Clinical trials: Genotype
Retinal Dystrophies, Color Vision Defects
Natural History Study of Inherited Retinal Diseases
This prospective, observational investigation seeks to delineate the interplay between chromatic vision deficits and both functional visual outcomes and anatomical retinal biomarkers in individuals affected by Inherited Retinal…
- Conditions
- Retinal Dystrophies, Color Vision Defects, Vision Disorders, Macular Degeneration
- Trial name
- MojiLVCDT (NCT07085533)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhongmou Therapeutics
Phenotype, Genotype
Phenotype - Genotype Correlation in a Sample of Egyptian Patients With Congenital Myopathies and Congenital Muscular Dystrophies
The aim of this study is to correlate the phenotype and genotype among a sample of Egyptian patients with Congenital myopathies and Congenital muscular dystrophies.
- Conditions
- Phenotype, Genotype, Correction, Sample
- Trial name
- NCT07138963
- Testing
- Genetic Testing and Muscle Biopsy
- Where
- Egypt
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Genotype
AI-Driven Genotype Prediction Using EHR and Multimodal Data
The goal of this clinical study is to explore the potential of using electronic health records (EHR) and multimodal data (such as imaging, lab results, and clinical history) to predict a patient's genotype.
- Trial name
- NCT06791421
- Testing
- AI-Predictng Model
- Where
- 4 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- The Eye Hospital of Wenzhou Medical University
Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately
Analysis of the Effect of Donor CYP3A5 Gene Polymorphism on Early Tacrolimus Concentration and Postoperative Acute Renal Injury After Liver Transplantation
Tacrolimus is the most commonly used immunosuppressant for preventing and treating rejection after liver transplantation. However, its treatment window is narrow, the pharmacokinetic individual differences are large, routine dose…
- Conditions
- Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately, Postoperative Tacrolimus Concentrations Were Accurately Recorded in 60 Patients, According to the Diagnosis and Grading Criteria of Acute Kidney Injury, the Cases and Grading of Postoperative Acute Kidney Injury in 60 Patients Were Counted
- Trial name
- NCT06319391
- Testing
- CYP3A5*1*、CYP3A5*1*3, CYP3A5*3*3
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziqiang Li
Cardiovascular Diseases, Cohort Studies
FAMILY INHERITANCE, GENE-GENE AND GENE-ENVIRONMENT INTERACTIONS IN THE FIELD OF CARDIOVASCULAR AND RENAL DISEASES. Fifth Visit of the STANISLAS Cohort
The Stanislas Cohort is a monocentric familial longitudinal cohort originally comprised of 1006 families consisting of two parents and at least two biological children and deemed healthy, recruited in 1993-1995 at the Centre for…
- Conditions
- Cardiovascular Diseases, Cohort Studies, Genotype, Risk Factors
- Trial name
- NCT05916287
- Testing
- Blood and urine samples, Blood samples, Cardiovascular assessment
- Where
- France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
High Blood Pressure, MTHFR C677T Genotype
Pilot Evaluation of the Effect of Riboflavin Supplementation on Blood Pressure and Possible Effect Modification by the MTHFR C677T Genotype
Hypertension, which results from a combination of multiple lifestyle and genetic factors, is a global public health problem affecting 1 billion people worldwide.
- Trial name
- RiboBP (NCT03151096)
- Testing
- Riboflavin
- Where
- The Gambia
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Genotype, Allelic Frequencies of Genetic Markers
Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers
The purpose of this study is to use brain imaging technology to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers.
- Conditions
- Genotype, Allelic Frequencies of Genetic Markers, Brain Mapping, Brain Disease
- Trial name
- NCT00001284
- Where
- United States
- Volunteers
- 2,802 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Genotype, Metabotype and Dietary Habits
Genotype, Metabotype and Diet in a Cohort of Children and Adolescents From the Southeast of Spain.
The objective of this study is to investigate the possible association between 60 SNPs related to obesity, metabolism and cardiovascular disease with BMI, intestinal microbiota and adherence to the Mediterranean diet in a cohort…
- Trial name
- PolyMicroBio (NCT03318042)
- Testing
- Walnuts, Pomegranate juice
- Where
- Spain
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Participants With the MTHFR 677TT Genotype
RIBOGENE: Optimisation of Riboflavin Status in Hypertensive Adults With a Genetic Predisposition to Elevated Blood Pressure
Approximately 10% of the world's population have a particular genetic makeup (known as the TT genotype) that may increase their risk of having higher blood pressure.
- Trial name
- RIBOGENE (NCT02463513)
- Testing
- 1.6mg riboflavin (Vitamin B2), 10mg riboflavin (Vitamin B2)
- Where
- 3 sites in United Kingdom
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Genotype-related Drug Metabolism
Open Label Study for the Functional Characterization of Drug Metabolism and Transport
Aim of this study is to comprehensively assess in healthy volunteers the metabolic processes and factors that define drug response.
- Trial name
- IKP243 (NCT01788254)
- Testing
- Codeine, Midazolam, pravastatin
- Where
- 2 sites in Germany
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Matthias Schwab
Carboxylesterase 1 (CES1) Genotype, CES1 Activity
Impact of CES1 Genotype on Metabolism of Methylphenidate
The purpose of this study is to determine whether differences in the gene coding for the liver enzyme carboxylesterase 1 (CES1) means differences in the metabolism of methylphenidate, a CES1 dependent drug.
- Trial name
- NCT02147535
- Testing
- Methylphenidate
- Where
- Denmark
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Carboxylesterase 1 (CES1) Genotype, CES1 Activity
Metabolism of Methylphenidate and Enalapril Based on CES1 Genotype
The purpose of this study is to determine whether differences in the gene coding for the liver enzyme carboxylesterase 1 (CES1) means differences in the metabolism of two CES1 dependent drugs, enalapril and methylphenidate.
- Trial name
- NCT02135263
- Testing
- Methylphenidate, Enalapril
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
CYP2C19 Genotypes
Impact of CYP2C19*17 on the Pharmacokinetics of Proguanil and Clopidogrel
The aim of this study is to investigate if the genetic variant CYP2C19*17 affects the pharmacokinetics of proguanil and clopidogrel.
- Trial name
- NCT01456546
- Testing
- Proguanil, Clopidogrel
- Where
- Denmark
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Methamphetamine Metabolism, CYP2D6 Genotype
The Impact of Genetic Variation in CYP2D6 on the Pharmacokinetics and Pharmacodynamics of Methamphetamine
Methamphetamine abuse and addiction are widespread and is causing increasing pressures on social, public health and criminal justice systems worldwide. Some of the risk for developing addiction may be genetic.
- Trial name
- NCT01529892
- Testing
- A single oral 5 mg of duterium labeled methamphetamine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- California Pacific Medical Center Research Institute
Influence of Genotype of Drug Metabolizing Enzyme or Transporter on the Pharmacokinetics/Pharmacodynamics of Clopidogrel, Influence of Aspirin on the Pharmacokinetics/Pharmacodynamics of Clopidogrel
Clinical Trial to Evaluate the Influence of Genotype on the Pharmacokinetics/Pharmacodynamics of Clopidogrel
This study has an open-label, five-period, single-sequence design. The purpose of this study is as follows; 1. Primary To evaluate the influence of genotype of drug metabolizing enzyme or transporter on the…
- Trial name
- NCT01503658
- Testing
- Clopidogrel+Aspirin
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Genotype Guided(HNF4a), Healthy Subjects
STUDY The Effect of HNF-4A G60D Variant on the In VIVO CYP2D6 Activity By Tolterodine Pharmacokinetic Study
This study was to investigate the pharmacokinetics of tolterodine, substrate of CYP2D6 in healthy subject in relation to the presence of HNF-4A G60D variant.
- Trial name
- HNF4a (NCT01181505)
- Testing
- Tolterodine
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Inje University
Cytochrome P450 Phenotype and Genotype Metrics
Development of Cocktail for Measuring the Activity of Important Cytochrome P450 Enzymes
The Cytochrome P450 enzymes are responsible for the metabolism of a wide range of drugs and other xenobiotics. Genetic variants of the encoding P450 genes have shown to influence the rate of metabolism of many clinically used…
- Trial name
- NCT00981929
- Testing
- Tramadol, Omeprazole, losartan, caffeine, Tramadol, omeprazole, losartan, caffeine
- Where
- Denmark
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Genotype, Pharmacokinetic
Cytochrome P450 2C19 Variant is Related to Pharmacokinetics of Glipizide Extended Release Tablet in Chinese Subjects
Diabetes mellitus is a growing global disease now and future, and in China, 1.2 million peoples per year have been diagnosed as diabetes mellitus. 90% diabetes mellitus patient is Type 2 diabetes mellitus.
- Trial name
- NCT01082796
- Testing
- Glipizide
- Where
- China
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences