Clinical trials: Geriatric Individuals
Aging, Endothelial Dysfunction
COMP-4 Supplementation and Brachial Artery FMD
In a young and healthy person, the production of nitric oxide (NO) by the endothelium, the inner lining of the blood vessel, is responsible for a) the ability of the blood vessel to dilate so it can increase its blood flow and b)…
- Conditions
- Aging, Endothelial Dysfunction, Senescence
- Trial name
- NCT05595915
- Testing
- COMP-4
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Streptococcus Pneumoniae Infection
Clinical Trial of the 24-valent Pneumococcal Polysaccharide Conjugate Vaccine (CRM197/Tetanus Toxoid)
This clinical trial consists of Phase I and Phase II. The objective is to evaluate the safety and immunogenicity of the 24-valent pneumococcal polysaccharide conjugate vaccine (CRM197/tetanus toxoid) in individuals aged 2 months…
- Trial name
- NCT07600983
- Testing
- 24-valent pneumococcal polysaccharide conjugate vaccine (CRM197/tetanus toxoid) (referred to as PCV24) (dose M), PCV24 vaccine (dose H), PCV24 vaccine (dose M)
- Where
- 2 sites in China
- Volunteers
- 854 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
Influenza
A Clinical Trial of Influenza Virus Split Vaccine for Individuals Aged 60 Years and Above
This is a randomized, blinded, controlled phase I clinical trial with a total of 120 participants aged ≥ 60 years. Experimental group: Influenza virus split vaccine (0.7mL/vial), control group 1: Influenza virus split vaccine…
- Trial name
- NCT07302256
- Testing
- Influenza virus split vaccine (0.7mL/vial), Influenza virus split vaccine, Phosphate buffer solution (PBS)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute Of Biological Products
Sedentary Behavior
Effect of Cocoa Supplementation and Aerobic Exercise on Pressure Parameters
This study evaluates the cocoa supplementation and aerobic exercise on central pressure and arterial stiffness parameters in physically inactive middle-aged individuals. 500mg capsules will be offered to all patients.
- Trial name
- NCT04732754
- Testing
- Aerobic exercise + Theobroma cocoa (AETC), Control Group (CG), Aerobic Exercise (AE)
- Where
- Brazil
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
COVID-19
Immunogenicity and Safety Study of Adjuvanted SARS-CoV-2 (SCB-2019) Vaccine in Adultsin China
The purpose of this clinical study, CLO-SCB-2019-010, is to assess the immunogenicity, reactogenicity and safety of the SCB-2019 vaccine in Chinese participants, and to show the comparability of the immune response versus…
- Trial name
- NCT04954131
- Testing
- Candidate Vaccine, SCB-2019
- Where
- 2 sites in China
- Volunteers
- 766 people, healthy volunteers welcome
- Sponsor
- Zhejiang Clover Biopharmaceuticals, Inc.
Pneumococcal Diseases
A Phase I Clinical Study to Evaluate the Safety of PCV26 in Individuals ≥60
This Phase I, randomized, double-blind, parallel-controlled study is to be conducted in healthy adults aged 60 and above. Participants will be randomly assigned in a 1:1 ratio to receive either 26-valent Pneumococcal Conjugate…
- Trial name
- NCT06970756
- Testing
- 26-valent Pneumococcal Conjugate Vaccine, 13-valent Pneumococcal Conjugate Vaccine
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd
Physical Performance, Quality of Life, and Mental Health in Older Adults
Comparison of Physical Performance, Quality of Life and Mental Health in Hiking and Sedentary Geriatric Individuals
This observational study aims to compare physical performance, quality of life, and mental health levels between older adults who participate in hiking at least once a week for at least 6 months and sedentary older adults.
- Trial name
- NCT07867756
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Halic University
Sarcopenia
Assessment of the Intervention Effectiveness of Branched-chain Amino Acids(BCAA) Combined With Medium-chain Fatty Acid(MCFA) Products in Sarcopenia Among Middle-aged and Elderly Individuals
Taiwan entered an aging society in 2018 and is expected to transition into a super-aged society by 2025. With the increasing elderly population, age-related diseases pose urgent challenges to modern society.
- Trial name
- NCT06376266
- Testing
- nutritional supplements
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Influenza
A Clinical Trial of Quadrivalent Influenza Virus Split Vaccine (MDCK Cells) for Individuals Aged 6 Months and Above.
To evaluate the safety of administering 1 or 2 doses of the quadrivalent influenza virus split vaccine (MDCK cells) (0.5ml/dose) in individuals aged 6 months and above.
- Trial name
- NCT06342349
- Testing
- Quadrivalent influenza virus split vaccine (MDCK cells), Quadrivalent influenza virus split vaccine (Chicken embryo), Phosphate buffer solution
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute Of Biological Products
Healthy Elderly Individuals With High LDL-cholesterol or Risk of Cardiovascular Disease
Low- and Moderate-intensity Statin and Clinical Outcome of Primary Prevention in Individuals Aged >70 Years: the SCOPE-70 RCT Study
One of the most effective drug in the primary prevention of cardiovascular disease is statins. The protective effects of statin on developement of cardiovascular disease has been demonstrated in elderly individuals.
- Trial name
- NCT03770312
- Testing
- Low intensity statin, Moderate intensity statin
- Where
- South Korea
- Volunteers
- 724 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Healthy, Mild Cognitive Impairment
Supporting Episodic Memory With Transcranial Direct Current Stimulation in Healthy Controls and Dementia Patients
Previous studies showed that anodal tDCS applied over the dorsolateral prefrontal cortex (DLPFC) improved episodic memory performance, indicating a possible use as an intervention for patients suffering from memory impairments.
- Conditions
- Healthy, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03227185
- Testing
- real anodal transcranial direct current stimulation (tDCS)
- Where
- Switzerland
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Bern
Cognitive Change, Cytokine Levels
The Effect of Oral Use of Lyophilised Royal Jelly on Cognitive Functions and Immune System in Elderly Individuals
Dementia is a significant public health problem, affecting 47 million people worldwide in 2015, according to World Health Organization data. It is expected to increase to 75 million in 2030 and reach 132 million in 2050.
- Conditions
- Cognitive Change, Cytokine Levels, Neuroinflammation
- Trial name
- NCT06404203
- Testing
- Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 500 mg/day, Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 1000 mg/day, Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 1500 mg/day
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medipol University
Geriatric İndividual Health
Group-based and Dual-task Focused Otago Exercises in Geriatric Individuals With Kinesiophobia
The aim of our study was to investigate the effects of group-based and dual-task focused otago exercises on kinesiophobia, musculoskeletal system and psychosocial status in geriatric individuals with kinesiophobia.
- Trial name
- NCT06577740
- Testing
- Otago Exercise, Dual Task Focused Otago Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Exercise Training, Blood Flow Restriction Training
Blood Flow Rextriction Training in Upper Extremity of Elderly
Our study aims to decrease independence by increasing upper extremity strength and performance by applying blood flow restrictive training, which has entered the literature as a new method, to the upper extremity in the elderly.
- Conditions
- Exercise Training, Blood Flow Restriction Training, Geriatrics
- Trial name
- NCT05803733
- Testing
- Blood flow restriction (BFR) with low load resistance training, Routine strength training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Aging, Cardiovascular Health Status
Effects of Resistance Training and Supplementation in Elderly: Cardiorespiratory and Metabolic Variables
Aging causes losses in strength, lean mass, and cardiovascular health in the elderly due to metabolic changes and alterations in body composition.
- Conditions
- Aging, Cardiovascular Health Status, Physical Training, Nutritional Interventions
- Trial name
- NCT06682221
- Testing
- Whey protein supplementation., Resistance training, Group Control
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Healthy
Isometric Exercises in Healthy Elderly Individuals
A total of 58 participants were selected and divided into two groups equally, namely, elderly, and young groups with the age groups of 60-80 years and 20-30 years, respectively.
- Trial name
- NCT04932733
- Testing
- Exercises, Young isometric exercise
- Where
- Jordan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Salameh Aldaja
Elderly Immune Senescence
Pilot Study to Evaluate Immunopotentiating Effects of Immulina in Elderly Individuals
This will be a small study aimed at determining the effects of oral Immulina consumption on the immune system in elderly individuals.
- Trial name
- NCT01784692
- Testing
- Immulina
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Influenza
Phase Ⅱ Clinical Trial of Influenza Virus Split Vaccine for Individuals Aged 60 Years and Above
To evaluate the immunogenicity of administering one dose of influenza virus split vaccine (0.7mL/dose) to individuals aged 60 and above.
- Trial name
- NCT07327398
- Testing
- Influenza virus split vaccine (0.7mL/vial), Influenza virus split vaccine
- Where
- 2 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute Of Biological Products
Diphtheria, Pertussis
A Phase I/II Clinical Trial of the Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine Adsorbed
This is a randomized, positive-controlled phase I/II clinical trial to evaluate the safety and preliminary immunogenicity of the Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine…
- Conditions
- Diphtheria, Pertussis, Tetanus, Poliomyelitis
- Trial name
- NCT07891104
- Testing
- Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine Adsorbed, Diphtheria, Tetanus and Acellular Component Pertussis Combined Vaccine, Diphtheria, Tetanus and Acellular Component Pertussis Combined Vaccine+Inactivated Poliomyelitis Vaccine Made From Sabin Strains
- Where
- 3 sites in China
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
Alzheimer's Disease (AD)
Cognitive-motor Intervention Using Virtual Reality for Middle-aged Individuals at High Dementia Risk
The primary objective of this program is to apply a virtual reality (VR) cognitive-motor intervention (compared to active and passive control groups) to delay or slow cognitive decline of middle-aged adults who have a family…
- Trial name
- NCT02832921
- Testing
- cognitive training by virtual reality, watching a scientific TV documentary, treadmill
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center