Clinical trials: Genitourinary Cancer
HPV Infection, Cervical Cancer
Clinical Correlation Between Self-collected and Physician-collected HPV Screening Kits
The objective of this study is to validate the of the Evalyn®Brush via self-collection to the standard clinician-collected technique using the BD SurePath™ collection vial and Rovers CombiBrush for detection of Human…
- Trial name
- NCT05679141
- Where
- Canada
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- Switch Health Solutions Inc.
Mass Screening, Early Detection of Cancer
Stepwise Strategy to Improve CANcer Screening Adherence: Cervical Cancer
This study aims to assess the effectiveness of a stepwise approach, with increasing complexity and cost, to improve adherence to organized cervical cancer screening: step 1a - customized text message invitation; step 1b …
- Conditions
- Mass Screening, Early Detection of Cancer, Uterine Cervical Neoplasm, Text Message
- Trial name
- SCAN-CC (NCT03122275)
- Testing
- Customized text message invitation ( Step 1a), Customized automatic phone call invitation (Step 1b), Secretary phone call (Step 2)
- Where
- 2 sites in Portugal
- Volunteers
- 1,220 people, healthy volunteers welcome
- Sponsor
- João Firmino Domingues Barbosa Machado
Polycystic Ovary Syndrome, Vitamin D Deficiency
Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
The purpose of this study is to investigate the mechanism that explain the beneficial clinical effect of vitamin D treatment in women with PCOS.
- Trial name
- NCT03644212
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Maimonides Medical Center
Polycystic Ovarian Syndrome, Pelvic Endometriosis
Prevalence of HbA1C in Women With PCOS
Women with PCOS have been observed to be potential diabetics.Recently,American Diabetes Association has suggested screening of women with PCOS for HbA1C.
- Conditions
- Polycystic Ovarian Syndrome, Pelvic Endometriosis, Insulin Resistance, Non-insulin Dependent Diabetes Mellitus
- Trial name
- WHI (NCT01838122)
- Where
- India
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Southern Cross Fertility Centre
Polycystic Ovary Syndrome, Ovarian Hyperstimulation Syndrome
In Vitro Maturation of Immature Oocytes
The aim of this study is to aspirate immature oocytes from antral follicles and mature the oocytes in vitro. These mature oocytes will serve for fertilization and the creation of embryos which will be replace in the uterus as…
- Trial name
- NCT00480337
- Testing
- In Vitro Maturation of immature oocytes
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cervical Cancer, HPV Infection
ELEVATE Acceptability Study
This study includes a community-based, two-arm prospective acceptability study, whereby arm 1 consists of an educational session on sexual health and cervical cancer (screening) and a follow-up assessment after 3 months.
- Conditions
- Cervical Cancer, HPV Infection, Acceptability of Health Care
- Trial name
- ELEVATE AS (NCT06136702)
- Testing
- Educational session, Self-sampling, Follow-up assessment
- Where
- 4 sites in Belgium, Brazil and 2 more
- Volunteers
- 1,048 people, healthy volunteers welcome
- Sponsor
- University Ghent
Prostate Cancer
A Study to Compare the Pharmacokinetics and Safety Between BR9004 and BR9004-1 in Healthy Male Volunteers
To compare the pharmacokinetics and safety between BR9004 and BR9004-1 in healthy male subjects after a single-dose administration while fasting.
- Trial name
- NCT04889651
- Testing
- BR9004, BR9004-1
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Prostate Cancer
UK Genetic Prostate Cancer Study: Epidemiology and Molecular Genetics Studies
The UKGPCS was set up to find genetic alterations which occur in patients who have prostate cancer. A man's risk of developing prostate cancer increases if he has a first-degree relative (father or brother) who was diagnosed with…
- Trial name
- UKGPCS (NCT01737242)
- Where
- United Kingdom
- Volunteers
- 23,826 people, healthy volunteers welcome
- Sponsor
- Institute of Cancer Research, United Kingdom
Prostate Cancer
Improving Engagement From Underserved Communities With Prostate Cancer Genetics Services
Earlier work explored barriers and facilitators to accessing prostate cancer screening, particularly in underserved communities, and provided valuable insights to build upon.
- Trial name
- INCLUDE PC (NCT07407686)
- Testing
- Surveys, Semi-structured interviews and focus groups
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Uterine Cervical Neoplasms
Conducting Outreach to Improve Cervical Cancer Screening Rates Among Underscreened Patients
The purpose of this project is to determine whether outreach to HIV-negative patients who are overdue for a Pap smear at a New England urban community health center can increase cervical cancer screening rates.
- Trial name
- NCT02427399
- Testing
- Letter and informational sheet, Email, Phone
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Fenway Community Health
Cancer
Clinical Study of Pan-cancer DNA Methylation Test in Plasma
We intend to establish an efficient method for plasma cfDNA extraction and Bisulfite transformation to facilitate the detection of DNA methylation status using multiplex fluorescence PCR.
- Trial name
- NCT05685524
- Testing
- DNA methylation test
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Wuhan Ammunition Life-tech Co., Ltd
Cervical Cancer
Standard Operating Procedures for Cervical (Pre)Cancer Biomarker Detection in First-void Urine (BM-SOP Study)
The aim of the study is to develop robust analytical protocols for first-void urine sample preparation and biomarker assays to analyze a panel of biomarkers in first-void urine for improved diagnosis of cervical (pre)cancer…
- Trial name
- BM-SOP (NCT02714127)
- Testing
- First-void urine collection, Cervicovaginal lavage fluid collection
- Where
- Belgium
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Game-Based Learning, Educational Intervention
Gamified Learning Methods and HPV Knowledge in Nursing Students
This study is a randomized controlled trial (RCT) with a pretest-posttest-follow-up design that compares the effectiveness of gamified teaching methods (Gimkit and educational escape room) with traditional theoretical education…
- Conditions
- Game-Based Learning, Educational Intervention, Nursing Education
- Trial name
- NCT07557719
- Testing
- Gimkit-Based Game-Based Learning, Escape Room-Based Game-Based Learning
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Polycystic Ovarian Syndrome (PCOS), Insulin Resistance
Potential Impact of Polycystic Ovarian Syndrome on Protein Modifications and Accumulation
A goal of this study is to use a novel methodology to determine whether insulin resistance in women with polycystic ovary syndrome (PCOS) is related to the accumulation of proteins with modifications.
- Conditions
- Polycystic Ovarian Syndrome (PCOS), Insulin Resistance, Overweight, Obese
- Trial name
- NCT02105428
- Testing
- Aerobic Exercise Training
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Uterine Cervical Neoplasms, Sexually Transmitted Diseases
Preventive Sexual Health Screening Among Female-to-Male (FTM) Transgender Adult Patients
The purpose of this study is to assess the acceptability and effectiveness of utilizing vaginal self-swabs for HPV DNA testing as compared to provider-collected cervical swabs for HPV, as well as to investigate the prevalence of…
- Trial name
- NCT02401867
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fenway Community Health
Cervical Cancer
Cervical Cancer Detection Using Optical Spectroscopy
The objective of the work described in this protocol is to determine the optical signatures of cervical dysplasia using optical technologies.
- Trial name
- NCT00900575
- Testing
- Optical Spectroscopy Bench-Top System, Portable Optical Spectrometer, Transvaginal colposcope
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Duke University
HPV VACCINATION
Health Belief Model-based Education and Motivational Interview Regarding the HPV Vaccination Decision
This research is a single-blind, randomized, parallel-controlled experimental study designed to determine the effect of Health Belief Model (SIM)-based motivational interviews given to mothers of high school students on mothers'…
- Trial name
- NCT04992741
- Testing
- education and motivational interview
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Yasemin ATEŞEYAN
Prostate Cancer
Prostasomes as Diagnostic Tool for Prostate Cancer Detection
Prostate cancer is the most frequently diagnosed cancer among men over 50 years old in Western societies, with an incidence that is steadily increasing in most countries.
- Trial name
- NCT03694483
- Testing
- Genetic analysis for the detection of prostasomes
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hackensack Meridian Health
Endometrial Cancer
The Clinical Utility of DNA Methylation Testing in Patient-collected Urine and Vaginal Samples to Detect Endometrial Cancer: a Case-control Study
The goal of this observational case-control study is to investigate the use of DNA-methylation testing in patient-collected urine and vaginal samples to detect endometrial cancer.
- Trial name
- NCT06846775
- Testing
- DNA-methylation testing in patient-collected urine and vaginal samples
- Where
- 3 sites in Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
HPV Infections
Reactogenicity Study of Cervarix and Gardasil in UK Adolescent Girls
This is a phase IV study to evaluate the body's immune response of participants to the Cervarix and Gardasil vaccines against the Human Papilloma Virus (HPV) types associated with increased risk of cervical cancer.
- Trial name
- HPV CSP01 (NCT00956553)
- Testing
- Cervarix, Gardasil
- Where
- 3 sites in United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Public Health England
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