Clinical trials: Geriatric Disorders
Sarcopenia
Trial in Elderly With Musculoskeletal Problems Due to Underlying Sarcopenia - Faeces to Unravel Gut and Inflammation Translationally
The overall aim of the TEMPUS-FUGIT study is to assess gut microbiota composition in older persons without sarcopenia and to determine the relationship with and between intestinal and systemic inflammation and with…
- Trial name
- TEMPUS-FUGIT (NCT05008770)
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pneumonia, Aging
Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines
This is a prospective, single-site, randomized, then open-label study designed to develop a detailed transcriptional and epigenetic profile of the immune response to pneumococcal vaccination with conjugated and non-conjugated…
- Trial name
- NCT03104075
- Testing
- Pneumococcal 13valent Conj Vaccine Diphtheria CRM197 Protein, Pneumococcal Vaccine Polyvalent
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Jackson Laboratory
Foot
Effect of The Foot Care Protocol Applied to Elderly People
The study was carried out randomized-controlled experimental research to determine the foot health status and factors affecting it among elderly individuals, to develop a protective and developmental protocol for foot health of…
- Trial name
- NCT03837002
- Testing
- foot care protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Ordu University
Orthomyxoviridae Infection, Influenza
Immunogenicity of High-dose Inactivated, Split-virion Influenza Vaccine Versus Standard Fluzone Vaccine in the Elderly
Compared to young adults, the elderly mount a lower antibody response to vaccination. Thus, improvement of the immune response to influenza vaccination in this age group, which is at higher risk for influenza-related morbidity…
- Conditions
- Orthomyxoviridae Infection, Influenza, Myxovirus Infection
- Trial name
- NCT00391053
- Testing
- High-Dose Inactivated, Split-Virion Influenza Vaccine, Inactivated, Split-Virion Influenza Vaccine
- Where
- 28 sites in United States
- Volunteers
- 3,851 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Emergencies
Optimized Acute Care for Geriatric Patients Using an Intersectoral Telemedical Cooperation Network - Around the Clock
Due to "demographic change", the composition of the population in Germany is changing. The consequence of this change is a population that is getting older on average.
- Trial name
- Optimal@NRW (NCT04879537)
- Testing
- Telemedical support
- Where
- Germany
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Varicella (chickenpox), MMR Vaccine
Study of Live Attenuated Varicella Vaccine Co-administered with MMR Vaccine or DTaP Vaccine
This is a phase Ⅳ clinical trial of live attenuated varicella vaccine manufactured by Sinovac (Dalian) Vaccine Technology Co., Ltd.The primary objective of this study is to evaluate the immunogenicity of live attenuated varicella…
- Conditions
- Varicella (chickenpox), MMR Vaccine, DTaP Vaccine
- Trial name
- NCT06891872
- Testing
- Vaicella Vaccine+DTaP on Day 0, MMR on Day 30, Varicella vaccine+MMR on Day 0，DTaP on Day 30, Varicella Vaccine
- Where
- China
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Sinovac (Dalian) Vaccine Technology Co., Ltd.
Diphtheria, Tetanus
The Transparent Safety Study of the 5 in 1 (DTwP-rHepB-Hib) Combination Vaccine Produced by the Indian Serine Institute in Children of Viet Nam Healthy From 6 to 12 Weeks of Age in a 3-dose Regimen, the Interval Between Doses is 4 Weeks
The objective of this study is to evaluate safety and tolerability of Diphtheria, Tetanus, Pertussis, Hepatitis B and Haemophilus influenzae type b Conjugate Vaccine Adsorbed in Vietnamese infants aged 6-12 weeks.
- Conditions
- Diphtheria, Tetanus, Pertussis, Hepatitis B
- Trial name
- NCT03931239
- Testing
- Study subjects will be vaccinated with 3 (three) vaccine doses. The first vaccine will be administered intramuscularly starting at 6-12 weeks of age followed by two doses at four-week interval
- Where
- Vietnam
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Vabiotech
Influenza
Immunogenicity and Safety Study to Assess Influenza Vaccine Formulated With Haemagglutinin (HA) Antigen From Two Different Suppliers
The purpose of this study is to assess the humoral immune response and safety of the parenteral formulation of the 2010/2011-season virosomal subunit influenza vaccine Inflexal V using two different HA antigen suppliers (AdImmune…
- Trial name
- NCT01412281
- Testing
- Virosomal influenza vaccine (AdImmune HA Antigen), Virosomal influenza vaccine (CSL HA Antigen)
- Where
- Switzerland
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
Aging, Healthy Aging
Eating Habits and Lifestyle Profile of an Italian Aging Cohort
Aging is characterized by low-grade inflammatory state, supported by impairment oxidative balance and endocrine changes, leading to changes in: body composition, such as decrease in lean body mass and increase in adipose tissue…
- Conditions
- Aging, Healthy Aging, Life Style, Eating Habit
- Trial name
- NCT04401930
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Diet; Deficiency
Cross-sectional Dietary Intake Survey on Ivorian School-Aged Children and Women of Reproductive Age
A cross-sectional dietary intake study was conducted with 423 Ivorian school aged children (SAC, 6-12 years) and 423 women of reproductive age (WRA, 15-49 years) from four cities, recruited by two-stage random sampling.
- Trial name
- AN (NCT06175130)
- Where
- Netherlands
- Volunteers
- 846 people, healthy volunteers welcome
- Sponsor
- FrieslandCampina
Influenza Immunization, Health Volunteers
A Study to Assess Tolerability of the Trivalent Recombinant Vaccine in Individuals Aged 18 and Older Using the Vaccinees Perception of Injection Questionnaire
This study aims to assess patient-reported experiences following trivalent recombinant influenza vaccine (RIV3) vaccination using the Vaccinees' Perception of Injection (VAPI) questionnaire, identify factors related to vaccine…
- Trial name
- NCT06765187
- Testing
- Trivalent Recombinant Influenza Vaccine
- Where
- United States
- Volunteers
- 1,007 people, healthy volunteers welcome
- Sponsor
- Sanofi
Influenza, Avian
Safety and Immunogenicity Study of a H5N1 Influenza Vaccine (Vero Cell-Derived, Whole Virus) in Healthy Infants, Children and Adolescents
The purpose of this study is to assess the safety and immunogenicity (i.e. primary immune response, immunogenicity of two different doses, antibody persistence 360 days after the first vaccination, immune response to a…
- Trial name
- NCT01052402
- Testing
- H5N1 Influenza Vaccine (Whole Virion, Vero Cell-Derived, Inactivated), non-adjuvanted formulation
- Where
- 20 sites in Australia, Finland and 2 more
- Volunteers
- 684 people, healthy volunteers welcome
- Sponsor
- Alachua Government Services, Inc.
Urinary Incontinence in Old Age, Dementia
Validity and Reliability of the Turkish Form of the Knowledge Assessment Scales for Dementia and Urinary Incontinence
The primary aim of the study was to determine the Turkish version of the "Validity and Reliability of the Knowledge Assessment Scales for Dementia and Urinary Incontinence in Community Older People".
- Trial name
- NCT06758219
- Testing
- There is no intervention in the study.
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Aging, Hyperthermia
Heat Waves and the Elderly - Cooling Modalities
The purpose of this study is to assess how well cooling modalities work in reducing cardiovascular stress of the elderly to heat wave conditions
- Trial name
- NCT05484739
- Testing
- Water Spray, Fan, Water Spray and Fan
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Obstructive Pulmonary Disease
Evaluation in Individuals with COPD and Asymptomatic Individuals
The literature does not provide sufficient information on the evaluation of frailty, handgrip strength, physical activity, kinesiophobia, and fatigue in elderly individuals with Chronic Obstructive Pulmonary Disease and…
- Trial name
- NCT06077357
- Testing
- MMSE Test, PASE Test, The PRISMA-7 Frailty Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Vascular Stiffness, Vasodilation
Effects of Betalains on Cardiovascular Health and Quality of Life
The goal of this randomized, double-blind, placebo-controlled, cross-over trial is to investigate the effects of beetroot-derived betalains on cardiovascular health, sleep and quality of life in healthy middle-aged individuals.
- Conditions
- Vascular Stiffness, Vasodilation, Sleep, Quality of Life
- Trial name
- NCT06117007
- Testing
- Betalains
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- King's College London
Cardiovascular Risk Factors
Cocoa Extract-enriched Meals and Cardiovascular Risk in Older Population
Obesity prevalence in elderly populations has increased in the last years, and the reduction of overweight and obesity is a priority target in populations of all age ranges worldwide.
- Trial name
- NCT01596309
- Testing
- Cocoa extract
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Elderly, Sarcopenia
Effect of Protein Consumption and Resistance Training on Body Composition, Muscular Strength and Functional Capacity in the Elderly
The increase in life expectancy of the world population is associated with a higher incidence of diseases, leading to functional incapacity and dependence in old age.
- Trial name
- NCT03862937
- Testing
- Exercise training + whey protein
- Where
- Brazil
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Non-Small-Cell Lung Carcinoma
Study of OSI-774 (Tarceva) in Previously Untreated Elderly Lung Cancer Patients
The primary purpose of this study is to determine whether the drug OSI-774 is less toxic and potentially as good as or better than standard chemotherapy drugs, when given to subjects with non-small cell lung cancer, who are 70…
- Trial name
- NCT00137800
- Testing
- OSI-774 (Tarceva)
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Healthy Elderly, Parkinson Disease
A Study to Assess Single and Multiple Doses of IkT-148009 in Healthy Elderly Participants and Parkinson's Patients
This study investigates the safety and tolerability of drug IkT-148009 in healthy elderly volunteers (55 to 70 years old). This first-in-human study is designed in 3 parts.
- Trial name
- NCT04350177
- Testing
- IkT-148009
- Where
- 4 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- ABLi Therapeutics, Inc.
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