Clinical trials: Genomic
Mitochondrial DNA Mutation, Endoscopy
Multimodal Imaging Based on Pathological and Genomic Characteristics
Mitochondrial DNA mutations in normal gastric tissue, early gastric cancer and advanced gastric cancer were identified by single cell sequencing, and the origin of gastric stem cells was traced and new molecular markers were…
- Trial name
- NCT05196243
- Testing
- Patients diagnosed as gastrointestinal mucosal lesions
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Periodontal Diseases, Diabetes
Genomic Determinants and Shared Genetic Pathways of Periodontal Disease
Despite significant improvement in treating periodontal disease (PD) and the identification of multiple risk factors, little is known about the specific contribution of genetics to PD pathogenesis.
- Conditions
- Periodontal Diseases, Diabetes, Osteoporosis, Cardiovascular Risk Factor
- Trial name
- NCT03437798
- Testing
- Disease status
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Tufts University
Gestatiaonl Diabetes Mellitus, Thyroid Disease Pregnancy
Gongji Pregnancy Endorine Cohort Study
To explore the relationship between genetic factors, lifestyle, and drug interventions and the occurrence, development, adverse pregnancy outcomes, and postpartum maternal-infant outcomes of gestational endocrine diseases.
- Conditions
- Gestatiaonl Diabetes Mellitus, Thyroid Disease Pregnancy, Hyperglycemia in Pregnant Diabetic Patients
- Trial name
- GREAT (NCT07125885)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Shanghai General Hospital, China
Diabetes Mellitus, Type 2
Effect of Type 2 Diabetes Genetic Risk Information on Health Behaviors and Outcomes
The primary objective of the study is to assess the clinical utility of a genetic test for Type 2 diabetes risk in combination with standardized risk assessment compared with standardized risk assessment alone, and to measure…
- Trial name
- TDE (NCT00849563)
- Testing
- Standardized Risk Assessment
- Where
- 2 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Duke University
Colorectal Cancer, Colorectal Cancer Metastatic
Dynamics of MSI and Genomic Profile of Colorectal Cancer In the Course of Immune Checkpoint Inhibitor Therapy
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Microsatellite instability or mismatch repair deficiency occurs in 20% of CRC, and is predominantly found in non-metastatic tumors.
- Conditions
- Colorectal Cancer, Colorectal Cancer Metastatic, MSI-H Colorectal Cancer, dMMR Colorectal Cancer
- Trial name
- BLOOMSI (NCT06414304)
- Where
- 2 sites in Russia
- Volunteers
- 30 people
- Sponsor
- OncoAtlas LLC
Major Depressive Disorder
Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)
This is a study that will test a predictive biomarker algorithm based on results from a previous study. The goal of this study is to integrate clinical, imaging, EEG, and molecular data across 8 sites to predict treatment outcome…
- Trial name
- CAN-BIND-17 (NCT05017311)
- Testing
- Escitalopram, Brexpiprazole
- Where
- 10 sites in Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Tumor Tissues and Non-tumor Tissues From PDAC Patients Were Used for Genomic and Transcriptome Sequencing Analysis and Proteomics and Phosphorylated Proteomics
Integrative Proteomic Characterization of Pancreatic Ductal Adenocarcinoma
A large-scale, high-throughput, multi-dimensional comprehensive study of PDAC multiomics will be carried out. In this study, clinical specimens of resected PDAC collected by our research group from 2017 to 2019 will be selected…
- Trial name
- NCT04525209
- Testing
- No intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ruijin Hospital
Prostate Cancer
Understanding of Genetics by Men at Risk for Prostate Cancer
With this greater certainty regarding prognosis, men with localized prostate cancer are now equipped with make better treatment planning decisions.
- Trial name
- NCT04550845
- Testing
- Focus group analyses
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Prostate Cancer
Early Prostate Cancer: Predicting Treatment Response
This study will replicate/validate the risk prediction model developed for the Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study in a more diverse patient population to assess generalizability of the…
- Trial name
- NCT03770351
- Where
- 5 sites in United States
- Volunteers
- 693 people
- Sponsor
- University of California, Irvine
Cancer, Paraneoplastic Syndromes
Tumor Characteristics in Patients With Paraneoplastic Neurological Syndromes (PNS)
Paraneoplastic neurological syndromes (PNS) are immune-mediated complications of cancer that can affect any part of the central or peripheral nervous system.
- Conditions
- Cancer, Paraneoplastic Syndromes, Neurologic Disorder, Immune System and Related Disorders
- Trial name
- GenePNS (NCT03963700)
- Where
- France
- Volunteers
- 980 people
- Sponsor
- Hospices Civils de Lyon
Chronic Rhinosinusitis (Diagnosis)
Aggravated Airway Inflammation: Research on Genomics and Optimal Medical Care (AirGOs-medical)
The study is performed as a randomized double-blinded prospective controlled trial. A total of 72 adult Acetyl salicylic acid (ASA) -exacerbated respiratory disease (AERD) -patients with uncontrolled chronic rhinosinusitis with…
- Trial name
- AirGOs-med (NCT03825757)
- Testing
- Acetyl Salicylic Acid
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Sanna Salmi
Tumor Genomic Profiling
Cancer Patients Decision Making and Family Communication About Secondary Findings From Tumor Genomic Profiling
The objective of this protocol is to characterize cancer patients' responses to learning their secondary findings arising from tumor genomic profiling, and the process and outcomes of their decisions to communicate these results…
- Trial name
- NCT02713334
- Testing
- survey, semi-structured interview
- Where
- United States
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
History of Cancer
A Safety Study Assessing the Effects of Receiving Genome Sequencing Results
This study uses new methods called "genome sequencing" that allow the investigators to study part or all of a person's genome. The genome is the collection of all of a person's genes.
- Trial name
- NCT01692223
- Testing
- qualitative interviews
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lung Cancer
Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01414595
- Testing
- DNA analysis, DNA methylation analysis, RNA analysis
- Where
- 11 sites in United States
- Volunteers
- 248 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Metastatic Solid Tumor
PREcision Medicine in Cancer in Odense, Denmark
The traditional approach to cancer treatment has changes from using drugs approved for the specific cancer diagnosis to a tumor agnostic approach when treating solid tumors.
- Trial name
- PRECODE (NCT05385081)
- Testing
- genomic profiling
- Where
- Denmark
- Volunteers
- 900 people
- Sponsor
- Odense University Hospital
Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa), Obstructive Sleep Apnea
Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders
Background: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever syndrome of childhood.
- Conditions
- Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa), Obstructive Sleep Apnea, Tonsillitis, Tonsil Disorder
- Trial name
- NCT05656365
- Where
- 3 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HNSCC
WGA in Platinum-refractory HNSCC Underwent Nivolumab
To choose a subgroup who could clearly benefit from Nivolumab, we are proposing a prospective observational study. Whole-genome study (WGS) analysis will be performed on archived cancer tissues from patients who were (1)…
- Trial name
- NCT03917537
- Testing
- HNSCC patients have used Nivolumab
- Where
- 2 sites in Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Coronary Artery Disease, Myocardial Infarction
Myocardial Infarction Genes (MI-GENES) Study
This study is being done to better understand how genetic information might improve assessment of heart attack risk.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Genomic Risk Communication
- Trial name
- MI-GENES (NCT01936675)
- Testing
- Genetic Risk Score
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Melanoma
Application of Genomic Techniques and Image Processing Using Artificial Intelligence to Obtain a Predictor Model Risk of Melanoma
The aim of this study is to develop a predictive model of risk of developing melanoma. The investigators will used artificial intelligence techniques to analysed images patterns obtained by clinical and dermoscopic pictures.
- Trial name
- NCT02511119
- Volunteers
- 300 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Heart Failure
MyLeukoMAP™ Genomic Survival Prediction Assay Pivotal Clinical Study
The MyLeukoMAP™ Pivotal Clinical Study will assess the accuracy of MyLeukoMAP™, a new molecular blood test, performed within 30 days before scheduled surgical / interventional therapies for Heart Failure, to determine its…
- Trial name
- NCT05258942
- Testing
- Observational
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- LeukoLifeDx Inc