Clinical trials: Genetic Information
Pulmonary Embolism, Deep Vein Thrombosis
Study to Develop a Reliable Nomogram That Incorporates Clinical and Genetic Information
In this research study, the investigators are trying to find a better way to set the dose of a common blood-thinning medication.
- Conditions
- Pulmonary Embolism, Deep Vein Thrombosis, Atrial Fibrillation
- Trial name
- NCT00401414
- Testing
- Warfarin
- Where
- 2 sites in United States
- Volunteers
- 344 people
- Sponsor
- Brigham and Women's Hospital
Urea Cycle Disorder
Observational Study That Will Collect Information on Patients With Urea Cycle Disorders (UCDs)
THRIVE is an observational study that will collect information on patients with UCDs. THRIVE will follow enrolled participants for up to 10 years.
- Trial name
- THRIVE (NCT01948427)
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Amgen
Sickle Cell Disease
Development and Evaluation of an Information Management System and Communication System for Population-wide Point-of-care Infant Sickle Cell Disease Screening
Although over 75% of children with sickle cell disease (SCD) are born in sub-Sahara where the disease highly contributes to under-5 mortality and causes life-long debilitation, evidence-based strategies to control SCD are not…
- Trial name
- SIMCS SCD (NCT06563440)
- Testing
- Digital app and information system
- Where
- 2 sites in United States, Uganda
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- Makerere University
Health Behavior, Alzheimer Disease, Protection Against
Genetic Information as a Life Style Change Motivator
The study investigates whether information on having a risk genotype (ApoE4) and life style advisory information affects lifestyle changes and sensory preferences.
- Trial name
- APOE4MOT (NCT03794141)
- Testing
- information on the risk gene status, life style advise
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- Natural Resources Institute Finland
Medication Adherence, Cystic Fibrosis
Interactive Mobile Health Information to Enhance Patient Care at a Cystic Fibrosis Center
Real-world adherence to inhaled and oral therapies for cystic fibrosis (CF) patients remains discouragingly low, ranging between 31-53% for inhaled antibiotics and 41-72% for hypertonic saline.
- Trial name
- MOMMI3CFCM (NCT03052231)
- Testing
- caremessage
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Landon Pediatric Foundation
Heart Failure, Cardiac Amyloidosis
A Multi-center Cardiac PYP Scan Registry in Taiwan
Amyloid deposition in the heart is called cardiac amyloidosis (CA); 95% is immunoglobulin light chain amyloidosis (AL) and transthyretin amyloidosis (ATTR).
- Trial name
- NCT05593679
- Testing
- Tc-99m PYP Cardiac scan
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- Far Eastern Memorial Hospital
Advanced Cancers
Rational Therapeutics Based on Matched Tumor and Normal Tissue
The goal of this laboratory research study is to learn if using molecular information (matched therapy) or not using molecular information and having the study doctor choose the therapy based on your past experience are more…
- Trial name
- NCT02272595
- Testing
- Treatment Based on Genetic Mutation, Treatment Based on No Genetic Mutation
- Where
- 4 sites in United States, France and 2 more
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer Genomic Profiling
A Study to Learn More About What Japanese Patients With Solid Tumors Think About Taking Medicine That is Based on Their Genetic Information
Researchers are looking for a better way to treat people with solid tumors. One new way is called cancer genomic medicine. In cancer genomic medicine, doctors use tests to look at the genetic information in a solid tumor.
- Trial name
- NCT04607889
- Testing
- Survey
- Where
- Japan
- Volunteers
- 605 people
- Sponsor
- Bayer
Short Stature, Growth Hormone Treatment
Web-based Adherence Information Integrated Nurse-led Monitoring Clinic
Non-adherence is a recognized problem with growth hormone treatment in children. In this study, we aim to utilize web-based information derived from easypod growth hormone injection devices and easypod connect devices in a…
- Trial name
- WAIN-MC (NCT04244123)
- Testing
- integrated information and nurse led telephone clinic
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Manchester University NHS Foundation Trust
Colorectal Cancer, Hereditary Non-polyposis Colon Cancer
Collecting Information From Patients and Family Members With Hereditary Colorectal Cancer Syndromes or Who Are at High Risk of Developing Colorectal Cancer
RATIONALE: Gathering medical and family history information from patients and family members may help doctors better understand hereditary colorectal cancer and hereditary polyposis syndrome and identify patients at high risk of…
- Conditions
- Colorectal Cancer, Hereditary Non-polyposis Colon Cancer, Precancerous Condition
- Trial name
- NCT00675636
- Testing
- study of socioeconomic and demographic variables, evaluation of cancer risk factors, study of high risk factors
- Where
- 3 sites in United States
- Volunteers
- 730 people
- Sponsor
- Vanderbilt University Medical Center
Acne Vulgaris
Phase IV Study to Gather More Information About the Safety of ACZONE Gel, 5% in Treating Subjects With Acne Who Have G6PD Deficiency
The purpose of this study is to gather more information about the safety of ACZONE Gel, 5% in treating subjects with acne who have certain blood disorders.
- Trial name
- NCT00243542
- Testing
- ACZONE Gel, 5%, Vehicle
- Where
- 29 sites in United States
- Volunteers
- 64 people
- Sponsor
- Allergan
Osteogenesis Imperfecta
Increasing Knowledge on Osteogenesis Imperfecta by Collecting Epidemiological Data
interventional pilot study with the enrollment of patients affected by Osteogenesis Imperfecta
- Trial name
- 4FRAILTY (NCT06193642)
- Testing
- experimental
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Istituto Ortopedico Rizzoli
Diabetes Mellitus, Type 2
Understanding of Genetic Risk Information for Type 2 Diabetes
This research study is being conducted to learn about how health and genetic literacy (i.e., how well a person understands health and genetic information) affects a person's ability to understand genetic risk information for Type…
- Trial name
- NCT01186354
- Testing
- Receiving results via genetic counselor
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Duke University
Disorder of Sex Development, Intersex Conditions
Decision Support for Parents Receiving Information About Child's Rare Disease
The birth of a child with a disorder of sex development (DSD) is stressful for parents and members of the healthcare team. The "right" decisions about gender assignment (is it a boy? a girl?) and the best course of action (e.g.…
- Conditions
- Disorder of Sex Development, Intersex Conditions, Congenital Adrenal Hyperplasia, Hypospadias
- Trial name
- DSD DST (NCT01875640)
- Where
- 4 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Bipolar Disorder
Utility of the Pharmacogenetic Information Provided by NEUROPHARMAGEN in the Treatment of Bipolar Depressionwith Bipolar Depression
Evaluation of the impact of the genetic variation of individual genes on the therapeutic response and side effects profile in a cohort of well-characterized patients with bipolar depression, using NEUROPHARMAGEN.
- Trial name
- NCT04923204
- Testing
- Pharmacogenomic-testing with NEUROPHARMAGEN
- Where
- Spain
- Volunteers
- 76 people
- Sponsor
- AB Biotics, SA
Duchenne Muscular Dystrophy
This is a Study to Get More Information About Non Ambulatory Boys & Men With Duchenne Muscular Dystrophy
Many therapeutic trials in DMD exclude non-ambulatory boys and men. Rate of progression in these non-ambulatory patients has been studied but consensus has not been reached for what measures are most reliable and reproducible.
- Trial name
- DMD (NCT01098708)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
All Types of Metastatic Solid Malignancy, 1st-line Treatment
Study of Cancer Patients' Preferences for Genetic Information Modalities Preceding Theranostic Exome Analysis.
Currently, the EXOMA2 study (NCT04614480) offers earlier and more comprehensive exome analysis in the management of cancer patients than EXOMA.
- Conditions
- All Types of Metastatic Solid Malignancy, 1st-line Treatment, Exome Analysis, Active File EXOMA2 Study
- Trial name
- INFOGENE (NCT06550687)
- Testing
- Cancer patients' preferences regarding genetic information modalities prior to theranostic exome analysis
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Centre Georges Francois Leclerc
Healthy
Genetic Information and Dietary Intake Behaviour
This study's primary objective is to determine if providing individuals with personal genetic information impacts dietary intake behaviour.
- Trial name
- NCT01353014
- Testing
- Dietary advice with genetic information, General dietary recommendations
- Where
- Canada
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Bipolar Disorder (BD), Schizophrenia Disorders
Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness
This observational study aims to provide new insights into the nature and classification of severe mental illness and dementias that in time should help improve diagnostic practise, and enable the development of new and improved…
- Conditions
- Bipolar Disorder (BD), Schizophrenia Disorders, Major Depressive Diorder, Dementia
- Trial name
- GlobalMinds (NCT06641726)
- Testing
- Not applicable- observational study
- Where
- United Kingdom
- Volunteers
- 50,000 people
- Sponsor
- Akrivia Health
Genetic Testing
Access to Genetic Information Leveraging Innovative Technology (AGILITY)
AGILITY is a type 1 hybrid trial that will test the effectiveness of a chatbot to provide pre-test information about genetic screening for tier 1 conditions.
- Trial name
- AGILITY (NCT05159011)
- Testing
- AGILITY (Access to Genetic Information Leveraging Innovative TechnologY)
- Sponsor
- RTI International