Clinical trials: Gerd
Gastroesophageal Reflux Disease, Acid Reflux
Efficacy of Gaviscon-Advance® in Suppressing Post-supper Acid-pocket and Night-time Acid-reflux in Obese Participants
A randomized, open-label study with antacid-control will be performed over 48 hours period by continuous pH impedance and bravo capsule monitoring.
- Conditions
- Gastroesophageal Reflux Disease, Acid Reflux, Obesity
- Trial name
- NCT03516188
- Testing
- Alginate-antacid group, Non antacid alginate group
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Air Insufflation, Regurgitation
Risk of Gastric Insufflation Related to Facemask Ventilation Technique During Anaesthetic Induction, With or Without PEEP
Continuous positive pressure during anesthetic induction is today not routinely used partly a to the risk of gastric insufflation because of higher ventilatory pressures.
- Trial name
- NCT02238691
- Testing
- Mask ventilation with PEEP via a face mask device
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Obstructive Sleep Apnea, Upper Airway Resistance Syndrome
Tongue Exercises and Reflux Therapy for Upper Airway Resistance Syndrome
Tongue exercises are described to improved snoring and acid reflux symptoms. Acid reflux treatment has been found to improve obstructive sleep apnea to a limited degree.
- Conditions
- Obstructive Sleep Apnea, Upper Airway Resistance Syndrome, Gastroesophageal Reflux
- Trial name
- NCT00364481
- Testing
- omeprazole, Tongue exercises
- Volunteers
- healthy volunteers welcome
- Sponsor
- West Side ENT
GERD
Twenty-Four Hour Combined Multi-Channel Impedance and pH Ambulatory Monitoring: Impedance Reflux Episodes of Patients On and Off Proton Pump Inhibitor Therapy
The purpose of this study is to determine the effects of proton pump inhibitors (PPIs) on the total number of reflux episodes in the distal esophagus measured by impedance in patients with and without gastroesophageal reflux…
- Trial name
- NCT01710800
- Testing
- Esomeprazole
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Acid Reflux Disease, Obstructive Sleep Apnea
Study of Pantoprazole for Sleepiness Associated With Acid Reflux and Sleep Apnea
The purpose of this study is to determine if using Pantoprazole decreases your daytime sleepiness and improves your reaction time when compared to using a placebo (sugar pill).
- Trial name
- NCT00307944
- Testing
- Pantoprazole
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Reflux
Study to Investigate the Pharmacodynamic Effect of a Single Dose of AZD2516 in Healthy Male Subjects
The purpose of this study is to investigate the pharmacodynamic effect of AZD2516 in healthy male subjects.
- Trial name
- NCT01154634
- Testing
- AZD2516, 5 mg, AZD2516, 16 mg, AZD2516, 40 mg
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Diaphragm Dysfunction
Effect of Manual Diaphragmatic Activation on Diaphragm Function in Patients With Gastroesophageal Reflux Disease
This study was conducted to investigate Effect of manual diaphragmatic activation on diaphragm function in patients with gastroesophageal reflux disease
- Trial name
- NCT06268548
- Testing
- Manual diaphragmatic activation
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gastro Esophageal Reflux, Barrett Esophagus
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
- Conditions
- Gastro Esophageal Reflux, Barrett Esophagus, Erosive Esophagitis
- Trial name
- NCT03228407
- Testing
- Confocal endomicroscopy, Endoscopic biopsies, Mucosal impedance (MI)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGuire Research Institute
Gastroesophageal Reflux Disease
The Potential Therapeutic Effect of Melatonin in Gastro-Esophageal Reflux Disease
Gastro-Esophageal Reflux Disease was defined as a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications.
- Trial name
- NCT00915616
- Testing
- Melatonin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mansoura University
Eosinophilic Esophagitis (EoE)
BURDEN OF ESOPHAGEAL CANCER IN EOSINOPHILIC ESOPHAGITIS (ESCAPE STUDY)
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disorder of the esophagus that can lead to symptoms such as dysphagia and food impaction.
- Trial name
- ESCAPE (NCT07102329)
- Where
- Italy
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Gastroesophageal Reflux Disease
Mass Balance Study of [14C]X842 in Healthy Adult Male Subjects
This study is a single-site, single-dose, non-randomized, open-label study to assess the absorption, metabolism, and excretion profile of [14C]X842 in healthy adult male subjects.
- Trial name
- NCT07107672
- Testing
- [14C]X842
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
Obesity and Obesity-related Medical Conditions
Management of Obese Patients With Gastroesophageal Reflux Disease .
The aim of this study is to evaluate the efficacy Sleeve gastrectomy with cruroplasty with or without ligamentum teres wrapping for management of morbidly obese patients with concomitant reflux symptoms.
- Trial name
- NCT06599489
- Testing
- surgery ..operation
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hossam Mahmoud Ibrahim
Gastro-esophageal Reflux Disease
Epithelial Damage in GERD
The purpose of this study is to characterize and compare epithelial damage in patients with erosive esophagitis and non-erosive reflux disease.
- Trial name
- NCT01867931
- Where
- Netherlands
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Gastroesophageal Reflux
MSG and Gastrointestinal Motility
The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility ( gastric emptying).
- Trial name
- NCT01009658
- Testing
- Monosodium glutamate, Sodium chloride
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gunma University
Sleep Apnea, Hypertension
Tri Staple Technology Stapler Used in Gastric Bypass
The objectives of this clinical trial are to assess in a pilot setting the overall performance and safety of the Endo GIA™ Stapler with Endo GIA™ SULU with Tri-Staple™ Technology when used in a gastric bypass procedure.
- Conditions
- Sleep Apnea, Hypertension, Hyperlipidemia, Coronary Artery Disease
- Trial name
- NCT01026103
- Testing
- Tri Staple Technology stapler
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Gastroesophageal Reflux, Heartburn
Esomeprazole and Gastric Emptying of Beer
To investigate the effect of 20 mg esomeprazole daily for one week on gastric emptying of 500 ml beer, the consecutive blood alcohol levels, the gastroesophageal reflux and plasma levels of gastrin and CCK in a randomized…
- Trial name
- NCT00472550
- Testing
- esomeprazole 20 mg
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
GERD (Gastroesophageal Reflux Disease)
Normal Values of Ambulatory 24-hour Oesophageal pH-impedance Monitoring in an Indian Cohort of Participants
This study aims to determine normal 24-hour pH-impedance monitoring values, including acid exposure time (AET), in healthy Indian adults. It will help improve GERD diagnosis in India by providing population-specific data.
- Trial name
- NCT06928350
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Non-erosive Reflux Disease, Gastroesophageal Reflux
Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection
Primary Objective: Evaluate response to NERD treatment between patients with normal endomicroscopy findings compared with patients with abnormal endomicroscopy findings.
- Trial name
- CENERDD (NCT02788591)
- Testing
- Proton Pump Inhibitor (PPI) Therapy, Sucralfate
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- LCMC Health
Gastroesophageal Reflux, Laryngopharyngeal Reflux
Precision Approach to PPI Therapy in Gastroesophageal Reflux Disease
This study plans to learn more about reflux associated laryngeal symptoms, and more efficient ways to diagnose and treat this condition.
- Trial name
- NCT03619811
- Testing
- Reflux Band® Upper Esophageal Sphincter (UES) Assist Device
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
GERD
A Study to Compare PK, PD and Safety of UI058 and UIC202004 in Healthy Subjects
A Study to compare pharmacokinetics, pharmacodynamics and safety of UI058 and UIC202004 in healthy subjects
- Trial name
- NCT05282914
- Testing
- administration of UI058, administration of UIC202004
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.