Clinical trials: Geriatric Cancer Patients
Metastatic Breast Cancer, Advanced Breast Cancer
Implementing Geriatric Assessment for Dose Optimization of Cyclin-dependent Kinase (CDK) 4/6-inhibitors in Older Breast Cancer Patients
IMPORTANT study is a multicenter, open-label, prospective, randomized-controlled, non-inferiority trial with a pragmatic approach involving older patients (≥ 70 years old) with advanced hormone receptor (HR)-positive/human…
- Conditions
- Metastatic Breast Cancer, Advanced Breast Cancer, Quality of Life, Toxicity
- Trial name
- IMPORTANT (NCT06044623)
- Testing
- CDK 4/6 inhibitors, Endocrine therapy
- Where
- 12 sites in Finland, Greece and 4 more
- Volunteers
- 495 people
- Sponsor
- Region Örebro County
Elderly Patients With a Solid Tumor
Are the Fried Criteria Predictive of a Functional Decline in Older People With Solid Malignant Tumors?
Identifying the frail elderly patients or those at risk of becoming frail has become a cornerstone of modern geriatric medicine. Many instruments have been developed to identify fragility at the individual level.
- Trial name
- NCT02662179
- Testing
- Quality of life evaluation, Functional decline assessment, Physical decline assessment
- Where
- 2 sites in Belgium
- Volunteers
- 62 people
- Sponsor
- Brugmann University Hospital
T-cell Lymphoma
Efficacy of a Treatment With CHOP and Lenalidomide in First Line in Angioimmunoblastic T-cell Lymphoma (AITL)
This study aims to evaluate the efficacy of lenalidomide associated with CHOP as measured by complete response rate at the end of treatment.
- Trial name
- NCT01553786
- Testing
- Lenalidomide
- Where
- 30 sites in Belgium, France
- Volunteers
- 80 people
- Sponsor
- The Lymphoma Academic Research Organisation
Multiple Myeloma
Subcutaneous Velcade Plus Oral Melphalan and Prednisone or Plus Cycloposphamide and Prednisone or Plus Prednisone
This protocol is a single-arm, three-cohort, phase II multicenter study designed to assess the safety and the efficacy of three all-oral combinations: Velcade with continuous low-dose melphalan and prednisone (VMP) or with…
- Trial name
- NCT01190787
- Testing
- velcade subcutaneous melphalan prednisone, velcade cyclophosphamide prednisone, velcade prednisone
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- European Myeloma Network B.V.
Sarcopenia, Gastrointestinal Neoplasms
Preoperative Sarcopenia and Postoperative Outcomes in Older Patients With Gastrointestinal Cancer
This prospective cohort study aims to evaluate the association between preoperative sarcopenia and postoperative outcomes in patients aged 60 years or older undergoing elective surgery for gastrointestinal cancer.
- Trial name
- NCT07817758
- Testing
- Preoperative Sarcopenia Status
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Van Training and Research Hospital
Leukemia, Myeloid, Acute
Treatment of Non Promyelocytic Acute Myeloid Leukaemia on Elderly Patients by Low Dose Cytosar Plus Arsenic Trioxide
Our purpose in this study is to explore the feasibility of treatment of non promyelocytic Acute myeloid leukaemia on elderly patients.
- Trial name
- NCT00850304
- Testing
- Cytosar, Arsenic trioxide
- Where
- Iran
- Volunteers
- 10 people
- Sponsor
- Tehran University of Medical Sciences
Acute Myeloid Leukemia
Integrating Geriatric Assessment for Older Patients Diagnosed With Acute Myelogenous Leukemia
Despite the suggestions that GA and frailty indices could be used to guide therapy selection, the ability to effectively incorporate the use of GA in older patients diagnosed with AML in a real-world clinic environment has not…
- Trial name
- NCT04158726
- Testing
- modified Geriatric Assessment (mGA)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Carevive Systems, Inc.
Acute Myeloid Leukemia
Accelerated Dose Schedule of Cytarabine Consolidation Therapy for Older Patients With Acute Myeloid Leukemia (AML) in Complete Remission
This phase 2, open label, non-randomized study will evaluate the safety of administering high dose cytarabine (HiDAC) consolidation therapy on days 1-3 of each cycle, as compared to standard administration on days 1, 3, and 5 of…
- Trial name
- NCT04914676
- Testing
- Cytarabine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Breast Cancer
Single Fraction Elderly Breast Irradiation (SiFEBI)
Irradiation and Accelerated Partial Breast (IPAS) to this day remains a therapeutic concept whose validity is being assessed on its non-inferiority in terms of local control compared to whole breast irradiation.
- Trial name
- SIFEBI (NCT01727011)
- Testing
- IPAS
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Centre Antoine Lacassagne
Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia
Venetoclax and ASTX727 for the Treatment of Relapsed, Refractory, or Newly Diagnosed Acute Myeloid Leukemia
This phase II trial studies the possible benefits of venetoclax and ASTX727 in treating patients with acute myeloid leukemia that has come back (relapsed) or does not respond to treatment (refractory), or elderly patients with…
- Conditions
- Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
- Trial name
- NCT04746235
- Testing
- Decitabine and Cedazuridine, Venetoclax
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer
Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00004860
- Testing
- leucovorin calcium, tegafur-uracil
- Where
- 51 sites in United States, Puerto Rico
- Sponsor
- Eastern Cooperative Oncology Group
Small Cell Lung Cancer
Adebrelimab Combined With Oral Etoposide for Elderly Patients and Patients With Poor Performance Status in Small Cell Lung Cancer: An Exploratory Clinical Study
This is a multicenter, single-arm, exploratory clinical study designed to observe and evaluate the efficacy and safety of adebrelimab combined with oral etoposide for elderly patients and patients with poor performance status in…
- Trial name
- NCT07398560
- Testing
- Adebrelimab, Oral etoposide soft capsules
- Where
- China
- Volunteers
- 47 people
- Sponsor
- The Third Affiliated Hospital of Harbin Medical University
Advanced Colorectal Cancer in Elderly Patient
The Management of Complicated Colo-rectal Cancer in Older Patients in the Emergency Setting: the CO-OLDER Study
This is a multicenter observational study aimed to investigate the management of older patients aged 75 years old and over admitted to the emergency department with complicated colorectal cancer.
- Trial name
- CO-OLDER (NCT05788224)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Poissy-Saint Germain Hospital
Progression Free Survival(PFS)
Safety and Efficacy Analysis of Oral Etoposide Combined With Anlotinib and Envafolimab in First-line Treatment of Elderly Patients With Small Cell Lung Cancer/ Open-label, Single-arm, Exploratory Phase II Clinical Study
This study aims to explore the safety and efficacy of etoposide capsules combined with Anlotinib and Envafolimab in elderly patients with extensive small cell lung cancer.This is a single-center, single-arm exploratory clinical…
- Trial name
- NCT05685550
- Testing
- Toposide capsules combined with Anlotinib and Envafolimab group
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Colorectal Cancer
Effect of Lidocaine on Postoperative Pain in Elderlypatients Undergoing Colorectal Cancer Surgery
Patients who meet the enrollment criteria will be randomized 1:1 to the lidocaine group or placebo group.
- Trial name
- NCT05920980
- Testing
- lidocaine
- Where
- China
- Volunteers
- 276 people
- Sponsor
- West China Hospital
Lymphoma
Clinical Trial to Evaluate R-COMP Versus R-CHOP in Newly Diagnosed Patients With Non-localised Diffuse Large B-cell Lymphoma (DLBCL)/Follicular Lymphoma Grade IIIb
The Phase II study proposed here assesses the hypothesis that replacing doxorubicin by Myocet® in the R-CHOP regimen would yield comparable antitumour efficacy with a lower cardiotoxicity for first-line treatment in elderly…
- Trial name
- NCT02012088
- Testing
- RCOMP, RCHOP
- Where
- 14 sites in Spain
- Volunteers
- 91 people
- Sponsor
- Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea
PET-CT, Lymphoma
PET-CT in Lymphoma Among the Eldery
This study investigates PET-CT imaging patterns and metabolic parameters in elderly patients (≥60 years) diagnosed with lymphoma, aiming to enhance diagnostic accuracy and prognosis using 18F-FDG PET/CT scans.
- Conditions
- PET-CT, Lymphoma, Elderly, Metabolic Parameters
- Trial name
- NCT07259941
- Volunteers
- 63 people
- Sponsor
- Assiut University
Lung Cancer Patients
Global, Regional, and National Burdens and Trends of Tracheal, Bronchial, and Lung Cancer in Individuals Aged 70 Years and Older from 1990 to 2021
Despite the increasing health burden of tracheal, bronchial, and lung (TBL) cancer patients aged ≥ 70 years worldwide, data on its burden and trends are limited.
- Trial name
- GDBlung70 (NCT06694194)
- Volunteers
- 111,627 people
- Sponsor
- Hongquan Xing
Can the Geriatric Questionnaires Predict Adverse Effects in Geriatric Breast Cancer Patients Treated With Cyclin-dependent Kinase 4 and 6 Inhibitors
Evaluation of Geriatric Questionnaires to Predict Toxicities of CDK 4/6 Inhibitors in Older Breast Cancer Patients?
CDK 4/6 inhibitors (palbociclib, ribociclib) have taken their place in our practice recently with their clinical benefits in the treatment of hormone-positive and HER2 negative metastatic breast cancer.
- Trial name
- NCT05051956
- Testing
- Palbociclib 125mg and Ribociclib 600 mg
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Namik Kemal University
Relapsed or Refractory Acute Myeloid Leukemia (AML), MDS (Myelodysplastic Syndrome)
A Single-arm, Prospective Study of a Clad-LABU Conditioning Regimen in HSCT for R/R MDS/AML in Elderly Patients
Acute myeloid leukemia (AML) is one of the most common hematologic malignancies. With increasing life expectancy and the aging of society, the incidence of AML in the elderly population is rising.
- Trial name
- NCT07500753
- Testing
- Allogeneic Hematopoietic Stem Cell Transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Soochow University
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