Clinical trials: Genital Diseases, Female
Ovarian Cancer, Nonsmall Cell Lung Cancer
First-in-Human Study of XMT-1592 in Patients With Ovarian Cancer and NSCLC Likely to Express NaPi2b
Phase 1b, a study in high grade serous ovarian cancer and nonsmall cell lung cancer to evaluate the safety and clinical activity of the antibody-drug conjugate (ADC) XMT-1592.
- Trial name
- NCT04396340
- Testing
- XMT-1592
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Mersana Therapeutics
Polycystic Ovarian Syndrome
Comparison of Clomid and Lezra With Lezra for Ovulation Induction in Clomid Resistant PCOS Case
Clomiphene citrate resistant i.e failure to ovulate after 6 cycles of ovulation induction effects 15-40% of patients with PCOS.Two treatment groups will be formed one recieving letrozole alone and another recieving CC and…
- Trial name
- NCT06813118
- Testing
- Clomiphene Citrate and letrozole
- Where
- Pakistan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- HITEC-Institute of Medical Sciences
NSCLC, SCLC
A First-in-Human, JAB-8263 in Adult Patients With Advanced Tumors
This is a Phase 1/2a, first-in-human, open-label study of JAB-8263, this study has two parts: solid tumor dose escalation and expansion study and hematology tumor dose escalation and expansion study.
- Conditions
- NSCLC, SCLC, CRPC, ESCC
- Trial name
- NCT04686682
- Testing
- JAB-8263
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Jacobio Pharmaceuticals Co., Ltd.
Vulvar Lichen Sclerosus
Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus
This is a randomized trial comparing progesterone with conventional clobetasol propionate in patients with vulvar lichen sclerosus.
- Trial name
- NCT01126255
- Testing
- Clobetasol propionate 0.05%, Progesterone 8%
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Bulky Stage IIIC and IV Epithelial Ovarian Cancer, Fallopian Tube Cancer
First-line Intraperitoneal Cisplatin and Etoposide Chemotherapy for Ovarian Cancer
The purpose of this study is to evaluate the role of an additional intraperitoneal chemotherapy with cisplatin and etoposide in bulky advanced epithelial ovarian cancer.
- Conditions
- Bulky Stage IIIC and IV Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- AICE (NCT01669226)
- Testing
- PEip (weekly) and TCiv, TCiv
- Where
- 7 sites in China
- Volunteers
- 215 people
- Sponsor
- Shanghai Gynecologic Oncology Group
Primary Ovarian Insufficiency, Premature Menopause
Injections of Autologous PRP in Women With Primary Ovarian Insufficiency
Premature ovarian failure is a loss of normal function before age 40, leading to infertility and hypoestrogenism. This study will involve only adult women with a diagnosis of POI.
- Trial name
- PRP4POI (NCT03542708)
- Testing
- A-PRP
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Chlamydia Trachomatis Infection, Chlamydial Urethritis
Mecillinam for Treatment of Genital Chlamydia Infection
The mainstay of treating both symptomatic and asymptomatic genital Chlamydia trachomatis infection has been macrolide antibiotics in the form of azithromycin, and alternatively tetracycline antibiotics in the form of doxycycline.
- Trial name
- MecillinamCT (NCT02083276)
- Testing
- Pivmecillinamhydrochlorid
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Epithelial Ovarian Cancer, Primary Peritoneal Carcinoma
Paclitaxel + Carboplatin With AVB-S6-500 in Women With Stage III or IV Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Receiving Neoadjuvant Chemotherapy
The receptor tyrosine kinase AXL is a pathway that plays a crucial role in metastasis and chemoresistance. Overexpression of AXL has been associated with metastasis, recurrence, and chemoresistance in various cancer including…
- Conditions
- Epithelial Ovarian Cancer, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
- Trial name
- NCT03607955
- Testing
- AVB-S6-500, Paclitaxel, Carboplatin
- Sponsor
- Washington University School of Medicine
Polycystic Ovary Syndrome
L-carnitine and COH in PCOS Women Undergoing IVF/ICSI Cycles
The aim of this study was to evaluate the effect of oral L-carnitine supplementation during controlled ovarian stimulation (COS) in patients with polycystic ovary syndrome (PCOS) in a double-blind randomized clinical trial.
- Trial name
- NCT04672720
- Testing
- L-carnitine 1000 Mg
- Where
- Iran
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Endometriosis, Endometriosis-related Pain
Relugolix for Endometriosis Associated Pain
Endometriosis is a chronic, estrogen-dependent condition frequently associated with pelvic pain and reduced quality of life. Relugolix combination therapy (CT), an oral GnRH receptor antagonist-based treatment, has demonstrated…
- Conditions
- Endometriosis, Endometriosis-related Pain, Pelvic Pain Syndrome
- Trial name
- RELAX (NCT07440043)
- Testing
- Patients with a diagnosis of endometriosis receiving treatment with Relugolix CT, according to clinical practice,
- Volunteers
- 33 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rectovaginal Fistula, Crohn Disease
Allogenic Stem Cells Derived From Lipoaspirates for the Treatment of Recto-vaginal Fistulas Associated to Crohn's Disease (ALOREVA)
The purpose of this study is to determine safety and efficacy of allogenic eASCs (expanded adult stem cells) for the treatment of recto-vaginal fistula in patients with Crohn´s disease.
- Trial name
- ALOREVA (NCT00999115)
- Testing
- Expanded allogenic adipose-derived adult stem cells
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz
Bowel Endometriosis, Endometriosis
Efficacy and Safety of Intra-operative Dual Laparoscopy and Neo-rectoscopy for Bowel Endometriosis: The LUMEN-01 Trial
The goal of this prospective, multicenter, randomized controlled trial is to compare the clinical efficacy and safety of intra-operative dual laparoscopy and neo-rectoscopy (IDLnR) versus conventional laparoscopy (CL) in patients…
- Conditions
- Bowel Endometriosis, Endometriosis, Intestinal Endometriosis
- Trial name
- LUMEN-01 (NCT07523308)
- Testing
- conventional laparoscopy group, intra-operative Dual Laparoscopy and Neo-rectoscopy
- Where
- 3 sites in China
- Volunteers
- 192 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Polycystic Ovary Syndrome
Multi-omics Analysis of Women With PCOS and Obesity Compared With Non-PCOS Obese Controls
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in reproductive-aged women， which associated with increased risks to develop metabolic disorders, including cardiovascular diseases, diabetes mellitus…
- Trial name
- NCT05468476
- Testing
- No intervention
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Zhang Manna
Endometrial Cancer
Uterine Manipulator in Endometrial Cancer Surgery: Pro MUCEI Study
The uterine manipulator is a device commonly used in minimally invasive hysterectomy surgery for endometrial cancer. However, without substantial evidence to support its use, surgeons are required to make decisions about its use…
- Trial name
- proMUCEI (NCT05242276)
- Testing
- USE OF UTERINE MANIPULATOR DURING THE HYSTERECTOMY
- Where
- Spain
- Volunteers
- 1,200 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Female Infertility, Female Infertility Due to Ovulatory Disorder
Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility
The study will describe the effectiveness of ovarian stimulation in correlation with female infertility causes in a Lebanese population: a comparative study using 5 protocols of ovulation induction (treatment with "A"…
- Conditions
- Female Infertility, Female Infertility Due to Ovulatory Disorder, Premature Ovarian Failure, Polycystic Ovary Syndrome
- Trial name
- CS-EOSP-ICSI (NCT04071574)
- Testing
- Human Chorionic Gonadotropin (hCG), Gonadotropins, GNRH-A Triptorelin
- Where
- Lebanon
- Volunteers
- 200 people
- Sponsor
- Lebanese University
Female Infertility
Recombinant Follicle-stimulating Hormone in Treatment for Infertility
This is a randomized multi-centre, assessor-blind, parallel-group study to be conducted in 250 women in the age group of 20 to 39 years (both inclusive), who are indicated to undergo COS as part of assisted reproductive…
- Trial name
- REFRESH (NCT05266924)
- Testing
- Recombinant Human Follicle Stimulating Hormone 900 IU (66.0 μg) / 1.5mL Solution for Injection in Prefilled Pen
- Where
- India
- Volunteers
- 250 people
- Sponsor
- Bharat Serums and Vaccines Limited
Endometriosis
Surgical Eradication of Deep Infiltrating Endometriosis of the Vagina
Multicentric retrospective study about the comparison of two different techniques of vaginal breach suturing after eradication surgery for deep infiltrating endometriosis and the surgical approaches (laparoscopic or vaginal) in…
- Trial name
- ENDO-VAG-r (NCT03744143)
- Testing
- longitudinal suture, transverse suture, Removal of vaginal endometriotic nodule
- Where
- 2 sites in Italy
- Volunteers
- 84 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified
Human Papilloma Virus (HPV) Circulating Tumor DNA (ctDNA) in Cervical Cancer
This study collects blood samples to determine if the DNA of HPV that causes cervical cancer can be detected in patients with cervical cancer that is new (primary), has come back (recurrent), or has spread to other places in the…
- Conditions
- Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified, Infiltrating Cervical Carcinoma, Metastatic Cervical Carcinoma
- Trial name
- NCT04574635
- Testing
- Biospecimen Collection
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Ovarian Neoplasms
Prospective Identification and Validation of "BRCANess" Profile in Ovarian Epithelial Cancer
This is an observational prospective study. Patients diagnosed with advanced epithelial ovarian cancer (stage IC or higher) since 2008 will be asked to participate in this study by signing an informed consent.
- Trial name
- FindBRCANess (NCT02524808)
- Where
- 4 sites in Spain
- Volunteers
- 230 people
- Sponsor
- Fundación de investigación HM
HIV Infections
A Study to Evaluate the Effects of Different Methods of Birth Control on the Drug Actions of Zidovudine (an Anti-HIV Drug) in HIV-Positive Women and to Compare Zidovudine Metabolism in Men and Women
The purpose of this study is to look at the effects of different methods of birth control (oral and injectable) on how the body absorbs, makes available, and removes zidovudine (ZDV).
- Trial name
- NCT00000897
- Testing
- Zidovudine
- Where
- 6 sites in United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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