Clinical trials: Genital Diseases, Female
Schistosomiasis Mansoni
Female Genital Schistosomiasis in Tanzania
A cross-sectional survey will be conducted among 200 volunteering women aged 18- 45 years and having had prior sexual activity living in the target villages of Itilima and Maswa districts, North-western Tanzania.
- Trial name
- ShWAB (NCT05788003)
- Testing
- self-collected and operator-collected swab followed by molecular analysis
- Where
- 2 sites in Italy, Tanzania
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Infertility, Female
Follicular Challenge Test to Predict Response to GnRH Agonist Triggering
GnRH agonist triggering is used during ART in order to reduce the risk of OHSS. Some studies described that in up to 5% of the cycles triggered with GnRH agonist, a lack of respone or suboptimal response was displayed.
- Trial name
- NCT04973969
- Testing
- Decapeptyl
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Endometriosis
Pilot Study to Characterize the Endometriosis Steroidome and Its Link to Endocrine Disruptors and Vaginal Dysbiosis
Endometriosis is a systemic, steroid-dependent, inflammatory disease characterized by the growth of endometrial-like tissue outside the uterus, affecting approximately 10 % of women of childbearing age.
- Trial name
- STERONLINE (NCT06820450)
- Testing
- Blood test, urine sample, vaginal sample
- Where
- France
- Volunteers
- 135 people
- Sponsor
- Nantes University Hospital
Polycystic Ovary Syndrome
Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome
Metformin is one of the most commonly prescribed drugs worldwide for the treatment of Type 2 Diabetes. It has been currently used for the treatment of: polycystic ovary syndrome, gestational diabetes, metabolic syndrome and…
- Trial name
- NCT01366391
- Testing
- Metformin
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Biocinese
Ovarian Cancer
Pelvic and Aortic-cava Lymphadenectomy Randomized for Ovarian Cancer
It is a multicenter randomized trial of superior cleaning compared the absence of dissection in stage III patients with optimal surgical resection without retroperitoneal lymph node palpable.
- Trial name
- CARACO (NCT01218490)
- Testing
- ovarian cancer surgery
- Where
- 19 sites in France
- Volunteers
- 450 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer, Endometrial Cancer
A Study of LY353381 (Arzoxifene) for Patients Who Benefitted From This Drug in Other Oncology Trials and Wished to Continue Treatment
Patients who were previously enrolled on the LY353381 arm of any LY353381 oncology trial could enroll in this "roll-over" study if they had exhibited clinical benefit from treatment and wished to continue on treatment.
- Conditions
- Breast Cancer, Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT00190697
- Testing
- arzoxifene
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Eli Lilly and Company
Urinary Incontinence, Sexual Dysfunction
The Mindfulness, Incontinence and Sexual Function Treatment Study
This study aims to determine if there is an impact on sexual distress using mindfulness-based sex therapy (MBST) in addition to standard urogynecologic care, in women with both urinary incontinence (UI) and sexual dysfunction.
- Trial name
- MIST (NCT02863497)
- Testing
- Mindfulness-based Sex Therapy
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of British Columbia
Perineal Trauma, Postpartum Pain
RELIEVE Study- Platelet-Rich Plasma to Reduce Postpartum Pain After Perineal Tears or Episiotomy
Perineal tears and episiotomies are common after vaginal birth and may cause persistent pain, impaired wound healing, pain during sexual activity, and concerns about genital appearance.
- Conditions
- Perineal Trauma, Postpartum Pain, Episiotomy, Perineal Laceration
- Trial name
- RELIEVE (NCT07727213)
- Testing
- Autologous Non-Activated Platelet-Rich Plasma, Saline (0.9%, sterile, for infusion)
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- University Hospital, Geneva
Bacterial Vaginoses
Treatment of BV With Donaxyl and a Molecular Test of Cure
. Treatment with dequalinium chloride vaginal tablets for 6 days had a cure rate lower than expected; only 37% of patients were considered cured one month after treatment.
- Trial name
- NCT04057482
- Testing
- D
- Volunteers
- 58 people
- Sponsor
- Skaraborg Hospital
Cancer Survivor, Endometrial Carcinoma
Health and Recovery Program in Increasing Physical Activity Level in Stage IA-IIIA Endometrial Cancer Survivors
This randomized phase II trial studies how well a health and recovery program works in increasing physical activity level in stage IA-IIIA endometrial cancer survivors.
- Conditions
- Cancer Survivor, Endometrial Carcinoma, Stage I Uterine Corpus Cancer AJCC v7, Stage IA Uterine Corpus Cancer AJCC v7
- Trial name
- NCT03367923
- Testing
- Communication Intervention, Counseling, Fitbit tracker
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Stanford University
Ovarian Cancer
Clinical Trial to Screen Participants Who Are at High Genetic Risk for Ovarian Cancer
RATIONALE: Screening tests may help doctors detect cancer cells early and plan more effective treatment for ovarian cancer. PURPOSE: Screening trial to determine the significance of cancer antigen 125 (CA125) levels in detecting…
- Trial name
- NCT00039559
- Testing
- Early detection
- Where
- United States
- Volunteers
- 2,430 people
- Sponsor
- Massachusetts General Hospital
Ovarian Cancer
Evaluation of Response to the Neoadjuvant Chemotherapy for Advanced Ovarian Cancer by Multimodal Functional Imaging
This study evaluates the therapeutic response by modern FMRI and PET techniques with the perspective to exploit multimodal data (fusion MRI/PET).
- Trial name
- IMOVA (NCT02792959)
- Testing
- Functional Imaging previous the second course, Functional Imaging previous the surgery
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Institut Bergonié
Women's Health, HIV Infection
Influence of Antiretroviral Regimen on Immune Reconstitution in the Female Genital Tract
Increases in cluster of differentiation 4 (CD4)+ T cells in the blood is well documented in human immunodeficiency virus (HIV)-infected individuals after starting antiretroviral therapy (ART), but increases CD4+ T cells in the…
- Conditions
- Women's Health, HIV Infection, Genital Diseases, Female
- Trial name
- NCT01456962
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Intrauterine Adhesion
The Value of Using Platelet Rich Plasma After Hysteroscopic Lysis of Severe Intrauterine Adhesions
The aim of present study is to evaluate the effect of the use of platelet rich plasma in decreasing recurrence of intrauterine adhesions after its lysis.
- Trial name
- NCT03541746
- Testing
- Platelet Rich Plasma, Intrauterine Foley's Catheter
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams Maternity Hospital
Ovarian Cancer
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
This study will evaluate the safety and efficacy of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer (PROC) With Cyclin E1 Overexpression.
- Trial name
- MAESTRA 1 (NCT07023627)
- Testing
- INCB123667
- Where
- 74 sites in United States, Australia and 6 more
- Volunteers
- 160 people
- Sponsor
- Incyte Corporation
Cervical Cancer
Human Papillomavirus in Cervical Cancer and Pre-cancer in Switzerland: The CIN3+Plus Study
This study will investigate the types of HPV in samples from women with cervical pre-cancer and cancer and gather information to help investigate the impact of HPV vaccination in Switzerland.
- Trial name
- CIN3+plus (NCT02323997)
- Where
- 10 sites in Switzerland
- Volunteers
- 767 people
- Sponsor
- University of Bern
Ovarian Cancer
Real-World Effectiveness of Bevacizumab Based on AURELIA in Platinum-resistant Recurrent Ovarian Cancer
This study will evaluate the efficacy and safety profile, response rate, progression free survival, overall survival of bevacizumab (Avastin) added to chemotherapy in patients with epithelial ovarian cancer, fallopian tube…
- Trial name
- REBECA (NCT03367182)
- Testing
- Weekly paclitaxel, Topotecan, Pegylated liposomal doxorubicin
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion
Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic Abnormalities
The goal of this clinical trial is to learn if an investigational vaginal suppository therapy works to treat low-grade cervical lesions (ASC-US and LSIL) associated with high-risk human papillomavirus (hr-HPV) infection in women.
- Conditions
- High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion, ASC-US, HPV Infection
- Trial name
- NCT07572396
- Testing
- EGCG and Quinine Sulfate Vaginal Suppository
- Where
- Hong Kong
- Volunteers
- 45 people
- Sponsor
- Amplexd Therapeutics, Inc.
Endometriosis, Pelvic Pain
Medical Treatment of Endometriosis-Associated Pelvic Pain
The Specific Aim of this project is to compare the efficacy and cost-effectiveness of continuous oral contraceptives versus leuprolide/norethindrone in the treatment of endometriosis-associated chronic pelvic pain.
- Trial name
- NCT00229996
- Testing
- Oral Contraceptive, Depot-Leuprolide/Norethindrone
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Depression, Anxiety
Validation of the Russian and Kazakh Versions of the Beck Depression Inventory and Beck Anxiety Inventory
Depression and anxiety in female patients with cancer are serious comorbidities that affect the quality of life for patients and their survival rates as they have poorer health outcomes.
- Conditions
- Depression, Anxiety, Breast Cancer, Ovarian Cancer
- Trial name
- NCT04630327
- Testing
- Beck Depression Inventory-21 (diagnostic survey), Beck Anxiety Inventory, Interview using The International Classification of Diseases in tenth edition (ICD-10) criteria
- Where
- 2 sites in Kazakhstan
- Volunteers
- 226 people
- Sponsor
- Kazakh Medical University of Continuing Education
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