Clinical trials: Genetic Polymorphism
Hypertension
Genetic Determinant of Blood Pressure Sensitivity to Salt Intake
Nedd4.2 is a regulator of ENac, a transporter of sodium involved in the regulation of salt retention by the kidney. The study address the consequence of a frequent genetic variation leading expected to impact the function of…
- Trial name
- JEU004 (NCT01706887)
- Testing
- Diet Amiloride
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventricular Fibrillation, Ventricular Arrythmia
Noninvasive Electrocardiographic Imaging for Individuals at Risk for Apparently Idiopathic Ventricular Fibrillation.
This study aims to evaluate the electrophysiological properties of the heart conduction system in patients with unexplained polymorphic ventricular tachycardia (VT) and/or ventricular fibrillation (VF), in patients with specific…
- Conditions
- Ventricular Fibrillation, Ventricular Arrythmia, Polymorphic Ventricular Tachycardia, Sudden Cardiac Death
- Trial name
- VIGILANCE (NCT03963271)
- Testing
- ECG-Imaging
- Where
- 3 sites in Netherlands
- Volunteers
- 500 people
- Sponsor
- Maastricht University Medical Center
Schizophrenia
Therapeutic Drug Monitoring for Individualized Clozapine Therapy
The purpose of this study is to evaluate the factors affecting the occurrence of adverse drug reactions (glucose and lipid metabolism abnormality, changes in liver function index and sleeping tendency) and clinical effects in…
- Trial name
- NCT03523741
- Testing
- Clozapine
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Parkinson Disease
Cell Studies of Parkinson's Disease
This study will examine and compare blood samples from healthy volunteers and patients with Parkinson's disease to identify abnormalities associated with Parkinson's disease.
- Trial name
- NCT00076505
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Obesity
Correlation Between COMT Val158Met Polymorphism and Dopaminergic Transporter Density (DAT) in Obese Women
The present study aims to evaluate the correlation between the presence of COMT Val158Met polymorphism and the density of dopaminergic transporters (DAT) in young obese women.
- Trial name
- NCT04815122
- Testing
- SPECT TRODAT-1
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- University of Sao Paulo
Silent Myocardial Ischemia, Acute Myocardial Infarction
Silent Myocardial Ischemia in Patients Undergoing Non-oncological Abdominal Surgeries
Perioperative mortality in non-cardiac surgical procedures is 1-2 % with half of these cases attributed to cardiovascular events.
- Trial name
- NCT06536686
- Testing
- Silent myocardial ischemia, STEMI
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Medical Centre Ljubljana
T2DM
The Imaging Genetic Study of Type 2 Diabetes and Depression
To investigate the structural/functional abnormalities and the possible genetic endophenotypes of in the Type 2 Diabetes Patient With Depression.
- Trial name
- NCT03564431
- Testing
- Magnetic resonance
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kunming Medical University
Non-Small Cell Lung Cancer
An Observational Research Of Crizotinib's Hepatic Toxicity In Non-small Cell Lung Cancer Patients
Crizotinib, an inhibitor of anaplastic lymphoma kinase (ALK), was approved by Food and Drug Administration (FDA) for the treatment of patients with ALK-positive non-small cell lung cancer (NSCLC) and its administration has…
- Trial name
- NCT02708667
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Recurrent Pityriasis Versicolor
Gene Polymorphism in Tinea Versicolor
Blood samples will be taken from cases presenting with recurrent tinea versicolor , after confirmation of diagnosis by wood's light and KOH examination, for the detection of gene polymorphism in IL17 A and IL17 F.
- Trial name
- NCT04769804
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Kasr El Aini Hospital
Hemophilia, AIDS
Host Genetic Factors Influencing HIV1 and HCV Viral Loads and AIDS Clinical Progression in a Hemophilia Cohort (HGDS-3)
Background: Over 80% of the hemophiliac population who became infected with HIV prior to 1985 are also co-infected with HCV. Thus, hemophiliacs represent an important population for studies of the natural history of these chronic…
- Trial name
- NCT00340548
- Where
- 15 sites in United States
- Volunteers
- 333 people
- Sponsor
- National Cancer Institute (NCI)
Liver Transplant Rejection
Role of NFKBIA and PTPN22 Genes Polymorphism in Acute Rejection Susceptibility After Living Donor Liver Transplantation in Egyptian Patients.
Our study aimed at studying the impact of gene polymorphism of NFKBIA and PTPN22 genes on rejection episodes in liver transplant Egyptian recipients. Also assess patients' factors associated with graft rejection.
- Trial name
- NCT06060808
- Testing
- gene polymorphism
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Helwan University
Psychotic Disorders, Depressive Disorder
Genetics of Symptomatology and Treatment Response in Psychotic Major Depression
We hope to learn more about the biology of psychiatric illness with the hope of improving the diagnosis and treatment of such psychiatric conditions as major depression.
- Conditions
- Psychotic Disorders, Depressive Disorder, Depressive Disorder, Major
- Trial name
- NCT00691535
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Stanford University
Primary Prevention
Genetical, Anthropometrical and Biochemical Factors Influencing High Risk Subclinical Atherosclerosis
Subclinical atherosclerosis is the atherosclerotic process identified before clinical symptoms and thus it can be a useful marker of future cardiovascular events. It can be evaluated by many methods.
- Trial name
- NCT02487615
- Where
- 2 sites in Brazil
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Kidney Failure, Acute, Critical Illness
Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)
Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated.
- Trial name
- NCT00316576
- Testing
- Blood sampling for PCR
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Caen
Cancer
The Role of SNP rs2910164 in Patients Treated With Immune Checkpoint Inhibitors
The objective of this study is to investigate whether the SNP rs2910164 in the pre-miR-146a gene is associated with outcome and toxicity of immune checkpoint inhibitor therapy.
- Trial name
- NCT04038996
- Volunteers
- 179 people
- Sponsor
- University of Freiburg
Oral Squamous Cell Carcinoma (OSCC)
Salivary IL-6 and Interleukin Gene Polymorphisms in Oral Squamous Cell Carcinoma
This observational study will evaluate whether salivary interleukin-6 levels and selected interleukin gene polymorphisms are associated with regional lymph node involvement in patients with oral squamous cell carcinoma.
- Trial name
- IL6-OSCC (NCT07692360)
- Testing
- Saliva Collection and Biomarker Analysis
- Where
- 2 sites in Italy
- Volunteers
- 38 people
- Sponsor
- University of Pavia
Preeclampsia
Vascular Endothelial Factor Gene Polymorphism in Preeclampsia
In this study, the investigators assessed one of the released protein factors during the pathophysiology of preeclampsia. They evaluated vascular endothelial growth factor gene mutation which affects the angiogenesis in case of…
- Trial name
- NCT03500588
- Testing
- PCR, Doppler ultrasound
- Where
- Egypt
- Volunteers
- 290 people
- Sponsor
- Beni-Suef University
Attention Deficit-Hyperactivity Disorder
TLR Polymorphism, ASO and Beta-hemolytic Group A Streptococcus Infections in ADHD: an Observational Study
The aim of this observational cross-sectional study is to evaluate the streptococcal infection (clinical history, ASLO title and anti-DNAse title B) and autoimmunity (ABGA antibodies) in a sample of 100 adult patients diagnosed…
- Trial name
- TLR; (NCT04038073)
- Testing
- Antistreptolysin O Test, Anti-Deoxyribonuclease B, TLR, MyD88, IRAK-4 polymorphism
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Turin, Italy
Blood Flow in Healthy Volunteers
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia
The endogenous nucleoside adenosine can induce various cardiovascular and neurohumoral effects by stimulation of specific adenosine receptors.
- Trial name
- NCT00253929
- Testing
- Intra-arterial infusion of adenosine, intra-arterial infusion of caffeine, intra-arterial infusion of acetylcholine
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pulmonary Tuberculosis
Randomized Trial for Pharmacogenomics-based Tuberculosis Therapy (RT-PGTT)
The purpose of this study is to elucidate whether the individualized medicine based on NAT2 gene polymorphism could improve the safety, efficacy and economical benefits of multi-drug therapy for the pulmonary tuberculosis with…
- Trial name
- NCT00298870
- Testing
- Isoniazid, isoniazed
- Where
- 4 sites in Japan
- Volunteers
- 172 people
- Sponsor
- Osaka University