Clinical trials: Genomic
Myopia
Identification of Genomic Loci Determining Susceptibility to the Development of High Myopia
Compelling evidence of genetic components in high myopia has been put forward by several studies. Twin cohorts, familial linkage studies and population studies has described at least 10 loci containing genes involved in the…
- Trial name
- ASSOMYP (NCT02583620)
- Testing
- blood sample
- Where
- 4 sites in France
- Volunteers
- 553 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Acute Ischemic Stroke, Haemorrhagic Stroke
Translational Immunodiagnostics in Stroke (TrImS)
In adult patients presenting to emergency departments within 24 hours of symptom onset with suspected acute stroke, we aim: 1. to identify early brain- and pathology-specific circulating, whole blood, plasma and serum panorOmic…
- Conditions
- Acute Ischemic Stroke, Haemorrhagic Stroke, Transient Ischemic Attacks, Cardioembolic Stroke
- Trial name
- TrImS (NCT05300997)
- Testing
- Biomarker blood draw and saliva collection
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Developmental Disorders
Risk of Recurrence of de Novo Mutations: Research and Quantification of Paternal Germinal Mosaicism by the Combined Use of Genomic Tools
1. Inclusion of 5 families Inclusions will be made by the clinical genetics department of the Rouen University Hospital (monocentric study) and will correspond to trios of parents + child with unexplained developmental…
- Trial name
- RRMUT (NCT04564235)
- Testing
- genome-wide analyses, Search for de novo mutations in paternal sperm samples
- Where
- France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Prenatal Genetic Diagnosis
guideSEQ: Genomic Understanding, Impact, Decision & Ethics in Prenatal Sequencing
This study looks at whether genome sequencing should be used more routinely during pregnancy, even when ultrasounds look normal.
- Trial name
- guideSEQ (NCT07610590)
- Testing
- Genome Sequencing (GS)
- Where
- 3 sites in United States
- Volunteers
- 1,042 people, healthy volunteers welcome
- Sponsor
- Columbia University
Computational Modeling of Individual Metabolic Pathways
Continuous N-of-1 Computational Feasibility Study of a Whole Genome Sequence
This is an observational, computational N-of-1 study that uses previously collected Whole Genome Sequencing (WGS) data from a single adult participant to evaluate the feasibility of a deterministic bioenergetic simulation model.
- Trial name
- B2026N1 (NCT07462234)
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bioactify LLC
Genetic Testing
Improving Genetic Medicine for Ethnic Minority Groups
A key aim of the nationally commissioned Genomic Medicine Service (GMS) in England is to encourage equity of access between different patient groups, however, there is evidence to suggest that it is being under-utilised by ethnic…
- Trial name
- NCT07309835
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Burn Pit Exposure, Airborne Hazard Exposure
Project PHOENIX: Molecular Signatures of Burn Pit Exposure
Project PHOENIX is an observational clinical research study designed to characterize molecular, genomic, cellular, and functional features in blood specimens from former U.S.
- Conditions
- Burn Pit Exposure, Airborne Hazard Exposure, Veteran Health, Deployment-Related Toxic Exposure
- Trial name
- PHOENIX (NCT07562243)
- Testing
- Prior Burn Pit Exposure, No Known Burn Pit Exposure
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Creative Medical Technology Holdings Inc
Endometrial Cancer, Atypical Endometrial Hyperplasia
Liquid Biopsy-Based Early Screening for Endometrial Cancer in Regional Chinese Populations
Endometrial cancer is one of the most common gynecological malignancies, and its incidence is rising. Currently, there is a lack of highly effective and non-invasive screening methods.
- Trial name
- NCT07892755
- Where
- China
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Guizhou Provincial People's Hospital
Multiple Myeloma, Bortezomib
Evaluation of Clinical Treatment of Multiple Myeloma Based on Multi-omics
With the emergence of new drugs, the short-term survival rate of multiple myeloma has been significantly increased. However, in clinical treatment, doctors found that different patients may present different clinical efficacy and…
- Trial name
- NCT04678089
- Testing
- Bortezomib
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Aspirin Exacerbated Respiratory Disease, Aspirin-Sensitive Asthma
Genetics and Genomics of Aspirin Exacerbated Respiratory Disease (AERD)
Aspirin Exacerbated Respiratory Disease (AERD) is a relatively homogeneous disease characterized by adult-onset severe asthma, development of non-cancerous growths in the nasal canal (i.e. nasal polyps) and aspirin allergy.
- Conditions
- Aspirin Exacerbated Respiratory Disease, Aspirin-Sensitive Asthma, Nasal Polyps
- Trial name
- AERD (NCT04261582)
- Where
- United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Pregnant Individuals Requesting Standard Microarray
Genomic Sequencing in Anatomically Normal Fetuses
This cohort study will examine the clinical utility of genomic sequencing (GS) in patients undergoing prenatal diagnostic procedures (chorionic villus sampling or amniocentesis) for routine indications other than a structural…
- Trial name
- NCT06211348
- Testing
- Genomic Sequencing
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Platelet Dysfunction Due to Aspirin
Genotypic and Phenotypic Correlates of Resistance to Aspirin
The study seeks to identify genomic markers associated with aspirin resistance.
- Trial name
- ARSENAL (NCT01361620)
- Testing
- aspirin
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- George Washington University
Rett Syndrome
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization
Rett syndrome (RTT) is a genetic encephalopathy and the typical form is caused by mutations in the gene MECP2. It is a genetically heterogeneous pathology.
- Trial name
- RETT (NCT02885090)
- Testing
- Blood sampling
- Where
- 9 sites in France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Genetic Disease
Accurate Assessment and Intervention Research on Newborn Whole Genome Sequencing and Genetic Disease Risk
Maternal and infant health is the foundation of public health, and its status directly reflects the overall health level of the population.
- Trial name
- NCT07365254
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Healthy Volunteers, Non-Healthy/Non-Frail
Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)
Background: Biomarkers are substances in people's blood and tissues. They help researchers understand diseases and signs of aging.
- Conditions
- Healthy Volunteers, Non-Healthy/Non-Frail, Frail
- Trial name
- NCT02339012
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Healthy Adults (Full Study and Extension Phase), Hypertrophic Cardiomyopathy or Dilated Cardiomyopathy
A Pilot Project Exploring the Impact of Whole Genome Sequencing in Healthcare
The MedSeq™ Project seeks to explore the impact of incorporating information from a patient's whole genome sequence into the practice of clinical medicine.
- Trial name
- NCT01736566
- Testing
- Family History + Whole Genome Sequencing, Family History Only
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Menstrual Cycle
Investigating the Endocrine-metabolic-immunological Axis During the Female Menstrual Cycle by Functional Genomics
As there are fluctuations in the hormonal balance during the menstrual cycle, it is assumed that due to the interaction between the hormonal system and the immune system, some diseases might be worsened in the course of a cycle.
- Trial name
- NCT06072391
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Stroke, Atherosclerosis
Stroke Prevention in the Wisconsin Native American Population
This project will develop a "Stroke Awareness Team" including training of Oneida Health Service Coaches working in partnership with the UW team for a population-based health awareness program.
- Trial name
- NCT04382963
- Testing
- High Risk - intensive coaching, High Risk - standard care, Low Risk - control
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Hearing Loss
Natural History of Autosomal Dominant Hearing Loss
Background: Hereditary hearing loss is one of the most common sensory disabilities affecting newborns. The main options for people with hereditary hearing loss are hearing aids and cochlear implants.
- Trial name
- NCT04501081
- Where
- United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Health, Subjective, Gastrointestinal Dysfunction
Personal Lifestyle Engine (PLX) - Personal Lifestyle Medicine Center (PLMC)
It has been suggested that the best medicine should include four principles (4P) - Medicine should be personalized, predictive, preventative and participatory.
- Conditions
- Health, Subjective, Gastrointestinal Dysfunction, Cardiovascular Risk Factor, Autoimmune Diseases
- Trial name
- NCT04007939
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.