Clinical trials: Geriatric Cancer Patients
Lung Cancer
First-Line Treatment of A Comparison of 2 Treatments in Elderly Patients With Advanced NSCLC
This trial will look at 2 different drug combinations that have well known safety profiles and are known to be active against non small cell lung cancer and combine them with bevacizumab, an experimental drug that has shown…
- Trial name
- NCT00456261
- Testing
- Pemetrexed, Gemcitabine, Bevacizumab
- Where
- 18 sites in United States
- Volunteers
- 110 people
- Sponsor
- SCRI Development Innovations, LLC
Lung Cancer, Lung Carcinoma
Observational Study of the Efficacy and Safety of Anlotinib Combined With Penpulimab in Elderly Lung Cancer Patients
This prospective observational study will evaluate the efficacy and safety of anlotinib in combination with Penpulimab in elderly patients with lung cancer.
- Conditions
- Lung Cancer, Lung Carcinoma, Non Small Cell Lung Cancer, Non-small Cell Carcinoma
- Trial name
- AP (NCT05319886)
- Testing
- Anlotinib and Penpulimab
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Leukemia, Myeloid, Acute, Myelodysplastic Syndromes
An Efficacy and Safety Study of Azacitidine Subcutaneous in Combination With Durvalumab (MEDI4736) in Previously Untreated Adults With Higher-Risk Myelodysplastic Syndromes (MDS) or in Elderly Patients With Acute Myeloid Leukemia (AML)
The primary objective of this study is to evaluate the efficacy of subcutaneous azacitidine in combination with durvalumab as compared with subcutaneous azacitidine alone in adults with previously untreated, higher risk MDS who…
- Trial name
- NCT02775903
- Testing
- Azacitidine, Durvalumab
- Where
- 103 sites in United States, Austria and 10 more
- Volunteers
- 213 people
- Sponsor
- Celgene
Colonic Adenocarcinoma
Randomised Study Evaluating Adjuvant Chemotherapy After Resection of Stage III Colonic Adenocarcinoma in Patients of 70 and Over
Colorectal cancer occurs mainly in elderly patients. Recent estimation showed that in France more than 50% of the patients diagnosed with a colorectal cancer are 70 years old or more.
- Trial name
- ADAGE (NCT02355379)
- Testing
- LV5FU2 or capectitabine, FOLFOX4 or XELOX, Observation
- Where
- 140 sites in France
- Volunteers
- 774 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Colorectal Cancer Metastatic
Radioembolization in Elderly/ Fragile Patients With mCRC
Radioembolization (RE) is a minimally invasive treatment with administration of radioactive microspheres into the hepatic artery via a microcatheter.
- Trial name
- CAIRO7 (NCT05092880)
- Testing
- radioembolization, Standard of care first-line systemic therapy
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- UMC Utrecht
Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS)
Treatment of Elderly Patients With Acute Myeloid Leukemia (AML) and High Risk Myelodysplastic (MD) Syndrome With Laromustine and Infusional Cytarabine
The purpose of the Phase I portion of this study is to evaluate the safety of this combination of medications and to determine the appropriate dose of VNP40101M to be used in combination with infusional cytarabine (araC) in…
- Trial name
- NCT00655395
- Testing
- Laromustine (VNP40101M) and Ara-C
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Viron Therapeutics Inc
Unspecified Adult Solid Tumor, Protocol Specific
Irinotecan in Treating Aging Patients With Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Aging may affect the way these drugs work.
- Trial name
- NCT00026195
- Testing
- irinotecan hydrochloride
- Where
- 47 sites in United States
- Volunteers
- 140 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Preoperative Care, Colorectal Neoplasms
Assessing The Effectiveness of a Preoperative High Intensity Interval Training Programme In Older Colorectal Cancer Patients
The primary aim of this study is to determine whether an improvement in aerobic fitness, as judged by an increase in VO2peak, can be achieved within 31 days via HIT programme in a group of older, colorectal cancer patients.
- Conditions
- Preoperative Care, Colorectal Neoplasms, Aged, Exercise
- Trial name
- HITCa (NCT02188342)
- Testing
- HIT
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Nottingham
Hypoxia, Gastric Cancer
Capnographic Monitoring in Gastrointestinal Endoscopy for Elderly Patients
Hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol and sufentanil, especially in elderly people.
- Conditions
- Hypoxia, Gastric Cancer, Gastric Polyp, Colon Polyp
- Trial name
- CapnoGI (NCT05030870)
- Testing
- Capnography monitoring, Standard monitoring
- Where
- 3 sites in China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Oesophagus Cancer, Elderly Patients
Chemoradiotherapy in Elderly Patients With Oesophagus Cancer
Management of elderly patient with cancer is a therapeutic challenge and a public health problem. The mean age of esophageal cancer is 64.5 years and 72.1 years in men and women respectively.
- Trial name
- OSAGE (NCT02735057)
- Testing
- Carboplatin
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Non-Small Cell Lung Cancer
Study of Chemotherapy and PD-1 Inhibitor Combination With Anti-angiogenesis to Treat Elderly Lung Cancer
This single-center, open-label, phaseⅠstudy is to evaluate the efficacy of Tislelizumab in combination with Bevacizumab and Pemetrexed for the first-line treatment of advanced Non-squamous Non-small Cell lung cancer in Elderly…
- Trial name
- NCT05273814
- Testing
- Tislelizumab, Pemetrexed, Bevacizumab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Hodgkin Lymphoma
A Multi-centre Study of MBVD in Elderly and/or Cardiopathic Patients Affected by Hodgkin's Lymphoma (HL)
The study has the purpose to evaluate in elderly and/or cardiopathic HL patients, the cardiologic toxicity of the MBVD regimen, where liposomal doxorubicin (Myocet®) is substituted for doxorubicin in the conventional ABVD regimen.
- Trial name
- HD0803 (NCT01523847)
- Testing
- MBVD (Myocet+BVD)
- Where
- 26 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Diffuse Large B-Cell Lymphoma, Lymphoma, Diffuse Large-Cell
Bendamustine + Rituximab in Older Patients With Previously Untreated Diffuse Large B-cell Lymphoma
The purpose of this research study is to learn about the safety of the treatment with a combination of bendamustine and rituximab and to find out what effects, both good and bad this treatment has on DLBCL.
- Conditions
- Diffuse Large B-Cell Lymphoma, Lymphoma, Diffuse Large-Cell, Diffuse Large-Cell Lymphoma, Lymphoma
- Trial name
- NCT01234467
- Testing
- Bendamustine, Rituximab
- Where
- 7 sites in United States
- Volunteers
- 23 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Diffuse Large B-Cell Lymphoma
Study of Bendamustine and Ofatumumab in Elderly Patients With Newly Diagnosed Diffuse Large B-Cell Lymphoma Who Are Poor Candidates for R-CHOP Chemotherapy
This is a single-arm, Phase II study designed to enroll and treat up to 64 patients. All patients in this study will receive ofatumumab and bendamustine as an IV infusion for 6 cycles (a cycle is defined as 21 days in length).
- Trial name
- NCT01626352
- Testing
- Bendamustine, Ofatumumab
- Where
- 11 sites in United States
- Volunteers
- 22 people
- Sponsor
- SCRI Development Innovations, LLC
Plasma Cell Myeloma
Exercise Prescription for the Improvement of Quality of Life in Elderly Patients With Multiple Myeloma
This trial studies how well exercise prescription works in improving quality of life in elderly patients with multiple myeloma. Engaging and adhering to an exercise program may improve functional status and quality of life and…
- Trial name
- NCT04100044
- Testing
- Exercise Counseling, Exercise Intervention, Questionnaire administration
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Thomas Jefferson University
Advanced Gastric Cancer
Laparoscopic Versus Open Gastrectomy for Elderly Local Advanced Gastric Cancer Patients
Gastric cancer is one of the most common malignant tumors worldwide. With the rapid aging of global population, the number of elderly patients with local advanced gastric cancer is increasing.
- Trial name
- NCT03564834
- Testing
- Laparoscopic gastrectomy, Open gastrectomy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Peking University
Nutrition Related Cancer, Aging
Effects of Chocolate Consumption in Elderly Patients With Cancer in Palliative Care
Elderly patients with advanced cancer stage constitute an important demand for palliative care, a scenario in which metabolic and nutritional status changes may be present.
- Trial name
- NCT04367493
- Testing
- Chocolate
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo
Colorectal Neoplasms
Study of Andrographolides With or Without Capecitabine to Treat Colorectal Cancer
The purpose of this study is to determine the efficacy and safety of Andrographolides combined with Capecitabine in treatment of elderly patients with locally advanced or recurrent or metastasis inoperable colorectal cancer
- Trial name
- AGCRC-013 (NCT01993472)
- Testing
- Andrographolides, Capecitabine
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Gu Yanhong
Diffuse Large B Cell Lymphoma (DLBCL)
Mosunetuzumab and Polatuzumab Vedotin With Split-Dose CHP Chemotherapy for Elderly Patients With Diffuse Large B-Cell Lymphoma
This single-arm, interventional phase 2 study is designed to evaluate whether the inclusion of mosunetuzumab subcutaneous and polatuzumab vedotin (Mosun-Pola) to a split-dose CHP chemotherapy backbone will improve outcomes for…
- Trial name
- NCT06594939
- Testing
- Polatuzumab Vedotin, Mosunetuzumab, Cyclophosphamide
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Medical College of Wisconsin
Diffuse Large B-cell Lymphoma
Trial of R-GemOx Regimen in Previously Untreated Elderly Patients With DLBCL.
The purpose of this study is to investigate efficacy and safety of GemOx(Gemcitabine and Oxaliplatin) combination with rituximab(R) as first-line treatment of elderly patients with DLBCL
- Trial name
- NCT01670370
- Testing
- R-GemOx
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
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