Clinical trials: Genetic Polymorphism
Fertility Disorders
TRAP Study: Testosterone for Androgen Receptor Polymorphism
To determine whether pretreatment with transdermal testosterone increases the number of cumulus-oocyte complexes (COCs) obtained after ovarian stimulation by more than 1.5 in patients with low ovarian reserve and androgen…
- Trial name
- TRAP (NCT06195163)
- Testing
- Transdermal Gel in Sachet Dosage Form, No pretreatment
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Stomach Ulcer
Influence of CYP2C19 Polymorphism on PK/PD of Omeprazole
A clinical trial to investigate the influence of CYP2C19 polymorphism on pharmacokinetic/pharmacodynamic characteristics of omeprazole in healthy Korean volunteers
- Trial name
- NCT02299687
- Testing
- Omeprazole
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Breast Cancer
An Investigation of the Effect of the Promoter Polymorphism in the Glucuronosyltransferase 2B7 in Patients on Breast Cancer Treatment
For many years scientists and cancer researchers have been trying to find out why some people benefit more from anti-cancer medications than other people who receive the same amount and same kind of medications.
- Trial name
- NCT00131612
- Testing
- FEC 100
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- AHS Cancer Control Alberta
Obesity Adult Onset
Preference of Protein Intake and FTO rs1558902 Gene Polymorphism Among Women Obese
The concept personalized gene-based nutrition combines genetic information with specific dietary intake that is crucial in managing obesity.
- Trial name
- NCT04740528
- Testing
- fto gene testing
- Where
- Indonesia
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Universitas Diponegoro
Prostate Cancer
Evaluation and Predictive Value of Genetic Polymorphisms in the Management of Hormonal Treatment of Prostate Cancer
Androgen deprivation therapy (ADT) by surgical castration or administration of LHRH agonists or antagonists is the gold-standard systemic treatment of Prostate Cancer.
- Trial name
- Feel+ (NCT02440802)
- Testing
- Saliva sample collection for genetic analyses
- Where
- 20 sites in Belgium
- Volunteers
- 250 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Folate, CML
FLOR3 Gene Polymorphism in Predicting Outcomes of Tyrosine Kinase Inhibitor（TKI）Stopping in Chronic Myeloid Leukemia
For patients with chronic myeloid leukemia in chronic phase (CML-CP) who have achieved a stable deep molecular response (DMR) using BCR-ABL1 tyrosine kinase inhibitors (TKIs), treatment-free remission (TFR) following TKI…
- Conditions
- Folate, CML, Treatment-free Remission
- Trial name
- NTU-CML-001 (NCT05152537)
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Affiliated Hospital of Nantong University
Malignant Pleural Mesothelioma
Effect of FAS and FAS Ligand Polymorphisms on Patients With Platinum-Based -Treated Malignant Pleural Mesothelioma
To Study the Effect of Polymorphisms in Fas Ligand Gene Promoter Region (rs 763110) and Fas gene (rs1800682) on Platinum-Based regimens used in treatment of malignant pleural mesothelioma (MPM)
- Trial name
- NCT02269878
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Ain Shams University
Myeloid Leukemia
Genome-wide Pharmacogenetic Candidate Gene Single Nucleotide Polymorphism (SNP) Array-based Approach to Predict Chemoresponse and Survival in Patients With Acute Myeloid Leukemia With Normal Karyotype
The most reliable prognostic marker of acute myeloid leukemia(AML) is cytogenetics by karyotyping. According to cytogenetic results, the patients with AML are classified as better, intermediate and poor prognosis groups.
- Trial name
- NCT01066338
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
Polymorphic Light Eruption, Psoriasis
Regulatory T Cells (Tregs) in Polymorphic Light Eruption
Polymorphic light eruption (PLE) is a photodermatosis with an extremely high prevalence, particularly among young women (up to 20%).
- Conditions
- Polymorphic Light Eruption, Psoriasis, Atopic Eczema
- Trial name
- NCT00555178
- Where
- 2 sites in Austria
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Chronic Obstructive Pulmonary Disease
Genetic Polymorphism in Matrix Metalloproteinase 9 in Chronic Obstructive Pulmonary Disease in Sohag University Hospital.
Chronic obstructive pulmonary disease (COPD) is a heterogeneous and complex disease with multiple clinical presentations or phenotypes and remains a highly prevalent condition, causing significant morbidity and mortality…
- Trial name
- NCT06503315
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sohag University
Pain, Postoperative, Pregnancy
The Impact of the SCN9A Gene Polymorphism on Postoperative Pain
The purpose of this study to determine the association between postoperative pain after cesarean section and several single nucleotide polymorphisms in SCN9A sodium channels gene.
- Trial name
- NCT02496455
- Testing
- cesarean section, Opioid Tramadol
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Tokat Gaziosmanpasa University
Pseudoexfoliation Syndrome
LOXL1 Polymorphism in Pseudoexfoliation Syndrome
To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, Genotypes of lysyl oxidase-like 1 gene were analyzed by direct sequencing.
- Trial name
- NCT01515735
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Psuedomas Infection, Cystic Fibrosis
The Role of Bacteria and Genetic Variations in Cystic Fibrosis
This study will examine 1) the role of hereditary factors in cystic fibrosis; i.e., the relationship of the disease to specific gene variations, and 2) the role of bacterial products involved in lung infections substances…
- Trial name
- NCT00043225
- Where
- 4 sites in United States
- Volunteers
- 76 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Breast Neoplasms
Prevalence of Genetic Polymorphisms in Genes Coding for Tamoxifen Metabolising Enzymes
CYPTAM-BRUT 3 is a prospective, multicentric study in Belgium within the CYPTAM study of the Leiden University Medical Center (NTR1509) including postmenopausal women receiving tamoxifen for estrogen-receptor positive breast…
- Trial name
- CYPTAMBRUT-3 (NCT00966043)
- Where
- 11 sites in Belgium
- Volunteers
- 158 people
- Sponsor
- Vlaamse Vereniging voor Obstetrie en Gynaecologie
Alzheimer Disease
Polymorphism of ApoE in Alzheimer's Disease: Genetic Study in Castile and Leon (Spain)
The general objective of this randomized and longitudinal clinical study was to estimate the frequencies of ApoE variants both in the user population of the "Messengers of Peace" Residences and the "Associations of Relatives of…
- Trial name
- NCT06275243
- Testing
- Kit Buccal swab collection & stabilization de Canvax®, Cholesterol levels according to ApoE Genotype, Assessing cardiovascular risk factors in all participants
- Where
- Spain
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- Universidad de León
Panic Disorder
Genetic Abnormalities and Biological Changes of Panic Disorder Patients After Pharmacotherapy
We plan to examine genetic polymorphism of catechol-O-methyltransferase in panic disorder and neurobiological changes of panic disorder patients after 12 weeks of pharmacotherapy with paroxetine.
- Trial name
- NCT00515996
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Stroke
Rehabilomics Study in Stroke Patients After Robotic Rehabilitation
Stroke is associated with disability and impaired quality of life. Persistent motor impairment is common with incomplete recovery of motor function after rehabilitation, mainly in the upper limbs (UL).
- Trial name
- NCT04223180
- Testing
- Robotic assisted intervention
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Hypertension
Target Organ Damage and Polymorphisms Vav-2 and Vav-3 in Hypertensive Subjects
Objectives: To analyze the influence on the presence of target organ damage renal, cardiac and vascular of peripheral and central blood pressure, retinal vessels caliber, oxidative stress and polymorphisms of genes VAV-2-3 in…
- Trial name
- LOD-HTA (NCT02022618)
- Where
- Spain
- Volunteers
- 454 people
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Uncoupling Protein-1, Polymorphism, Restriction Fragment Length
Effect of an Exercise on Serum Uncoupling Protein-1 Level and the Role of Uncoupling Protein-1-3826 A/G Polymorphism
This study aims to determine the effect of an acute maximal exercise on serum uncoupling protein-1, irisin, interleukin 6 levels, and on blood lipid and lipoprotein concentrations.
- Conditions
- Uncoupling Protein-1, Polymorphism, Restriction Fragment Length, Irisin
- Trial name
- NCT04156113
- Testing
- Yo-Yo intermittent recovery test (level 1)
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Kidney Failure, Acute, Critical Illness
Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)
Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated.
- Trial name
- NCT00316576
- Testing
- Blood sampling for PCR
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Caen