Clinical trials: Geriatric Cancer Patients
Colorectal Neoplasms, Colorectal Carcinoma
FOLFIRI + Panitumumab First-line Treatment in Elderly Patients With Unresectable Metastatic Colorectal Cancer, RAS/BRAF Wild-type and Good Performance Status
To estimate progression-free survival at one year in elderly patients with RAS/BRAF wild-type unresectable mCRC and good performance status treated with FOLFIRI + panitumumab as first-line therapy.
- Conditions
- Colorectal Neoplasms, Colorectal Carcinoma, Colorectal Cancer Metastatic, Neoplasm Metastasis
- Trial name
- OPALO (NCT03142516)
- Testing
- Panitumumab, Irinotecan, Folinic acid
- Where
- 12 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Grupo Espanol Multidisciplinario del Cancer Digestivo
Gastric Cancer
Tislelizumab Plus Chemotherapy as Postoperative Adjuvant Therapy in Elderly Patients With LA GC/GEJC
The purpose of study is to evaluate the efficacy and safety of postoperative adjuvant chemotherapy with tislelizumab in combination with tegafur-gimeracil-oteracil potassium (S-1 therapy) or tegafur-gimeracil-oteracil potassium +…
- Trial name
- NCT06238167
- Testing
- Tislelizumab, S-1 therapy, low dose SOX therapy
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Rectal Cancer
Laparoscopic Intersphincteric Resection in Elderly Patients
The aim of the present study is to assess if it is possible to offer intersphincteric rectal resection (IRR) to selected patients older than 70 years affected by ultra-low rectal cancer.
- Trial name
- NCT04673526
- Testing
- Laparoscopic intersphincteric resection, Laparoscopic abdomino-perineal procedures
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- ASL Verbano Cusio Ossola
Head and Neck Squamous Cell Carcinoma
Non Inferiority Trial of Standard RT Versus Hypofractionated Split Course in Elderly Vulnerable Patients With HNSCC
Randomized comparison between standard radiotherapy and hypofractionated split course schedule. Compared to standard radiotherapy, the investigators expect that hypofractionated split course (interruption of 2 weeks) radiotherapy…
- Trial name
- ELAN-RT (NCT01864850)
- Testing
- Standard RT, Hypofractionated RT
- Where
- 2 sites in France, Monaco
- Volunteers
- 202 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Breast Cancer, Old Age
CDK4/6 Inhibitors in Breast Cancer Elderly Patients: an Observational Ambispective Longitudinal Multicenter Study
Breast cancer is one of the tumors with the highest incidence and current evidence indicates a higher prevalence in elderly patients (≥70 years) with a higher mortality rate due to immunosenescence, diagnostic delay and under…
- Trial name
- NCT07399808
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Acute Myeloid Leukemia
ALFA-0703 Study in Older Patients With Acute Myeloblastic Leukemia (AML)
A Randomized Multicenter Phase III Study to Evaluate the Role of All-trans Retinoic Acid (ATRA) in Combination with Induction Chemotherapy, or Azacitidine and Idarubicin as salvage therapy and Idarubicin with Cytarabine or…
- Trial name
- ALFA-0703 (NCT01067274)
- Testing
- Vesanoid (ATRA), AZACITIDINE (VIDAZA), CYTARABINE
- Where
- 26 sites in France
- Sponsor
- Acute Leukemia French Association
Breast Cancer
Early Cardiac Toxicity of Adjuvant CT in Elderly BC.
The primary objective is to evaluate the difference in cardiac strain rate evolution in elderly early BC patients treated with (neo) adjuvant anthracycline-based chemotherapy compared with a non-anthracycline regimen…
- Trial name
- NCT01301040
- Testing
- epirubicin, cyclophosphamide, docetaxel
- Where
- Belgium
- Volunteers
- 2 people
- Sponsor
- Jules Bordet Institute
Colonic Neoplasms
Reduced Dose of Prophylactic Dexamethasone for Elderly Patients Receiving Moderate Emetogenic Chemotherapy
Feasibility study to evaluate the efficacy of reduced prophylactic dose of dexamethasone in elderly patients receiving moderate emetogenic chemotherapy
- Trial name
- NCT03177317
- Testing
- Dexamethasone
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Bundang Hospital
Non-small-cell Lung Cancer
Randomized Trial of Docetaxel and Gemcitabine Versus Gemcitabine in Elderly Patients With NSCLC
This trial will compare the efficacy of the docetaxel and gemcitabine combination versus monotherapy with gemcitabine as first-line treatment in elderly patients with advanced NSCLC
- Trial name
- NCT00442026
- Testing
- Docetaxel, Gemcitabine
- Where
- 9 sites in Greece
- Volunteers
- 106 people
- Sponsor
- Hellenic Oncology Research Group
Prostate Cancer
CyberKnife for Prostate Cancer Patients Aged 70 y or More
Robotic Stereotactic Radiation treatment of prostatic adenocarcinoma of the elderly. Inclusion criteria : T1-T3b, MRI pelvic nodes negative, M0, any Gleason Score, PSA (Prostate Specific Antigen) <30ng/ml.
- Trial name
- ProRobot (NCT03235557)
- Where
- Luxembourg
- Volunteers
- 150 people
- Sponsor
- Centre Francois Baclesse, Luxembourg
Kidney Cancer, Renal Cell Cancer
Cabozantinib and Nivolumab Among Older Patients With Renal Cell Carcinoma
The goal of the study is to describe real-life use and exposition to nivolumab-cabozantinib among older patients with metastatic clear-cell renal cell cancer
- Trial name
- CABOLD (NCT06934057)
- Testing
- Nivolumab, Cabozantinib
- Where
- 7 sites in France
- Volunteers
- 50 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Elderly Patient, Cancer
the Impact of Occupational Therapy : a Multicenter Randomized Controlled Trial
The purpose of this randomized controlled superiority trial is to evaluate the impact of occupational therapy assessment and intervention on the quality of life of elderly cancer patients.
- Conditions
- Elderly Patient, Cancer, Quality of Life
- Trial name
- OCEAN-OT (NCT05878782)
- Testing
- MCRO+Occupational therapy, MCRO without intervention
- Volunteers
- 232 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-small Cell Lung Cancer
Efficacy of Cadonilimab in Non-squamous Non-small Cell Lung Cancer Patients Resistant to EGFR-TKI
This study was designed to evaluate the efficacy and safety of cadonilimab (anti PD-1 and CTLA-4 bispecific antibody) in combination with pemetrexed and anlotinib for treatment of elderly patients with T790M-negative advanced…
- Trial name
- NCT06277674
- Testing
- Cadonilimab plus Pemetrexed and Anlotinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Rectal Cancer
Organ Preservation in Elderly Patients With Rectal Cancer
In elderly patients postoperative mortality measured 3-6 months after total mesorectal excision is high. Thus, less toxic treatments may lead to a survival benefit for elderly patients even if a risk of local recurrence is…
- Trial name
- NCT01863862
- Testing
- Radiochemotherapy or radiotherapy
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Carcinoma, Non-Small-Cell Lung
Biweekly Gemcitabine and Docetaxel as First Line Treatment for Advanced Disease in Elderly Non-Small Cell Lung Cancer (NSCLC) Patients
Lung cancer is one of the most common malignancies worldwide and the leading cause of cancer-related deaths in Western countries.
- Trial name
- NCT00905983
- Testing
- Gemcitabine and Docetaxel
- Where
- 11 sites in Spain
- Volunteers
- 48 people
- Sponsor
- Hospital Arnau de Vilanova
Old Injury
Prehabilitation & Rehabilitation in Oncogeriatrics: Adaptation to Deconditioning Risk and Accompaniment of Patients' With Cancer
With the conjunction of increased life expectancy and the increasing incidence of cancer with aging, older patient represent an increasing proportion of cancer patients.
- Trial name
- PROADAPT (NCT03659123)
- Testing
- standardized geriatric intervention
- Where
- 10 sites in France
- Volunteers
- 148 people
- Sponsor
- Hospices Civils de Lyon
Acute Myeloid Leukemia
Safety and Efficacy Study of Pracinostat With Azacitadine in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)
The purpose of this study is to determine the safety and effectiveness of pracinostat when combined with azacitadine for patients who are 65 years of age or older and have Acute Myelogenous Leukemia (AML)
- Trial name
- NCT01912274
- Testing
- Pracinostat, Azacitidine
- Where
- 17 sites in United States
- Volunteers
- 50 people
- Sponsor
- Helsinn Healthcare SA
Acute Myeloid Leukemia, AML
Decitabine Maintenance in Elderly Acute Myeloid Leukemia Patients
The study aims at determining the feasibility of using maintenance Decitabine therapy following remission induction and consolidation in elderly Acute Myeloid Leukemia patients who are fit for aggressive therapy.
- Trial name
- NCT01149408
- Testing
- Decitabine (Dacogen)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Gynecologic Cancers
Geriatric Patients Undergoing Gynaecological Cancer Surgery
Sınce old age includes variables such as genetics, chronic diseases, lifestyle, aging can be classified as chronological, social, physiological and psychological.
- Trial name
- NCT07077629
- Testing
- morbidity and mortality
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Prostate Cancer
Geriatric Determinants of General Repercussion of Radiotherapy for Patient Over 75 Years With Prostate Cancer
The investigators propose to carry out a prospective analysis of physical impact, psychological, cognitive and social of radiotherapy in all patients over 75 years bearer of localized prostate cancer with an indication of…
- Trial name
- PROGERAD (NCT02876237)
- Testing
- geriatric assessment and quality of life, Radiotherapy
- Where
- 10 sites in France
- Volunteers
- 208 people
- Sponsor
- Institut Cancerologie de l'Ouest
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