Clinical trials: Geriatric Cancer Patients
Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
Radiolabeled Monoclonal Antibody Therapy, Fludarabine Phosphate, and Low-Dose Total-Body Irradiation Followed by Donor Stem Cell Transplant and Immunosuppression Therapy in Treating Older Patients With Advanced Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes
This phase I trial studies the side effects and best dose of iodine I 131 monoclonal antibody BC8 when given together with fludarabine phosphate and low-dose total-body irradiation followed by donor stem cell transplant and…
- Conditions
- Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
- Trial name
- NCT00008177
- Testing
- iodine I 131 monoclonal antibody BC8, total-body irradiation, allogeneic hematopoietic stem cell transplantation
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Fred Hutchinson Cancer Center
Acute Myeloid Leukemia
GRASPA Treatment for Patients With Acute Myeloblastic Leukemia
The protocol aims at adding GRASPA (L-asparaginase encapsulated in red blood cells, eryaspase) to standard chemotherapy (low-dose cytarabine) to treat patients older than 65 years diagnosed with AML and unfit for intensive…
- Trial name
- ENFORCE (NCT01810705)
- Testing
- GRASPA
- Where
- 21 sites in France
- Volunteers
- 123 people
- Sponsor
- ERYtech Pharma
Delirium, Aged
Impact of Maxigesic on Delirium After Minimally Invasive Lung Surgery in Elderly Patients
The primary aim of this interventional study is to investigate the impact of perioperative administration of Maxigesic (combination of acetaminophen and ibuprofen) on delirium after minimally invasive lung surgery in elderly…
- Conditions
- Delirium, Aged, Lung Neoplasms, Robotic Surgical Procedures
- Trial name
- NCT05834569
- Testing
- Acetaminophen and Ibuprofen, Normal saline
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Korea University Guro Hospital
Ovarian Cancer, Frailty
FRAGINOC Study: Screening and Geriatric Assessment and Intervention in Older Patients With Epithelial Ovarian Cancer
Ovarian cancer (OC) is the fifth most common cause of cancer death. More than 40% are older than 70 years. The standard treatment is radical surgery combined with chemotherapy.
- Trial name
- FRAGINOC (NCT05810701)
- Testing
- Comprehensive geriatric assessment and individualised physical training
- Where
- 5 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Odense University Hospital
Glioblastoma
Daily Temozolomide for Elderly Patients With Unmethylated MGMT- Promoter Newly Diagnosed GliOblatoma
Glioblastoma is an aggressive type of brain cancer. Standard treatment usually includes three weeks of radiation therapy alone or combined with chemotherapy using Temozolomide.
- Trial name
- TEMPO (NCT07476794)
- Testing
- Daily TMZ
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- Sunnybrook Health Sciences Centre
Frailty, Postoperative Complications
Mortality Predictors in Patients 80+ After Major Abdominal Surgery: Role of Frailty and Physiological Reserve
The aim of this study is to identify independent risk factors for 30-day mortality in patients aged 80 and over who have undergone major abdominal surgery.
- Conditions
- Frailty, Postoperative Complications, Aged, 80 and Over, Abdomen Cancer
- Trial name
- NCT07440095
- Testing
- Major Abdominal Surgery and Frailty Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Multiple Myeloma in Older Patients
Vulnerability and Therapeutic Changes in Older Patients With Multiple Myeloma.
The aim of this study is to determine whether the presence of vulnerability detected by geriatricians is associated with treatment discontinuation in older patient.
- Trial name
- MYELOME-PA (NCT02063113)
- Testing
- Vulnerability and therapeutic changes in older patients with multiple myeloma.
- Where
- 2 sites in France
- Volunteers
- 48 people
- Sponsor
- Nantes University Hospital
Leukemia, Lymphoblastic, Acute
Dasatinib and Low Intensity Chemotherapy for Ph+ Acute Lymphoblastic Leukemia
1. The use of imatinib in combination or in association with chemotherapy is now considered as the gold standard for the treatment of Ph+ ALL. The complete remission (CR) rate is 90% versus 20% to 40% with chemotherapy alone.
- Trial name
- EWALLPH01 (NCT02888990)
- Testing
- Dasatinib
- Where
- 64 sites in Belgium, France and 2 more
- Volunteers
- 71 people
- Sponsor
- Versailles Hospital
Postoperative Delirium, Gastrointestinal Tumors
Opioid-free Anesthesia and Postoperative Delirium
Postoperative delirium (POD) is a common acute and transient form of brain dysfunction in elderly patients following surgery that can lead to serious adverse clinical outcomes and even death.
- Trial name
- NCT07603596
- Testing
- OFA group, OBA group
- Volunteers
- 174 people
- Sponsor
- Qianfoshan Hospital
Frailty, Multiple Myeloma
ICOPE Program Feasibility in the Management of Myeloma Patients
This project proposes to adapt monthly the existing ICOPE (Integrated Care for Older People) MONITOR program for elderly myeloma patients. This adaptation aims to detect earlier functional decline and prevent loss of autonomy.
- Trial name
- Onco-ICOPE (NCT06247189)
- Testing
- ICOPE Monitoring
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Elderly
Cardiovascular Prevention Strategies in Elderly Patients With Cancer (CARTIER Clinical Trial)
The CARTIER study is a randomized, multicenter, open-label clinical trial comparing, in elderly patients with cancer under anti-tumoral treatment, two different cardiotoxicity prevention strategies: primary (intensive…
- Conditions
- Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Elderly, Antineoplastic Agents, Cardiotoxicity
- Trial name
- CARTIER (NCT03711110)
- Testing
- Intensive cardiovascular monitoring, No intervention
- Where
- 14 sites in Spain
- Volunteers
- 514 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Breast Cancer
Treatment for Elderly Patients With High Risk Breast Cancer
This open-label, multicenter study explored primary and secondary prophylaxis treatment with a single, fixed-dose, subcutaneous (SC) injection of pegfilgrastim in elderly subjects with high-risk breast cancer receiving…
- Trial name
- NCT00117910
- Testing
- pegfilgrastim
- Sponsor
- Amgen
Multiple Myeloma
Iberoamerican Protocol With Thalidomide in Patients With Symptomatic Newly Diagnosed Multiple Myeloma Over 65 Years
This protocol is an international, multicenter, comparative, open and randomized study designed to compare the safety and efficacy (in terms of response rate) from three induction chemotherapy schemes…
- Trial name
- NCT01532856
- Testing
- Thalidomide, Cyclophosphamide, Dexamethasone, Thalidomide, Dexamethasone, Thalidomide, Melphalan, Prednisone
- Where
- 3 sites in Brazil
- Volunteers
- 64 people
- Sponsor
- Grupo de Estudos Multicentricos em Onco-Hematologia
Acute Myeloid Leukemia (AML), High Risk Acute Myeloid Leukemia(AML)
Thiotepa Combined With Busulfan and Fludarabine Conditioning Regimen for Haploidentical Hematopoietic Stem Cell Transplantation in Elderly Patients With High-Risk Acute Myeloid Leukemia
Abstract: This clinical study is designed to evaluate the efficacy and safety of a thiotepa, busulfan, and fludarabine (TBF) conditioning regimen for haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in elderly…
- Conditions
- Acute Myeloid Leukemia (AML), High Risk Acute Myeloid Leukemia(AML), Relapsed/Refractory Acute Myeloid Leukemia (AML)
- Trial name
- NCT06869265
- Testing
- Thiotepa ;busulfan;fludarabine
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Peking University People's Hospital
Lymphoma
A Phase I Study of Bendamustine and Melphalan Conditioning and Autologous Stem Cell Transplantation for Treatment of Multiple Myeloma and Relapsed/Refractory B-cell Lymphoma in Elderly Patients
This study is testing a combination of chemo-immuno therapy called RBM. RBM consists of combination of drugs: rituximab, bendamustine, and melphalan followed by reinfusion of the participants own stem cells which is called…
- Trial name
- NCT03352765
- Testing
- rituximab, bendamustine, melphalan
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
NSCLC
Docetaxel Plus Bevacizumab for Elderly Patients With Stage IV NSCLC
The investigators propose to study the efficacy and safety of the combination of Docetaxel plus Bevacizumab in a Phase II trial of elderly subjects with non-small cell lung cancer
- Trial name
- NCT02179567
- Testing
- Docetaxel, Bevacizumab
- Where
- 5 sites in Greece
- Volunteers
- 26 people
- Sponsor
- Hellenic Oncology Research Group
Colorectal Neoplasms
Yield and Safety of Colonoscopy in Patients Older Than 80 Years
The aim of the study is to study the risk of colorectal cancer and polyps in people older than 80 years compared to the younger age group.
- Trial name
- NCT00590434
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Midwest Biomedical Research
Non-Hodgkin's Lymphoma
Pegylated Liposomal Doxorubicin Containing Chemotherapy in the Treatment of Older Non-Hodgkin's Lymphoma Patients
Currently there is no one standard of care for older patients with Non-Hodgkin's Lymphoma (NHL). The study will examine the tolerability and feasibility to the combination of Cyclophosphamide, Pegylated Liposomal Doxorubicin…
- Trial name
- NCT00120198
- Testing
- CDOP plus rituximab
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Geriatric Oncology Consortium
Cancer
Assessing Patient-reported & Patient-related Outcomes in Randomized Cancer Trials for Older Adults
As older adults with cancer are underrepresented in randomized clinical trials (RCT), there is limited evidence on which to rely for treatment decisions for this population.
- Trial name
- DATECANelderly (NCT03676218)
- Testing
- Elderly cancer patients
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Institut Bergonié
Malignant Haemopathies, Acute Leukemia
Unicentric Retrospective Analysis of a Cohort of 602 Young Adult and Adolescent Patients (AJA), Aged 15 to 30 Years, With Haematological Malignancies, and Managed Between 2000 and 2016
Unicentric retrospective analysis of a cohort of 602 young adult and adolescent patients, aged 15 to 30 years, with haematological malignancies, and managed between 2000 and 2016
- Conditions
- Malignant Haemopathies, Acute Leukemia, Non-hodgkin Lymphoma, Hodgkin Lymphoma
- Trial name
- HEMAJA (NCT03469921)
- Testing
- administered therapeutic regimens
- Where
- France
- Volunteers
- 602 people
- Sponsor
- Institut Paoli-Calmettes
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