Clinical trials: Genetic Polymorphism
Development, Child
The Relationship Between VDR Gene Polymorphism and Children's Physical and Intellectual Development
This study was used to determine the relationship between vitamin D receptor gene polymorphism and children's physical and intellectual development, further adjust the doses of vitamin D supplementation after birth, and provide…
- Trial name
- RVDRGPCPID (NCT03742310)
- Testing
- Vitamin D
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Androgenetic Alopecia
Association of Polymorphisms in the Androgen Receptor Gene and Finasteride Response in Women With Androgenetic Alopecia
Previous studies of finasteride treatment in women with hair loss have failed to show positive results, yet, some women have responded anecdotally.
- Trial name
- NCT01052870
- Testing
- Finasteride
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- HairDx, LLC
Parkinson Disease
Cell Studies of Parkinson's Disease
This study will examine and compare blood samples from healthy volunteers and patients with Parkinson's disease to identify abnormalities associated with Parkinson's disease.
- Trial name
- NCT00076505
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Breast Cancer
Role of Cytochrome P450 2D6 (CYP2D6) *4 Polymorphism,in Malignant Breast Diseases
The aim of our study is to investigate the potential role of the CYP2D6*4 polymorphism in breast cancer and furthermore to assess the role of oxidative stress, antioxidant capacity and ferretin in pathogenesis of breast cancer in…
- Trial name
- NCT00539422
- Testing
- pcr and serum markers for breast cancer
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mansoura University
Sinus Arrhythmia
Identification of Gene Polymorphism in Patients With Sick Sinus Syndrome in Chinese Population in Taiwan
Background: Sinus node dysfunction is a major cause of bradycardia necessitating pacemaker implantation. Evidences of genetic study supported that some genes involved in the pacemaker current or renin-angiotensin system were…
- Trial name
- NCT00314223
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Oral Squamous Cell Carcinoma (OSCC)
Determination of ALDH1b1 and ALDH2 Polymorphisms Frequency in the Brazilian Population
A case-control study with oral squamous cell carcinoma (OSCC) patients from Instituto do Câncer do Estado de São Paulo (ICESP) and healthy volunteers.
- Trial name
- ALDH2020 (NCT04270201)
- Testing
- Saliva collection
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Schizophrenia
Program for the Introduction Into Clinical Practice of the Principles of Personalized and Preventive Medicine Based on the Isolation of Gene Polymorphism in Schizophrenia in People of the Kazakh Ethnic Group
This is a GWAS study that aims to identify possible candidate genes associate to schizophrenia by exploring single nucleotide polymorphism (SNP) in a group of schizophrenia, in the Kazakh population.
- Trial name
- NCT05090644
- Testing
- DNA analysis
- Where
- Kazakhstan
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Asfendiyarov Kazakh National Medical University
Acidosis, Renal Tubular, Nephrolithiasis
Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
Purpose 1. To compare the performance of the two currently employed urinary acidifications tests in stone formers, the furosemide/fludrocortisone and ammonium chloride loading test. 2.
- Conditions
- Acidosis, Renal Tubular, Nephrolithiasis, Vacuolar Proton-Translocating ATPases
- Trial name
- NCT01690039
- Testing
- Furosemide-Fludrocortisone-Test (test for urinary acidification)
- Where
- Switzerland
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Tuberculosis
The Role of Vitamin D, A, and Beta Carotene in Tuberculosis Patients With Vitamin D Receptor Gene Polymorphism
Recent studies showed that vitamin D and A has an effect in improving sputum conversion in tuberculosis. This study aims to find out the effect of vitamin D 1000 IU and A 6000 IU supplementation on Tuberculosis patients with…
- Trial name
- NCT04593524
- Testing
- vitamin D 1000 IU and A 6000 IU supplementation and nutritional counseling, nutritional Counseling
- Where
- Indonesia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Universitas Sumatera Utara
Periodontitis, Type 2 Diabetes Mellitus (DM)
Evaluation of MTHFR and DNMT3B Gene Polymorphisms Along With Periodontal Clinical Parameters in Healthy Individuals and Individuals With Type 2 Diabetes and Periodontitis
Periodontitis is a chronic inflammatory disease that affects the tissues supporting the teeth and can lead to progressive tissue destruction.
- Trial name
- NCT07905209
- Testing
- MTHFR and DNMT3B Genetic Polymorphism Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Psoriasis, Psoriatic Arthritis
IKBKB Gene Polymorphism (Single Nucleotide Polymorphism) (SNP) in Psoriatic and Psoriatic Arthritis Patients
Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema. It impairs patients' quality of life enormously. Psoriasis refers to a persistent inflammatory illness of the skin and joints.
- Trial name
- NCT06729463
- Testing
- Humira
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- South Valley University
Pharmacokinetics of Three PDE5Is, Healthy Subjects
The Effect of CYP3A Genetic Polymorphism on the Pharmacokinetics of Phosphodiesterase type5 Inhibitors in Male Subjects
In order to evaluate the effect of CYP3A5*3 allele on the pharmacokinetics of sildenafil, udenafil, and vardenafil, the clinical trial using a single oral dose was conducted in Korean healthy male subjects whose genotype of…
- Conditions
- Pharmacokinetics of Three PDE5Is, Healthy Subjects, Genetic Polymorphic CYP3A5
- Trial name
- CYP3APDE5I (NCT00767598)
- Testing
- phosphodiesterase type 5 inhibitor
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Inje University
Prostate Cancer
Study of a Polymorphism in Patients With Prostate Cancer
RATIONALE: Studying samples of blood from patients with cancer and from healthy participants in the laboratory may help doctors learn more about changes that may occur in DNA.
- Trial name
- NCT00900185
- Testing
- mutation analysis, polymerase chain reaction, polymorphism analysis
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Pain, Surgery
The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population
Objective: This study was conducted to explore the possible correlation between some gene related to pain sensation and individual basal pain perception and postoperative pain intensity in the general population.
- Trial name
- NCT01950078
- Where
- China
- Volunteers
- 1,533 people, healthy volunteers welcome
- Sponsor
- Xianwei Zhang
Peri-Implantitis
Analysis of Genetic Variations in Patients With Peri-implantitis
The primary objective of this study is to evaluate interleukin-1(IL-1) gene group polymorphisms in patients with peri-implantitis and to compare them with patients with peri-implant health (control group), taking into account…
- Trial name
- NCT04807725
- Testing
- Analysis of genetic polymorphisms, Biochemical analysis
- Where
- Portugal
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Leprosy
TGF β 1 Expression Related Gene Polymorphism
Leprosy is one of the oldest human infectious diseases. It is a chronic infectious contagious, granulomatous disease caused by intracellular bacillus.
- Trial name
- NCT06683690
- Testing
- Measurement of TGF- β1 in leprosy patients
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aswan University
Exercise
Gene-Exercise Interactions in Athletes
Athlete status is a heritable trait that could be explained with a number of potentially important DNA polymorphisms contributing to predisposition to success in certain types of sport.
- Trial name
- GE-EX (NCT03279380)
- Testing
- SNP, High Intensity Interval Training (HIIT), Low Intensity Continuous Training
- Where
- Slovenia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Urolithiasis
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study
Many things, like not drinking enough fluids, contribute to making kidney stones and there is also a genetic tendency. We looked into this in 1998-2000 in 14 families with several stone-formers.
- Trial name
- NCT06211842
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Autism Spectrum Disorders
Susceptibility Genes in Autism Spectrum Disorders
The main objective of the study is to define, for Autism Spectrum Disorder, the extent of genetic variation in synaptic pathways that may be targeted for therapeutic development.
- Trial name
- NCT02628808
- Where
- 5 sites in France
- Volunteers
- 1,616 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Myasthenia Gravis, Ocular, Gene Polymorphism
Association Study Between VDR Gene Polymorphisms and Risk and Features of MG in Han Chinese Population
The Vitamin D receptor gene (VDR) polymorphisms are the candidate genetic variants for susceptibility to autoimmune diseases. In the present study, the investigators aimed to assess the association between VDR polymorphisms and…
- Trial name
- NCT05380128
- Testing
- Genotype analysis for VDR rs1544410, rs2228570, rs731236, and rs7975232 polymorphisms
- Where
- China
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital