Clinical trials: Geriatric Syndromes
Metabolic Syndrome, Aging
Sustainable Exercise and Nutrition Programs for Managing Metabolic Disorders in Older Women
This study aims to evaluate the impact of sustainable diet and exercise programs on metabolic health and quality of life in older women.
- Conditions
- Metabolic Syndrome, Aging, Sarcopenia, Obesity
- Trial name
- NCT07015307
- Testing
- Sustainable Diet Program, Supervised Physical Exercise Program, Combined Sustainable Diet and Exercise Program
- Where
- Spain
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Alicante
The Critically Ill Patient is Requiring Intubation, Septic Shock
Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation
The study is a prospective randomized controlled trial comparing the efficacy and safety of propofol-ketamine ("Ketofol") versus propofol monotherapy in geriatric ICU patients.
- Conditions
- The Critically Ill Patient is Requiring Intubation, Septic Shock, Pneumonia
- Trial name
- NCT07530146
- Testing
- Ketofol, propofol (drug)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Helwan University
Frailty in Adult Surgery, Frail Elderly Syndrome
Patient's Database: Prepare for Your Surgery Program
Frailty is a multidimensional syndrome that predominantly affects older people and people with long-term treatments such as cancer and chronic pain.
- Conditions
- Frailty in Adult Surgery, Frail Elderly Syndrome, Database, Perioperative Care
- Trial name
- NCT06857981
- Testing
- Clinical data collection
- Where
- 2 sites in Chile
- Volunteers
- 120 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Basophilic Leukemia
Tipifarnib in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
Tipifarnib may stop the growth of cancer cells by blocking the enzymes necessary for their growth. Phase II trial to study the effectiveness of tipifarnib in treating older patients who have previously untreated acute myeloid…
- Conditions
- Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Erythroid Leukemia (M6)
- Trial name
- NCT00027872
- Testing
- tipifarnib, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- National Cancer Institute (NCI)
Frailty Syndrome, Fall in Nursing Home
Digital Intelligent Assistant for Nursing Application
This is an observational study that intends to compare falls or fall-risk related alarms derived from a three-dimensional sensor system with the clinical reality definded by attending nurses.
- Conditions
- Frailty Syndrome, Fall in Nursing Home, Dementia, Delirium in Old Age
- Trial name
- DIANA (NCT04393272)
- Testing
- Three dimensional sensor system designed for fall detection (Fearless)
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- Geriatrische Klinik St. Gallen
Malnutrition, Sarcopenia
Post - Hospital Syndrome: Profile of Functional Status by Malnutrition
Malnutrition is common problem in hospitalized geriatrics at discharge. Malnutrition is a high risk for functional limitations, impaired muscle strength and reduced quality of life.
- Trial name
- NCT03126500
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Eating Disorder
Reducing Eating Disorder Risk Factors Among College-Aged Males
The purpose of the present study was to investigate the acceptability and efficacy of a cognitive dissonance-based (DB) intervention in reducing eating disorder and muscle dysmorphia risk factors in men with body dissatisfaction.
- Trial name
- NCT03013244
- Testing
- The Body Project: More Than Muscles
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Florida State University
Frail Elderly Syndrome
Effects of WBV Associated With IMT on Inflammatory Markers, Body Composition, Muscle Strength and Thickness
Aging generates immune, muscular and functional changes. In the pre-frail elderly these changes may be increased and, therefore, preventive interventions are indicated to minimize the consequences of sarcopenia in this…
- Trial name
- NCT03689322
- Testing
- WBV + IMT
- Where
- Brazil
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
HIV Infections, Drug Interactions
Drug-drug Interactions Between Antiretroviral Drugs and Cardiovascular Drugs in Elderly Patients
Ageing is characterized by physiological changes, which can impact drug pharmacokinetics and thereby cause drug-drug interactions.
- Conditions
- HIV Infections, Drug Interactions, Cardiovascular Diseases
- Trial name
- NCT03515772
- Testing
- Co-administration of darunavir with a cardiovascular drug
- Where
- 2 sites in Switzerland
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Frail Elderly Syndrome, Sarcopenia
Physical Fitness, Body Composition and Frailty in Elderly People.Exercise Program Effecsts. EXERNET Elder 3.0
One of the major changes occurring in developed societies is a significant ageing of the population. Nowadays, because of an enhanced life expectancy, 17% of the Spanish population is composed of people over 65 and the number is…
- Conditions
- Frail Elderly Syndrome, Sarcopenia, Physical Activity
- Trial name
- EXERNETElder (NCT03831841)
- Testing
- Multicomponent exercise programe
- Where
- Spain
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Dyspnea, Respiratory Distress Syndrome
LUng and Cardiac Ultrasound for REspiratory Distress in ElDerly
Prospective trial to evaluate the impact on the initial therapeutic inadequacy of a management strategy for acute dyspnea in the elderly based on the use of lung and cardiac ultrasonography.
- Trial name
- LUCREED (NCT06807983)
- Testing
- diagnostic strategy based on lung and cardiac ultrasonography
- Where
- France
- Volunteers
- 504 people
- Sponsor
- University Hospital, Toulouse
Myasthenia Gravis
A Study of Nipocalimab in Children Aged 2 to Less Than 18 Years With Generalized Myasthenia Gravis
The purpose of this study is to determine the effect of nipocalimab on total serum immunoglobulin G (IgG) in pediatric participants 2 to less than (<) 18 years of age (globally) and 8 to <18 years of age (for Unites Stated (US)…
- Trial name
- NCT05265273
- Testing
- Nipocalimab
- Where
- 19 sites in United States, Japan and 2 more
- Volunteers
- 12 people
- Sponsor
- Janssen Research & Development, LLC
Heart Failure, Prefrail Elderly
High-technology TeleRehabilitation for the Treatment of the FRAgile Patient
The aim of this randomized controlled clinical trial is to evaluate the efficacy of an 8-week sensorimotor and cognitive telerehabilitation program in frail and pre-frail older adults with stable chronic heart failure.
- Conditions
- Heart Failure, Prefrail Elderly, Frail Elderly Syndrome
- Trial name
- TeleRiab4Fra (NCT07561021)
- Testing
- Telerehabilitation, Caregiver-Supervised Home Exercise Program
- Volunteers
- 70 people
- Sponsor
- University of Salerno
Vasculitis, Wegener's Granulomatosis
Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years
The aim of this trial is to lower the morbidity rate in elderly patients affected with systemic necrotizing vasculitides, by reducing mortality and improving global outcome.
- Conditions
- Vasculitis, Wegener's Granulomatosis, Microscopic Polyangiitis, Churg-Strauss Syndrome
- Trial name
- CORTAGE (NCT00307671)
- Testing
- prednisone, methylprednisolone,cyclophosphamides, Cyclophosphamide, Azathioprine,prednisone,methylprednisolone, Mycophenolate mofetil,methotrexate
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metabolic Syndrome
Effect of Aged Garlic Extract on Atherosclerosis
The investigators will be assessing the effect of Aged Garlic Extract on the coronary arteries. The investigators will enroll patients in a double blind study, where half the patients will receive placebo, and have the patients…
- Trial name
- Garlic4 (NCT01534910)
- Testing
- aged garlic extract
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Frail Elderly Syndrome
Frailty and Surgery
Frailty has been recently re-defined as a condition that is evident over time through an excess of vulnerability to stressors, with reduced ability to maintain or regain homeostasis after a destabilizing event, and occurrence of…
- Trial name
- NCT05594277
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Heart Failure With Preserved Ejection Fraction, Sarcopenia
Effectiveness of a Cardiac Rehabilitation Program in Elderly Patients With Heart Failure.
The main objective of the study is to assess the effectiveness of a cardiac rehabilitation program on functionality, measured by kinematic analysis, cardiorespiratory capacity, and ventricular ejection fraction in elderly…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Sarcopenia, Frail Elderly Syndrome, Comorbidities and Coexisting Conditions
- Trial name
- FUNNEL+ (NCT05393362)
- Testing
- Cardiac Rehabilitation Program (CR), Control Group (CG)
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- University of Malaga
The Frailty Syndrome
Ghrelin Dose Finding In Frail Elderly
Frailty is a geriatric syndrome leading to physical deterioration including muscle wasting (sarcopenia) and unintentional weight loss. There are currently no approved therapies for frailty.
- Trial name
- NCT01605435
- Testing
- Ghrelin Group 1, Ghrelin Group 2
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Acute Myelogenous Leukemia, Myelodysplastic Syndromes
Clofarabine and Ara-C for the Treatment of Relapsed AML and Untreated MDS
The purpose of this trial is to to determine the safety and effectiveness of therapeutic combination - Clofarabine and Cytarabine for the treatment of AML and MDS.
- Conditions
- Acute Myelogenous Leukemia, Myelodysplastic Syndromes, Chronic Myelogenous Leukemia
- Trial name
- NCT00334074
- Testing
- Clofarabine and Cytarabine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute
Short Bowel Syndrome
Study in Japanese Pediatric Subjects With Short Bowel Syndrome (SBS) Who Are Dependent on Parenteral Support
The purpose of this study is to determine if an investigational treatment (teduglutide) is safe and effective in Japanese children (age 4 months through 15 years of age) with SBS who are dependent on parenteral support.
- Trial name
- NCT02980666
- Testing
- Teduglutide
- Where
- 5 sites in Japan
- Volunteers
- 10 people
- Sponsor
- Shire