Clinical trials: Genital Diseases, Female
Vaginosis, Bacterial
Safety and Tolerability of Metronidazole Gel 1.3%
Multicenter, open-label study to evaluate safety and tolerability of Metronidazole Vaginal Gel in females 12 to <18 years for the treatment of bacterial vaginosis.
- Trial name
- NCT02392026
- Testing
- Metronidazole Gel
- Where
- 8 sites in United States
- Volunteers
- 60 people
- Sponsor
- Insud Pharma
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Chordoma, Kidney Cancer
- Trial name
- NCT00003926
- Testing
- amifostine trihydrate, busulfan, filgrastim
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Ovarian Cancer
A Bioequivalence Study to Evaluate Pharmacokinetics and Safety of BR2022 and BR2022-1 in Patients With Deleterious or Suspected Deleterious Germline BRCA-Mutated Advanced Ovarian Cancer
This was a multicenter, open-label, randomized, crossover bioequivalence study to evaluate the pharmacokinetics and safety of BR2022 and BR2022-1 in Patients with deleterious or suspected deleterious germline BRCA-mutated…
- Trial name
- NCT07069335
- Testing
- Olaparib 150 MG
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Platinum-resistant Ovarian Cancer
A Study of Mitoxantrone Hydrochloride Liposome Injection in the Treatment of Relapsed Ovarian Cancer
This is a multicenter, open-label, single-arm, phase Ib study to evaluate the safety and efficacy of Mitoxantrone Hydrochloride Liposome in subjects with Platinum-Resistant or Platinum-Refractory Relapsed Ovarian Cancer.
- Trial name
- NCT04718376
- Testing
- Mitoxantrone Hydrochloride Liposome, intravenous injection (IV)
- Where
- 7 sites in China
- Volunteers
- 56 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
HIV Infection
Zambian Peer-Educators for HIV Self-Testing Study
ZEST is a cluster-randomized trial designed to determine whether HIV self-tests are acceptable and improve HIV testing rates and HIV status knowledge among female sex workers in Zambian transit towns.
- Trial name
- ZEST (NCT02827240)
- Testing
- Oral HIV Self-Testing
- Where
- 3 sites in Zambia
- Volunteers
- 965 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Ovarian Cancer
Study of NMS-03305293 in Adult Patients With Relapsed Ovarian Cancer
This is a multicenter, open-label Phase Ia/b study on the safety and efficacy of the combination of NMS-03305293 and topotecan in patients with recurrent ovarian cancer, with dose-limiting toxicity (DLT) escalation.
- Trial name
- NCT06930755
- Testing
- NMS-03305293, Topotecan
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- Nerviano Medical Sciences
Cervical Intraepithelial Neoplasia, Cervical Cancer
Visual Inspection With Acetic Acid Compared to Lugol's Iodine in HIV-infected Women
The clinical trial is part of a larger study to evaluate the safety and efficacy of screening techniques for cervical cancer among HIV-infected women.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, HIV
- Trial name
- SAVE (NCT02237326)
- Testing
- Visual Inspection with Acetic Acid, Visual Inspection with Lugol's Iodine
- Where
- Kenya
- Volunteers
- 654 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
High Risk for HIV
Zambia SiVET MMR Tdap-IPV
Participants will receive vaccination for measles, mumps, and rubella (MMR) and tetanus, diphtheria, pertussis, and inactivated polio (Tdap-IPV).
- Trial name
- SiVET (NCT02589678)
- Testing
- Tdap - IPV Vaccine, MMR Vaccine
- Where
- 2 sites in Zambia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Emory University
Vaginosis, Bacterial
Safety, Tolerability and Efficacy of Vaginal Suppository WO3191 in the Post-treatment of Bacterial Vaginosis
Bacterial Vaginosis (BV) is a common infectious disorder and is characterized by a disturbance in the vaginal microbiological milieu.
- Trial name
- NCT02687789
- Testing
- Medical Device: WO3191, Medical Device: Vagisan® Lactic Acid
- Where
- 13 sites in Germany
- Volunteers
- 43 people
- Sponsor
- Dr. August Wolff GmbH & Co. KG Arzneimittel
Endometrium Cancer, Gynecologic Cancer
The Surveillance, Epidemiology, and End Results Database Program on Endometrial Cancer in the Italian Population
The aim of this study is to lay the bases for an ambitious project that reports and records all the epidemiological-clinical information of the cases of endometrial carcinoma diagnosed and treated in the reference oncology…
- Trial name
- ENDOCancerDATA (NCT07558889)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ovarian Cancer, Epithelial
Ultrasensitive SERS Platform With Highly Efficient Enrichment of Analyte for Screening and Diagnosis of Epithelial Ovarian Cancer
This project is an open, single-center, prospective study aimed at developing high-sensitivity, high-specificity enrichment SERS chips using femtosecond laser processing technology.
- Trial name
- NCT06640348
- Testing
- No intervention
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
Premature Ovarian Insufficiency
Treatment of Premature Ovarian Insufficiency Using Bone Marrow Cells
investigator is doing single armed clinical interventional study to treat premature ovarian insufficiency with autologous bone marrow derived mononuclear cells to be given systematically and locally to the ovaries under…
- Trial name
- alfarah (NCT06302543)
- Testing
- autologous bone marrow cells injection
- Where
- Iraq
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- abdulmajeed hammadi
Benign Prostatic Hyperplasia
Prostate Artery Embolization With Embosphere Microspheres Compared to TURP for Benign Prostatic Hyperplasia
The purpose of this study is to evaluate improvement of symptoms from benign prostatic hyperplasia (BPH) as assessed by the International Prostate Symptom Score (IPSS) for prostatic artery embolization (PAE) using Embosphere…
- Trial name
- NCT01789840
- Testing
- Embosphere Microspheres, TURP
- Where
- 10 sites in United States
- Volunteers
- 59 people
- Sponsor
- Merit Medical Systems, Inc.
Chlamydia Trachomatis Infection, Chlamydial Urethritis
Mecillinam for Treatment of Genital Chlamydia Infection
The mainstay of treating both symptomatic and asymptomatic genital Chlamydia trachomatis infection has been macrolide antibiotics in the form of azithromycin, and alternatively tetracycline antibiotics in the form of doxycycline.
- Trial name
- MecillinamCT (NCT02083276)
- Testing
- Pivmecillinamhydrochlorid
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Intrauterine Adhesion
Comparing the Efficacy of Two Methods in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis
Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility.
- Trial name
- NCT03346317
- Testing
- disposable balloon uterine stent, dried biological amnion graft, estradiol valerate tablets+dydrogesterone tablets
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Placenta Previa, Vaginal Bleeding
The Rate and Predictors of Vaginal Bleeding Among Women With Placenta Previa
Placenta previa is usually diagnosed when the placenta implanted in the lower uterine segment, thus partially or totally overlying the internal os . It occurs with an incidence of 0.3-0.5%.
- Conditions
- Placenta Previa, Vaginal Bleeding, Antepartum Hemorrhage
- Trial name
- NCT05645848
- Testing
- Ultrasonography
- Volunteers
- 250 people
- Sponsor
- Assiut University
HIV Infections
Sex, Aging and Antiretroviral Pharmacokinetics
The purpose of this research study is to learn about levels of antiretroviral drug levels and response to HIV virus in the genital tract of women who are post-menopausal.
- Trial name
- NCT00666055
- Testing
- ARV regimen chosen by treating physician
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Kristine Patterson, MD
Subfertility, Female, Ovulation Disorder
Low Dose GnRHa Early Luteal Phase Down Regulation Versus GnRHa Ultra-short Protocol for Poor Ovarian Response
The management of the poor responder patients is very difficult. Currently, there is no any standard treatment for poor responder patients.
- Trial name
- NCT02940535
- Testing
- Diphereline (Triptorelin embonate), Decapeptyl (Triptorelin), human menopausal gonadotropin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Navy General Hospital, Beijing
Hiv, Contraception Behavior
TwySHE - An Mhealth Peer-navigator Intervention to Increase PrEP and Contraceptive Use
The goal of this clinical trial is to learn if the TwySHE intervention can increase the use of HIV prevention in at-risk female university students aged 18-24 in Zambia.
- Trial name
- NCT06852508
- Testing
- TwySHE
- Where
- Zambia
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Neoplasms, Solid Tumor
Methylation Profile Test (Methylscape) in Body Fluids for Multi-Cancer Detection and Monitoring in Colombia
DNA methylation changes occur early and broadly during carcinogenesis. Methylscape is a rapid assay that detects global DNA methylation patterns in body fluids (blood, urine, and saliva) and may detect a cancer signal and predict…
- Conditions
- Neoplasms, Solid Tumor, Breast Neoplasms, Lung Neoplasms
- Trial name
- METHYLSCAPE-CO (NCT07741435)
- Testing
- Methylscape DNA methylation assay
- Where
- Colombia
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
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