Clinical trials: Genital Neoplasms
Neoplasms, Prostate
First-Time-in-Human Study of GSK5471713 in Adults With mCRPC
This first-time-in-human study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, preliminary clinical activity, and establish the benefit/risk of GSK5471713 given as a monotherapy in mCRPC.
- Trial name
- NCT07332455
- Testing
- GSK5471713
- Where
- 20 sites in United States, Australia and 6 more
- Volunteers
- 54 people
- Sponsor
- GlaxoSmithKline
Cancer, Autoimmune Diseases
Ovarian Tissue Cryopreservation for Fertility Preservation
The goal of this observational study is to learn about fertility preservation for pre-pubertal, peri-pubertal, and adult participants that are unable to pursue clinical standard of care fertility preservation such as egg (oocyte)…
- Trial name
- NCT05875155
- Testing
- Infectious Disease Labwork, Fertility-Based Labwork
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Pittsburgh
Extragonadal Germ Cell Tumor, Testicular Germ Cell Tumor
Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors
RATIONALE: Drugs used in chemotherapy, such as ifosfamide, cisplatin, paclitaxel, and vinblastine, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00072215
- Testing
- cisplatin, ifosfamide, paclitaxel
- Where
- 79 sites in United States, Canada
- Volunteers
- 1 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Endometrial Cancer
END-1: First Line Chemotherapy for Advanced or Recurrent Endometrial Carcinoma With Carboplatin and Liposomal Doxorubicin
The purpose of this study is to evaluate activity and toxicity of the combination of carboplatin and liposomal doxorubicin as first-line chemotherapy of patients with advanced or recurrent endometrial carcinoma.
- Trial name
- NCT00401635
- Testing
- liposomal doxorubicin, carboplatin
- Where
- 4 sites in Italy
- Volunteers
- 42 people
- Sponsor
- National Cancer Institute, Naples
Uterine Fibroids (UF)
HIFU Versus Myomectomy for the Treatment of Symptomatic Uterine Fibroids
The goal of this clinical trial is to learn if High-Intensity Focused Ultrasound (HIFU) is as effective as myomectomy for treating symptomatic uterine fibroids in women aged 18 to 50.
- Trial name
- NCT06692335
- Testing
- High-Intensity Focused Ultrasound (HIFU), myomectomy
- Where
- Hong Kong
- Volunteers
- 112 people
- Sponsor
- Chinese University of Hong Kong
Prostatic Neoplasms, Frailty
The Effect of Frailty on Blood Biology Indicators, Quality of Life and Survival of Patients With Radical Prostatectomy
The goal of this observational study is to evaluate the effect of frailty on blood biology indicators, quality of life and survival of patients with radical prostatectomy. The main questions it aims to answer are: 1.
- Conditions
- Prostatic Neoplasms, Frailty, Blood Biological Indicators, Quality of Life
- Trial name
- NCT05941104
- Testing
- frailty
- Volunteers
- 100 people
- Sponsor
- Anhui Provincial Hospital
Cervical Cancer, Cervix Cancer
Investigating the Combination of VB10.16 and Atezolizumab in Patients With HPV 16-positive Cervical Cancer
This phase IIa study is designed to evaluate the safety and efficacy of multiple dosing with VB10.16 immunotherapy in combination with atezolizumab in patients with advanced or recurrent non-resectable HPV16-positive cervical…
- Trial name
- NCT04405349
- Testing
- VB10.16, Atezolizumab
- Where
- 21 sites in Belgium, Bulgaria and 4 more
- Volunteers
- 52 people
- Sponsor
- Nykode Therapeutics ASA
Polycystic Ovary Syndrome
Simvastatin Therapy in Women With Polycystic Ovary Syndrome.
The purpose of this study is to determine whether statins (simvastatin) improve clinical (excessive hair, skin problems), endocrine (androgens) and metabolic (lipids, markers of systemic inflammation) in women with polycystic…
- Trial name
- NCT00365638
- Testing
- simvastatin
- Where
- Poland
- Sponsor
- Poznan University of Medical Sciences
Breast Cancer, Leukemia
High-Dose Chemotherapy, Total-Body Irradiation, and Autologous Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Hematologic Cancer or Solid Tumors
RATIONALE: Radiation therapy uses high-energy x-rays to damage cancer cells. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
- Conditions
- Breast Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00060255
- Testing
- busulfan, carboplatin, carmustine
- Where
- United States
- Volunteers
- 451 people
- Sponsor
- Roswell Park Cancer Institute
Cervical Cancer, HPV Infection
Human Papilloma Virus (HPV) Self-collection and Women Adherence
Despite declining mortality in high-income countries, cervical cancer continues to be a public health problem in low and middle -income countries.
- Trial name
- NCT05059015
- Testing
- CERVICAL HPV, SELF SAMPLING HPV
- Where
- Colombia
- Volunteers
- 80 people
- Sponsor
- Instituto Nacional de Cancerologia, Columbia
Ovarian Neoplasms, Fallopian Tube Neoplasms
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
This is a clinical study that has three parts. It is testing a potential new medicine called Sofetabart Mipitecan (Sofe-M) for people with certain types of ovarian, peritoneal, and fallopian tube cancers.
- Conditions
- Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms, Neoplasm Metastasis
- Trial name
- FRAmework-01 (NCT07213804)
- Testing
- Sofetabart Mipitecan, Paclitaxel, Topotecan
- Where
- 264 sites in United States, Australia and 25 more
- Volunteers
- 1,630 people
- Sponsor
- Eli Lilly and Company
Ovarian Cancer, Fallopian Tube Cancers
Targeting Immune Modulation in High Grade Serous Carcinoma: Combined Effects of Chemotherapy and Atorvastatin
The goal of this clinical trial is to learn how atorvastatin in patients with advanced high grade serous cancer of the ovary, fallopian tube, or peritoneum changes the tumor immune environment.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancers, Primary Peritoneal Cancer, High Grade Serous Adenocarcinoma of Ovary
- Trial name
- NCT07815704
- Testing
- Standard of Care + atorvastatin, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Prostate Cancer
Quantitative Prostate Cancer Contrast-enhanced Ultrasound
Background: Bracco has released the VueBoxTM-Prostate software, aimed at distinguishing prostate cancer from prostate benign peripheral zone (PZ) at contrast-enhanced ultrasound (CEUS) using SonoVue® as contrast agent.
- Trial name
- SONOCAP (NCT02295449)
- Testing
- biopsy sample performed after the SonoVue® injection
- Where
- 3 sites in France
- Volunteers
- 130 people
- Sponsor
- Hospices Civils de Lyon
Prostate Cancer
MRI-guided Ultrahypofractionated SBRT Prostate Program
The goal of this clinical trial is to learn if the use of MRI-guided asymmetric ultrahipofractionated irradiation (2 fractions with dose increase in the tumor areas and dose sparing in urethra, rectum and neurovascular bundles)…
- Trial name
- NCT07132658
- Testing
- MR-Guided SBRT
- Volunteers
- 40 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Cancer, Prostate Cancer
Physicians' Health Study II
The use of vitamin E, vitamin C, beta carotene, and/or multivitamins may keep cancer, cardiovascular disease, eye diseases, or cognitive decline from occurring.
- Conditions
- Cancer, Prostate Cancer, Colorectal Cancer, Cardiovascular Disease
- Trial name
- PHS II (NCT00270647)
- Testing
- Vitamin E, Vitamin C, Multivitamin
- Volunteers
- 14,641 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Solid Tumor, Colorectal Cancer
A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors
The main purpose of this study is to establish the safety and the recommended dose of TRK-950 in combination with FOLFIRI, Gemcitabine / Cisplatin, Gemcitabine / Carboplatin, Ramucirumab / Paclitaxel, PD1 inhibitors (Nivolumab or…
- Conditions
- Solid Tumor, Colorectal Cancer, Cholangiocarcinoma, Bladder Cancer
- Trial name
- NCT03872947
- Testing
- TRK-950, Irinotecan, Leucovorin
- Where
- 14 sites in United States, France
- Volunteers
- 138 people
- Sponsor
- Toray Industries, Inc
Malignant Neoplasms of Female Genital Organs, Ovarian Cancer
Bevacizumab in Ovarian Cancer Patients With Disease at Second-Look Surgery
The goal of this clinical research study is to learn if Avastin (bevacizumab) can help to control ovarian, fallopian, or primary peritoneal cancer that has been found during second-look surgery.
- Conditions
- Malignant Neoplasms of Female Genital Organs, Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
- Trial name
- NCT02884648
- Testing
- Bevacizumab
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancer
Prostatectomy Adaptive Radiation Therapy (ART)
This study will ultimately aim to evaluate the side effects of treatment by asking 20 subjects to receive post-operative radiotherapy for prostate cancer with the treatment plan adapted after the first week of treatment to…
- Trial name
- NCT02034955
- Testing
- Post-operative Adaptive Radiation Therapy
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University Health Network, Toronto
Human Papillomavirus
Evaluate the Safety of Recombinant Human Papillomavirus Bivalent (Types 16 and 18) Vaccine (Yeast) in Healthy Females
This study will evaluate the safety of a novel recombinant human papillomavirus bivalent ( types 16 and 18 ) vaccine ( Yeast ) with different dose in healthy females between 9-45 years of age at enrollment.
- Trial name
- NCT01548118
- Testing
- HPV 16/18 vaccine, 0,5ml, HPV 16/18 vaccine, 1.0ml
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Zerun Biotechnology Co.,Ltd
Condylomata Acuminata
A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for the Treatment of External Genital Warts
This trial will be a phase 2, open-label, study to evaluate the safety, tolerability, and efficacy of VIR007 when administered topically for up to 60 days to adults between the ages of 18 to 65 years with a clinical diagnosis of…
- Trial name
- NCT03158974
- Testing
- East Indian Sandalwood Oil Cream
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- ViroXis Corporation
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