Clinical trials: Genome
Cancer, Pancreatic Cancer
Prospectively Defining Metastatic Pancreatic Ductal Adenocarcinoma Subtypes by Comprehensive Genomic Analysis
Researchers are looking for better ways of understanding and treating pancreatic cancer. The purpose of this study is to see how useful it is to look for changes and characteristics in your genes (molecules that contain…
- Trial name
- PanGen (NCT02869802)
- Testing
- Tumour Biopsy, Serial Collection of Plasma and Serum Samples
- Where
- 4 sites in Canada
- Volunteers
- 190 people
- Sponsor
- British Columbia Cancer Agency
Coronary Artery Disease, Myocardial Infarction
Myocardial Infarction Genes (MI-GENES) Study
This study is being done to better understand how genetic information might improve assessment of heart attack risk.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Genomic Risk Communication
- Trial name
- MI-GENES (NCT01936675)
- Testing
- Genetic Risk Score
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hospital Acquired Infection
Transmission of ESBL-producing Enterobacteriaceae
The aim of this research project is to investigate the transmission of ESBL-producing Enterobacteriaceae on both, the level of bacterial strains and mobile genetic elements, and to determine the source of hospital-acquired…
- Trial name
- NCT03465683
- Testing
- ESBL-producing Enterobacteriaceae
- Where
- Switzerland
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Gastric Cancer (GC)
Development and Validation of the Surgical Assessment and Healthcare (SAH) Index for Gastric Cancer Treatment Evaluation
This study develops the Surgical Assessment and Healthcare (SAH) Index, a new tool to fairly evaluate gastric cancer surgery outcomes.
- Trial name
- SAH (NCT07180966)
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Ruijin Hospital
Hemoglobinopathies, Hemolysis
Clinical and Laboratory Investigation of Humans With Informative Iron or Erythroid Phenotypes
This study will examine blood for factors that may cause or prevent diseases involving iron or red blood cells. Iron is an important nutrient for human health that is needed to produce red blood cells.
- Conditions
- Hemoglobinopathies, Hemolysis, Iron Deficiency and Overload, Anemias
- Trial name
- NCT00102245
- Where
- United States
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Non-small Cell Lung Cancer
Dose-Dense Induction/Neoadjuvant Chemotherapy in Locally Advanced Non-Small Cell Lung Cancer
Dose-dense chemotherapy is a chemotherapy treatment plan in which drugs are given with less time between treatments than in standard chemotherapy.
- Trial name
- NCT02157116
- Testing
- cisplatin, Docetaxel, Pegfilgrastim
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Duke University
Malignant Tumor
Cancer Genome Analysis
Next generation sequencing (including targeted gene seqeuncing, exome and transcriptome sequencing) will be performed from fresh frozen tumor samples to understand the genetic alteration of tumors and to aid in optimal selection…
- Trial name
- NCT01458704
- Testing
- next generation sequencing
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Influenza
B-cell Immunity to Influenza (SLVP017) - Years 2 (2010) & 3 (2011)
In this exploratory study, investigators will be looking at immune response differences between age groups and between the two different influenza vaccines given to identical twins, vaccine-naive young adults and elderly…
- Trial name
- NCT03020498
- Testing
- Fluzone, FluMist
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Stanford University
Multiple Myeloma
Detecting Minimal Residual Diseases (MRD) and Monitoring Clonal Evolution Using Ultrasensitive Chromosomal Aberrations Detection (UCAD) in Multiple Myeloma
The presence of minimal residual disease (MRD) is an important prognostic factor for multiple myeloma, while copy number variation (CNV) is a widely accepted biomarker used for multiple myeloma (MM).
- Trial name
- NCT06302699
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Leukemia
Studying Biomarkers in Tissue Samples From Young Patients With Acute Myeloid Leukemia Previously Enrolled on Clinical Trial POG-9421
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01035307
- Testing
- gene expression analysis, microarray analysis, proteomic profiling
- Volunteers
- 90 people
- Sponsor
- Children's Oncology Group
Hypercholesterolemia, Autosomal Dominant, Hypercholesterolemia, Autosomal Recessive
Integrating Whole Genome Sequencing and Digital Twins Into the Management of Hypercholesterolemia in Emiratis
This pilot study investigates integrating whole genome sequencing and digital twin technology for managing hypercholesterolemia in Abu Dhabi clinics.
- Conditions
- Hypercholesterolemia, Autosomal Dominant, Hypercholesterolemia, Autosomal Recessive, Familial Combined Hypercholesterolemia
- Trial name
- NCT06535542
- Testing
- Whole Genome Sequencing
- Where
- United Arab Emirates
- Volunteers
- 40 people
- Sponsor
- Abu Dhabi Health Services Company
Non-Small Cell Lung Cancer
A Phase III Study of HS-20093 Injection Combined With Adebrelimab Versus Docetaxel in Previously Treated Patients With Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer Without Actionable Genomic Alterations
This is a multicenter, randomized, open-label, controlled phase III clinical study to evaluate the efficacy and safety of HS-20093 injection combined with adebrelimab versus docetaxel in previously treated patients with advanced…
- Trial name
- NCT07464327
- Testing
- HS-20093, Docetaxel
- Volunteers
- 450 people
- Sponsor
- Hansoh BioMedical R&D Company
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Clinical Utility of a Genomic Predictor Test on the Management of Cardiorenal Complications of Type 2 Diabetes
The goal of this pragmatic trial is to provide Real World Evidence (RWE) on the impact of the result of a polygenic risk prediction test of cardiorenal complications of T2D, so that more patients at high risk of these…
- Conditions
- Diabetes Mellitus, Type 2, Cardiovascular Diseases, Diabetic Nephropathy Type 2
- Trial name
- GENOCORDIA (NCT06586203)
- Testing
- Polygenic Risk Score
- Where
- 2 sites in Canada
- Volunteers
- 2,714 people
- Sponsor
- Optithera
Uveal Melanoma
Comparison Between Fotemustin to Intensive Surveillance in Patients With High Risk Uveal Melanoma
After the local treatment of the primary tumor (protonbeam-therapy, enucleation, external radiotherapy) patients with high risk of metastasis are randomized between: Adjuvant chemotherapy with Fotemustin.
- Trial name
- FOTEADJ (NCT02843386)
- Testing
- Adjuvant chemotherapy by Fotemustin, Intensive surveillance
- Where
- 6 sites in France, Switzerland
- Volunteers
- 302 people
- Sponsor
- Institut Curie
Colorectal Cancer, Endometrial Cancer
Discovering New Targets for Colorectal and Endometrial Cancer Risk Reduction
The primary aim of this study is to collect and store data, tissue, and personal and family histories from patients being screened for colorectal cancer and/or endometrial cancer at NYPH and WCM for routine clinical care and to…
- Conditions
- Colorectal Cancer, Endometrial Cancer, Hereditary Cancer Syndromes
- Trial name
- NCT06096688
- Where
- United States
- Volunteers
- 1,120 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
HPV-Related Carcinoma
Radiosensitivity of HPV-related Tumors: Towards a Genomic Approach
The purpose of this study is therefore to analyze the genomic profiles of prognosis and radiosensitivity of Human Papilloma Virus (HPV) related tumors from different body sites (oropharynx, uterine cervix, and anus), considering…
- Trial name
- ICARUS (NCT06321627)
- Testing
- Radiation therapy as curative treatment
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- European Institute of Oncology
Lung Cancer
NGS Genome Analysis in Personalisation of Lung Cancer Treatment
The identification of driver mutations in the epidermal growth factor receptor (EGFR) as the primary oncogenic event in a subset of lung adenocarcinomas led to a model of targeted treatment and genetic profiling of the disease.
- Trial name
- ALCAPONE (NCT02281214)
- Testing
- blood sample, biopsy
- Where
- France
- Volunteers
- 165 people
- Sponsor
- Centre Georges Francois Leclerc
Asthma, Asthma Attack
Genomics and Metagenomics of Asthma Severity
The Genomics and Metagenomics of Asthma Severity (GEMAS) study aims to assess the role of genomics, the microbiome, and the interaction between them in the development of asthma exacerbations in European patients with asthma.
- Trial name
- GEMAS (NCT04501926)
- Where
- 6 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Maria Pino-Yanes
Crohn Disease
Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease
Crohn's disease (CD) is a condition that causes inflammation (swelling, redness) of the lining and wall of the small intestine, large intestine, or both.
- Trial name
- CAMEO (NCT05781152)
- Testing
- Anti-TNF therapy
- Where
- 26 sites in United States, Canada
- Volunteers
- 1,270 people
- Sponsor
- Connecticut Children's Medical Center
Myocardial Ischemia, Coronary Artery Bypass Grafting
The Effects of Allicor on Patients After Coronary Arteria Revascularization Treatment
Coronary revascularization interventions such as coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) are the standard of surgical treatment of patients with myocardial ischemia.
- Conditions
- Myocardial Ischemia, Coronary Artery Bypass Grafting, Coronary Arteriosclerosis, Percutaneous Coronary Revascularization
- Trial name
- TEA-CART (NCT05803759)
- Testing
- Allicor
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Institute for Atherosclerosis Research, Russia
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