Clinical trials: Genital Infection
Human Immunodeficiency Virus, Lipodystrophy
Growth Hormone Dynamics and Cardiac Steatosis in HIV
Cardiac steatosis is increased among individuals with HIV, and may predispose to cardiac mechanical dysfunction and subsequent heart failure. The pathogenesis and treatment of cardiac steatosis is not well understood.
- Conditions
- Human Immunodeficiency Virus, Lipodystrophy, Cardiac Disease
- Trial name
- NCT03826160
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
HIV Infection, Carotid Atherosclerosis
Influence of Pravastatin on Carotid Artery Structure and Function in HIV-infected Patients Under Antiretroviral Therapy
The advent of new antiretroviral agents, in particular Highly Active Antiretroviral Therapy (HAART), spectacularly reduced HIV-associated morbidity and mortality.
- Conditions
- HIV Infection, Carotid Atherosclerosis, Dyslipidemia
- Trial name
- NCT00147797
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Saint Antoine University Hospital
Heart Diseases, Hiv
Whole Food Plant-Based Diet for HIV-Associated Reduction in Cardiovascular Risk (PLANT-HART)
The goal of this clinical trial is to evaluate the impact of using a whole food plant-based diet in the reduction of cardiovascular risk related to HIV in people who live with HIV infection.
- Trial name
- PLANT-HART (NCT05796882)
- Testing
- Whole Food Plant-Based Diet Ad Libitum, Nutritional Standard Care
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Universidad Autonoma de Chihuahua
HIV Infection
Study of Adherence Effects and Clinical Outcomes of Kaletra Based HIV Antiviral Therapy
The purpose of this study is to evaluate the effects of adherence on HIV antiviral response to treatment regimens containing Kaletra or other HIV protease inhibitors.
- Trial name
- NCT00234962
- Testing
- Lopinavir/Ritonavir
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Abbott
HIV-1, AIDS
A Comparison Study of Kaletra Soft-Gel Capsules and Kaletra Tablets in an African American Cohort
The purpose of this study is to compare Kaletra tablets with Kaletra soft-gel capsules to see if there is any change in the side effects you may have and to see how people in the study feel about using the tablets.
- Trial name
- NCT00268827
- Testing
- Kaletra soft-gel capsules switched to Kaletra tablets, MOS-HIV Health and Medication Satisfaction Survey, Global Conditioning Improvement and Therapy Preference Questionnaire
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- AIDS Arms Inc.
Partner Notification Following STI Diagnosis
Partner Notification Strategies for MSM in Peru
The goal of the proposed research is to assess new strategies for partner management and sexually transmitted infection (STI) control to reduce the spread of HIV-1 among men who have sex with men (MSM) in Latin America.
- Trial name
- NCT01720641
- Testing
- Internet, Referral Card, Internet and Referral Card
- Where
- Peru
- Volunteers
- 370 people
- Sponsor
- University of California, Los Angeles
Vaginal Discharge
Safety and Clinical and Microbiological Efficacy of the Combination of Fluconazole and Secnidazole for the Treatment of Symptomatic Vaginal Discharge
Genital tract infections (GTIs) have increased in the past decade and there is an association between sexually transmitted infections (STIs) and other infections like bacterial vaginosis (BV), with the HIV transmission.
- Trial name
- NCT02111629
- Testing
- Fluconazole and Secnidazole
- Where
- Colombia
- Volunteers
- 118 people
- Sponsor
- Universidad Nacional de Colombia
HIV Infections
Safety and Immunogenicity of Clade C ALVAC and gp120 HIV Vaccine
The purpose of this study is to evaluate the safety and immune response to an HIV clade C vaccine and to an MF59- or alum-adjuvanted clade C Env protein in healthy, HIV-uninfected adults.
- Trial name
- HVTN107 (NCT03284710)
- Testing
- ALVAC-HIV (vCP2438), Bivalent Subtype C gp120/MF59, Bivalent Subtype C gp120 admixed with Al(OH)3 Suspension
- Where
- 6 sites in Mozambique, South Africa and 1 more
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
An Open-Label, Crossover Study to Assess the Effect of Food on the Oral Bioavailability and Pharmacokinetic Profile of 3'-Deoxy-3'-Fluorothymidine (FLT) in Asymptomatic Human Immunodeficiency Virus (HIV)-Infected Subjects
To characterize the pharmacokinetics of orally administered FLT (in a liquid formulation) after single doses in both the fed and fasting states; to assess the effect of food on the oral bioavailability of FLT
- Trial name
- NCT00002260
- Testing
- Alovudine
- Where
- United States
- Sponsor
- Lederle Laboratories
Meningococcal Meningitis, Human Papillomavirus Infection
A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Conjugate Vaccine In Adolescents
This study will evaluate the safety and immune response of the Novartis Meningococcal ACWY conjugate vaccine when administered with Tdap and HPV vaccinations to healthy adolescents
- Conditions
- Meningococcal Meningitis, Human Papillomavirus Infection, Pertussis, Tetanus
- Trial name
- NCT00518180
- Testing
- Novartis Meningococcal ACWY Conjugate Vaccine, Tdap Vaccine
- Where
- Costa Rica
- Volunteers
- 1,620 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
HIV Infections
Molecular Diversity of HIV-1 Group O Strains and Treatment Management in Cameroon
Infections with HIV-1 group O are found in 1 to 3 % of persons living with HIV in Cameroon. The natural history and treatment response is not well understood.
- Trial name
- NCT00658346
- Testing
- Treatment initiation for HIV-1 group O infected patients, Treatment initiation for HIV-1 group M infected patients
- Where
- 2 sites in Cameroon
- Volunteers
- 141 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Acquired Immunodeficiency Syndrome, Human Immunodeficiency Virus Type
Adherence & Health Outcome Differences Amongst HIV Infected Patients Prescribed HAART
This study is designed to see how HIV infected patients perform when taking a single fixed dose HIV medication compared to a regimen with multiple tablets.
- Trial name
- HOST (NCT02322827)
- Where
- United States
- Volunteers
- 445 people
- Sponsor
- Olayemi Osiyemi MD
Cervical Cancer, Human Papillomavirus
Accuracy of Portable Colposcopy and HPV Genotypes Among HIV+ Women
This study will evaluate the effectiveness of portable colposcopy when compared to conventional colposcopy (25x magnification of the cervix, the gold standard) and Visualization Inspection with Acetic acid (VIA, with 1x…
- Conditions
- Cervical Cancer, Human Papillomavirus, Human Immunodeficiency Virus
- Trial name
- NCT02338141
- Testing
- Portable colposcopy (Cerviscope), Conventional colposcopy (Wallach Zoomscope)
- Where
- Haiti
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Duke University
Papillomavirus Infections
Safety and Immunogenicity of Extended 2-dose Regimens of 9-valent Human Papillomavirus (9vHPV) Vaccine (V503-069)
This is a 96-month safety and immunogenicity study conducted in boys and girls 9 to 14 years of age and in young women 16 to 26 years of age.
- Trial name
- NCT04708041
- Testing
- 9vHPV vaccine
- Where
- 30 sites in United States, Colombia and 4 more
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
Safety of and Immune Response to a Prime-Boost Vaccine Regimen in HIV-Uninfected Vaccine-Naive Adults
The purpose of this study is to evaluate the safety of and immune response to a two-vaccine regimen in healthy, HIV-uninfected adults who have never received an HIV preventive vaccine before.
- Trial name
- NCT00820846
- Testing
- pGA2/JS7 DNA vaccine, MVA/HIV62 vaccine
- Where
- 12 sites in United States, Peru
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Herpes, Herpes Simplex
Study of the Efficacy and Safety of Combined Treatment of Patients With Severe Herpes Simplex (HSV) Infection by Valacyclovir and Interferon Inducer Kagocel
This study examined the efficacy, safety and benefits of modern treatment and changes in the dynamics of the life of adult patients quality with severe herpes simplex in the current medical practice when combined therapy by…
- Conditions
- Herpes, Herpes Simplex, Herpes Oral, Herpes Simplex 2
- Trial name
- NCT04664127
- Testing
- Kagocel+Valacyclovir, Valacyclovir
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Nearmedic Plus LLC
HIV/AIDS
Same-Day Treatment With Genvoya vs. EFV/TDF/3TC
Randomized, open-label study comparing Elvitegravir-Cobicistat-Tenofovir Alafenamide-Emtricitabine (Genvoya) vs. Efavirenz-Tenofovir Disoproxil Fumarate-Lamivudine (EFV-TDF-3TC) in patients starting ART on the day of HIV…
- Trial name
- NCT03405194
- Testing
- Elvitegravir, Cobicistat, TAF, FTC, Efavirenz, TDF, and 3TC
- Sponsor
- Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic
HIV Infections
Acupressure to Treat Nausea and Vomiting in HIV/AIDS Patients
The purpose of this study is to see whether acupressure (acupuncture using pressure applied by the hands instead of needles) can help nausea and vomiting in persons with HIV/AIDS.
- Trial name
- NCT00017823
- Testing
- Acupressure
- Where
- United States
- Sponsor
- National Institute of Nursing Research (NINR)
HIV Infections, HPV Infection
Adjuvant 5-Fluorouracil Following Thermal Ablation to Improve HPV Treatment Outcomes in Women With HIV in Kenya
This randomized, placebo-controlled trial will evaluate self-administered 5-fluorouracil (5FU) to improve human papillomavirus (HPV) clearance after thermal ablation (TA) in Women With Human Immunodeficiency Virus (HIV) (WWH) in…
- Conditions
- HIV Infections, HPV Infection, Cervix Cancer, CIN2
- Trial name
- ASCEND (NCT07545746)
- Testing
- 5% 5-fluorouracil Topical Cream
- Where
- 2 sites in Kenya
- Volunteers
- 140 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
HIV Infections
Study of Itraconazole in Patients With Advanced HIV Infection
To demonstrate a dosage regimen for intravenous itraconazole that produces a plasma concentration range comparable to that obtained after currently used oral dosages of itraconazole oral solution; and to obtain preliminary safety…
- Trial name
- NCT00002370
- Testing
- Itraconazole
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Janssen, LP
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