Clinical trials: Geriatric
Aging, Inflammation
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence
The MIRACLE study aims to investigate age-related mitochondrial dysfunction, mitochondrial RNA (mtRNA) release, inflammation, and cellular senescence in adult participants across three age groups.
- Conditions
- Aging, Inflammation, Healthy Ageing
- Trial name
- MIRACLE (NCT07596615)
- Testing
- Skin biopsy and venous blood sampling
- Where
- 2 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Sarcopenia, Chronic Lower Back Pain
Prevalence and Factors Associated With Sarcopenia in Pre-retirement Aged Adults With Chronic Non-specific Lower Back Pain
To study the prevalence of sarcopenia in a pre-retirement group with chronic lower back pain and factors associated between sarcopenia and chronic lower back pain in the pre-retirement group.
- Trial name
- NCT05894213
- Where
- Thailand
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Constıpatıon
Acupressure for Constipation in the Elderly
This study was carried out to determine the effect of acupressure applied to LI4, CV12, ST25 and ST36 acupuncture points for a total of 21 minutes, three to each point, on the symptoms of constipation and quality of life of…
- Trial name
- NCT05506397
- Testing
- Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Early Childhood Development (ECD)
Development and Validation of a Screening Tool for Preschool Children Aged 1-6 Years
This study develops and validates the Chatbot-Assisted Developmental Assessment Scale for Preschool Children (CADAS), a screening tool for 1-6-year-olds.
- Trial name
- NCT07248397
- Testing
- No Intervention: Observational Cohort
- Where
- Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Acute Myeloid Leukemia
Safety and Efficacy of Venetoclax in Combination With Azacitidine and HA Regimen in the Treatment of AML in the Elderly
This is a prospective phase II, single-arm clinical study that plans to enroll 45 patients aged 60 years or older with primary AML diagnosed after April 1, 2023.The purpose of this trial is to evaluate the efficacy of Venetoclax…
- Trial name
- NCT05949762
- Testing
- Venetoclax in Combination With Azacitidine and HA Regimen
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- ZePing Zhou
Sarcopenia in Elderly
The Study, Conducted With 54 Individuals Over the Age of 65, Aimed to Reveal the Advantages and Disadvantages of a Combined Exercise Program Compared to Otago Exercise Alone.
Falls are a leading cause of morbidity and mortality in older adults. Approximately one-third of individuals over 65 years of age fall each year, and 10-15% of these falls result in serious injury.
- Trial name
- OPEP-SARCOBAL (NCT07689903)
- Testing
- Proprioception Exercise, Exercise Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Healthy Subjects
A Study of E2022 Tape Formulation (Overlay-integrated E2022 18 mg Tape Formulation) for Different Application Sites and Intervals in Japanese Healthy Elderly Males
This is a single-center, 4-group, open-label study in Japanese healthy elderly males. A total of 48 subjects will be randomized to one of four groups (A to D, 12 subjects/group) to administer one E2022 tape to designated sites.
- Trial name
- NCT02225288
- Testing
- E2022
- Where
- Japan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Eisai Co., Ltd.
Aging
Cognitive Effects of Transcranial Direct Current Stimulation in Older Adults
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain mental abilities.
- Trial name
- NCT01611103
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Post-operative Cognitive Dysfunction
Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly
BACKGROUND: Post-operative cognitive dysfunction (POCD) is a potentially irreversible loss of brain functions observed in elderly patients after surgical operations under general anaesthesia.
- Trial name
- THE BRIDGE (NCT02428062)
- Testing
- Hemodynamic target, Phenylephrine, Intravenous fluids
- Where
- Italy
- Volunteers
- 1,812 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Conscious Sedation Under Spinal Anesthesia
The Optimal Effect Site Concentration of Propofol for Conscious Sedation in Elderly Male Patients Undergoing Urologic Surgery Under Spinal Anesthesia With or Without Intrathecal Fentanyl
Since intrathecal fentanyl is known to sedation effect, intrathecal fentanyl will result in lowering propofol requirement for conscious sedation under spinal anesthesia.
- Trial name
- NCT01232270
- Testing
- propofol
- Where
- South Korea
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Geriatric Individuals
Light-Up Shoes on Balance, Fall Risk, and Walking in Geriatric Individuals
Objectives: The aim of this study is to investigate the effects of a light-up shoe that creates visual stimuli on balance, walking and fall risk in geriatric individuals.
- Trial name
- Geriatric (NCT07515157)
- Testing
- barefoot, with oxford-style shoes, with the shoes use daily
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Dental Plaque, Bleeding of Subgingival Space
Antibacterial Photodynamic Therapy as an Adjunctive Treatment on Oral Hygiene in Elderly Persons
On average, the dental condition of elderly people is poor due to various reasons. The importance of oral health maintenance of the ageing population has been recognized by the World Health Organization (WHO), as oral health…
- Conditions
- Dental Plaque, Bleeding of Subgingival Space, Oral Complication
- Trial name
- NCT06576063
- Testing
- Lumoral Treatment, Standard oral hygiene methods
- Where
- 3 sites in Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Koite Health Oy
Aging, Endothelial Dysfunction
Effect of a Daily Supplement on Plasma PAI-1 Levels
In a healthy person, the production of nitric oxide (NO) by the endothelium, the inner lining of the blood vessel, is responsible for a) the ability of the blood vessel to dilate so it can increase its blood flow and b) act as an…
- Conditions
- Aging, Endothelial Dysfunction, Senescence
- Trial name
- NCT07469475
- Testing
- Supplement with ginger extract, L-citrulline, Paullinia cupana, and muira puama
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Frail Elderly
Increasing the Winter Community Participation of Older Adult Wheelchair Users
The purpose of this study is to examine whether intervention strategies targeted at the level of the environment (e.g. improving access to community based leisure groups, transportation) can successfully promote the community…
- Trial name
- NCT02622828
- Testing
- Participant-identified community based activity
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
MENINGOCOCCAL INFECTION
A Study to Describe the Immunogenicity, Safety, and Tolerability of Neisseria Meningitidis Serogroup B Bivalent Recombinant Lipoprotein 2086 Vaccine (Bivalent rLP2086) in Healthy Subjects Aged ≥24 Months to <10 Years
This study is looking at a new vaccine that might prevent meningococcal disease, and will study the immune response elicited by this vaccine when given to healthy young children.
- Trial name
- NCT02531698
- Testing
- Bivalent rLP2086 Vaccine, Licensed pediatric hepatits A vaccine, Normal Saline
- Where
- 15 sites in Finland, Poland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pre-frail Elderly, Frail Elderly
Dose Finding Study in Physically Frail Elderly to Measure 25(OH) Vitamin D Levels After Supplementation With Hy.D Calcifediol 25 SD/S and Vitamin D3
The purpose of this study is to assess the dose of Hy.D Calcifediol 25 SD/S (a metabolite of vitamin D3) which will achieve the range of mean serum 25(OH)D between 75-100nmol/L in physically frail elderly people after 24 weeks of…
- Trial name
- D-DOSE (NCT01868945)
- Testing
- 5 µg/day Hy.D Calcifediol, 10 µg/day Hy.D Calcifediol, 15 µg/day Hy.D Calcifediol
- Where
- Netherlands
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Healthy Subjects, Plasma Concentration of Mirabegron
A Study to Evaluate Absorption, Distribution and Elimination of Mirabegron After Oral Administration to Non-elderly Healthy Chinese Subjects
The purpose of this study is to evaluate safety and absorption, distribution and elimination of mirabegron after oral administration to Chinese subjects.
- Trial name
- NCT01747564
- Testing
- YM178 (mirabegron)
- Where
- Japan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Brain Vascular Function, Cerebral Blood Flow
Soy and Brain Vascular Function
Cognitive performance is negatively related to an impaired glucose metabolism, possibly due to impairments in brain vascular function.
- Conditions
- Brain Vascular Function, Cerebral Blood Flow, Glucose Metabolism, Cognitive Performance
- Trial name
- NCT03627637
- Testing
- Soy nuts
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Asthma
Online Asthma Self-Management for Children Aged 5-10 and Their Parents
The potential benefits of this research to public health include improved understanding of cultural factors in pediatric asthma self-management, improved self-management skills for children, and better asthma management skills…
- Trial name
- ChildAsthma (NCT02602392)
- Testing
- Lungtropolis, Asthma educational booklet
- Where
- United States
- Volunteers
- 622 people, healthy volunteers welcome
- Sponsor
- Oregon Center for Applied Science, Inc.
Healthy
Study to Evaluate the Safety, Tolerability, PK and PD of PB2452 in Healthy Younger, Older and Elderly Subjects
This is a Phase 2A, randomized, double-blind, placebo-controlled, single dose, sequential group study to evaluate the safety, tolerability, PK, and PD of PB2452 vs matching placebo with ticagrelor (with or without acetylsalicylic…
- Trial name
- NCT03928353
- Testing
- PB2452 Infusion, Ticagrelor Oral Tablet - Pre-Treatment, Ticagrelor Oral Tablet - Pre-Treatment and Post-Treatment
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- SFJ Pharmaceuticals, Inc.
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