Clinical trials: Ghrelin
Obesity, Bariatric Surgery Candidate
Investigating the Role of Ghrelin in Regulating Appetite and Energy Intake in Patients Following Bariatric Surgery (BARI-INSIGHT)
Bariatric surgery helps patients with severe obesity to lose weight, cures and prevents diseases linked to obesity and reduces the risk of death.
- Conditions
- Obesity, Bariatric Surgery Candidate, Appetitive Behavior
- Trial name
- BARI-INSIGHT (NCT03641417)
- Testing
- GLWL-01
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- University College, London
Anorexia Nervosa, Adipokines
Adipokines and Ghrelin Concentrations in Different Stages of Anorexia Nervosa
The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric…
- Trial name
- NCT00602264
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Diabetes
Ghrelin Effect on Beta Cell Function in Health and Disease
To determine the role of nutrient status on ghrelin regulation of insulin secretion. We hypothesize that ghrelin and glucagon-like peptide-1 (GLP-1)(both are hormones made in the gut,) have differential effects on β-cell function…
- Trial name
- NCT01729299
- Testing
- Exendin (9-39), acyl ghrelin, saline
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- David Dalessio
fMRI, Alcohol Drinking
Ghrelin for Alcohol Use in Non-Treatment-Seeking Heavy Drinkers
Background: Ghrelin is a hormone in the human body that is mostly produced by the stomach. It makes people feel hungry, and also is connected with the desire to drink alcohol.
- Conditions
- fMRI, Alcohol Drinking, Alcoholism
- Trial name
- NCT01779024
- Testing
- Ghrelin, fMRI, Alcohol
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Obesity, Childhood, Eating Behavior
Interoception and Eating Behaviors in Children
The purpose of this study is to examine how individual differences in interoception (the ability to sense, interpret, and act on bodily feelings like hunger, fullness, thirst, hot, cold, etc.) relate to eating behaviors in…
- Trial name
- I-EAT (NCT06504654)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Penn State University
Obesity, Overweight
Effect of Food Temperature and Diet Composition on Satiety, Satiety Hormones, Chewing Time and Neuronal Activity
Obesity and its related illnesses have become serious health issues, obesity is today the fifth most common cause of death. Obesity rate has dramatically enhanced in both male and female, and across all ages.
- Trial name
- NCT05822167
- Testing
- High Protein Meal at Cold Temperature, High Protein Meal at Warm Temperarute, High Protein Meal at Hot Temperature
- Where
- Pakistan
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Weight Loss, Adolescent Obesity
The Effect High Protein-Fiber Diet With Exercise on Acylated Ghrelin and Leptin in Obese Adolescents
Obesity has been reported to impair regulation of appetite and lead uncontrollably hunger and satiety response. Ghrelin is orexigenic hormone from the stomach meanwhile, leptin is anorexigenic from adipose.
- Trial name
- NCT04377906
- Testing
- Modification Lifesyle
- Where
- Indonesia
- Volunteers
- 56 people
- Sponsor
- Universitas Diponegoro
Healthy
Brain Natriuretic Peptide Effects on Appetite Regulating Hormones and Endothelial Derived Peptides
Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic peptide (BNP) from the ventricular myocytes.
- Trial name
- BNP/Appetite (NCT01375153)
- Testing
- BNP, 0.9% NaCl
- Where
- 2 sites in Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Insulin Resistance, Type2 Diabetes Mellitus
High-fat Overfeeding, Hepatokines and Appetite Regulation
The present study will investigate the effect of high-fat overfeeding on a group of liver-secreted proteins linked to worsened blood sugar control, as well as proteins involved in appetite control.
- Conditions
- Insulin Resistance, Type2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, Obesity
- Trial name
- OVEREAT (NCT03369145)
- Testing
- High-fat diet
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Aging, Appetite Loss
Effect of a Novel Protein Supplement on Appetite in Older Adults
An acute randomized crossover trial comparing the effects of the whey hydrolysate, whey protein concentrate and placebo (still flavored water) on appetite and energy intake in older adults.
- Trial name
- NCT05871060
- Testing
- Whey Protein Concentrate, Whey hydrolysate
- Where
- Ireland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Obesity, Weight Loss
Bariatric Embolization of Arteries for the Treatment of Nonalcoholic Steatohepatitis
Obesity is an epidemic in the US. With progression of obesity, Nonalcoholic steatohepatitis (NASH) has been a growing public health issue.
- Conditions
- Obesity, Weight Loss, Body Weight, Nonalcoholic Steatohepatitis
- Trial name
- NCT02933554
- Testing
- Embospheres Microspheres
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Keith Pereira, MD:
Endocrine System Diseases
Gastric and Intestinal Satiation in Obese and Normal Weight Healthy People
The purpose of this study is to determine the reciprocal control between gastric functions and intestinal parameters in the development of satiation in obese people.
- Trial name
- NCT01456572
- Testing
- ensure plus, standardized test meal
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Gestational Diabetes Mellitus (GDM)
Gestational Diabetes and Human Milk Composition Study
This study aims to compare hormone levels and milk composition in women with and without gestational diabetes through postpartum human milk and blood samples.
- Trial name
- NCT07051681
- Testing
- Individualized Medical Nutrition Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Marmara University
Type 2 Diabetes
Preprandial Ghrelin Effect
Background and Significance: The peptide hormone ghrelin drives hunger and feeding behavior, making it a focus of obesity research.
- Trial name
- NCT02913703
- Testing
- Ghrelin, Saline
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jenny Tong, MD, MPH
Breast Cancer Survivors
Effects of Green Coffee Extract Supplementation on Leptin, Ghrelin, Adiponectin,Anthropometric Measurements, Lipid Profile in Breast Cancer Survivors
To study the effects of green coffee supplement on leptin, adiponectin, ghrelin, anthropometric measurements, lipid profile in breast cancer survivors.50 breast cancer survivors who their treatment is over and referred to follow…
- Trial name
- NCT03394690
- Testing
- green coffee, control
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- National Nutrition and Food Technology Institute
Arterial Embolization, Other Surgical Procedures
Gastric Artery Embolization Trial for Lessening Appetite Nonsurgically
The purpose of this pilot study is to achieve the collection of safety and efficacy data in patients undergoing left gastric artery embolization for morbid obesity in the United States.
- Conditions
- Arterial Embolization, Other Surgical Procedures, Obesity
- Trial name
- GETLEAN (NCT02248688)
- Testing
- BeadBlock 300 - 500 Micron, Left Gastric Artery Embolization
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Dayton Interventional Radiology
Appetitive Behavior
Effect of Oral Lactate Ingestion on Appetite Regulation
The goal if this study is to determine how oral lactate ingestion affects markers of appetite regulation. Researchers will compare oral lactate ingestion to a sodium chloride placebo.
- Trial name
- NCT06379815
- Testing
- Sodium Lactate, Sodium Chloride
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Wilfrid Laurier University
Eating Disorder
Validation of the Concept of the Autoantibodies Directed Against the Neuropeptides Involved in Food Intake Regulation on the Incidental Cases of Eating Disorders
This study should lead to the validation of the concept of the autoAc directed against the neuropeptides involved in food intake regulation.
- Trial name
- EDILS-AutoAC (NCT03510533)
- Testing
- Evaluation of the rates of the autoantibodies directed against the neuropeptides (ghrelin and alpha-MSH) controlling involved in food intake regulation
- Where
- France
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Type 2 Diabetes Mellitus
Ghrelin and Beta Cell Function in Diabetes
Ghrelin is a hormone naturally produced in the stomach and the gut. The purpose of this research study is to determine the role of this gut hormone in the regulation of insulin secretion from the pancreas and glucose disposal…
- Trial name
- NCT02440061
- Testing
- Synthetic human AG, Arginine, 0.9% saline solution
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jenny Tong, MD, MPH
DEMMMI, Nine-Hole-PEG-Test, mRS, Stroke, Acute
Ghrelintrial With Patients With Stroke
Patients are assigned to KSW's Stroke Unit as part of the emergency treatment. There the patients are included in the study and treated according to the concept on the Stroke Unit within the complex treatment.
- Trial name
- NCT03264742
- Testing
- Ghrelin
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- Kantonsspital Winterthur KSW