Clinical trials: Genital Diseases, Female
Cervical Cancer
A Phase II Study of Serplulimab Plus Bevacizumab in Combination With Chemotherapy in 1L Treatment of Untreated Recurrent or Metastatic Cervical Cancer
This study is a single-arm, multicenter, Phase II study to evaluate the efficacy and safety of the treatment of Serplulimab plus Bevacizumab in combination with chemotherapy in 1L treatment of patients with untreated recurrent or…
- Trial name
- NCT05444374
- Testing
- Serplulimab, Bevacizumab
- Where
- 4 sites in China
- Volunteers
- 48 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Vulvodynia
Vulvodynia: Identification of Potential Relevant Biomarkers
Vulvodynia is a syndrome of unexplained vulvar pain that is frequently accompanied by physical disabilities, limitation of daily activities (such as sitting and walking), sexual dysfunction and psychologic disability.
- Trial name
- NCT02981433
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- St. Louis University
Ovarian Cancer, Fallopian Tube Cancer
Phase 1 Study of a Cancer Vaccine to Treat Patients With Advanced Stage Ovarian, Fallopian or Peritoneal Cancer
Immunotherapy is a novel way to treat cancer and does so by targeting the immune system to destroy tumor cells. Many different therapeutic vaccines have been evaluated in phase 1, 2, and even phase 3 trials.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- NCT01416038
- Testing
- DPX-Survivac, low dose cyclophosphamide (oral)
- Where
- 7 sites in United States, Canada
- Volunteers
- 19 people
- Sponsor
- ImmunoVaccine Technologies, Inc. (IMV Inc.)
Endometriosis
Biomarkers in Endometriosis
Endometriosis is a common gynecological benign disease which significantly compromise quality of life in patients and is a major cofactor of infertility.
- Trial name
- NCT04591548
- Testing
- proteomic analyses, ELISA validation of peritoneal fluid, blood and uterine fluid sample
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
HIV Infections
Evaluating the Safety and Efficacy of the VRC01 Antibody in Reducing Acquisition of HIV-1 Infection in Women
This study will evaluate the safety and efficacy of the human monoclonal antibody (mAb) VRC-HIVMAB060-00-AB (VRC01) in preventing HIV-1 infection in high-risk, HIV-uninfected women.
- Trial name
- NCT02568215
- Testing
- VRC01
- Where
- 21 sites in Botswana, Kenya and 5 more
- Volunteers
- 1,924 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cervical Cancer
Optimizing Cervical Cancer Screening Modalities
This project aims to optimize cervical cancer screening adherence comparing Arm A (VIA) and Arm B self-sampled Human Papilloma Virus (HPV) testing and determine the molecular epidemiology of HPV, persistence level and identify…
- Trial name
- NCT03281135
- Testing
- HPV testing
- Volunteers
- 1,760 people, healthy volunteers welcome
- Sponsor
- Addis Ababa University
Endometriosis (Diagnosis), Identification of Biomarkers in Serum
CellAdhesionMolecule EndometriosisRatio - CAMERA
Background: Endometriosis, which is characterized by the growth of endometrial stroma and glands outside of the uterine cavity, is estimated to occur in 6-10% of women of reproductive age.
- Trial name
- CAMERA (NCT04294017)
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Heinrich Husslein
Uterine Cancer
Neo-adjuvant Pembrolizumab in dMMR/ POLE-EDM Uterine Cancer Patients: a Feasibility Study
In this feasibility study the investigators intend to treat patients with high mutational uterine cancer with two cycles immune checkpoint inhibition before standard-of-care hysterectomy.
- Trial name
- PAM (NCT04262089)
- Testing
- Pembrolizumab (Keytruda)
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Pancreatic Cancer, Breast Cancer
Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors
Study of NGM831 as Monotherapy and in Combination with Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors
- Conditions
- Pancreatic Cancer, Breast Cancer, Gastric Cancer, Non-small Cell Lung Cancer
- Trial name
- NCT05215574
- Testing
- NGM831, NGM831 plus pembrolizumab (KEYTRUDA®), NGM831 and NGM438 plus pembrolizumab (KEYTRUDA®)
- Where
- 9 sites in United States
- Volunteers
- 130 people
- Sponsor
- NGM Biopharmaceuticals, Inc
Infertility, Female
Clinical Efficacy of Virtual Reality During Office Hysteroscopy and Endometrial Biopsy in Subfertility
This study is a comparison between the current standard practice of performing a diagnostic hysteroscopy and a relatively recently developed technology that is added to the standard diagnostic hysteroscopy.
- Trial name
- HYSVIR (NCT04438759)
- Testing
- Oncomfort, commercially available Virtual Reality headset
- Where
- Belgium
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Microbiota, Ovarian Neoplasms
Pelvic Microbiomes of Benign and Malignant Ovarian Diseases
This case-control study aims to compare the pelvic microbiomes of benign ovarian diseases and ovarian malignancies by 16s RNA techniques and culture.
- Conditions
- Microbiota, Ovarian Neoplasms, Ribosome Alteration
- Trial name
- MTBOD-1 (NCT03388996)
- Testing
- microbiomes
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Lei Li
Epithelial Ovarian Cancer
Torvutatug Samrotecan Plus Bevacizumab as First-line Maintenance in Homologous Recombination Deficiency (HRD) Negative Advanced Epithelial Ovarian Cancer
This study will evaluate the efficacy, safety and tolerability of Torvutatug samrotecan (torvu-sam) in combination with bevacizumab compared with bevacizumab monotherapy as first line maintenance treatment in patients with…
- Trial name
- TREVI-OC-02 (NCT07851025)
- Testing
- Torvutatug samrotecan, Bevacizumab
- Where
- 186 sites in United States, Argentina and 22 more
- Volunteers
- 950 people
- Sponsor
- AstraZeneca
HIV Infection
Safety Of VIRACEPT® 625mg Administered To HIV-Infected Women During Pregnancy
This study is an evaluation of the safety of 625 mg formulation when administered to HIV-infected pregnant women from their second trimester through six weeks postpartum.
- Trial name
- NCT00246610
- Testing
- Nelfinavir mesylate, 625 mg
- Where
- 6 sites in United States, Canada
- Volunteers
- 16 people
- Sponsor
- Pfizer
Female Infertility, Obesity
Effect of the Glycemic Index of Diet on Metabolic and Reproductive Parameters in Overweight and Obese Infertile Women
Infertility has been currently recognized as a disorder related to obesity. Among several metabolic changes associated with obesity, insulin resistance appears to be linked to hormonal disorders that affect reproductive system.
- Trial name
- NCT02416960
- Testing
- Low Glycemic Index Diet Group, Conventional Diet Group
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
HIV/AIDS
Improving Uptake and Adherence to HIV Prevention Services With Pre-exposure Prophylaxis (PrEP), HIV Self- Testing and Adherence Support for Very High Risk HIV-negative Young Women Aged 15-24 in Kampala, Uganda
The main aim is to develop and assess an intervention to enhance initiation and adherence to PrEP among HIV negative young women of high risk (YWHR).
- Trial name
- POPPi (NCT04030520)
- Testing
- POPPi, Comparison
- Where
- Uganda
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV/AIDS, Adherence, Medication
Improving Engagement in HIV Care for High-risk Women
Transgender women (assigned 'male' at birth but who do not identify as male) are disproportionately impacted by HIV and have culturally unique barriers and facilitators to engagement in HIV care.
- Trial name
- NCT03081559
- Testing
- Healthy Divas
- Where
- 2 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility, Female, Trauma, Psychological
Adverse Childhood Experiences and Infertility : ACESI
Adverse childhood experiences can have powerful effects on health and quality of life in adulthood. Thus, having a history of childhood trauma, before the age of 18 (physical aggression, sexual abuse, death of a close person…
- Conditions
- Infertility, Female, Trauma, Psychological, Child Development, Child Abuse
- Trial name
- ACESI (NCT05952427)
- Testing
- ACE Questionnaire
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Cervical Cancer, Radiation Toxicity
the Re-irradiation of Recurrent Cervical Cancer by IMRT
this is a prospective clinical trial using intensity modulated radiotherapy（IMRT）for the treatment of cervical cancer patients with recurrent disease within the previously irradiated field.
- Conditions
- Cervical Cancer, Radiation Toxicity, Recurrent Cervical Carcinoma
- Trial name
- NCT03170570
- Testing
- intensity-modulated radiotherapy
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Sun Yat-sen University
Cervical Cancer
Study of Adjuvant Topotecan and Cisplatin With Concurrent Radiation Therapy for Advanced Cervical Cancer
A Phase I Study of Adjuvant Topotecan and Cisplatin with Concurrent Radiation Therapy for Advanced Cervical Cancer.
- Trial name
- NCT00320983
- Testing
- Topotecan, Cisplatin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of New Mexico
Ovarian Cancer, Fallopian Tube Cancer
The Activity of TroVax® Versus Placebo in Relapsed Asymptomatic Ovarian Cancer
The purpose of this trial is to assess the effectiveness of TroVax® compared to placebo in extending the time to progression in patients with asymptomatic relapsed platinum resistant ovarian, fallopian tube or primary peritoneal…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- TRIOC (NCT01556841)
- Testing
- TroVax®
- Where
- 12 sites in United Kingdom
- Volunteers
- 94 people
- Sponsor
- University College, London
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