Clinical trials: Geriatric Disorders
Influenza
Study to Evaluate the Immunogenicity and the Safety of an Adjuvanted Influenza Vaccine Candidate
The purpose of this study is to evaluate the immunogenicity and the safety of the candidate vaccine compared to Fluarix™ administered intramuscularly in elderly aged 60 years and above
- Trial name
- NCT00363077
- Testing
- GSK1247446A Group, Fluarix™
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gait Disorders in Old Age
Usability and Satisfaction Test to the Wearable Walking-assist Robot (GEMS-H) in the Community-dwelling Healthy Adults
The purpose of this study is to investigate the userbility and satisfaction of one-off functional gait training with the Gait Enhancing and Motivating System-Hip type (GEMS-H) on locomotor function in normal adults including the…
- Trial name
- NCT05106881
- Testing
- Training with Gait Enhancing and Motivating System (GEMS-H) Robot
- Where
- South Korea
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Hepatitis B, Hepatitis A
Long Term F/U Studies at Y5&6 to Demonstrate the Equivalence of 2 Vaccination Schedules of Combined Hepatitis A & B Vaccine
To evaluate the persistence of immune response 5 years and 6 years after the first vaccine dose.
- Trial name
- NCT00197171
- Testing
- Combined Hepatitis A and B vaccine
- Where
- 2 sites in Australia
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Elderly ; Moderate Risk Surgery
Optimized Anesthesia to Reduce Postoperative Cognitive Impairment in the Elderly
The aim of this study is to demonstrate that in elderly and frail patients, a narrower control of intraoperative blood pressure (BP) by the use of a continuous and noninvasive BP monitoring, coupled with an adequate depth of…
- Trial name
- NCT02698982
- Testing
- Depth of anesthesia monitoring (BIS, Covidien USA) and Continus non invasive blood pressure monitoring (Clearsight, Edwards LifeScience, USA), moderate risk surgery
- Where
- Belgium
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Subjective Cognitive Decline
Polyamine-enriched Diet in Healthy Older Adults With Subjective Cognitive Decline
The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance of individuals with subjective cognitive decline.
- Trial name
- preSmartAge (NCT02755246)
- Testing
- Polyamine supplementation
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Influenza
Immunogenicity Trial of Egg- Versus Non-Egg-Based Influenza Vaccines Among HCP
This randomized, open-label trial will assess humoral and cell-mediated immune responses to cell culture-based and recombinant unadjuvanted quadrivalent influenza vaccines compared to conventional egg-based unadjuvanted…
- Trial name
- NCT03722589
- Testing
- Flublok, Flucelvax, Fluarix
- Where
- 2 sites in United States
- Volunteers
- 944 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Drug Safety
Safety and Tolerability of Namisol in the Elderly
The results of phase I Namisol® study (Klumpers et al. Br J Clin Pharmacol, 2012), implicate that Namisol® may have a favorable PK and PD characteristics and is safe to use in people.
- Trial name
- THC (NCT01740960)
- Testing
- delta-9-tetrahydrocannabinol
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Problematic Social Media Use
Cross-cultural Adaptation and Validation of the French Version of the Social Media Disorder Scale for Parents in a Sample of Parents of Children Aged 10 to 17
During the first lockdown related to the COVID-19 crisis, more than 12 million students in France were affected by school closures.
- Trial name
- MEDUSA-P (NCT07476755)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Versailles Hospital
Fear of Falling, Pelvic Joint/Ligament Damage
Impact of Pelvic Joint Stiffness on the Fear of Falling in Subjects Aged Over 75 Years
The pelvic girdle is the mechanical structure at the center of the balance and walking systems. The lack of amplitude of the joints that compose it could induce a fear of falling, common in the geriatric population and often…
- Trial name
- RAAPC (NCT07023718)
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier Sud Ile-de-France
Sleep Apnea, Elderly Adults
Sleep Apnea in Elderly
Sleep-disordered breathing (SDB or sleep apnea) is very common among elderly Veterans and leads to increased morbidity and mortality in this population.
- Trial name
- NCT02703220
- Testing
- Hyperoxia/oxygen, Acetazolamide, Finasteride
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Bronchodilators in Mild Chronic Obstructive Pulmonary Disease (COPD)
In people with mild COPD, the ability to exhale air from the lungs is partly limited because of narrowing and collapse of the airways.
- Trial name
- NCT00202176
- Testing
- Ipratropium Bromide
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Queen's University
Periodontitis, Alzheimer Disease
Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study
The neurological disorders that accompany aging represent a major public health problem. The management of these diseases is a major medical and social priority.
- Trial name
- ORAMICAL (NCT05077618)
- Testing
- sampling of dental plaque and blood sample during the treatment
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
COVID-19
Study of the Tolerability, Safety, Immunogenicity and Preventive Efficacy of the EpiVacCorona Vaccine for the Prevention of COVID-19
The objective of the clinical study is to evaluate the tolerability, safety, immunogenicity and prophylactic efficacy of the EpiVacCorona vaccine in volunteers aged 18 and above.
- Trial name
- NCT04780035
- Testing
- EpiVacCorona (EpiVacCorona vaccine based on peptide antigens for the prevention of COVID-19)
- Where
- 8 sites in Russia
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Federal Budgetary Research Institution State Research Center of Virology and Biotechnology "Vector"
Sarcopenia
Cardiorespiratory Training and Ventilatory Muscle Strength
The cardiorespiratory training can increase muscle strength ventilatory.
- Trial name
- RMS (NCT01912482)
- Testing
- Cardiorespiratory training, ventilatory training
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Gama Filho
Subjective Cognitive Decline (SCD)
Polyamine-enriched Diet in Elderly Individuals With Subjective Cognitive Decline
The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance and further characterization of individuals with subjective cognitive decline.
- Trial name
- SmartAge (NCT03094546)
- Testing
- Polyamine
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
COVID-19, Vaccines
Safety and Immunogenicity of COVID-19 Vaccine, AdCLD-CoV19-1
The immunogenicity and safety profiles of AdCLD-CoV19-1 (5.0×10^10 VP/dose) will be assessed for 1-dose or 2-dose regimen in SARS-CoV-2 seronegative healthy adults.
- Trial name
- NCT05520970
- Testing
- AdCLD-CoV19-1
- Where
- 4 sites in South Korea
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Cellid Co., Ltd.
Alzheimer Disease, Neurodegenerative Diseases
Cognitive Impairment Cohort Study of the Elderly Population in YuGarden
The goal of this prospective observational research with an 8-year follow-up is to study the cognitive changes in the elderly in YuGarden community, Shanghai, China.
- Conditions
- Alzheimer Disease, Neurodegenerative Diseases, Cognitive Impairment, Mild Cognitive Impairment
- Trial name
- NCT06325527
- Where
- China
- Volunteers
- 1,872 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Hypertension
Flaxseed Lignan Supplementation in Elderly Participants With Stage I Hypertension
Current recommendations today suggest that use of therapeutic lifestyle changes, such as supplementation with specific dietary components and moderate exercise, are appropriate interventions for individuals with borderline high…
- Trial name
- NCT02391779
- Testing
- BeneFlax®, Walking training, Flexibility training
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Elderly, Hormones
Aerobic Exercise With Diet Induces Hormonal, Metabolic, and Psychological Changes
PURPOSE: to determine the effect of aerobic exercise training and diet on sex hormones , insulin resistance and depression and if is there correlation between these factors effect in postmenopausal obese women BACKGROUND: The…
- Conditions
- Elderly, Hormones, Insulin Resistance, Depression
- Trial name
- NCT05136742
- Testing
- aerobic exercise and diet program, diet program
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Infections, Meningococcal
Lot Consistency, Immuno, Safety of Meningococcal Vaccine GSK134612 Given With Fluarix™ to 18-55 Year-Old Adults
The purpose of this study is to demonstrate, in 18-55 year old adults, the consistency of different manufactured lots of meningococcal vaccine GSK134612, the non-inferiority of GSK134612 compared to licensed meningococcal vaccine…
- Trial name
- NCT00453986
- Testing
- Meningococcal vaccine GSK134612, Mencevax™ACWY, Fluarix™
- Where
- 4 sites in Lebanon, Philippines
- Volunteers
- 1,352 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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