Clinical trials: Genetics Predisposition
Enterovirus 71, Host Genetics, Social, Behavior, Environmental Factors
Children's Susceptibility to Enterovirus 71 in Different Areas of Taiwan
EV71 has caused large epidemics with lots of fatal cases and cases with sequelae. However, the clinical syndromes and severity of the same EV71 strain are very diverse, ranging from asymptomatic (71%) to fatal (0.05%) disease…
- Trial name
- DMR100-IRB-010 (NCT01311921)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Prostate Cancer, Genetic Predisposition to Disease
Prophylactic Prostatectomy for Prostate Cancer (PPPC)
Prostate cancer affects 1-in-8 people assigned male at birth in the UK and kills almost 12,000 annually. Half the cases occur due to genetic factors.
- Conditions
- Prostate Cancer, Genetic Predisposition to Disease, BRCA Mutation
- Trial name
- PPPC (NCT06470685)
- Testing
- Qualitative Research Interviews
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Crohn Disease, Genetic Predisposition
The Biologic Onset of Crohn's Disease: A Screening Study in First Degree Relatives
Pursuing very early diagnosis is standard of care for several diseases including colon cancer, diabetes and liver disease where an early and aggressive diagnostic and therapeutic approach has been shown to change their natural…
- Conditions
- Crohn Disease, Genetic Predisposition, IBD
- Trial name
- NCT03291743
- Testing
- Capsule endoscopy
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Parkinson's Disease
Parkinson's Diseases Susceptibility Genes and Pesticides
Parkinson's disease (PD) occurrence is higher in rural than in urban populations of industrialized countries. Epidemiologic and human tissue studies suggest that pesticides may be responsible for causing dopaminergic cell death…
- Trial name
- NCT00044590
- Where
- United States
- Volunteers
- 1,870 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Coronary Artery Disease, Genetic Predisposition to Disease
Genetic Risk Stratification for Primary Prevention of CAD in Men and Pre & Post-menopausal Women
The investigators propose to genotype males and females at age 40 years and older, who are asymptomatic and without known heart disease (N=2000).
- Trial name
- NCT05169840
- Testing
- Genetic Risk Score for Coronary Artery Disease
- Where
- 3 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Vitamin B12 Deficiency
Supplementary Vitamin B12 Effects on Elevated Homocysteine Levels of Vegetarians - Clinical Trial
Vegetarians are known to be deficient in vitamin B12, due to a lack or absence of dietary animal produce, which can elevate homocysteine.
- Trial name
- NCT01661309
- Testing
- Inactive lozenge, Methylcobalamin
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of West London
Genetic Predisposition to Disease
Aswan Heart Centre - Egyptian Healthy Volunteers
To define the genotype of a healthy Egyptian cohort as a crucial step in determining the possible clinical implications of mutations detected in patients recruited in the registry.
- Trial name
- AHC-EHVol (NCT05661305)
- Testing
- Whole Genome Sequencing to compare healthy volunteers genome with that of cardiomyopathies patients.
- Where
- Egypt
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Magdi Yacoub Heart Foundation
Genetic Predisposition to Disease, Healthy Volunteer
Effects of Sirolimus on Asymptomatic ApoE4 Carriers
Alzheimer's disease is a devastating neurodegenerative disease characterized by accumulation of clumps (also called plaques) and bundles of fibers (also called tangles) in the brain, for which there is currently no cure.
- Conditions
- Genetic Predisposition to Disease, Healthy Volunteer, APOE-4 Positive
- Trial name
- NCT07728175
- Testing
- Sirolimus (rapamycin)
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Rheumatoid Arthritis, Leukocytes, Mononuclear
Genetics and Mechanisms of Rheumatoid Arthritis
The study is aimed at revealing genetic background in rheumatoid arthritis (RA). For that purpose samples of DNA will be collected from 500 RA patients and similar number of controls from whole Slovakia.
- Conditions
- Rheumatoid Arthritis, Leukocytes, Mononuclear, Genetic Association Studies
- Trial name
- RASGENAS (NCT01788098)
- Where
- Slovakia
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Multiple Sclerosis
Genes and Environment in Multiple Sclerosis
The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS).
- Trial name
- GEMS (NCT01353547)
- Where
- 5 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Breast Carcinoma, Genetic Predisposition to Cancer
MEASUREMENT OF CIRCULATING MUTATION BURDEN
Cancer-free women with a hereditary predisposition to breast and/or ovarian cancer
- Conditions
- Breast Carcinoma, Genetic Predisposition to Cancer, BRCA Mutation, cfMB
- Trial name
- cRISK (NCT06792721)
- Testing
- Mutation Burden cfMB analysis
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Francois Baclesse
Metabolic Disease, Nutrition Disorders
Observational Study on a Chinese Population
An observational study was conducted in a health examination center to distinguish risk factors for health in a randomly recruited volunteers of Chinese population.
- Conditions
- Metabolic Disease, Nutrition Disorders, Genetic Predisposition to Disease
- Trial name
- NCT03406234
- Testing
- No intervention.
- Where
- China
- Volunteers
- 2,650 people, healthy volunteers welcome
- Sponsor
- Shenzhen Center for Chronic Disease Control
Infectious Disease
Genetic Susceptibility to Severe Infections
Only a fraction of individuals infected with microbes develop clinical disease. This observation raises fundamental questions about the pathogenesis of infectious diseases.
- Trial name
- PREDISPOSITI (NCT06102070)
- Testing
- Blood samples drawing, Skin biopsy
- Where
- France
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Genetic Predisposition, Carrier, Gestational
Prevalence of Carriers of Genetic Diseases in the Mexican Jewish Community
The Jewish Population is at an increased risk for genetic diseases, especially autosomal recessive, thus, screening should be done to determine carrier status of several genetic diseases.
- Trial name
- NCT04307719
- Where
- Mexico
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Anahuac University
Meningioma
Androcur® (Cyproterone Acetate) and Meningioma Development: a Genotype-environment Association Study
The primary objective of the study is to create a biobank of oral smears permitting to identify the genetic locus/loci associated with an increased risk to develop meningiomas after cyproterone acetate (CPA) (Androcur®)…
- Trial name
- ANDROMEDE-F (NCT04372095)
- Testing
- oral smears
- Where
- France
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hereditary Cancer Syndrome, Hereditary Breast and Ovarian Cancer
Evaluation of the Adhesion to the GENEPY Network
In order to best meet the needs of all those affected by the genetic risk of cancer in our region, it is important to identify the factors likely to influence the course leading to the GENEPY surveillance network.
- Conditions
- Hereditary Cancer Syndrome, Hereditary Breast and Ovarian Cancer, Hereditary Colorectal Endometrial Cancer Syndrome
- Trial name
- GENEPY (NCT03979612)
- Testing
- inclusion of subjects in the GENEPY network
- Where
- France
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Institut Claudius Regaud
Systemic Lupus Erythematosus
Hormonal and Environmental Risk Factors for Developing Systemic Lupus Erythematosus: The Carolina Lupus (CLU) Study
Systemic lupus erythematosus (SLE) is severe, chronic, disabling autoimmune disease that significantly affects health status and quality of life.
- Trial name
- NCT00342095
- Where
- 6 sites in United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Prostate Cancer, Hereditary Prostate Cancer
Targeted Prostate Cancer Screening in Men With BRCA1/2 Mutations
This interventional study is a follow-up component of the IMPACT project, which aims to identify men at increased hereditary risk of prostate cancer.
- Trial name
- IMPACT (NCT07416812)
- Testing
- Targeted Prostate Cancer Screening, Telephone Follow-Up Interview
- Where
- Slovenia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Institute of Oncology Ljubljana
Genetic Predisposition to Disease, Environment
Correlation Between Psychological Resilience and Genetic, Inflammatory Indicators
The goal of this observational study is to evaluate and analyze the influencing factors of the adaptive ability of young people, explore the impact of the interaction of environment and gene on the psychological adaptive ability…
- Conditions
- Genetic Predisposition to Disease, Environment, Adaptation, Psychological, Inflammation
- Trial name
- NCT06193005
- Testing
- no intervention
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Alcoholism, HIV Infection
Genetic Factors and Interrelationships for Sexual Orientation, Susceptibility to HIV and Kaposi's Sarcoma, Alcoholism and Psychological Traits, and Histocompatibility Antigens
We propose to test, by DNA linkage analysis of family pedigree members, the following interrelated hypotheses: 1) that sexual orientation is genetically influenced; 2) that the development of Kaposi's sarcoma and other outcomes…
- Conditions
- Alcoholism, HIV Infection, Homosexuality, Kaposi's Sarcoma
- Trial name
- NCT00001294
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)