Clinical trials: Genetic Polymorphism
Carcinoma, Non-Small-Cell Lung
The Correlation Between MAGE-A3, PRAME Polymorphism and Expression Levels of MAGE-A3 and PRAME in NSCLC Patients
Considering the low expression rate of Melanoma-associated antigen 3 (MAGE-A3) in Asian especially Southeast Asian, it would be great interests to investigate the potential polymorphism of MAGE-A3 in Non-Small-Cell Lung Cancer…
- Trial name
- NCT02714335
- Volunteers
- 200 people
- Sponsor
- Szu-Hua Pan
Pain, Postoperative, Thoracic Surgery, Video-Assisted
Single Nucleotide Polymorphisms (SNPs) Associated With Postoperative Analgesic Failure
Postoperative pain remains relatively high within 48h for Chinese patients who receive video-assisted thoracoscopic surgery. Different patients experience different pain intensity.
- Conditions
- Pain, Postoperative, Thoracic Surgery, Video-Assisted, Polymorphism, Single Nucleotide
- Trial name
- NCT03916120
- Testing
- Genetic analysis
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Exposures Associated With Pregnancy, Delivery and Lactation
Impact of Perinatal Exposure to Non-caloric Sweeteners on Food Preferences and Weight Gain in the First Year of Life
During last years, non-caloric sweeteners (NCSs) have been increasingly incorporated into foodstuffs in replacement of sucrose in Chile.
- Trial name
- NCT03972176
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University of Chile
Nicotine Dependence
Association of Functional COMT Val108/Met Polymorphism With Smoking Cessation in Nicotine Replacement Therapy
Nicotine replacement treatment (NRT) can be efficacious for smoking cessation, but used by only a minority of smokers in China. Pharmacogenetic matching may improve treatment outcomes for NRT in subgroups of smokers.
- Trial name
- NCT01980550
- Testing
- sublingual nicotine
- Volunteers
- 250 people
- Sponsor
- National Institute on Drug Dependence, China
Sleep Apnea, Obstructive
Hypoxia Inducible factor1-Alpha Genetic Polymorphism of Obstructive Sleep Apnea
Specific Aim 1. To identify specific SNPs of HIF-1 gene related to cardiovascular disease in OSA patients (CVD-OSA) 2. To assay the functional activity of high risk SNPs of HIF-1 on the transcription of VEGF gene 3.
- Trial name
- NCT00498693
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- National Taiwan University Hospital
Atopic Dermatitis, Asthma
Vitamin D and Its Receptor Gene Polymorphisms in Lithuanian, Latvian and Taiwanese Patients With Atopic Dermatitis and Asthma
The role of vitamin D is well known in calcium and phosphate homeostasis; however, in addition to traditional functions, vitamin D has an important role in pathogenesis of different allergic diseases, such as asthma, atopic…
- Trial name
- NCT04354207
- Testing
- Peripheral vein punction, Stool collection
- Where
- Lithuania
- Volunteers
- 500 people
- Sponsor
- Lithuanian University of Health Sciences
Emergence Delirium
The Association of Cardiac Ion Channel Related Gene Polymorphism and Prolonged QTc Interval After Endotracheal Intubation
The QTc interval is affected by heart rate, medications and changes in the autonomic nervous system. The endotracheal laryngoscopy, the necessary step during general anesthesia, prolongs QTc interval.
- Trial name
- NCT03788564
- Where
- South Korea
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Hepatitis C
Prevalence of IL28B Polymorphism in Hepatitis C Patients
Response to peginterferon and ribavirin treatment in hepatitis C (HCV) depends on viral and host factors. Single nucleotide polypmorphisms (SNP) near to IL28B gene (especially at rs12979860 and rs8099917) are strongly associated…
- Trial name
- NCT03415009
- Where
- Singapore
- Volunteers
- 39 people
- Sponsor
- Changi General Hospital
Lymphoma, Follicular, Lymphoma, Non-Hodgkin
Study of Lymphoma in Asia
Background: Lymphoma rates in Asia have been lower than in the West, but rates have been rising in recent years. Most studies of lymphoma patients have been conducted in the West.
- Conditions
- Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Multiple Myleoma, Lympocytic, Follicular
- Trial name
- NCT01584141
- Where
- 4 sites in China, Hong Kong and 1 more
- Volunteers
- 13,433 people
- Sponsor
- National Cancer Institute (NCI)
Blood Flow in Healthy Volunteers
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia
The endogenous nucleoside adenosine can induce various cardiovascular and neurohumoral effects by stimulation of specific adenosine receptors.
- Trial name
- NCT00253929
- Testing
- Intra-arterial infusion of adenosine, intra-arterial infusion of caffeine, intra-arterial infusion of acetylcholine
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Genetic Polymorphism
The Frequency of Thiopurine Methyltransferase Polymorphism in Systemic Lupus Erythematosus SLE
ABSTRACT Background: Thiopurine S-methyltransferase (TPMT) is the rate-limiting enzyme for azathioprine (AZA) metabolism. Polymorphisms of this gene induce adverse effects of AZA.
- Trial name
- TPMT (NCT07012239)
- Testing
- Azathioprine (AZA), TPMT
- Where
- Bangladesh
- Volunteers
- 348 people
- Sponsor
- Bangladesh Medical University
Myocardial Infarction
Effect of Diabetes and Hepatic Enzymes Mutation on Clopidogrel VS Ticagrelor Activity in Myocardial Infarction (MI) Patients Undergoing Primary Percutaneous Coronary Intervention (PCI)
In this study the combined effect of diabetes mellitus and cyp2c19 polymorphism on platelet aggregation inhibitory activity of the highest traditionally used loading dose 600 mg clopidogrel and ticagrelor 180 mg loading dose will…
- Trial name
- NCT03613857
- Testing
- Clopidogrel, Ticagrelor 90mg
- Where
- Egypt
- Volunteers
- 1,022 people
- Sponsor
- Cairo University
Alopecia Areata
Polymorphism of Janus Kinase 1 and 2 (JAK 1&2) in Patients With Alopecia Areata
Introduction Alopecia areata (AA) is a complex inflammatory disease characterized by cellular infiltration of T- lymphocytes targeting hair follicles, disrupting the anagen phase, with spontaneous remission, recurrence, and…
- Trial name
- NCT05861401
- Testing
- Janus Kinase 1 and 2
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Preeclampsia
ECLAXIR:Search for an Association Between CX3CR1 V249I Polymorphism, Preeclampsia and Endothelial Injury
The study hypothesis is the involvement of the couple CX3CR1/CX3CL1 in occurrence of endothelial injury in preeclampsia. According to this hypothesis, Carriers of the I249 allele who express less CX3CR1 shoud be protected against…
- Trial name
- NCT00190177
- Where
- France
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke
Mobile Terminal Based Management of Stroke Secondary Prevention Adminstration Effect Research
The investigators want to verify whether mobile application based on stroke strengthen prevention management is more effective than traditional management model or open stroke management platform.
- Trial name
- NCT02618265
- Testing
- Mobile terminal, traditional management, website platform management
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Labor Pain, Post-cesarean Delivery
Mu-Opioid Receptor Genetic Polymorphism and Intrathecal Analgesia
Pharmacogenetics has allowed clinicians to identify associations between an individual's genetic profile and his/her response to drugs.
- Trial name
- NCT00418015
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 293 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Kidney Transplantation
Genetic Factors on Outcomes of Kidney Transplant Patients With Tacrolimus-based Therapy
The purpose of this study is to identify the influence of genetic and clinical factors on the clinical outcomes of kidney transplant patients with tacrolimus (TAC) based immunosuppression in Taiwan.
- Trial name
- NCT03764670
- Where
- Taiwan
- Volunteers
- 98 people
- Sponsor
- National Taiwan University Hospital
Attention Deficit Hyperactivity Disorder
Genetic Polymorphism and OROS-Methylphenidate Treatment in Attention Deficit Hyperactivity Disorder(ADHD)
The purpose of this study is to examine whether genetic polymorphisms in drug transporters were associated with the side effects of OROS-methylphenidate medication in attention deficit/hyperactivity disorder(ADHD).
- Trial name
- NCT00842127
- Testing
- OROS-methylphenidate (Concerta)
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Bundang CHA Hospital
Polymorphism, Restriction Fragment Length, Premature
Neurological Fate, Prematurity and Genetic Susceptibility Factors
This study could help identify aggravating or protective genetic polymorphisms associated with cerebral palsy. Populations of premature babies at different risk of cerebral palsy could thus be individualized with an impact on…
- Conditions
- Polymorphism, Restriction Fragment Length, Premature, Infertility of Cervical Origin
- Trial name
- GENIMOC (NCT04298346)
- Testing
- no intervention
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Nantes University Hospital
Oral Squamous Cell Carcinoma (OSCC)
Salivary IL-6 and Interleukin Gene Polymorphisms in Oral Squamous Cell Carcinoma
This observational study will evaluate whether salivary interleukin-6 levels and selected interleukin gene polymorphisms are associated with regional lymph node involvement in patients with oral squamous cell carcinoma.
- Trial name
- IL6-OSCC (NCT07692360)
- Testing
- Saliva Collection and Biomarker Analysis
- Where
- 2 sites in Italy
- Volunteers
- 38 people
- Sponsor
- University of Pavia