Clinical trials: Genomic
Diabetes Mellitus, Type 2 Diabetes Mellitus
Collection of Blood for Gene Expression/Genomic Studies in Individuals With Diabetes (Qatar)
This protocol is designed to gather a small amount of blood for extraction of DNA for the study of the genetic basis of diabetes. The study population will include individuals with known diabetes, and controls without diabetes.
- Trial name
- NCT01172743
- Where
- Qatar
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Genetic Disease
The Electronic Medical Records and GEnomics (eMERGE) Network Genomic Risk Assessment
The eMERGE Network embraces the opportunity to use new methods in genomic medicine, information science, and research participant engagement to identify people at very high risk for specific diseases and recommend individualized…
- Trial name
- eMERGE (NCT05277116)
- Testing
- Genome Informed Risk Assessment (GIRA) report
- Where
- 12 sites in United States
- Volunteers
- 26,877 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Eczema/Atopic Dermatitis, Cancer
Patient Forward Access to Clinical and Technological Research: Genetic Influences on Cancer and Atopic Dermatitis
This Patient Forward study intends to conduct research to investigate potential genetic factors causing cancer and eczema/atopic dermatitis.
- Trial name
- PFACTR02 (NCT04362852)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Oncology, Hematologic Malignancy
AUD Biomarkers Study (Proteomic and Genomic Analysis of Biospecimens)
Study purpose: to explore the entire spectrum of proteomic and genomic changes (amongst others) involved in diseases and in healthy/control populations.
- Conditions
- Oncology, Hematologic Malignancy, Gastro-Intestinal Disorder, Autoimmune Diseases
- Trial name
- NCT05889806
- Testing
- Observational Study Only. NO Intervention.
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Audubon Bioscience
MRSA
Tracing MRSA in Households With Patients Infected With CA-MRSA by WGS
From the 1980s to the late 1990s, highly toxic methicillin-resistant Staphylococcus aureus (MRSA) strains (called community-associated [CA] MRSA) appeared in the community.
- Trial name
- NCT04312776
- Testing
- none intervention
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Apoptosis, Apoptosis Regulatory Proteins
Genomic and Proteomic Analyses of Apoptosis Mechanisms in Diseased Peri-implant Tissue
A total of 72 individuals were included in the study: 23 with peri-implant mucositis, 25 with peri-implantitis, and 24 healthy controls.
- Conditions
- Apoptosis, Apoptosis Regulatory Proteins, Proteases, Peri-Implantitis and Peri-implant Mucositis
- Trial name
- NCT06865976
- Testing
- Non-Surgical Intervention, Surgical peri-implant therapy, Second stage surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Healthy, Estrogen Replacement Therapy
Beneficial Effects of Oral Premarin Estrogen Replacement Therapy Assessed by Human Genome Array
The purpose of this study is to assess the immunological status of patients using Premarin. Premarin use is associated with an enhanced immune status, and possibly even some anti-cancer effect.
- Trial name
- NCT00318318
- Testing
- Premarin
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pituitary Adenomas
Genome-wide Association Study of Pituitary Tumors
Pituitary adenomas is a very common disease, but the cause and genetics hasn't been identified. The investigators are going to use genome-wide association study to identify genes that may be related to pituitary adenomas.
- Trial name
- NCT01442220
- Where
- China
- Volunteers
- 12,500 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Hematuria, Bladder Cancer
Role of Novel Urinary Genomic and Metablomic Markers in Diagnosis of Bladder Cancer in Patients With Hematuria
Our goal is to develop a noninvasive, fast and simple assay to detect BCa on the GeneXpert system and metablomic genes.
- Trial name
- NCT04317261
- Testing
- Xpert Bladder Cancer Monitor (Xpert Monitor) test and assay of urinary metabolomics (gene expression of CRAT and SLC)
- Where
- Egypt
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Breast Cancer, Preneoplastic Conditions
The Breast Duct: Pilot Study of Genomic Sequencing of Exfoliated Ductal Cells Obtained Through Endoscopy and Lavage
The objective of this study is to determine whether we can use minimally invasive techniques to gain access to exfoliated ductal epithelial cells for whole genome sequencing. 1.
- Conditions
- Breast Cancer, Preneoplastic Conditions, Ductal Carcinoma in Situ
- Trial name
- NCT02121873
- Testing
- Nipple aspirator, Ductal lavage microcatheter, Blood draw
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Atossa Therapeutics, Inc.
Major Depressive Disorder
Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)
This is a study that will test a predictive biomarker algorithm based on results from a previous study. The goal of this study is to integrate clinical, imaging, EEG, and molecular data across 8 sites to predict treatment outcome…
- Trial name
- CAN-BIND-17 (NCT05017311)
- Testing
- Escitalopram, Brexpiprazole
- Where
- 10 sites in Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Obesity
Nutrigenomics: Personalizing Weight Loss for Obese Veterans
This study aims to determine if providing genomic information to veterans can help them lose weight compared to usual care.
- Trial name
- NCT01859403
- Testing
- Personalized Genomics, Usual Care
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Precision Diagnostics of Functional and Organic Intestinal Pathology Based on Cellular and Molecular Profiling
Differential diagnosis of functional and organic intestinal pathology is carried out in line with approved clinical guidelines and includes a significant list of interventions.
- Conditions
- Inflammatory Bowel Diseases, Irritable Bowel Syndrome, Healthy Volunteers
- Trial name
- NCT05277662
- Testing
- cell and molecular diagnostics in accordance with functional test results
- Where
- 2 sites in Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Moscow State University of Medicine and Dentistry
Coronary Artery Disease
Personal Genomics for Preventive Cardiology
The purpose of this study is to see if providing information to a person on their inherited (genetic) risk of cardiovascular disease (CVD) helps to motivate that person to change their diet, lifestyle or medication regimen to…
- Trial name
- NCT01406808
- Testing
- genetic risk score for coronary risk factors
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stanford University
Genes
Scripps Genomics Health Initiative
The specific aims for this project are to enroll up to 10,000 subjects who will have their genomes surveyed using the Navigenics™ Health Compass technology.
- Trial name
- NCT00808587
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Genetic Predisposition to Disease
Assesment of Multiomics Profiles in Health and Disease.
This study will determine reference genomic, transcriptomic, proteomic and metabolomic profiles in Czech population and will evaluate its correlation with the disease phenotype.
- Trial name
- ENIGMA (NCT04427163)
- Testing
- Blood sample analysis, Health status, Race and ethnicity
- Where
- Czechia
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
COPD, Chronic Obstructive Pulmonary Disease
An Integrative Genomic Approach to Solve tHe Puzzle of sevERe earLy-Onset COPD
Chronic Obstructive Pulmonary Disease (COPD) is characterized by a chronic airflow limitation associated with an abnormal inflammatory response of the airways to inhaled noxious particles or gases.
- Conditions
- COPD, Chronic Obstructive Pulmonary Disease, Severe Early-Onset COPD, SEO-COPD
- Trial name
- SHERLOCk (NCT04263961)
- Where
- 2 sites in Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
T-Cell and NK-Cell Neoplasm
A Global Study of the PETAL Consortium
The goal of this observational study is to correlate molecular alterations with outcomes including overall survival (OS), progression-free survival (PFS), response rates for patients with a new diagnosis, primary refractory or…
- Trial name
- PETAL (NCT06067347)
- Where
- 14 sites in United States, Australia and 2 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
BRCA1 Gene Mutation, BRCA2 Gene Mutation
Transformation Potential of E2 Exposed Breast Cancer Susceptibility Gene Mutation Heterozygous Epithelial Breast Cells
Susceptibility to breast cancer is related to the combination of genetic, hormonal and multiple other environmental risk factors, such as mutations in the BRCA gene and excess exposure to exogenous estrogen, respectively.
- Trial name
- NCT01907438
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Influenza
B-cell Immunity to Influenza (SLVP017) - Years 2 (2010) & 3 (2011)
In this exploratory study, investigators will be looking at immune response differences between age groups and between the two different influenza vaccines given to identical twins, vaccine-naive young adults and elderly…
- Trial name
- NCT03020498
- Testing
- Fluzone, FluMist
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Stanford University