Clinical trials: Genetic Markers
Familial Hypercholesterolemia
Soy Food Intervention Trial
Familial hypercholesterolemia (FH MIM#143890), an inherited disorder of lipoprotein metabolism, is a risk for early cardiovascular disease (CVD).
- Trial name
- SOYFIT (NCT00924339)
- Testing
- soy protein diet, rapeseed oil
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Sickle Cell Disease
Pathophysiology of Acute Pain in Patients With Sickle Cell Disease
Background: Sickle Cell Disease (SCD) is a blood disorder that occurs mainly in people of African descent. Researchers want to learn more about the painful attacks and complications associated with SCD.
- Trial name
- NCT03049475
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sexual Addiction
A Study of Gene Polymorphisms Associated With Specific Presentations of Sexual Addiction
The study is intended to identify gene polymorphisms significantly associated with specific behavioral- and preoccupation-typologies of sexual addiction, and to identify additional potential genetic markers of sexual addiction.
- Trial name
- NCT02844985
- Testing
- No Intervention
- Where
- 8 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- American Foundation for Addiction Research
Chronic Obstructive Pulmonary Disease
Pennsylvania Study Of Chronic Obstructive Pulmonary Exacerbations
The overall purpose of PA-SCOPE is to determine why black and rural residents of Pennsylvania might be at higher risk for deadly, debilitating, and costly hospitalizations for chronic obstructive pulmonary disease (COPD)- and…
- Trial name
- PA-SCOPE (NCT00774176)
- Where
- 3 sites in United States
- Volunteers
- 1,066 people, healthy volunteers welcome
- Sponsor
- Temple University
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Schizophrenia
Genetic Research in Schizophrenia Using DNA Markers and Clinical Phenotypes
Schizophrenia has long been known to be an illness with significant evidence for a genetic predisposition. The purpose of this study is to determine the genetic abnormalities that cause childhood and adult onset schizophrenia.
- Trial name
- NCT00108303
- Testing
- Diagnostic
- Where
- United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Obsessive-Compulsive Disorder, Social Anxiety Disorder
Neurobiological Markers of Treatment Response for Anxiety and OCD
Obsessive-compulsive disorder (OCD) and anxiety disorders are common and debilitating conditions which are often chronic when treatment is not provided.
- Conditions
- Obsessive-Compulsive Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT05663489
- Testing
- Bergen 4-Day Treatment (B4DT)
- Where
- Norway
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Cystic Fibrosis
Non-Invasive Biomarkers in Cystic Fibrosis
Background Chronic airway inflammation is present in cystic fibrosis. Non-invasive inflammometry may be useful in disease management.
- Trial name
- NCT00413140
- Where
- 4 sites in Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Pancreatic Disease
A Study of Synthetic Human Secretin (ChiRhoStim®) Administered Intravenously to Stimulate Exocrine Pancreas Fluid Secretion for Collection Via Endoscope and Laboratory Analysis of DNA Markers
The following are the study hypothesis: Secretin administration compared to placebo will result in a statistically significantly greater percentage of collected fluid samples being predominantly of exocrine pancreas origin when…
- Trial name
- CRC2006-05 (NCT01087801)
- Testing
- ChiRhoStim
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- ChiRhoClin, Inc.
Atherosclerosis, Coronary Arteriosclerosis
Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study
Atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in Western societies. It is a complex genetic disorder with many genes involved and significant gene-environment interactions.
- Conditions
- Atherosclerosis, Coronary Arteriosclerosis, Carotid Artery Diseases, Genetic Predisposition to Disease
- Trial name
- LE-Heart (NCT00497887)
- Where
- 2 sites in Germany
- Volunteers
- 4,000 people
- Sponsor
- University of Leipzig
Sepsis
Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis
Aims of the study were to find vascular markers of inflammation and endothelial damage during the course of severe sepsis in septic patients and the effects of treatment with anti-inflammatory medication (such as Drotregocin alfa…
- Trial name
- NCT00222222
- Testing
- vein puncture
- Where
- Germany
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Advanced Cancers
Rational Therapeutics Based on Matched Tumor and Normal Tissue
The goal of this laboratory research study is to learn if using molecular information (matched therapy) or not using molecular information and having the study doctor choose the therapy based on your past experience are more…
- Trial name
- NCT02272595
- Testing
- Treatment Based on Genetic Mutation, Treatment Based on No Genetic Mutation
- Where
- 4 sites in United States, France and 2 more
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Non-Tuberculous Mycobacterial Pneumonia
Cellular Markers in Treated or Untreated Non-tuberculous Mycobacterial Respiratory Infection in Patients With Cystic Fibrosis
This study evaluates a diagnostic serological test for Non-Tuberculous Mycobacteria (NTM) infection in cystic fibrosis patients by measuring T cell response.
- Trial name
- MUCEM (NCT06602869)
- Testing
- Scheduled visit (V1)
- Where
- France
- Volunteers
- 76 people
- Sponsor
- University Hospital, Montpellier
Bone Remodeling Disorder, Child Development
Clinical and Genetic Markers of Bone Metabolism in Children Under One Year
The study of children under one year of age for molecular genetic testing-VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759) with the study of the frequency distribution of alleles and genotypes by polymorphisms, analysis…
- Conditions
- Bone Remodeling Disorder, Child Development, Genetic Change
- Trial name
- NCT05375331
- Where
- Kazakhstan
- Volunteers
- 245 people
- Sponsor
- West Kazakhstan Medical University
Carcinoma, Squamous Cell
Phase I Study of Olaparib With Cisplatin Based Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck
The aim of this study is to find the safe dose and best dosing schedule of olaparib to give in combination with cisplatin based chemoradiotherapy (CRT) in patients with locally advanced head and neck cancer.
- Trial name
- ORCA (NCT01491139)
- Testing
- olaparib, cisplatin, Intensity Modulated Radiotherapy
- Sponsor
- University College, London
Cystic Fibrosis
Omega 3 Supplementation in Cystic Fibrosis Patients
Essential fatty acids (EFA) deficiency has been often reported in patients with cystic fibrosis (CF), particularly in those homozygous for the DF508 mutation.
- Trial name
- NCT00959010
- Testing
- omega-3 triglycerides
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Queen Fabiola Children's University Hospital
Cardiovascular Diseases
Identification of Genetic Markers for Cardiopulmonary Diseases (Genotype)
This study is designed to investigate whether an association exists between certain genes/protein levels and the development of various cardiopulmonary diseases.
- Trial name
- Genotype (NCT00616369)
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- University of Alabama at Birmingham
Suicidal Intention
Suicidal Thought and Biological Markers
Thought Markers (Tm) and Biomarkers(Bm) to accurately predict the likelihood of a repeated suicide attempt.
- Trial name
- STM (NCT01992445)
- Where
- 3 sites in United States
- Volunteers
- 375 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acute Pancreatitis
Assessment of the Different Etiological and Susceptibility Markers in Patients With Pancreatitis: Investigating IG4, Cytomegalovirus, Coxsackie- Virus, Genetic Polymorphism of Vitamin D Receptor Gene
Acute pancreatitis (AP) is a multifactorial disease. AP represents a significant number of hospital admissions. Most of the patients are admitted in an acute setting.
- Trial name
- NCT03830073
- Testing
- Measurement of VDR genetic polymorphism
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Breast Cancer
Determination of Predictive Genetic Markers of Toxicity After Hypofractionated Radiotherapy in Breast Cancer Patients Post-Conservative Surgery
The single shot partial breast irradiation (SSPBI) trial was designed as a prospective Phase II "single-arm study". The use of a single dose tumor bed is expected to be very effective in terms of tumor control, but it could…
- Trial name
- HYPOPRONE (NCT01316328)
- Where
- Italy
- Sponsor
- Regina Elena Cancer Institute