Clinical trials: Genital Diseases, Female
BRCA1/2-Associated Hereditary Breast and Ovarian Cancer Syndrome
Clinical Impact of Enhanced Risk Assessments in Women With a BRCA1/2 Mutation, CARE Study
This clinical trial evaluates the impact of enhanced risk assessments on knowledge, perceptions, and decisional conflict about cancer prevention in women with a BRCA1 or BRCA2 mutation.
- Trial name
- NCT06534424
- Testing
- Best Practice, Biospecimen Collection, Counseling
- Where
- 2 sites in United States
- Volunteers
- 152 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cervical Cancer, Precancerous Condition
Eflornithine To Prevent Cervical Cancer in Patients With Cervical Intraepithelial Neoplasia
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of eflornithine may be an effective way to prevent the recurrence of or further development of…
- Trial name
- NCT00006079
- Testing
- Eflornithine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- M.D. Anderson Cancer Center
Diffuse Astrocytoma, IDH-Mutant, Glioblastoma, IDH-wildtype
Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
This multi-site, Phase 1/2 clinical trial is an open-label study to identify the safety, pharmacokinetics, and efficacy of a repeated dose regimen of NEO212 alone for the treatment of patients with radiographically-confirmed…
- Conditions
- Diffuse Astrocytoma, IDH-Mutant, Glioblastoma, IDH-wildtype, Brain Metastases, Adult, Cervical Cancer
- Trial name
- NCT06047379
- Testing
- NEO212 Oral Capsule, Ipilimumab, Pembrolizumab
- Where
- 8 sites in United States
- Volunteers
- 134 people
- Sponsor
- Neonc Technologies, Inc.
Cervical Precancer
Cervical Cancer Screening in Madagascar Using Smartphone Photos and Mobile Telemedicine
The purpose of this study is to determine whether smartphone photos may assist health-care worker (on-site) and to evaluate the diagnostic reliability and accuracy of cervical examination with smartphone photos of VIA (D-VIA)…
- Trial name
- NCT02693379
- Testing
- D-VIA
- Where
- Madagascar
- Volunteers
- 1,041 people, healthy volunteers welcome
- Sponsor
- Prof. Patrick Petignat
Endometrioma
Laparoscopic Ovarian Cystectomy of Endometrioma vs Deroofing and Ovarian Reserve
The purpose of this study is to evaluate the impact of laparoscopic ovarian cystectomy versus laparoscopic cyst deroofing on ovarian reserve measured by serum levels of anti mullerian hormone and antral follicle count in patients…
- Trial name
- NCT01808170
- Testing
- Laparoscopic ovarian cystectomy, laparoscopic cyst deroofing
- Where
- Egypt
- Volunteers
- 122 people
- Sponsor
- Ain Shams University
Ovarian Cancer
Adjuvant Chemotherapy of Three-step Regimen in BRCA1/2 Wide Type Ovarian Cancer (ACTS-2)
Ovarian cancer was mostly diagnosed at late stage (III/IV) with high rate of recurrence after first line of therapy by optimal cytoreductive sugery and 6cycle of TP chemotherapy.
- Trial name
- NCT04520074
- Testing
- Etoposide, Cyclophosphamide, Carboplatin/Cisplatin
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Fudan University
Cervical Dysplasia
A Dose-finding Study of MAL and HAL Photodynamic Therapy of Cervical Premalignant Lesions.
The study will determine the best drug (MAL or HAL) dosage for photodynamic therapy of cervical precancerous lesions (dysplasia) in women that are referred for conisation (surgery).
- Trial name
- NCT00369018
- Testing
- methyl aminolevulinate (MAL) and hexaminolevulinate (HAL)
- Where
- 2 sites in Germany, Norway
- Volunteers
- 96 people
- Sponsor
- Photocure
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
IVF\ICSI Outcome in Women With Polycystic Ovary Syndrome
Polycystic ovarian syndrome (PCOS) occurs in 5% to 10% of all women of reproductive age and 50% of women who present with sub-fertility due to anovulatory infertility .
- Trial name
- NCT05756023
- Testing
- the pregnancy rate at IVF / ICSI cycles
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- Egymedicalpedia
Ovarian Cancer
Gonadal Dysgenesis Tissue Cryopreservation for Fertility Preservation
The "Gonadal Dysgenesis Tissue Cryopreservation for Fertility Preservation" study is open to a subset of patients with disorders of sex development (DSD) which is associated with the risk of malignancy and a high risk of…
- Trial name
- NCT06518746
- Testing
- Cryopreservation of gonadal tissue
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Cervical Cancer Screening
Post Colposcopy Management of ASC-US and LSIL Pap Tests
There is weak evidence supporting optimal follow-up of women with ASC-US or LSIL cytology found to have low grade disease or normal findings at initial colposcopy.
- Trial name
- NCT03466710
- Testing
- Colposcopy, Pap test, HPV test
- Volunteers
- 133 people
- Sponsor
- University of Calgary
Breast Cancer Female, Localized Cancer
Systematic Intervention to Improve Sexual Dysfunction
The aim of this clinical trial is to compare the benefit of early, systematic, multidisciplinary oncosexological care versus on-demand care on the sexual health of women with breast cancer.
- Trial name
- SISTER (NCT06583460)
- Testing
- Early and systematic oncosexological supporting care
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Center Eugene Marquis
Solid Tumor
Dose Escalation and Dose Expansion Study of CPO-100 in Patients With Advanced Solid Tumors
This is a Phase 1, multicenter, open-label, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, and preliminary evidence of antitumor activity of CPO-100 administered intravenously in…
- Trial name
- NCT04931823
- Testing
- CPO-100
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Conjupro Biotherapeutics, Inc.
Ovarian Cancer
Topotecan in Combination With Gemcitabine in Patients With Platinum-resistant Ovarian Carcinoma
Topotecan and gemcitabine are drugs globally registered for recurrent ovarian carcinoma. This trial will determine the maximum tolerated dose and the efficacy of this combination administered weekly in patients with platinum…
- Trial name
- NCT00429559
- Testing
- Hycamptin, Gemcitabine
- Where
- 6 sites in Greece
- Volunteers
- 31 people
- Sponsor
- Hellenic Oncology Research Group
Breast Cancer, Cervical Cancer
CROSSROAD II: Activating Rural Clinics and Women With Disabilities to Improve Cancer Screening
The goal of this project is to develop and pilot test an innovative approach for overcoming barriers to cancer screening among women with physical disabilities (WWD) in rural Oregon.
- Conditions
- Breast Cancer, Cervical Cancer, Colorectal Cancer
- Trial name
- NCT01773980
- Testing
- Clinic Intervention, Patient Intervention
- Where
- United States
- Volunteers
- 1,570 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Cervix Cancer
CAmpto-CISplatine Plus Radiotherapy in Advanced Cervix Cancer : Search of Tolerated Maximum Dose of Campto
Search of maximum tolerated irinotecan dose in association with cisplatin and pelvic radiotherapy in patients with an advanced cervix cancer.
- Trial name
- NCT00251888
- Testing
- campto (irinotecan), cisplatin (cisplatyl)
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- ARCAGY/ GINECO GROUP
Recurrent Epithelial Ovarian Cancer, Recurrent Fallopian Tube Cancer
Study of DPX-Survivac Therapy in Patients With Recurrent Ovarian Cancer
T cell activating therapy DPX-Survivac, low dose oral cyclophosphamide, and IDO1 inhibitor epacadostat will be tested together for the first time in patients with recurrent ovarian, fallopian tube, or peritoneal cancer to…
- Conditions
- Recurrent Epithelial Ovarian Cancer, Recurrent Fallopian Tube Cancer, Recurrent Peritoneal Cancer
- Trial name
- NCT02785250
- Testing
- DPX-Survivac, Cyclophosphamide, Epacadostat (INCB024360)
- Where
- 9 sites in United States, Canada
- Volunteers
- 85 people
- Sponsor
- ImmunoVaccine Technologies, Inc. (IMV Inc.)
Cervical Cancer
Study With Intensity Modulated Radiation Therapy With Cisplatin to Treat Stage I-IVA Cervical Cancer
The purpose of this study is to find out whether patients with cervical cancer treated with PET-guided Bone Marrow Sparing IMRT have less side effects with equal cancer control compared to standard radiation techniques (IMRT).
- Trial name
- NCT01554397
- Testing
- PET-guided Bone Marrow-Sparing Intensity Modulated Radiation Therapy (IMRT), Cisplatin, IMRT
- Where
- 7 sites in United States, China and 4 more
- Volunteers
- 101 people
- Sponsor
- University of California, San Diego
HIV Infections, Domestic Violence
Using Implementation Science to Increase Pre-Exposure Prophylaxis Uptake Among African American Women
Pre-exposure prophylaxis may be a viable option for African American women at-risk for HIV infection, but few studies have identified optimal strategies to reach African American women in need of Pre-Exposure Prophylaxis nor…
- Trial name
- NCT05139069
- Testing
- Trauma-Informed Toolkit
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Hypospadias
Isoamyl 2-Cyanoacrylate in the Urethro-cutaneous Fistula Repair
cyanoacrylate has an impact that may aid in the successful repair of urethra-cutaneous fistula (UCF) that occur after hypospadias surgical repair
- Trial name
- NCT04876976
- Testing
- Cyanoacrylate, Isobutyl, Classic surgical repair
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Ovarian Carcinoma, Fallopian Tube Cancer
Autologous T-Cells Combined With Autologous OC-DC Vaccine in Ovarian Cancer
This is a phase-I clinical trial to determine the feasibility and safety of Cyclophosphamide/Fludarabine Lymphodepletion and an immunomodulatory combination of Interferon-alpha Bevacizumab and Aspirin followed by adoptive…
- Conditions
- Ovarian Carcinoma, Fallopian Tube Cancer, Primary Peritoneal Cancer
- Trial name
- NCT01312376
- Testing
- OC-DC vaccine, Bevacizumab, cyclophosphamide 300 mg/m2/d for 3 days
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
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