Clinical trials: Genomic
Mitochondrial DNA, Quality of Life
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes
The goal of this pilot clinical trial is to learn if a subtle energy transmission and Tao Calligraphy Mindfulness Practice works to improve mitochondrial DNA.
- Trial name
- NCT07261111
- Testing
- Mindfulness practice with Tao Art (Calligraphy and Song Greatest Love)
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sha Research Foundation
Pneumococcal Carriage
Post Pandemic Pneumococcal Carriage Among Children and Adults
The PI propose to conduct a genomic epidemiology study of pneumococcal carriage among children and adults in a large metropolitan city.
- Trial name
- NCT06373328
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Influenza
B-cell Immunity to Influenza (SLVP017)- Year 1, 2009
This is an exploratory study using a strategy that has not been previously employed to investigate the effects of age and vaccine type on specific kinds of immune responses to licensed, seasonal 2009-2010 influenza vaccines in…
- Trial name
- NCT02133781
- Testing
- Fluzone® 2009-2010 Formula, FluMist® 2009-2010 Formula
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Stanford University
SLE, Rheumatoid Arthritis
Efferocytosis and Genomic Polymorphism in Autoimmune Diseases
Over the past few years, growing evidences revealed that clearance of apoptotic cells by phagocytosis can result in powerful anti-inflammatory and immunosuppressive effects.
- Conditions
- SLE, Rheumatoid Arthritis, Healthy Subjects
- Trial name
- NCT00364728
- Where
- Taiwan
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pneumonia, Aging
Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines
This is a prospective, single-site, randomized, then open-label study designed to develop a detailed transcriptional and epigenetic profile of the immune response to pneumococcal vaccination with conjugated and non-conjugated…
- Trial name
- NCT03104075
- Testing
- Pneumococcal 13valent Conj Vaccine Diphtheria CRM197 Protein, Pneumococcal Vaccine Polyvalent
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Jackson Laboratory
Intracerebral Hemorrhage
Chinese Multicenter Cohort Study of Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage is a severe form of stroke associated with high mortality and long-term disability. The Chinese Multicenter Cohort Study of Intracerebral Hemorrhage (CASA) is a prospective observational…
- Trial name
- CMCS-ICH (NCT07833410)
- Where
- China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Obesity
Nutrigenomics: Personalizing Weight Loss for Obese Veterans
This study aims to determine if providing genomic information to veterans can help them lose weight compared to usual care.
- Trial name
- NCT01859403
- Testing
- Personalized Genomics, Usual Care
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Developmental Disorders
Risk of Recurrence of de Novo Mutations: Research and Quantification of Paternal Germinal Mosaicism by the Combined Use of Genomic Tools
1. Inclusion of 5 families Inclusions will be made by the clinical genetics department of the Rouen University Hospital (monocentric study) and will correspond to trios of parents + child with unexplained developmental…
- Trial name
- RRMUT (NCT04564235)
- Testing
- genome-wide analyses, Search for de novo mutations in paternal sperm samples
- Where
- France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Early Diagnosis, Cancer
Role of Genomic Imprinting in Cancer Diagnosis
The current research focus for cancer diagonosis is classical genetics, named "driving genes". However, not all cancer patients have typical genetic alterations, especially at early stage.
- Conditions
- Early Diagnosis, Cancer, Biomarker, Genomic Imprinting
- Trial name
- NCT03882684
- Testing
- In-situ imprinting detection
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Chinese Alliance Against Lung Cancer
Gene Expression in Response to Acute Stress
Temporal Genomics Mechanisms Underlying Disease and Aging
Given the salient role of early-life adversity and the resulting biological embedding in disease risk, there is a critical need to understand the mechanisms operating at multiple levels of analysis in order to promote effective…
- Trial name
- NCT03637751
- Testing
- Behavioral, Control condition
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Penn State University
Hypertension
Predisposition and Transition Mechanisms From Arterial Hypertension to Heart Failure
This project aims at investigating the genetic, genomic and proteomic basis of hypertension and susceptibility to hypertension-related end organ damage (renal damage and heart failure).
- Trial name
- Hypercare (NCT02430805)
- Testing
- dna extraction and genotyping
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Healthy
PCR-Based Detection of Bacterial Agents in Platelet Concentrates and Whole Blood
Using methods of molecular biology bacteria can be detected in blood. In comparison to conventional blood cultures "bacterial DNA" is isolated using a new sample preparation system in platelet apheresis concentrates and in the…
- Trial name
- NCT00482339
- Where
- Germany
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Jena
Pancreatic Cancer, Thymic Cancer
Genetic Evaluation of Families With Endocrine Cancers
This study is being conducted to identify altered genetic factors that may exist and influence endocrine cancers in unrelated MEN1 families with different cancers.
- Conditions
- Pancreatic Cancer, Thymic Cancer, Parathyroid Disease, MEN1 Syndrome
- Trial name
- MEN1 (NCT01794676)
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Jersey Shore University Medical Center
Asthma
Real World and Genomic Data Based Asthma Insight Through Network Analysis
A retrospective and prospective observational study of asthma designed to determine real-world and molecular description of asthma according to treatment and type 2 biology
- Trial name
- REGAIN (NCT06623435)
- Where
- 5 sites in United States
- Volunteers
- 1,075 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Radiation; Reaction
Genomic Assessment of Patients With Severe Radiation Reactions
Determine an underlying etiology behind unexpectedly severe reactions to radiation by blood draw.
- Trial name
- NCT03287349
- Testing
- Blood draw, Photograph, Autoimmune testing
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Kidney Transplantation
TOlerance MOlecular and Genome-wide Studies With Renal Allograft Recipient Material
TOMOGRAM is a European multicentric, prospective, experimental, controlled study that aims to increase our understanding of the causative mechanisms of operational tolerance in kidney transplantation through the achievement of…
- Trial name
- TOMOGRAM (NCT05124444)
- Testing
- High throughput DNA and RNA sequencing
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
Endometrial Cancer, Atypical Endometrial Hyperplasia
Liquid Biopsy-Based Early Screening for Endometrial Cancer in Regional Chinese Populations
Endometrial cancer is one of the most common gynecological malignancies, and its incidence is rising. Currently, there is a lack of highly effective and non-invasive screening methods.
- Trial name
- NCT07892755
- Where
- China
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Guizhou Provincial People's Hospital
Trauma; Complications, Multiple Organ Failure
A Validation of a Genomics Based Prognostic in Severe Trauma
The purpose of this study is to learn more about how to treat patients with severe injuries related to trauma and to prevent failure of vital organs in this patient population.
- Trial name
- NCT01810328
- Testing
- Traumatized population, Healthy Volunteers
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Florida
Endometriosis, Endometrioma
Genomic Maps of Endometrial Tissues of Patients With Endometriosis and Healthy Controls
Endometriosis is a chronic inflammatory disease that affects 10-17% of women in childbearing age, 35-60% of women with chronic pelvic pain and can cause infertility, costing as much as 2.8 billion dollars per year.
- Trial name
- NCT03687398
- Testing
- genetic testing with nanoclonal technique
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Any Disease Condition and Reportedly-healthy Subjects
Precision Genomics Medicine Biobank
The immediate goal of this study is to collect biological samples (i.e., tissue and/or fluid), clinical information, and laboratory data from disease and non-disease subjects seen at Intermountain Healthcare affiliated…
- Trial name
- PRECISE (NCT04187729)
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.