Clinical trials: Genotoxicity
DNA Damage, Anesthesia
Comparison of the Genotoxicity of Desflurane and Propofol
The purpose of this study is to evaluate if the anesthetics propofol and desflurane can damage DNA according to comet essay in patients submitted to lumbar disc surgery.
- Trial name
- NCT05185167
- Testing
- Anesthetics, General Desflurane Maintenance, Anesthetics, General Propofol Maintenance
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Metabolic Disturbance, Protein Deficiency
Biological Signatures Resulting From Occupational Exposure to Complex Mixtures of PAHs
This research project aims at better understanding the early biological effects resulting from occupational exposure to complex Polycyclic Aromatic Hydrocarbon (PAH) mixtures.
- Conditions
- Metabolic Disturbance, Protein Deficiency, Genotoxicity
- Trial name
- PAH-ProMetGen (NCT05679544)
- Testing
- Characterization of early biological effects following exposure to PAHs
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Hyperbaric Oxygen, Genotoxicity
Assessment of the Impact of Increased Production of Reactive Oxygen Species Produced During Repeated Sessions of Hyperbaric Oxygen Therapy in Patients Undergoing Radiotherapy for Neoplasia, on the Occurrence of DNA Damage
Hyperbaric Oxygen Therapy (HBOT) is a treatment involving the administration of oxygen at pressures higher than atmospheric pressure, with numerous potential indications such as radiation-induced tissue damage, chronic wounds…
- Conditions
- Hyperbaric Oxygen, Genotoxicity, Malignancy
- Trial name
- OXYBAR (NCT06999785)
- Testing
- Blood test
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Angers
Drug Toxicity
Phase I Clinical Study of Soy Isoflavones in Healthy, Post-Menopausal Women
The purpose of this research study is to examine the safety of specific soy components, known as isoflavones, and to find out what effects (good and bad) these components have on tissues that are sensitive to the hormone estrogen…
- Trial name
- NCT00491595
- Testing
- High Dose Soy isoflavones
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of North Carolina
Asthma, Lung Disease
Swimming Pool Environment Impact on the Human Respiratory Health
This study aims to assess the influence of exposure to swimming pool environment on respiratory symptoms and diseases, and on cancer outcomes among swimmers and swimming pool attendants.
- Conditions
- Asthma, Lung Disease, Genotoxicity
- Trial name
- SWAN (NCT03017976)
- Where
- Portugal
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
PreDiabetes
Effect of Phytoecdysterone Administration in Subjects With Prediabetes
Prediabetes is the term used for people whose glucose levels do not meet the criteria for diabetes but are too high to be considered normal.
- Trial name
- NCT03906201
- Testing
- Ecdysterone
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- University of Guadalajara
Industrial Hygiene, Epidemiology
Cancer Markers Associated With Occupational Exposure to Trichloroethylene
Background: Trichloroethylene (TCE) is a solvent used in many medical and industrial processes. TCE is a carcinogen (causes cancer) in rats, but its carcinogenicity in humans is unclear.
- Conditions
- Industrial Hygiene, Epidemiology, Neoplasms
- Trial name
- NCT00481611
- Where
- China
- Volunteers
- 125 people
- Sponsor
- National Cancer Institute (NCI)
Sleep Disorders, Circadian Rhythm, Depression
Melatonin as a Circadian Clock Regulator, Neuromodulator and Myelo-protector in Adjuvant Breast Cancer Chemotherapy
Breast cancer is the second most common cancer in the world, the most common in women, representing the leading cause of death in Brazil.
- Conditions
- Sleep Disorders, Circadian Rhythm, Depression, Genotoxicity, Pain
- Trial name
- NCT03205033
- Testing
- Melatonin 20 MG Oral Capsule
- Volunteers
- 36 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Genotoxicity
Genotoxicity Assessment of Dental Implants in Gingival Epithelial Cells
Due to the strong correlation between genotoxicity and carcinogenesis, it is necessary to clarify the potential genotoxic effects of titanium dental implant systems.
- Trial name
- NCT04540991
- Testing
- implant placement, gingiva former placement, Collecting gingival epithelial cellsusing the swab technique
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Daniel Jerković
Neoplasms
Genotoxicity Assessment for Patients Undergoing Radiation Treatment
The purpose of the research study is to evaluate an automated, laser-based technique for measuring DNA damage caused by radiation during cancer treatment in immature red blood cells.
- Trial name
- NCT00167427
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Yuhchyau Chen
Cancer, Pregnancy
Genomic and Epigenomic Alterations After Cancer Treatment in Pregnancy
The investigators want to obtain a fundamental understanding if and which chemotherapeutic agents used for treating cancer during pregnancy are associated with placental and/or offspring (epi)genetic changes, potentially causing…
- Trial name
- GE-CIP (NCT04125446)
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Cardiovascular Function, Genotoxicity
Health Effects of Occupational Exposure to Combustion Particles - a Study on Volunteers Performing as Train Conductors
Ambient air pollution is a complex mixture of gaseous pollutants and particulate matter (PM). PM has a recognized important role in human health.
- Trial name
- BioTrack (NCT03104387)
- Testing
- Electric train, Diesel train
- Where
- Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
DNA Damage
Assessment of the Cytotoxic and Genotoxic Effect of Toothpastes With Different Forms of Fluoride on the Buccal Mucosa
The remarkable therapeutic anticaries effect of fluoride is well recognized, but in recent years, toxic effects on the oral mucosa have been discussed.
- Trial name
- NCT05596149
- Testing
- Toothpaste without fluoride, Toothpaste with sodium fluoride, Toothpaste with sodium monofluorophosphate
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Patients in Good Health, Types of General Anesthesia
Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery
The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokines profile in patients…
- Conditions
- Patients in Good Health, Types of General Anesthesia, DNA Damage
- Trial name
- NCT00854178
- Testing
- Comparison of two anesthetic drugs
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Occupational Exposure, Genotoxicity
Biomonitoring of Occupationally Populations Exposed to Micro and Nanoplastic
The biomonitoring study aims to evaluate genotoxic damage and other parameters of exposure in different occupational exposed populations that work directly with different plastics.
- Conditions
- Occupational Exposure, Genotoxicity, Damage Dna
- Trial name
- NCT06323603
- Testing
- Micro and nanoplastic
- Where
- 4 sites in Finland, Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ricard Marcos
Sun Damaged Skin
Photoprotective Effects of a SPF50+ Sunscreen on Skin Genotoxicity Induced by Repeated Chronic Outdoor Sun Exposure
Between 2 and 3 million non-melanoma skin cancers and 132,000 melanoma skin cancers occur globally each year. Sun protection continues to be a major public health issue and has always been a priority research area for Pierre…
- Trial name
- NCT05926791
- Testing
- Cosmetic product
- Where
- France
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Dermo Cosmetique
Colorectal Cancer
The Effects of Replacing Red and Processed Meat With Quorn on Biomarkers of Gut Health
This study will evaluate the effects of substituting red and processed meat in the diet with Quorn; a meat replacement product, on biomarkers of gut health.
- Trial name
- MYCOMEAT (NCT03944421)
- Testing
- Red and Processed Meat, Quorn
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Drug Abuse, Genotoxicity
Effect of Folic Acid on the Presentation of Nuclear Abnormalities in People With a History Drug Abuse
Background: Multiple studies have pointed to the harmful potential of licit and illicit drugs. as agents associated with neoplastic processes and other non-communicable diseases, for which reason It has become a problem of global…
- Trial name
- NCT05712044
- Testing
- Folic Acid 5 MG
- Where
- Mexico
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centro Universitario de Tonalá
Genotoxicity, Cytotoxicity
Assessment of Cytotoxicity, Genotoxicity
Goal: The goal of this observational study is to evaluate the genotoxic and cytotoxic effects of OPG and CBCT on exfoliated buccal mucosal cells Main question: Does CBCT cause greater genotoxic and cytotoxic effects on buccal…
- Conditions
- Genotoxicity, Cytotoxicity, Ionizing Radiation Exposure, Dental X-Ray Exposure
- Trial name
- NCT07330401
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yaxin Wang
PreDiabetes
Effect of Melatonin and Metformin on Glycemic Control Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes
Melatonin is a hormone that regulates the circadian cycle in addition to having an antioxidant effect. Patients with prediabetes state, has a deregulation of glucose metabolism and an overproduction of reactive oxygen species…
- Trial name
- NCT03848533
- Testing
- melatonin, metformin
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- University of Guadalajara