Clinical trials: Genital Neoplasm
Prostatic Neoplasms
Mobicox: Study of Meloxicam to Reduce Prostate Swelling in Permanent Seed Prostate Brachytherapy
Swelling of the prostate can occur during and after a brachytherapy. This swelling can cause urinary problems ranging from difficulty voiding to urinary retention.
- Trial name
- NCT00152919
- Testing
- Meloxicam
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Anovulation, Polycystic Ovary Syndrome
Letrozole Versus Clomiphene Citrate for Ovulation Induction in Women With Poly Cystic Ovary Syndrome ( PCOS )
110 infertile women diagnosed as polycystic ovary syndrome (PCOS) at the age group of 20-35 distributed randomly : 55 women will receive letrozole 2.5mg twice daily orally from the 2nd day to the 6thday of the cycle for three…
- Trial name
- LVCCFOROI (NCT02551367)
- Testing
- Letrozole, Clomiphene citrate, hcg hormone
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- mostafa gomaa hamid halawa
Testicular Cancer, Survivorship
Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors
Late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant
- Conditions
- Testicular Cancer, Survivorship, ASCVD, Coronary Artery Disease
- Trial name
- NCT05611307
- Testing
- Lipid profile, Coronary artery assessment, Hormone levels for hypogonadism
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Polycystic Ovary Syndrome
Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine if the combination therapy of lifestyle intervention and use of Metformin together will improve ovulation induction and hyperandrogenemia in women with polycystic ovary syndrome, by…
- Trial name
- NCT00151411
- Testing
- Metformin, Lifestyle Intervention
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Gynaecomastia, Prostate Cancer
Casodex - Nolvadex Combination
This study looks at the relationship in the dose of nolvadex and the incidence of gynaecomastia and also Prostate Specific Antigen (PSA) inhibition when co-administered with Casodex.
- Trial name
- NCT00637871
- Testing
- Casodex, Tamoxifen
- Sponsor
- AstraZeneca
Anal Squamous Intraepithelial Neoplasia
Seville Cohort of People Living With HIV at Risk for Anal Cancer
There is increasing awareness of augmenting risk of anal cancer in people living with HIV, especially among men who have sex with men (MSM).
- Trial name
- SeVIHanal (NCT03713229)
- Testing
- Screening for anal squamous intraepithelial lesions
- Where
- Spain
- Volunteers
- 3,000 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Prostate Cancer
Long Acting Neuraxial Peri-prostatic Block in Cancer
Disease progression after definitive therapy for prostate cancer is a major source of morbidity and mortality. Adrenergic/sympathetic innervation of the prostate is essential for prostate cancer progression, and abrogation of…
- Trial name
- NCT06703437
- Testing
- Dehydrated alcohol, Lidocaine IV
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
BRCA1 Gene Mutation, BRCA2 Gene Mutation
Olaparib, Durvalumab, and Tremelimumab in Treating Patients With Recurrent or Refractory Ovarian, Fallopian Tube or Primary Peritoneal Cancer With BRCA1 or BRCA2 Mutation
This phase I/II trial studies the side effects and best dose of olaparib when give together with durvalumab and tremelimumab and to see how well they work in treating patients with ovarian, fallopian tube, or primary peritoneal…
- Conditions
- BRCA1 Gene Mutation, BRCA2 Gene Mutation, Ovarian Serous Adenocarcinoma, Recurrent Fallopian Tube Carcinoma
- Trial name
- NCT02953457
- Testing
- Durvalumab, Laboratory Biomarker Analysis, Olaparib
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Roswell Park Cancer Institute
Metastatic Prostate Carcinoma, Stage IIIB Prostate Cancer AJCC v8
Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network
This trial evaluates whether a network of peer genetic coaches is useful for addressing disparities in genetic testing and screening among African American men with prostate cancer that has spread from where it first started…
- Conditions
- Metastatic Prostate Carcinoma, Stage IIIB Prostate Cancer AJCC v8, Stage IIIC Prostate Cancer AJCC v8, Stage IV Prostate Cancer AJCC v8
- Trial name
- NCT05627219
- Testing
- Training and Education, Educational Intervention, Discussion
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Prostate Cancer
Fulvestrant in Treating Patients With Recurrent Prostate Cancer
RATIONALE: Estrogen may cause the growth of prostate cancer cells. Hormone therapy using fulvestrant may fight prostate cancer by blocking the use of estrogen by the tumor cells.
- Trial name
- NCT00217464
- Testing
- fulvestrant
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Roswell Park Cancer Institute
Testicular Germ Cell Tumor
Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00004077
- Testing
- cisplatin, ifosfamide, paclitaxel
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Medical Research Council
Prostate Carcinoma
Multiparametric Ultrasound for the Diagnosis of Clinically Significant Prostate Cancer
This phase III trial compares the use of contrast-enhanced multiparametric ultrasound (mp-US) to multiparametric magnetic resonance imaging (mp-MRI) for the diagnosis of clinically significant prostate cancer (PCa).
- Trial name
- NCT06024772
- Testing
- ultiparametric Magnetic Resonance Imaging, Perflutren lipid microsphere, Transrectal Ultrasound
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 300 people
- Sponsor
- Thomas Jefferson University
Human Papilloma Virus Infection, Cervical Intraepithelial Neoplasia Grade 2/3
The HPV Self-test as a Test of Cure in Madagascar
The purpose of this study is to find out whether Self-HPV may be an accurate method for the follow-up of women with a history of HPV infection.
- Trial name
- NCT02811367
- Testing
- HPV test
- Where
- Madagascar
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Cervical Cancer, Sentinel Lymph Node
HPV in Sentinel Lymph Nodes of Cervical Cancer Patients
This study examines sentinel lymph node tissue from early stage cervical cancer patients treated with radical surgery and removal of pelvic sentinel lymph nodes (SLN).
- Conditions
- Cervical Cancer, Sentinel Lymph Node, HPV-Related Cervical Carcinoma
- Trial name
- NCT03749707
- Testing
- HPV analysis
- Where
- Denmark
- Volunteers
- 127 people
- Sponsor
- University of Aarhus
Hormone-Resistant Prostate Cancer, Metastatic Prostate Carcinoma
Dexamethasone Prior to Re-treatment With Enzalutamide in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Previously Treated With Enzalutamide and Docetaxel
This pilot trial studies how well dexamethasone and re-treatment with enzalutamide work in treating patients with prostate cancer that has spread to other places in the body (metastatic), does not respond to hormone therapy…
- Conditions
- Hormone-Resistant Prostate Cancer, Metastatic Prostate Carcinoma, Prostate Adenocarcinoma, Stage IV Prostate Cancer
- Trial name
- DEXTER (NCT02491411)
- Testing
- Dexamethasone, Enzalutamide, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Prostate Cancer
Gadopiclenol in Contrast Enhanced MRI of the Prostate
The fundamental aim of this study is to show that the novel contrast agent Gadopiclenol (Elucirem), with its high relaxivity, facilitates increased contrast enhancement and improved differentiation of clinically significant…
- Trial name
- NCT06226129
- Testing
- Gadopiclenol
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Columbia University
Prostate Cancer
Evaluating Symptom Management Educational Materials for Patients With Prostate Cancer
RATIONALE: Collecting feedback from patients with prostate cancer may help doctors develop better symptom management educational materials for patients.
- Trial name
- NCT00769431
- Testing
- educational intervention, study of socioeconomic and demographic variables
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Baylor College of Medicine
Urinary Retention After Procedure
Donepezil Prevents Urinary Retention After Extensive Total Hysterectomy
Patients were randomly divided into experimental group and control group. The control group received routine postoperative treatment, while the experimental group took donepezil 5mg orally before going to bed every night from the…
- Trial name
- NCT05540977
- Testing
- Donepezil, Usual care
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Ovarian Cancer, Primary Peritoneal Cancer
Neoadjuvant Chemotherapy IV Carboplatin With Weekly Paclitaxel \Bevacizumab for Primary Ovarian
The purpose of this study is to determine the maximum tolerated dose (MTD) of intravenous weekly paclitaxel given with intravenous carboplatin and bevacizumab in patients with epithelial ovarian, primary peritoneal, or fallopian…
- Conditions
- Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer
- Trial name
- NCT01219777
- Testing
- carboplatin, Bevacizumab, Paclitaxel
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Ritu Salani
Prostate Cancer
High-Intensity Focused Ultrasound Ablation in Treating Patients With Progressive Prostate Cancer
RATIONALE: High-intensity focused ultrasound ablation uses high-energy sound waves to kill tumor cells. PURPOSE: This phase II trial is studying the side effects of high-intensity focused ultrasound ablation and to see how well…
- Trial name
- NCT00987675
- Testing
- pharmacological study, questionnaire administration, assessment of therapy complications
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University College London Hospitals
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