Clinical trials: Genitourinary System Neoplasm
Prostate Cancer, Spine, Open
Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac Surgery
The primary endpoint of this study is the completion time of hemostasis treatment when administered Fresh frozen plasma (FFP) and frozen powder coagulation factor concentrate (PCC) in goal-directed bleeding management for…
- Conditions
- Prostate Cancer, Spine, Open, Hip Osteoarthritis, Knee Disease
- Trial name
- NCT06144099
- Testing
- fresh frozen plasma, prothrombin complex concentrate
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Polycystic Ovary Syndrome
Recombinant Versus Highly Purified FSH in Polycystic Ovary Syndrome (PCOS)
Control ovarian stimulation responses, pregnancy and miscarriage rates are indifferent when either recombinant or highly purified follicle stimulating hormone (FSH) is used.
- Trial name
- NCT01337531
- Testing
- Gonal-F, Fostimon
- Where
- Cyprus
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Genesis Center for Fertility & Human Pre-Implantation Genetics
Polycystic Ovary Syndrome
Effects of Metformin vs Oral Contraceptives on CV Risk Markers in PCOS
Cardiovascular risk factors cluster in hyperandrogenic women - including those presenting with the polycystic ovary syndrome - in association with insulin resistance, obesity, and other metabolic disorders.
- Trial name
- NCT00428311
- Testing
- Metformin, Ethynyl-estradiol plus cyproterone acetate
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Ramon y Cajal
Genital Wart, Penile Cancer
A Phase III Study to Evaluate the Efficacy, Immunogenicity and Safety of the 9-valent HPV Vaccine in Chinese Males
This study is designed to evaluate the vaccine efficacy, immunogenicity and safety of the 9-valent (Types 6, 11, 16, 18, 31, 33, 45, 52 and 58) Human Papillomavirus (HPV) Recombinant Vaccine (Hansenula Polymorpha) in Chinese male…
- Conditions
- Genital Wart, Penile Cancer, Anal Cancer, PIN-1
- Trial name
- NCT06465914
- Testing
- 9-valent Human Papillomavirus (Types 6, 11, 16, 18, 31, 33, 45, 52 and 58) Recombinant Vaccine (Hansenula Polymorpha)
- Where
- 5 sites in China
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Testicular Cancer, Colorectal Neoplasms
Diagnostic Yield of Colonoscopy Surveillance in Testicular Cancer Survivors Treated With Platinum-based Chemotherapy
Testicular cancer (TC) survivors treated with platinum-based chemotherapy have an increased risk of colorectal cancer (CRC) (hazard ratio (HR) 3.9 for platinum-containing chemotherapy versus no platinum-containing chemotherapy…
- Trial name
- CATCHER (NCT04180033)
- Testing
- Colonoscopy surveillance
- Where
- 4 sites in Netherlands
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- The Netherlands Cancer Institute
Polycystic Ovary Syndrome
Lifestyle Change in Women With Polycystic Ovary Syndrome
This project aims to compare "diet" and "diet and exercise combination" interventions in obese women with polycystic ovary syndrome.
- Trial name
- NCT05377021
- Testing
- Lifestyle change
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Colon Cancer, Endometrial Cancer
Healthcare Decisions Post-Testing, Risk-reducing and Preventative Strategies Using LYNCH Genetic Testing Reducing, and Preventative Strategies Using LYNCH Genetic Testing
Increase surveillance for LYNCH Syndrome
- Trial name
- NCT03322176
- Testing
- Genetic testing
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Data Collection Analysis Business Management
Polycystic Ovary Syndrome, Diminished Ovarian Reserve
Clinical Trial of Anovulatory Infertility
This project aims to study the expression of clock genes and related proteins in follicular fluid and granulosa cells, depicting the periodic, amplitude, and phase changes of biological clock genes and related proteins in women…
- Conditions
- Polycystic Ovary Syndrome, Diminished Ovarian Reserve, Ovulation Disorder
- Trial name
- NCT06601452
- Testing
- a compound prescription of Chinese medicine
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nanjing University of Chinese Medicine
Breast Cancer, Cervical Cancer
Improving Compliance With Medical Testing Guidelines
The study hypothesis is that clearer visual presentation of guideline recommendations and educational outreach, or academic detailing, can improve guideline compliance.
- Conditions
- Breast Cancer, Cervical Cancer, Prostate Cancer, Colon Cancer
- Trial name
- NCT02430948
- Testing
- Color-coded materials, Academic detailing, Standard support
- Where
- 2 sites in United States
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Beth Israel Medical Center
Endometrial Cancer
A Randomized, Controlled, Comparative Study of a Levonorgestrel Intrauterine System for the Prevention of Endometrial Cancer in Patients Aged 40-50 With BMI Greater Than 35
Endometrial (uterine) cancer affects over 40,000 women each year in the United States. At this time there are no medications to prevent endometrial cancer. Women who are heavy are at increased risk of this cancer.
- Trial name
- NCT00161226
- Testing
- Levonorgestrel intrauterine system
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Dentistry of New Jersey
Immunosuppression, Cancer
Clinical Trial for Assessment of Anti-SARS-CoV-2 Serum for Early Treatment of COVID-19 Cases
Phase I/II Randomized Clinical Trial to evaluate the safety, pharmacokinetic and efficacy of Anti-SARS-CoV-2 hyperimmune serum. The study will include patients at early stage of COVID-19 with increased risk for severe disease due…
- Conditions
- Immunosuppression, Cancer, COVID-19, Other Complication of Kidney Transplant
- Trial name
- SOROCOV (NCT04834089)
- Testing
- AntiSARS-CoV-2 Serum
- Where
- 2 sites in Brazil
- Volunteers
- 618 people, healthy volunteers welcome
- Sponsor
- Butantan Institute
Tumor of Female Reproductive System, Ovarian Cancer
A Cohort Establishment Study of Total Management of Ovarian Cancer
A cohort establishment study of total management of ovarian cancer (including fallopian tube cancer and primary peritoneal cancer).
- Trial name
- NCT06018935
- Testing
- No intervention
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Polycystic Ovary Syndrome, Exercise
The Effects of High-intensity and Moderate-intensity Exercise on Polycystic Ovary Syndrome
This study will investigate the impact of high- and moderate-intensity exercise on the cardiometabolic and brain health of women with Polycystic Ovary syndrome (PCOS).
- Conditions
- Polycystic Ovary Syndrome, Exercise, Cerebrovascular Circulation
- Trial name
- NCT05394935
- Testing
- High-Intensity Exercise, Moderate-Intensity Exercise
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cardiff Metropolitan University
Quality of Life, Stroke, Acute
Cerebrovascular Disease: Quality of Life (CODE: QoL)
The goal of this observational study is to learn about quality of life, stress and caregiver burden in patients with stroke and their caregivers.
- Conditions
- Quality of Life, Stroke, Acute, Sexual Behavior, Stress
- Trial name
- CODE:QoL (NCT06443268)
- Testing
- questionnaire, hair samples, blood samples, clinical exam
- Where
- Switzerland
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Anal HSIL, Anal AIN3
Anal Cancer Prevention in High-Risk Categories of Men Who Have Sex With Men
The incidence of anal cancer is increasing, particularly among high-risk groups such as men who have sex with men (MSM), especially those living with HIV.
- Conditions
- Anal HSIL, Anal AIN3, Anal HPV Infection
- Trial name
- DACaP (NCT07123558)
- Testing
- High resolution anoscopy
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Polycystic Ovary Syndrome (PCOS)
Fertility and Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age and affects approximately 10% of women worldwide.
- Trial name
- FERTIOPK (NCT07499518)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 473 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HER2-positive Breast Cancer, HER2 Low
ISPY-P1.01:Evaluating the Safety of Weekly Paclitaxel With Trastuzumab Duocarmazine (SYD985) in Patients With Metastatic Cancer
This is an open-label, single-arm, multi-site phase I/Ib trial with SYD985, an antibody-drug conjugate (ADC) targeting HER2 on the cell membrane, combined with paclitaxel.
- Conditions
- HER2-positive Breast Cancer, HER2 Low, SYD-985, SYD985
- Trial name
- NCT04602117
- Testing
- Vic-trastuzumab duocarmazine (SYD985) + paclitaxel
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- QuantumLeap Healthcare Collaborative
BRCA Mutation, Ovarian Cancer
Prediction of Germline BRCA 1/2 Genes From Healthy Ovaries
The project aims at enhancing performance metrics and prospectively validating a radiogenomics model based on ovarian US images for predicting germline breast cancer susceptibility gene 1 and/or 2 (BRCA) status in women with…
- Conditions
- BRCA Mutation, Ovarian Cancer, Ultrasound Therapy; Complications
- Trial name
- PROBE-II (NCT05769517)
- Testing
- Germinal BRCA
- Where
- Italy
- Volunteers
- 6,465 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Obesity, Polycystic Ovary Syndrome
Mindfulness-based Stress Reduction in Obese Women With Polycystic Ovary Syndrome (PICOS)
The aim of this study was to evaluate the effects of a mindfulness-based stress reduction (MBSR) program on Stress, depression, anxiety, cognitive triad and emotional appetite in obese women with polycystic ovary syndrome (PCOS).
- Conditions
- Obesity, Polycystic Ovary Syndrome, Stress
- Trial name
- NCT06665789
- Testing
- Mindfulness-based Stress Reduction
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Breast Cancer, Bowel Cancer
EQUITA - A Feasibility Trial of a Faith-placed Intervention to Increase Screening Uptake in Black Adults
The goal of this randomised feasibility trial is to examine feasibility and acceptability of a co-produced and faith-placed intervention to increase uptake of breast, cervical, bowel, and abdominal aortic aneurysm (AAA) screening…
- Conditions
- Breast Cancer, Bowel Cancer, Cervical Cancer, Abdominal Aortic Aneurysm
- Trial name
- EQUITA (NCT06981182)
- Testing
- Faith-placed intervention to promote breast, cervical, bowel, and AAA screening uptake in Black communities.
- Where
- 3 sites in United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Sunderland