Clinical trials: Ghrelin
Obesity
Ghrelin Regulation and Structure: Effect of Diet Composition on Ghrelin
The purpose of this study is to learn more about how diet affects the hormone ghrelin. Ghrelin is made in the stomach and causes appetite to increase.
- Trial name
- NCT00694512
- Testing
- Low fat diet, High fat diet, MCT diet
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Protein C Deficiency
Ghrelin Levels in Patients With Protein C Deficiency
In rodents with protein C deficiency elevated levels of ghrelin has been observed. The purpose of this study is to investigate if patients with protein C deficiency also have elevated levels of ghrelin, and if so, how this…
- Trial name
- NCT04180657
- Testing
- Protein C deficiency
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Anemia
Does Increase in Appetite After Iron Treatment Induced by Ghrelin Hormone
The purpose of this study is to examine whether iron therapy in patients with intravenous iron deficiency anemia causes an increase in appetite. And whether this increase is mediated by the hormone ghrelin.
- Trial name
- NCT02734641
- Where
- Israel
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Healthy Subjects
Ghrelin Decreases Insulin Sensitivity
Ghrelin administration increases appetite and, in rodents, induces weight gain. The aim of this study is to investigate the effect of short term ghrelin administration to humans on metabolism.
- Trial name
- NCT00512525
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Polycystic Ovarian Syndrome
The Relationship Between Adipokines, Obesity and Insulin Resistance in Women With Polycystic Ovarian Syndrome
To evaluate possible clinical effects of adipokines , ( ghrelin, resistin and adiponectin), in obese and non-obese patients with polycystic ovary syndrome (PCOS).
- Trial name
- NCT02869750
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Stroke, Ischemic
RCT of Ghrelin in Stroke Patients
About half of the patients with acute ischemic stroke treated with endovascular thrombectomy (EVT) remain dependent on the help of others or die in the first 90 days.
- Trial name
- MR GENTLE (NCT05726240)
- Testing
- Ghrelin
- Where
- 3 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- Rijnstate Hospital
REM Sleep Behavior Disorder, Parkinson s Disease
Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's Disease
This study will test whether taking ginger supplements can increase ghrelin, a hunger hormone that is decreased in the blood of people with Parkinson's disease (PD) and REM Sleep Behaviour disorder (RBD).
- Trial name
- Ginger-PD (NCT07882108)
- Testing
- Ginger
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Hypopituitarism
Ghrelin, Growth Hormone and Cortisol Interaction in Growth Hormone Deficient Patients
In growth hormone deficient patients: Determination of endogenous circulating ghrelin levels, ghrelin effects on insulin sensitivity, appetite, energy metabolism, and signal transduction in fat and muscle.
- Trial name
- NCT00139945
- Testing
- Human acylated ghrelin
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- University of Aarhus
Eating Behavior
Effect of Food Acceptability on Appetite Hormones' Response in Normal Weight vs. Obese Male Subjects
Male subjects with specific body characteristics were recruited for the study. Subjects did an acceptability test on custard and completed a screening questionnaire.
- Trial name
- NCT03779321
- Testing
- Acceptability
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Gastric Cancer Patients Treated by Subtotal Gastrectomy
Obestatin Change in Distal Gastrectomy
According to Seoul cancer registry data (2000), cancer became the leading cause of death in Korea, accounting for 23.9% of all deaths and gastric cancer is the most prevalent malignant neoplasm, comprising 20.8% of all cancers.
- Trial name
- NCT00822718
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Satiety in Healthy Volunteers
Assessment of Satiety Following Oral Administration of an Erythritol Sweetened Beverage
Erythritol is a low calorie sugar substitute that is being increasingly used to sweeten beverages and other food items. Greater amounts of erythritol are required to reach the sweetness level of a common soft drink as compared to…
- Trial name
- NCT02934321
- Testing
- Erythritol, Aspartame
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Florida
Overweight, Obesity
Interactive Effects of an Isocaloric High-protein Diet and Resistance Exercise in Untrained Overweight Young Men
Background: The interactive effects of resistance training and dietary protein on hormonal responses in overweight or obese adults are not clear and remain controversial.
- Trial name
- NCT01714700
- Testing
- High protein diet, Resistance exercise, Standard diet, Resistance exercise
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Obesity
Carbohydrate Intake and Gut Hormone Release During Exercise
It is well known that following a single session of moderate-to-high intensity exercise individuals experience a temporary suppression of hunger and a delay in the commencement of eating.
- Trial name
- NCT04019418
- Testing
- Maltodextrin (carbohydrate), Exercise, Rest
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Bariatric Surgery (Gastric Bypass), Overweight
The Effect of Different Macronutrients on Gastrointestinal Hormone Secretion After Gastric Bypass Operation
The purpose of this study is to determine the type of macronutrient (carbohydrate, lipid or protein) that most potently stimulates the endogen secretion of different gut hormones (primary outcome = Glucagon-Like peptide-1) in…
- Trial name
- NCT02372526
- Testing
- Mealtest: High protein 200 kcal 200 ml liquid meal consumed during 10 minutes, Mealtest: High fat 200 kcal 200 ml liquid meal consumed during 10 minutes, Mealtest: High carbohydrate 200 kcal 200 ml liquid meal consumed during 10 minutes
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Kirstine Nyvold Bojsen-Moeller
PYY, Ghrelin
The Effect of Breakfast With Different Macronutrient Composition on PYY, Ghrelin, GLP-1,Glucose Level, VAS for Hunger, VAS for Satiety and Ad Libitum Intake 4 Hours After Breakfast in Obese Women
Gut hormones, such as PYY and ghrelin, are associated with appetite control and obesity. Protein is thought to be the most satieting nutrient and could affect production of several gut hormones.
- Conditions
- PYY, Ghrelin, Appetite, Gut Hormones
- Trial name
- NCT03697486
- Testing
- diet with different composition
- Where
- Indonesia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Energy Supply; Deficiency, Carbohydrate Availability
Endocrinological and Physiological Responses to Short-term Reduced Carbohydrate Availability in Males
Using a randomised crossover design, nine weight-stable men, aged 18 - 40 years old, will be recruited via convenience sampling from the staff and student body of LJMU and local area.
- Trial name
- NCT05551455
- Testing
- Nutritional/dietary intake manipulation ('Normal'), Nutritional/dietary intake manipulation ('Low')
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Gestational Diabetes Mellitus (GDM)
Gestational Diabetes and Human Milk Composition Study
This study aims to compare hormone levels and milk composition in women with and without gestational diabetes through postpartum human milk and blood samples.
- Trial name
- NCT07051681
- Testing
- Individualized Medical Nutrition Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Marmara University
Polyuria-polydipsia Syndrome
Copeptin After an Oral Stimulation With Macimorelin in Healthy Volunteers
This study investigates stimulation of the posterior pituitary gland by oral Macimorelin (a ghrelin receptor Agonist) to be a novel diagnostic test in the polyuria-polydipsia syndrome.
- Trial name
- Macicop (NCT03844217)
- Testing
- Macimorelin 0.5mg/kg body weight, Macimorelin 0.75mg/kg body weight
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Major Depressive Disorder
Effects of Ghrelin Administration on Motivation
Everyday humans are confronted with a plethora of rewards competing for their attention. Nevertheless, to obtain a goal or reward, humans often need to invest effort.
- Trial name
- NCT06576440
- Testing
- Ghrelin, Saline
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Obesity, Insulin Resistance
Ghrelin Changes After Roux-en-Y Gastric Bypass
The purpose of this study is to determine whether gastric division (via Roux-en-Y gastric bypass) with resultant fundic isolation will alter the pattern(s) of Ghrelin secretion in the early post-operative period following feeding…
- Trial name
- NCT00765596
- Testing
- Liquid diet for 3 days
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Vanderbilt University