Clinical trials: Geriatric Cancer Patients
Gastric Cancer
Gastric Cancer Surgery in Elderly Patients
Gastric cancer is most frequent after the fifth decade of life. Surgical risk is higher in aged population because of general health condition may affect the postoperative result.
- Trial name
- GCSEP (NCT03777540)
- Testing
- Gastric resection
- Volunteers
- 236 people
- Sponsor
- University of Bologna
Acute Myeloid Leukemia
TBF Conditioning Regimen for Haploidentical Stem Cell Transplantation in Elderly AML Patients in First Complete Remission
Acute myeloid leukemia (AML) is a serious blood cancer that mainly affects older adults. For patients who achieve their first complete remission (CR1), allogeneic hematopoietic stem cell transplantation (HSCT) may provide a…
- Trial name
- TBF-AML (NCT07563920)
- Testing
- Thiotepa, Busulfan (BU), Fludarabine
- Volunteers
- 93 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
DLBCL, Diffuse Large B-Cell Lymphoma
Clinical Study of HiR+X Therapy for Newly Diagnosed Elderly Patients With DLBCL Intolerant to Chemotherapy
To explore the application of HiR (Zebtorizumab, Lenalidomide) + X (targeted drug) guided by NGS molecular typing, the aim is to assess the therapeutic efficacy and safety in newly diagnosed unfit or frail elderly patients with…
- Trial name
- HiR+X (NCT06758037)
- Testing
- Drug therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Acute Myelogenous Leukemia (AML)
Eltrombopag in Elderly Acute Myelogenous Leukemia (AML)
This is a phase I/II open label study being conducted to evaluate the overall safety and initial effectiveness of an investigational drug, Eltrombopag in patients who are 60 years of age and older and who have Acute Myelogenous…
- Trial name
- NCT01113502
- Testing
- Eltrombopag
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Metastatic Colorectal Cancer
Efficacy/Safety Study of Bevacizumab,Capecitabine,Oxaliplatin to Metastatic Colorectal Adenocarcinoma Elderly Patients.
The purpose of this study is to determine whether bevacizumab, capecitabine and oxaliplatin are an effective and safe first line of treatment for elderly patients with metastatic colorectal adenocarcinoma.
- Trial name
- BECOX (NCT01067053)
- Testing
- bevacizumab, capecitabine, oxaliplatin
- Where
- 15 sites in Spain
- Volunteers
- 69 people
- Sponsor
- Grupo Espanol Multidisciplinario del Cancer Digestivo
Multiple Myeloma
Compare Lenalidomide and Subcutaneous Daratumumab vs Lenalidomide and Dexamethasone in Frail Subjects With Previously Untreated Multiple Myeloma Who Are Ineligible for High Dose Therapy
This is a Phase 3, randomized (study drug assigned by chance), open-label (participants and researchers are aware about the treatment, participants are receiving), active-controlled (study in which the experimental treatment or…
- Trial name
- IFM2017_03 (NCT03993912)
- Testing
- Daratumumab SC in combination with Lenalidomide, Lenalidomide PO (25mg), Dexamethasone PO (20mg): days 1, 8, 15, 22 of each 28-day cycle, until progression
- Where
- 23 sites in France
- Volunteers
- 294 people
- Sponsor
- University Hospital, Lille
Multiple Myeloma, Frailty
Individualized Dynamic Frailty-tailored Therapy (DynaFiT) in Elderly Patients With NDMM
Frailty is dynamic and confers poor outcomes in elderly patients with newly diagnosed multiple myeloma (NDMM), mainly because of the high prevalence of treatment discontinuation due to intolerability.
- Trial name
- DynaFiT (NCT06099912)
- Where
- China
- Volunteers
- 131 people
- Sponsor
- FengYan Jin
Advanced or Metastatic Melanoma, Advanced or Metastatic NSCLC
Elderly Cancer PatIents, Safety and qualiTy of Life Under immunOtheraPies
The co-primary objectives will be to assess the safety and quality of life under treatment.
- Trial name
- EPITOP-01 (NCT03673332)
- Testing
- immune-checkpoint inhibitors therapies
- Where
- 9 sites in France
- Volunteers
- 40 people
- Sponsor
- Institut Paoli-Calmettes
Octogenarian Patients With Non-metastatic Resectable Colorectal Cancer
SGA-OCRC: Prediction of 90-Day Major Adverse Postoperative Outcomes in Octogenarians With Resectable Colorectal Cancer
Octogenarian patients with colorectal cancer are a growing population with substantial heterogeneity in frailty, functional reserve, nutritional status, and comorbidity.
- Trial name
- NCT07903129
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Myelogenous Leukemia
Phase I Using Velcade & Idarubicin in Elderly and Relapsed AML
The purpose of this study is to determine the maximal tolerated dose (MTD) of bortezomib and idarubicin given in combination to newly diagnosed AML patients >60 years or relapsed AML patients.
- Trial name
- NCT00382954
- Testing
- Velcade, Idarubicin
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Kentucky
Lung Cancer, Nutrition, Healthy
The Effect of Nutritional Risk Parameters on Postoperative Pulmonary Complications in Geriatric Thoracic Surgery Cases
Preoperative evaluation of nutritional status in geriatric patients with lung cancer and implementation of these practices in elective patients are very important in terms of reducing postoperative complications and accelerating…
- Conditions
- Lung Cancer, Nutrition, Healthy, Postoperative Complications
- Trial name
- NCT05890820
- Testing
- Preoperative nutritional assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Multiple Myeloma
Melphalan+Prednisolon With or Without Thalidomide in Previously Untreated Elderly Patients With Multiple Myeloma
This is a multi-centre Phase III randomized controlled study of patients with multiple myeloma (MM). Eligible patients who are not candidates for transplantation will be randomized to receive eight courses of…
- Trial name
- NCT00934154
- Testing
- Thalidomide, Melphalan+Prednisolone
- Where
- 9 sites in Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Cigdem Sahinbas YILMAZ
Breast Cancer
Study of the P16 Gene as a Predictor of Myelosuppression in Breast Cancer Patients
The primary purpose of this study is to measure the association between baseline expression of the senescence effector protein p16INK4a and myelosuppression due to chemotherapy in patients with breast cancer.
- Trial name
- NCT01305954
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Bladder Cancer
Early Intervention for Impairments Identified During Comprehensive Geriatric Assessment in Patients With Bladder Cancer
A Comprehensive Geriatric Assessment (CGA) is a set of tests used to evaluate a patient's medical, social, and functional status, and can identify impairments in these domains that may not be noticed otherwise.
- Trial name
- NCT04273724
- Testing
- Targeted Interventions for Impairments Identified During Geriatric Assessment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer Female
Prospective Research for Elderly (≥65 Years Old) Early Breast Cancer Patients
The elderly patients over 65 years old with breast cancer have concomitant diseases, poor tolerance to conventional treatment, and the specific prognosis of breast cancer is relatively good.
- Trial name
- EEBC (NCT05680194)
- Testing
- operation, Bisphosphonate
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking Union Medical College Hospital
Acute Myeloid Leukemia
A Trial to Evaluate Two Schedules of MS275 in Combination With 5AC in Elderly Patients With Acute Myeloid Leukemia (AML)
This research is being done to help us learn how to best use new drugs which may be active against acute myeloid leukemia (AML). Two study drugs will be tested: 5AC (5-azacitidine) and entinostat.
- Trial name
- NCT01305499
- Testing
- Entinostat days 3, 10, 5AC, Entinostat days 10,17
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- Hetty Carraway
Acute Myeloid Leukemia
Clinical Study Protocol of Maintenance Therapy With Venetoclax in Elderly Patients With AML in First Complete Remission
This clinical study evaluates the efficacy and safety of maintenance therapy with BCL-2 inhibitors in elderly patients with acute myeloid leukemia (AML) in first complete remission.
- Trial name
- NCT05909293
- Testing
- Venclexta 100 MG Oral Tablet
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Non-Small Cell Lung Cancer (NSCLC), Rehabilitation
Wireless Wearable Home Prehabilitation for Older Adults With NSCLC
This randomized controlled trial evaluates the efficacy and safety of a home-based prehabilitation program using wireless wearable monitoring devices in older patients (aged 65-85 years) with non-small cell lung cancer scheduled…
- Conditions
- Non-Small Cell Lung Cancer (NSCLC), Rehabilitation, Thoracic Surgery, Prehabilitation
- Trial name
- NCT07809763
- Testing
- Digital Home-Based Prehabilitation, Standard Perioperative Care
- Where
- China
- Volunteers
- 196 people
- Sponsor
- West China Hospital
NSCLC Stage IV, NSCLC, Stage III
Phase II Efficacy Study of Repotrectinib in Frail and/or Elderly Patients With ROS1-rearranged Advanced NSCLC
ROS1 rearrangements are rare, accounting for only 1-2% of NSCLC cases, but have been associated with response to ROS1 inhibitors, such as crizotinib and entrectinib.
- Trial name
- REPOROS (NCT06552234)
- Testing
- Repotrectinib
- Where
- 20 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Non-Hodgkin's Lymphoma
Non-Hodgkin Lymphoma in Elderly Patients Above the Age of 80 in the Rituximab Era
This is an exploratory analysis that is investigating the pattern of care in patients over the age of 80 who were diagnosed with non-Hodgkin lymphoma (NHL).
- Trial name
- NCT00902434
- Volunteers
- 50 people
- Sponsor
- Oncology Specialists, S.C.
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