Clinical trials: Genetic Polymorphism
Obesity, Childhood, Asthma in Children
Asthma and Obesity Diet Versus Exercise
Obesity is recognized as a pro-inflammatory condition associated with multiple chronic diseases, including asthma. The specific mechanisms linking asthma and obesity remain hypothetical.
- Conditions
- Obesity, Childhood, Asthma in Children, Inflammatory Response, Metabolic Syndrome
- Trial name
- NCT03644355
- Testing
- Lifestyle counseling
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Genetic Polymorphisms
NIEHS/UNC Environmental Polymorphism Study
The Environmental Genome Project (EGP) has completely or partially resequenced the protein coding and regulatory regions of 53 environmentally sensitive genes from 72 anonymous individuals of varying ethnic backgrounds to date.
- Trial name
- NCT00340886
- Where
- United States
- Volunteers
- 485 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
BDNF, Polymorphism, Genetic
BDNF and Motor Learning
The purpose of the study is to assess the status of brain-derived neurotrophic factor brain (BDNF) and how the brain behaves in response to skill acquisition.
- Trial name
- BDNF (NCT02074696)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Head and Neck Neoplasms, Fibrosis
The Fibrosis-Lymphedema Continuum in Head and Neck Cancer
Goal: The primary goal of this study is to longitudinally investigate, in head and neck cancer (HNC) patients, the potential fibrosis-lymphedema continuum.
- Conditions
- Head and Neck Neoplasms, Fibrosis, Lymphedema, Biomarkers
- Trial name
- NCT01187173
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University
Hemodynamics, Coronary Circulation
FFR Versus iFR in Assessment of Hemodynamic Lesion Significance
The study will compare two invasive methods (FFR -fractional flow reserve and iFR-instantaneous wave free ratio) for assessment of hemodynamic impact of coronary stenosis on myocardial perfusion.
- Conditions
- Hemodynamics, Coronary Circulation, Tomography, Optical Coherence, Endothelial Cells
- Trial name
- FiGARO (NCT03033810)
- Testing
- Fractional flow reserve and instantaneous wave-free ratio
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- General University Hospital, Prague
Busulfan Pharmacokinetic Analysis, GST Genetic Polymorphism
Busulfan Pharmacokinetic Analysis and GST Polymorphism in Adults Undergoing Hematological Stem Cell Transplantation
Between 100 up to 200 adults undergoing HSCT for their primary disease will be included in this pharmacokinetic/pharmacogenetic study. In the preparative protocol Busulfan (BU)will be included as indicated in a known protocol.
- Trial name
- NCT01071486
- Testing
- Hematological Stem Cell Transplantation
- Where
- Israel
- Sponsor
- Rambam Health Care Campus
Libido, Receptors, Androgen
Genetic Polymorphism of the Androgen Receptor-Gene and Sexual Function in Middle Aged Women
It is known that with increasing age sexual desire is declining in women. Decreasing levels of androgens are believed to have an influence, but cannot explain the loss of libido completely.
- Conditions
- Libido, Receptors, Androgen, Polymorphism, Genetic, Androgen Effect
- Trial name
- CAG-Libido (NCT01977313)
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Genetic Blood Group (bg) Polymorphism in U Negativity and St(a) of MNSs
Whole Genome Sequencing for Blood Group Genotyping and Definition as Exemplified on U- and St(a)+.
No health condition(s) are studied. Genetic background of blood groups is studied. U- and Stones(a)+ ("Caucasian type") are used as proof-of-principle samples.
- Trial name
- Blood Genome (NCT02534519)
- Testing
- Whole Genome Sequencing (WGS)
- Where
- Switzerland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Blood Donation Service Zurich, SRC
Genetic Polymorphism
The Role of Platelet Surface α2β1 Integrin Expression as a Risk Factor in Thrombotic and/or Bleeding Complications
This study will begin to define these critical determinants for patients undergoing procedures in the hybrid interventional cardiology/cardiac surgery suite.
- Trial name
- NCT00603148
- Where
- United States
- Volunteers
- 475 people
- Sponsor
- Vanderbilt University
Postoperative Nausea and Vomiting, Genetic Polymorphisms
Developing Individualized Strategies to Prevent Nausea and Vomiting
Every year, more than 5 million patients in the US experience postoperative nausea and/or vomiting (PONV) and in the ambulatory setting post-discharge nausea and/or vomiting (PDNV) is the most common cause for unanticipated…
- Trial name
- PDNVF (NCT01393288)
- Testing
- Ondansetron, Lorazepam, Aprepitant
- Where
- 6 sites in United States
- Sponsor
- University of California, San Francisco
Genetic Polymorphism, Macular Degeneration
Does Complement Factor H Gene Polymorphism Play a Role in the Regulation of Vascular Tone in the Choroid?
Age related macular degeneration (AMD) is a multifactorial disease with a strong genetic component. Most importantly a genetic polymorphism in the gene encoding for the complement factor H (CFH) has been recently identified which…
- Conditions
- Genetic Polymorphism, Macular Degeneration, Regional Blood Flow, Ocular Physiology
- Trial name
- NCT00708929
- Testing
- Squatting
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy Subjects, Heme Oxygenase
Effects of Heme Arginate in Healthy Male Subjects
Heme oxygenase 1 (HO-1) serves as a protective gene. It has been shown that one factor modulating HO-1 activity is a genetic variation in the HO-1 gene (functional GT length polymorphism in the promotor region).
- Conditions
- Healthy Subjects, Heme Oxygenase, Genetic Polymorphism
- Trial name
- HEMAHS (NCT00682370)
- Testing
- saline solution, heme arginate
- Where
- Austria
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Daniel Doberer
Azathioprine, Thiopurine Methyltransferase
Correlation of Genetic Polymorphism of Azathioprine Metabolizing Enzymes and Correlation to Clinical Adverse Effects
Azathioprine (AZA) has long been used in dermatology in treating autoimmune bullous dermatoses and generalized eczematous disorders as well as some photodermatoses.
- Conditions
- Azathioprine, Thiopurine Methyltransferase, Inosine Triphosphate Pyrophosphatase, Genetic Polymorphism
- Trial name
- NCT00525473
- Testing
- Azathioprine
- Where
- Taiwan
- Volunteers
- 166 people
- Sponsor
- National Taiwan University Hospital
Genetic Polymorphism Connected to Top-level Swimmers
Genetic Polymorphism and Israeli Top-level Swimmers' Performance and Expertise
In a study conducted in our laboratory few years ago, we genotyped 22 genes in 2 athletic groups (endurance and sprinters) and in age and gender matched nonathletic controls.
- Trial name
- NCT01319032
- Testing
- Extraction of whole blood
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Breast Neoplasms, Arthralgia
CYP19 Genetic Polymorphism & Aromatase Inhibitor(AI)
The purpose of this study is to investigate the relationship between the side effects(especially arthralgia and arthritis) which appear in the patients who are prescribed aromatase inhibitor(AI) and the CYP19 genetic…
- Conditions
- Breast Neoplasms, Arthralgia, Arthritis, Genetic Polymorphism
- Trial name
- AI-CYP19 (NCT00973505)
- Testing
- Aromatase Inhibitor(Femara or Arimidex)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Korea University Anam Hospital
Schizophrenia, Metabolic Syndrome
Association of Multiple Genetic Polymorphisms With Clozapine-Associated Metabolic Change in Schizophrenia
We are going to investigate the association of multiple genetic polymorphisms with the metabolic side effects in patients with schizophrenia taking clozapine.
- Conditions
- Schizophrenia, Metabolic Syndrome, Genetic Polymorphism
- Trial name
- NCT00717509
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National Hospital
Genetic Polymorphism, Coronary Artery Disease
Association Study of Gene Polymorphisms With Cardiac Performance
The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.
- Conditions
- Genetic Polymorphism, Coronary Artery Disease, Hemodynamics
- Trial name
- NCT00730899
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital, Essen
Hepatitis B, Carcinoma, Hepatocellular
Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma
The purpose of this study is to determine the effect of polymorphisms in the IL-1 gene complex on the development of chronic hepatitis and hepatocellular carcinoma.
- Conditions
- Hepatitis B, Carcinoma, Hepatocellular, Polymorphism, Genetic
- Trial name
- NCT00155103
- Where
- Taiwan
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital