Clinical trials: Genetic Information
Type 1 Diabetes Mellitus, Stage 2 Type 1 Diabetes
Information, Follow-up and Early Diagnosis of Children at Risk for Type 1 Diabetes
The aim is to investigate whether screening for islet autoantibodies, regular follow-up, and increased knowledge in families about the progression of the disease in children at high genetic risk or with single or multiple islet…
- Conditions
- Type 1 Diabetes Mellitus, Stage 2 Type 1 Diabetes, Stage 1 Type 1 Diabetes, Stage 3 Type 1 Diabetes
- Trial name
- iT1D (NCT06676566)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Lund University
Melanoma, Young Adult
Risk Information and Skin-cancer Education for Undergraduate Prevention
The purpose of this study will be to provide undergraduate students information about skin cancer risk and prevention. The study will last between 2-3 months.
- Trial name
- RISE-UP (NCT03979872)
- Testing
- MC1R Genetic Testing, Skin Cancer Education, UV Photo
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Utah
HIV,
Microparticles, Vector of Genetic Information During HIV Infection
The aim of the investigators study is to demonstrate in healthy subjects and a cohort of patients infected with HIV, the presence of miRNAs in circulating peripheral blood microparticles (MPs).
- Trial name
- NCT01687452
- Testing
- Blood samples
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Autism, Autism Spectrum Disorder
Autism Genomics Sweden - Genetic Guidance and Information Trial
This observational clinical trial aims to evaluate whether providing genetic information about the origins of autism and related psychiatric disorders enhances understanding, well-being, and empowerment in adolescents and young…
- Conditions
- Autism, Autism Spectrum Disorder, ADHD - Attention Deficit Disorder With Hyperactivity, Depression Anxiety Disorder
- Trial name
- AuGeS-GV (NCT06740760)
- Testing
- Genetic counselling, Leaflet
- Where
- Sweden
- Volunteers
- 63 people
- Sponsor
- Karolinska Institutet
Cancer, Genetic Predisposition
Value of Information of Secondary dAta in ONCOGEnetics
VISAGE-ONCO study is a qualitative transversal study aiming to identify and describe processes and mechanisms that explain in cancerology the feelings and experience of patients and health professionals with regard to the…
- Conditions
- Cancer, Genetic Predisposition, Secondary Fundings
- Trial name
- VISAGE-ONCO (NCT04972409)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Georges Francois Leclerc
Healthy, Chronic Disease
BioGene Bank Cohort Study for Approved Research Requests
The BioGene bank: Is a centralized collection of human blood samples along with de-identified (coded) health information, environmental factors, family disease histories and information from DNA.
- Trial name
- BGB (NCT02550171)
- Where
- United States
- Volunteers
- 7,056 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Educational Materials for Genetic Testing, Breast Cancer
Developing New Educational Materials About Genetic Testing for a Diverse Group of Cancer Patients
Genetic testing is a type of test that detects changes to the genes-the DNA instructions that are passed on from the mother and father.
- Conditions
- Educational Materials for Genetic Testing, Breast Cancer, Ovarian Cancer, Prostate Cancer
- Trial name
- IMAGINE (NCT04751435)
- Testing
- Cognitive interview, LCAM intervention, Standard of care
- Where
- 4 sites in United States
- Volunteers
- 445 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Adoption, Genetic Counseling
The Value of Genetic Information to Adult Adopted Individuals
This study will explore adult adoptees' perceptions of the potential value of genetic and family history information. Unlike most people, many adopted individuals do not have access to personal or family medical information…
- Trial name
- NCT00057694
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Alzheimer Disease
Information About Alzheimer's Disease for Latinos in New York City
This study will assess the psychosocial and behavioral impacts of receiving Alzheimer's disease genetic risk assessment incorporating APOE genotypes among Latinos in northern Manhattan.
- Trial name
- IDEAL (NCT04471779)
- Testing
- Disclosure of APOE genotype
- Where
- United States
- Volunteers
- 374 people
- Sponsor
- Columbia University
Prostatic Neoplasms, Psychological Distress
ComCancer: Use of Let's Discuss Health Website by Patients With Prostate Cancer Undergoing Radiation Oncology Treatment
In Canada, the prevalence of cancer is growing and contributes significantly to health costs. The prevention and treatment of cancer is a major concern of our health system.
- Conditions
- Prostatic Neoplasms, Psychological Distress, Physician-Patient Relations, Communication
- Trial name
- NCT05787145
- Testing
- Let's Discuss Health Group
- Where
- 3 sites in Canada
- Volunteers
- 300 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Cardiovascular Diseases
The Genetics and Vascular Health Check Study (GENVASC) Aims to Help Determine Whether Gathering Genetic Information Can Improve the Prediction of Risk of Coronary Artery Disease (CAD)
The Genetics and Vascular Health Check study (GENVASC) is a large study run in conjunction with Clinical Commissioning Groups and Primary Care practices across Leicester, Leicestershire and Northamptonshire.
- Trial name
- GENVASC (NCT04417387)
- Testing
- Observational
- Where
- United Kingdom
- Volunteers
- 30,000 people
- Sponsor
- University of Leicester
Gene Mutation-Related Cancer, Genetic Predisposition
Genetic Information Assistant in Telegenetics
The goal of this clinical trial is to learn about different ways cancer genetic screening can be provided to rural communities in participants at high risk for certain cancers.
- Trial name
- NCT06089421
- Testing
- Genetic Information Assistant, Telegenetics with UVA genetic counselor
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Hemophilia A
Study to Gain More Information on How Safe and Effective Jivi Works in Patients With Severe Hemophilia A (Post-marketing Investigation)
The goal of this study is to give gather more information on how safe and well Jivi works in patients with severe hemophilia A. Jivi has been approved by various regulatory agencies, including the FDA, Health Canada, Japanese…
- Trial name
- NCT04085458
- Testing
- Damoctocog alfa pegol (Jivi, BAY94-9027)
- Where
- 13 sites in Bulgaria, Denmark and 5 more
- Volunteers
- 32 people
- Sponsor
- Bayer
Lung Cancer, Blood Relatives of Patient w/Lung Cancer
Effect of Lung Cancer Diagnoses on Family Behaviors
Background: A health event can be a powerful motivator for abrupt behavior changes. For instance, many people who smoke stop after having a heart attack or being diagnosed with cancer.
- Conditions
- Lung Cancer, Blood Relatives of Patient w/Lung Cancer, Cigarette Smokers
- Trial name
- NCT01862770
- Where
- 2 sites in United States
- Volunteers
- 507 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Alcohol Use Disorder
Understanding Genetic Risk for Alcohol Use Disorder
The purpose of this study is to evaluate an online educational tool that will help individuals better understand alcohol use disorder, risk factors, and genetic risk information and to better understand participant's beliefs…
- Trial name
- NCT05143073
- Testing
- Alcohol use disorder and strategies to reduce risk educational material, Complex polygenic risk scores, alcohol use disorder, and strategies to reduce risk educational material
- Where
- United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Coronary Heart Disease, Type 2 Diabetes
Coronary Heart Disease Risk in Type 2 Diabetes
The primary objective of the CORDIA study is to use an effective evidence-based self-management intervention (SMI) for type 2 diabetes, with and without a novel test to give a personalised genetic and lifestyle risk of coronary…
- Trial name
- CORDIA (NCT01891786)
- Testing
- Self-Management Intervention, Risk Result
- Where
- 10 sites in United Kingdom
- Volunteers
- 211 people
- Sponsor
- City, University of London
Newly Diagnosed Carcinoma of Breast, Genetic Predisposition to Disease
4R for Guideline Indicated BRCA Testing of Breast Center Patients
Currently, many breast center patients with a positive family history receive information about BRCA testing after breast cancer diagnosis, typically after definitive breast surgery or at a time point that does not allow them to…
- Trial name
- 4R (NCT01320540)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Duchenne Muscular Dystrophy
A Study on Safety and Effectiveness of Long-term Treatment With Vamorolone in Boys With Duchenne Muscular Dystrophy
This study aims to assess safety and effectivness of long-term treatment with vamorolone in boys with Duchenne Muscular Dystrophy (DMD) who have completed prior studies with vamorolone.
- Trial name
- GUARDIAN (NCT06713135)
- Testing
- vamorolone 40 mg/mL oral suspension
- Where
- 18 sites in Belgium, Czechia and 7 more
- Volunteers
- 80 people
- Sponsor
- Santhera Pharmaceuticals
Prostate Carcinoma
Genetic Information to Inform Treatment and Screening for Prostate Cancer, GIFTS Study
This trial studies the role of inherited (present at birth) mutations in cancer risk genes such as BRCA2, BRCA1, ATM, CHEK2, and others in relation to prostate cancer.
- Trial name
- GIFTS (NCT04254133)
- Testing
- Questionnaire, Biospecimen Collection, Genetic Testing
- Where
- United States
- Volunteers
- 1,360 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Genetic Predisposition to Disease, Genetic Predisposition
Enhancing Information Management for Young Adults After Genetic Cancer Risk Testing
This research is being done to develop the electronic platform Nest for young adults (ages 18-39) who have had prior cancer genetic testing.
- Trial name
- NCT05759143
- Testing
- Nest Platform
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute