Cirrhosis
Thrombin Generation Test in Patient With Liver Cirrhosis
Cirrhotic patients are patients with high morbidity and mortality, it is very important for determining the prognosis of these patients. The importance increases when these patients waiting for a liver transplant.
- Trial name
- NCT02484534
- Where
- Israel
- Volunteers
- 36 people
- Sponsor
- HaEmek Medical Center, Israel
Cancer
TEMPUS ARIES: A Biobank Registry Platform Study in Oncology
This study is a non-interventional, multicenter, multicohort evaluation of participants with cancer who will undergo longitudinal plasma ctDNA biomarker profiling at specific time points in addition to standard of care therapy.
- Trial name
- NCT06207032
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 500 people
- Sponsor
- Tempus AI
VAP - Ventilator Associated Pneumonia
Early Identification of Pathogens in Children With Respiratory Tract Infection by Mechanical Ventilation Using mNGS
VAP（Ventilator-associated pneumonia）is the most common complication of mechanical ventilation in severely ill patients. VAP is defined as pneumonia occurring 48 hours after patients receive mechanical ventilation, including…
- Trial name
- NCT04955821
- Testing
- mNGS diagnose of VAP
- Volunteers
- 400 people
- Sponsor
- Children's Hospital of Fudan University
Holoprosencephaly
Retrospective Study Using Next Generation Sequencing (NGS) on Biological Samples to Improve Genetic Counseling for Patients With Previously Explored Craniofacial Midline Defects.
Holoprosencephaly, or HPE, is the most common congenital cerebral malformation in humans and the most severe of a group of pathologies related to a deficiency of the SHH signalling pathway (Sonic Hedgehog SHH-D).
- Trial name
- EXOMEDIANE (NCT04691414)
- Testing
- NGS
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Rennes University Hospital
Acute Coronary Syndrome
5th Generation cTnT in ED ACS
This study intends to investigate the usefulness of the new "5th generation" cardiac troponin enzyme in determining which patients presenting with possible acute coronary syndrome can be quickly and safely discharged or admitted…
- Trial name
- NCT03590535
- Testing
- 4th Gen cTnT, 5th Gen cTnT
- Where
- United States
- Volunteers
- 1,949 people
- Sponsor
- Columbia University
Acute Coronary Syndrome, Chest Pain
Are Serial Electrocardiograms Additive to SeriAl Second-generations Troponins in Predicting Acute CoronAry Syndromes in PatienTs With Undifferentiated cHest Pain
Our research will examine whether the presence or absence of serial electrocardiogram (ECG) changes aids in reclassifying participants' risk for major adverse cardiac events (MACE) over and above serial blood testing.
- Trial name
- ASAP Cath (NCT01953276)
- Testing
- Serial Electrocardiograms
- Where
- United States
- Volunteers
- 382 people
- Sponsor
- Wake Forest University Health Sciences
Late Acquired Stent Malaposition
Late Acquired Malaposition and Different Polymers
The polymers releasing the drug of first-generation drug-eluting stents (DES) may induce allergic reactions and inflammation, resulting in late-acquired stent malaposition (LASM) with uncoverage of struts, and risk of stent…
- Trial name
- NCT02018991
- Testing
- Everolimus-Eluting Stent (EES), Zotarolimus-Eluting-Stent (ZES), Biolimus-Eluting-Stent (BES)
- Where
- Austria
- Volunteers
- 69 people
- Sponsor
- Medical University of Vienna
Echocardiography, Aortic Valve
Short- and Medium-term Results of New Generation Aortic
Over the past decade, aortic valve replacement surgery has undergone significant changes in terms of both the approaches and the prostheses used.
- Conditions
- Echocardiography, Aortic Valve, Cardiac Surgery, Mortality
- Trial name
- RVANG (NCT05055089)
- Where
- France
- Volunteers
- 172 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Voice Disorder Due to Iatrogenic Factor
First-generation OTC Antihistamine Use and Voice Function: A Preliminary Study
The goal of this clinical trial is to learn about voice function before and 3 hours after administration of first generation over-the-counter antihistamine in individuals who have been medically diagnosed with allergies and…
- Trial name
- NCT05858216
- Testing
- Chlor-Trimeton.
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Auburn University
Tuberculosis
Evaluation of the 4th Generation QuantiFERON-TB Test (QFT-Plus) for the Detection of Tuberculosis Infection
To compare the positivity rate of the investigational assay to the currently approved QuantiFERON-TB Gold In-Tube assay.
- Trial name
- NCT02687529
- Testing
- CST001
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- QIAGEN Gaithersburg, Inc
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