Clinical trials: Genital Neoplasms
Ovarian Cancer
A Bioequivalence Study to Evaluate Pharmacokinetics and Safety of BR2022 and BR2022-1 in Patients With Deleterious or Suspected Deleterious Germline BRCA-Mutated Advanced Ovarian Cancer
This was a multicenter, open-label, randomized, crossover bioequivalence study to evaluate the pharmacokinetics and safety of BR2022 and BR2022-1 in Patients with deleterious or suspected deleterious germline BRCA-mutated…
- Trial name
- NCT07069335
- Testing
- Olaparib 150 MG
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Polycystic Ovarian Syndrome
In-Vitro Maturation of Oocytes From Polycystic Ovarian Patients Undergoing IVF
Retrieval of immature oocytes from women with polycystic ovaries, their in-vitro maturation, fertilization and embryo transfer can prevent hormonal treatment that can lead to ovarian hyperstimulation.
- Trial name
- IVM (NCT00561808)
- Testing
- In-vitro maturation oocytes
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Prostate Cancer
A Pilot Study Evaluating Oral Triamcinalone in Patients With Androgen Independent Prostate Cancer
The primary purpose of this study is to evaluate the ability of oral triamcinalone given twice a day to patients with androgen independent prostate cancer to produce a sustained biochemical response.
- Trial name
- NCT00186108
- Testing
- Oral Triamcinalone
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Stanford University
Prostate Cancer
Trial to Evaluate Radiotherapy Followed by Endocrine Therapy Vs Endocrine Therapy Alone for PSA Failure After Radical Prostatectomy
The purpose of this study is to evaluate radiotherapy followed by endocrine therapy in comparison with endocrine therapy alone for PSA failure after radical prostatectomy.
- Trial name
- NCT00138008
- Testing
- endocrine therapy, radiotherapy
- Where
- 34 sites in Japan
- Volunteers
- 200 people
- Sponsor
- Haruhiko Fukuda
Cancer Prostate
Prospective Validation of PSMA-RADS
This is a prospective, multicenter study aimed at evaluating the diagnostic accuracy and reliability of the Prostate-Specific Membrane Antigen Reporting and Data System (PSMA-RADS) version 1.0 in detecting prostate cancer using…
- Trial name
- PSMA-RADS (NCT06359717)
- Where
- Egypt
- Volunteers
- 477 people
- Sponsor
- Zagazig University
Ovarian Neoplasms
Best Approach in Recurrent-Ovarian-Cancer-with Cediranib-Olaparib
This is a Phase II, randomized, multi-centre study aiming at comparing the efficacy of Olaparib and Cediranib vs. weekly Paclitaxel in terms of progression free survival (PFS) in platinum refractory or resistant recurrent ovarian…
- Trial name
- BAROCCO (NCT03314740)
- Testing
- Paclitaxel, Cediranib, Olaparib
- Where
- 6 sites in Italy
- Volunteers
- 123 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Epithelial Ovarian Cancer, Peritoneal Cancer
LCC-CARIS-01: Molecular Profiling in Gynaecological Cancer
This is a pilot feasibility study assessing the use of a commercial molecular profiling service in the UK's National Health Service (NHS).
- Conditions
- Epithelial Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer, Gynaecological Malignancy
- Trial name
- NCT02668913
- Testing
- Diagnostic analysis
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- Geoff Hall
Prostatic Neoplasms
A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer
The purpose of this study is to determine the relative bioavailability (rBA; Period 1) and bioequivalence (BE; Period 2 and 3) of various strengths and formulations of niraparib and abiraterone acetate (AA) at steady state under…
- Trial name
- NCT04577833
- Testing
- Niraparib, Abiraterone Acetate (AA), Prednisone
- Where
- 16 sites in United States, Belgium and 9 more
- Volunteers
- 136 people
- Sponsor
- Janssen Research & Development, LLC
Prostate Cancer
Postoperative Prognosis Management Service Based mHealth for Prostate Cancer Patients
Recently, the use of mobile health is increasing for the purpose of managing prognosis such as recurrence, survival and quality of life by using a wearable smart band and a smartphone application.
- Trial name
- NCT05021952
- Testing
- mHealth App and wearable device
- Where
- South Korea
- Volunteers
- 324 people
- Sponsor
- Seoul St. Mary's Hospital
Papillomavirus Infections
Efficacy, Immunogenicity, and Safety of V503 in Chinese Males (V503-052)
This study will evaluate the efficacy, immunogenicity, and safety of 9-valent human papillomavirus (9vHPV; V503) vaccine in Chinese men 20 to 45 years of age.
- Trial name
- NCT05285826
- Testing
- 9vHPV Vaccine
- Where
- 34 sites in China
- Volunteers
- 8,100 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Cervical Cancer, Ovarian Clear Cell Carcinoma
Asian Multicenter Prospective Study of ctDNA Sequencing
This study is a genetic analysis of aberrations in circulating tumor DNA (ctDNA) in patients in Asian countries. This study protocol is divided into parts describing several subanalyses that differ in terms of cancer types…
- Conditions
- Cervical Cancer, Ovarian Clear Cell Carcinoma, Nasopharyngeal Carcinoma, Ovarian Cancer
- Trial name
- A-TRAIN (NCT05099978)
- Testing
- NGS analysis of ctDNA
- Where
- 19 sites in Japan, Malaysia and 6 more
- Volunteers
- 506 people
- Sponsor
- National Cancer Center, Japan
Cancer, Infertilty
Assessing Reproductive Outcomes in Young Female Cancer Survivors Through a National Fertility Preservation Registry
The FIRST project is a national fertility preservation registry for young women facing cancer treatments. The investigators will examine how different cancers and treatments affect the reproductive health of young survivors.
- Trial name
- NCT01843140
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of California, San Diego
Breast Neoplasms, Ovarian Neoplasms
Outcomes of Education and Counseling for BRCA1 Testing
This study will identify how personal beliefs, values and family experiences affect a person's decision as to whether or not to be tested for changes in a gene called BRCA1 or BRCA2.
- Trial name
- NCT00001468
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Human Papilloma Virus Infection
Clinical Evaluation of the APTIMA® HPV Assay Using the PANTHER™ System
The objective is to establish that APTIMA HPV Assay performance on the PANTHER System is comparable to performance on the TIGRIS System.
- Trial name
- NCT01446198
- Where
- 3 sites in United States
- Volunteers
- 11,816 people, healthy volunteers welcome
- Sponsor
- Gen-Probe, Incorporated
Metastatic Castration-Resistant Prostate Cancer
A Study of FG-3246 in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
The purpose of this study is to evaluate the safety, efficacy, tolerability, and pharmacokinetics (PK) of FG-3246, a cluster of differentiation 46 (CD46) targeting antibody-drug conjugate (ADC), in the treatment of participants…
- Trial name
- NCT06842498
- Testing
- FG-3246
- Where
- 23 sites in United States
- Volunteers
- 75 people
- Sponsor
- Kyntra Bio
Prostate Cancer
Predicting Cognitive Decline From Androgen Deprivation Therapy
Androgen Deprivation Therapy (ADT) is associated with cognitive impairment and dementia in men with prostate cancer. Pre-clinical data suggest that ADT-induced hypogonadism leads to accumulation of beta-amyloid plaques in the…
- Trial name
- ABC (NCT05820932)
- Testing
- Blood-based assay, Cognitive assessments, Quality of Life Surveys
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Prostate Cancer
Phase 1 Trial of PAN-301-1 (SNS-301) in Cancer Patients
This is a Phase I, open-label, parallel design study of PAN-301-1 (SNS-301), a HAAH directed nanoparticle vaccine, given intradermally in cohorts of patients with biochemically relapsed prostate cancer, using a fixed dose…
- Trial name
- NCT03120832
- Testing
- PAN-301-1
- Where
- 4 sites in United States
- Volunteers
- 12 people
- Sponsor
- Sensei Biotherapeutics, Inc.
Ovarian Cancer
Development for the Peritoneal Carcinomatosis Index (PCI) in Ovarian Cancer
Primary objectives: To develop peritoneal carcinomatosis index (PCI) for ovarian cancer, tubal cancer and primary peritoneal cancer that can represent perioperative intraperitoneal tumor burden objectively Secondary objectives…
- Trial name
- NCT01538498
- Where
- South Korea
- Volunteers
- 134 people
- Sponsor
- National Cancer Center, Korea
Cervical Cancer
Phase III Study of Socazolimab as First-Line Treatment in Persistent, Recurrent, or Metastatic Cervical Cancer
The goal of this clinical trial is to evaluate the efficacy and safety of Socazolimab combined with chemotherapy with or without bevacizumab as first-Line treatment in persistent, recurrent, or metastatic cervical cancer.
- Trial name
- NCT06459687
- Testing
- Socazolimab+cisplatin/carboplatin+paclitaxel+Bevacizumab
- Where
- 5 sites in China
- Volunteers
- 440 people
- Sponsor
- Lee's Pharmaceutical Limited
Condylomata Acuminata, Papillomavirus Infections
Safety and Efficacy Study of Topical Ranpirnase to Treat Genital Warts (HPV)
Ranpirnase in topical formulation is an antiviral drug being evaluated for the topical treatment of anogenital warts. The aims of this study is to evaluate the efficacy and safety of a topical formulation of ranpirnase in…
- Conditions
- Condylomata Acuminata, Papillomavirus Infections, Sexually Transmitted Diseases
- Trial name
- NCT02535104
- Testing
- Ranpirnase, Vehicle
- Where
- Bolivia
- Volunteers
- 70 people
- Sponsor
- Tamir Biotechnology, Inc.
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