Clinical trials: Genomic
Hematologic Diseases, Healthy Volunteers
Identification and Analysis of Immunomodulatory Molecules in Patients With Hematologic Disorders and Healthy Volunteers
This research study goal is to analyze the plasma and the cells that make up part of the immune system. We want to learn how the plasma and cells work.
- Trial name
- NCT00223483
- Testing
- Isolation of genomic DNA
- Where
- 2 sites in United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Dysbacteriosis
Longitudinal Study of the Human Intestinal Microbiome
The purpose of this study is to identify the human intestinal microbiota (microbes that live inside and on human bodies) in healthy adults over a 6-month period and to study the effect of an antibiotic on the intestinal…
- Trial name
- NCT00832286
- Testing
- Ciprofloxacin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Genetics
Parental Irradiation of Ukrainian Cleanup Workers and Evacuees and Germline Mutations in Their Offspring (Trio Study)
Data on transgenerational effects following nuclear accidents are important for understanding fully the consequences of parental exposure to ionizing radiation.
- Trial name
- NCT02566161
- Where
- Ukraine
- Volunteers
- 957 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Endometriosis, Endometrioma
Genomic Maps of Endometrial Tissues of Patients With Endometriosis and Healthy Controls
Endometriosis is a chronic inflammatory disease that affects 10-17% of women in childbearing age, 35-60% of women with chronic pelvic pain and can cause infertility, costing as much as 2.8 billion dollars per year.
- Trial name
- NCT03687398
- Testing
- genetic testing with nanoclonal technique
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Pneumococcal Carriage
Post Pandemic Pneumococcal Carriage Among Children and Adults
The PI propose to conduct a genomic epidemiology study of pneumococcal carriage among children and adults in a large metropolitan city.
- Trial name
- NCT06373328
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Host-Pathogen Interactions
Genomic Approaches to Dissect Human Host-pathogen Interactions in the Amazonian Rainforest
This observational study, aims to characterize with a multi-omic approach, the impact of host genetics and the pathogenic environment on immune response variation in Native Amazonians in comparison with Mestizo Amazonian, a…
- Trial name
- PATHO-NAT (NCT05981378)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universidad Peruana Cayetano Heredia
Genomics, Postprandial Metabolism
Postprandial Effects of Milk Fats
Nowadays, mostly vegetable fat blends are used in infant formula, but the use of bovine milk fat is increasing. In terms of fat structure, bovine milk fat and vegetable fats differ.
- Conditions
- Genomics, Postprandial Metabolism, Nutrition, Metabolism
- Trial name
- POEMI (NCT04178681)
- Testing
- 100% vegetable blend, 100% AMF, 100% cream
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Nursing, Students
Effectiveness of Web-based Genomic Nursing Education Intervention
There is a research gap of integrating genomics into nursing practice, education and research. Nursing students seldom use genetic-genomic data for understanding the individuality of patients and utilize this in delivering…
- Trial name
- NCT03963687
- Testing
- Standard Nursing Education Intervention, New Nursing Education Intervention
- Where
- Finland
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Diabetes Mellitus, Insulin Resistance
Diabetes Genome Project: A Prospective Registry to Identify Genetic Variation Among Diabetic Patients
Previous scientific research has found multiple genes that affect the risk for developing heart disease or complications during the treatment of heart disease.
- Conditions
- Diabetes Mellitus, Insulin Resistance, Atherosclerosis
- Trial name
- DGP (NCT00428961)
- Where
- United States
- Volunteers
- 1,607 people, healthy volunteers welcome
- Sponsor
- Saint Luke's Health System
Autism Spectrum Disorder (ASD)
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study
The goal of this observational study is to investigate the genetic and epigenetic mechanisms that may contribute to the development of Autism Spectrum Disorder (ASD) in individuals of different age groups.
- Trial name
- ASD-Omics-TR (NCT06662591)
- Where
- 20 sites in Turkey (Türkiye)
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Research and Treatment Society of Genetic Disorders
Healthy
Human Genomic Population Structure and Phenotype-genotype Variation in ADME Genes in Four Populations
Physicians know that their patients can react differently to the same medical treatment: for some of them, the drug will prove inefficient, whereas for others it might provoke side-effects, sometimes rather serious.
- Trial name
- NCT02789527
- Testing
- Phenotyping, Genotyping
- Where
- 4 sites in Czechia, Ethiopia and 2 more
- Volunteers
- 367 people, healthy volunteers welcome
- Sponsor
- Estella S. Poloni
Healthy
Genetic Polymorphisms Affecting Effect of High Intensity Training
The objective of the study is to investigate the effect of high intensity training on maximal oxygen uptake according to the genetic polymorphisms in healthy Korean volunteers.
- Trial name
- NCT02241850
- Testing
- High intensity training
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Cardiovascular Diseases, Cancer
Genomic Medicine Risk Assessment Care for Everyone - Implementation Phase
The "Genomic medicine Risk Assessment Care for Everyone" (GRACE)" intervention project will develop a scalable end-to-end solution for risk assessment and management that meets the needs of those populations living in low…
- Conditions
- Cardiovascular Diseases, Cancer, Liver Diseases, Hyperthermia
- Trial name
- GRACE (NCT06278883)
- Testing
- Disease Risk Assessment
- Where
- 4 sites in United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Duke University
Gastrointestinal Infection
Identification of Host Factors of Norovirus Infections in Mini-Gut Model
The primary objective in this study is to establish a list of host cellular proteins that mediate norovirus infection. Norovirus is one of the most common pathogens attributed to diarrheal diseases from unsafe food.
- Trial name
- NCT03342547
- Testing
- Duodenal biopsy, Saliva
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Anemia, Genetics
Genomic of CONgenital Sideroblastic Anemias
Congenital sideroblastic anemias (CSA) are a group of rare disorders characterized by abnormal iron utilization during erythropoiesis, leading to mitochondrial iron overload, the formation of ring sideroblasts, and ineffective…
- Conditions
- Anemia, Genetics, Erythropoiesis
- Trial name
- GASCON-2 (NCT07459816)
- Testing
- blood redrawal
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Obesity and Overweight
The Effects of Environmental Factors on the Macro-genome and Metabolism of Obese Patients.
The present study was designed to include obese patients diagnosed with obesity in the First Affiliated Hospital of Chongqing Medical University and a healthy control population.
- Trial name
- NCT06673433
- Testing
- obesity, health
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Dong Peng
Healthy, Major Depressive Disorder (MDD)
Neurobiological and Genomic Predictors of Relapse in Depression
The goal of this observational study is to test whether the discontinuation of antidepressant medications for patients with depression can be decided after the normalization of biological parameters.
- Trial name
- MDD (NCT07328373)
- Testing
- Antidepressant Medications
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Mehmet Kemal Arikan
Primary Osteoporosis
Vitamin D Status and Multi-Omics Profiles in Primary Osteoporosis
This observational study aims to explore the relationships between vitamin D status and genomic, proteomic, and metabolomic profiles in patients with primary osteoporosis.
- Trial name
- OP-MultiOmics (NCT07296471)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dr. Li Chen
Hereditary Diseases
Multicenter Analysis of Genomic and Metabolic Data of Neonatal Genetic Diseases
object name: Multicenter analysis of genomic and metabolic data of neonatal genetic diseases. goal of study:(1) Gene sequencing data (138 genes related to 133 common genetic diseases) and tandem mass spectrometry metabolomics…
- Trial name
- MAOFGAMDNGD (NCT06183138)
- Testing
- Genomic sequencing
- Where
- China
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
COVID-19, Molecular Sequence Variation
COVID-19 Genomic Sequencing for Nosocomial Outbreak Investigations
This is a tertiary care hospital-based prospective molecular epidemiology study in Montreal, Canada. When nosocomial transmission was suspected by local infection control teams' investigations, SARS-CoV-2 viral genomic sequencing…
- Conditions
- COVID-19, Molecular Sequence Variation, Nosocomial Infection
- Trial name
- NOSO-COVID (NCT05411562)
- Testing
- SARS-CoV-2 genomic sequencing
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)